PE33795A1 - Procedimiento en una etapa para la fabricacion de derivados de acido 3-quinoloncarboxilico - Google Patents

Procedimiento en una etapa para la fabricacion de derivados de acido 3-quinoloncarboxilico

Info

Publication number
PE33795A1
PE33795A1 PE1994256625A PE25662594A PE33795A1 PE 33795 A1 PE33795 A1 PE 33795A1 PE 1994256625 A PE1994256625 A PE 1994256625A PE 25662594 A PE25662594 A PE 25662594A PE 33795 A1 PE33795 A1 PE 33795A1
Authority
PE
Peru
Prior art keywords
formula
chinoloncarboxylic
manufacture
acid derivatives
coor
Prior art date
Application number
PE1994256625A
Other languages
English (en)
Inventor
Rudolf Zerbes
Herbert Diehl
Paul Naab
Gerhard Franckowiak
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE33795A1 publication Critical patent/PE33795A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Photolithography (AREA)

Abstract

CARACTERIZADO POR COMPRENDER: 1) HACER REACCIONAR UN HALOGENURO DE ACIDO DE FORMULA XXVI DONDE HAL, X2 Y X3 SON F o Cl, CON: A) UN ESTER DE ACIDO DIMETILAMINOACRILICO DE FORMULA (CH3)2N-CH=CH-COOR, SEGUIDA POR LA ADICION DE UNA AMINA R1-NH2; o B) UN AMINOACRILESTER DE FORMULA R1NH-CH=CH-COOR; SIENDO R METILO, ETILO O PROPILO; 2) CALENTAR (1) A UNA TEMPERATURA DE 60°C A 100°C, EN UN DISOLVENTE COMO N-METILPIRROLIDONA CON UNA BASE AUXILIAR COMO CARBONATO DE POTASIO, FORMANDOSE UN CICLO NITROGENADO; 3) HACER REACCIONAR (2) CON UN COMPUESTO HETEROCICLICO R`R"N, FORMANDOSE UN COMPUESTO DE FORMULA I DONDE: R'R" JUNTO CON N FORMAN UN HETEROCICLO MONO O BICICLICO; A ES CH, CF, CCl, C-OCH3, C-CH3; X1 ES H, HALOGENO, NH2, CH3; R1 ES ALQUILO C1-C3, FCH2CH2-, CICLOPROPILO QUE PUEDE ESTAR SUSTITUIDO POR UNO A TRES HALOGENOS; EL CUAL ES UTIL COMO ANTIBACTERIANO
PE1994256625A 1993-12-10 1994-12-07 Procedimiento en una etapa para la fabricacion de derivados de acido 3-quinoloncarboxilico PE33795A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4342186A DE4342186A1 (de) 1993-12-10 1993-12-10 Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten

Publications (1)

Publication Number Publication Date
PE33795A1 true PE33795A1 (es) 1995-12-15

Family

ID=6504693

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994256625A PE33795A1 (es) 1993-12-10 1994-12-07 Procedimiento en una etapa para la fabricacion de derivados de acido 3-quinoloncarboxilico

Country Status (35)

Country Link
US (1) US5639886A (es)
EP (1) EP0657448B1 (es)
JP (1) JP3963490B2 (es)
KR (1) KR950018008A (es)
CN (1) CN1109877A (es)
AT (1) ATE163645T1 (es)
AU (1) AU693818B2 (es)
BG (1) BG61947B1 (es)
CA (1) CA2137523C (es)
CO (1) CO4180607A1 (es)
CZ (1) CZ288078B6 (es)
DE (2) DE4342186A1 (es)
DK (1) DK0657448T3 (es)
EE (1) EE03215B1 (es)
ES (1) ES2113040T3 (es)
FI (1) FI945776A (es)
GR (1) GR3026383T3 (es)
HR (1) HRP940950B1 (es)
HU (1) HU220597B1 (es)
IL (1) IL111921A (es)
LV (1) LV11470B (es)
MY (1) MY113302A (es)
NO (1) NO307180B1 (es)
NZ (1) NZ270086A (es)
PE (1) PE33795A1 (es)
PL (1) PL180022B1 (es)
RO (1) RO113345B1 (es)
RU (1) RU2138483C1 (es)
SI (1) SI0657448T1 (es)
SK (1) SK279950B6 (es)
SV (1) SV1994000071A (es)
TW (1) TW401412B (es)
UA (1) UA41323C2 (es)
YU (1) YU48865B (es)
ZA (1) ZA949830B (es)

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DE19826050A1 (de) * 1998-06-12 1999-12-16 Bayer Ag Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
KR20020075447A (ko) * 2000-02-25 2002-10-04 다이이찌 세이야꾸 가부시기가이샤 퀴놀론카복실산의 제조방법 및 이의 중간체
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
DE10026903A1 (de) * 2000-06-03 2002-01-10 Cpc Cellular Process Chemistry Verfahren zur Herstellung von Chinolon-3-carbonsäuren
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003099815A1 (en) * 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
ATE366734T1 (de) 2003-09-04 2007-08-15 Wockhardt Ltd Benzochinolizin-2-carbonsäureargininsalz- tetrahydrat
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
CN100412075C (zh) * 2004-06-22 2008-08-20 浙江医药股份有限公司新昌制药厂 左旋氧氟沙星和氧氟沙星的制备方法
AU2007320997B2 (en) 2006-11-13 2012-11-08 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride
FR2916446B1 (fr) * 2007-05-24 2009-08-21 Biocodex Sa Nouveau procede de synthese de fluoroquinolones
EP2083010A1 (en) 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
CN101781299B (zh) * 2010-01-13 2012-06-27 杭州师范大学 一种喹诺酮类药物关键中间体的一锅法合成方法
IT1398952B1 (it) * 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint Processo di preparazione della moxifloxacina e suoi sali
CN102675306A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种莫西沙星或其盐的制备方法
CN102267994B (zh) * 2011-06-17 2013-01-30 江苏正大丰海制药有限公司 一种盐酸莫西沙星已知杂质的制备方法
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
US9388178B2 (en) 2012-12-04 2016-07-12 Mankind Research Centre Process for the preparation of moxifloxacin hydrochloride
UA106556C2 (uk) 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ
US11059788B2 (en) 2017-06-12 2021-07-13 Virginia Commonwealth University Streamlined syntheses of fluoroquinolones
CN115385856A (zh) * 2022-09-05 2022-11-25 常州大学 一锅法合成诺氟沙星中间体的方法

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US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63179856A (ja) 1987-01-21 1988-07-23 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法並びにその中間体
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US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
TW209865B (es) * 1992-01-10 1993-07-21 Bayer Ag
DE4208789A1 (de) 1992-03-19 1993-09-23 Bayer Ag Enantiomerenreine chinolincarbonsaeure-derivate
DE4208792A1 (de) 1992-03-19 1993-09-23 Bayer Ag Enantiomerenreine chinolincarbonsaeure-derivate
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
JP2758722B2 (ja) * 1993-08-13 1998-05-28 ドング ホワ ファーマシューチカル インダストリアル カンパニー，リミテッド 新規キノロンカルボン酸誘導体

Also Published As

Publication number Publication date
TW401412B (en) 2000-08-11
IL111921A (en) 1