GB2047244B - 4-amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds - Google Patents

4-amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds

Info

Publication number
GB2047244B
GB2047244B GB8009991A GB8009991A GB2047244B GB 2047244 B GB2047244 B GB 2047244B GB 8009991 A GB8009991 A GB 8009991A GB 8009991 A GB8009991 A GB 8009991A GB 2047244 B GB2047244 B GB 2047244B
Authority
GB
United Kingdom
Prior art keywords
antisecretory
esters
amino
quinolinecarboxylic acids
ulcer compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8009991A
Other versions
GB2047244A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of GB2047244A publication Critical patent/GB2047244A/en
Application granted granted Critical
Publication of GB2047244B publication Critical patent/GB2047244B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB8009991A 1979-03-26 1980-03-25 4-amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds Expired GB2047244B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2398179A 1979-03-26 1979-03-26
US06/127,153 US4343804A (en) 1979-03-26 1980-03-04 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds

Publications (2)

Publication Number Publication Date
GB2047244A GB2047244A (en) 1980-11-26
GB2047244B true GB2047244B (en) 1983-02-23

Family

ID=26697875

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8009991A Expired GB2047244B (en) 1979-03-26 1980-03-25 4-amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds

Country Status (31)

Country Link
US (1) US4343804A (en)
JP (1) JPH02117663A (en)
AR (1) AR230268A1 (en)
AT (1) AT372373B (en)
AU (1) AU528388B2 (en)
BR (1) BR8001779A (en)
CA (1) CA1147338A (en)
CH (1) CH644105A5 (en)
DE (1) DE3011490A1 (en)
DK (1) DK156056C (en)
EG (1) EG15009A (en)
ES (1) ES489887A0 (en)
FI (1) FI77452C (en)
FR (1) FR2452485B1 (en)
GB (1) GB2047244B (en)
GR (1) GR68006B (en)
HK (1) HK67983A (en)
IE (1) IE49577B1 (en)
IL (1) IL59628A (en)
IN (1) IN151446B (en)
IT (1) IT1133079B (en)
MX (1) MX6264E (en)
NL (1) NL8001752A (en)
NO (1) NO153927C (en)
NZ (1) NZ193252A (en)
PH (1) PH16416A (en)
PL (1) PL125030B1 (en)
PT (1) PT71008B (en)
SE (1) SE435837B (en)
SG (1) SG33683G (en)
YU (1) YU41702B (en)

Families Citing this family (42)

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GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5432182A (en) * 1989-02-23 1995-07-11 Smithkline Beecham Intercredit B.V. Compounds substituted quinoline derivatives
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
DE3917233A1 (en) * 1989-05-26 1990-11-29 Basf Ag 8-SUBSTITUTED 4- (HETEROCYCLYLMETHYLAMINO) -INCHINOLINES, THEIR USE AND DRUGS DERIVED THEREFROM
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (en) * 1993-06-11 1994-12-12 Ab Astra Compounds that inhibit gastric acid flow
CA2167154A1 (en) * 1993-08-10 1995-02-16 Sarkis Barret Kalindjian Gastrin and cck receptor ligands
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
KR0169813B1 (en) * 1995-07-12 1999-01-15 김종인 4-amino-3-acylnaphthyridine derivatives
US5760041A (en) * 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
US6875769B2 (en) * 1996-05-23 2005-04-05 Pfizer Inc. Substituted6,6-hetero-bicyclicderivatives
US5929080A (en) * 1997-05-06 1999-07-27 American Cyanamid Company Method of treating polycystic kidney disease
US6251912B1 (en) 1997-08-01 2001-06-26 American Cyanamid Company Substituted quinazoline derivatives
US6323209B1 (en) 1997-11-06 2001-11-27 American Cyanamid Company Method of treating or inhibiting colonic polyps
BR9914164A (en) 1998-09-29 2001-06-26 American Cyanamid Co Compound, method for treating, inhibiting the growth of, or eradicating a neoplasm, and polycystic kidney disease, in a mammal in need thereof, pharmaceutical composition, and, process for preparing a compound
MXPA02006474A (en) * 1999-12-28 2002-11-29 Eisai Co Ltd Heterocyclic compounds having sulfonamide groups.
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
US6576644B2 (en) * 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
UA80393C2 (en) 2000-12-07 2007-09-25 Алтана Фарма Аг Pharmaceutical preparation comprising an pde inhibitor dispersed on a matrix
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US8293751B2 (en) 2003-01-14 2012-10-23 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
ME00524B (en) 2003-03-10 2011-10-10 Astrazeneca Ab Novel process for the preparation of roflumilast
WO2005007658A2 (en) * 2003-07-14 2005-01-27 Arena Pharmaceuticals, Inc. Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
CA2601250C (en) * 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
WO2011022216A1 (en) * 2009-08-17 2011-02-24 High Point Pharmaceuticals, Llc Substituted pyridine derivatives, pharmaceutical compositions, and methods of use to treat oxidative stress
EP3378854B1 (en) 2010-01-27 2022-12-21 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
BR112013008100A2 (en) 2010-09-22 2016-08-09 Arena Pharm Inc "gpr19 receptor modulators and the treatment of disorders related thereto."
CN116850181A (en) 2015-01-06 2023-10-10 艾尼纳制药公司 Treatment and S1P 1 Methods of receptor-related disorders
MX2017016530A (en) 2015-06-22 2018-03-12 Arena Pharm Inc Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluo romethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)a cetic acid(compound1) for use in sipi receptor-associated disorders.
ES2884073T3 (en) * 2016-11-11 2021-12-10 Bayer Animal Health Gmbh New anthelmintic derivatives of quinoline-3-carboxamide
CN110520124A (en) 2017-02-16 2019-11-29 艾尼纳制药公司 For treating the Compounds and methods for of primary biliary cholangitis
EP3700527A4 (en) * 2017-10-25 2021-03-10 Children's Medical Center Corporation Papd5 inhibitors and methods of use thereof
WO2019215182A1 (en) 2018-05-09 2019-11-14 Bayer Animal Health Gmbh New quinoline derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
JPS4838712A (en) * 1971-09-18 1973-06-07

Also Published As

Publication number Publication date
IE800605L (en) 1980-09-26
NO153927C (en) 1986-06-18
CA1147338A (en) 1983-05-31
SE8002292L (en) 1980-09-27
IT1133079B (en) 1986-07-09
EG15009A (en) 1985-03-31
PH16416A (en) 1983-09-29
SG33683G (en) 1985-03-29
DK156056C (en) 1989-11-06
SE435837B (en) 1984-10-22
PL222993A1 (en) 1981-01-30
PT71008A (en) 1980-04-01
GR68006B (en) 1981-10-26
IT8067465A0 (en) 1980-03-26
FI77452B (en) 1988-11-30
ATA156480A (en) 1983-02-15
PT71008B (en) 1981-06-25
AT372373B (en) 1983-09-26
IE49577B1 (en) 1985-10-30
DE3011490A1 (en) 1981-03-12
MX6264E (en) 1985-02-19
BR8001779A (en) 1980-11-18
DE3011490C2 (en) 1988-12-22
NO800858L (en) 1980-09-29
CH644105A5 (en) 1984-07-13
AU5684880A (en) 1980-10-02
JPH02117663A (en) 1990-05-02
FI800910A (en) 1980-09-27
DK128380A (en) 1980-09-27
AU528388B2 (en) 1983-04-28
US4343804A (en) 1982-08-10
YU84480A (en) 1983-10-31
NL8001752A (en) 1980-09-30
NZ193252A (en) 1984-04-27
FR2452485A1 (en) 1980-10-24
IN151446B (en) 1983-04-23
FI77452C (en) 1989-03-10
PL125030B1 (en) 1983-03-31
NO153927B (en) 1986-03-10
AR230268A1 (en) 1984-03-01
ES8103048A1 (en) 1981-02-16
GB2047244A (en) 1980-11-26
YU41702B (en) 1987-12-31
HK67983A (en) 1983-12-23
IL59628A (en) 1983-06-15
FR2452485B1 (en) 1986-09-12
IL59628A0 (en) 1980-06-30
ES489887A0 (en) 1981-02-16
DK156056B (en) 1989-06-19

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee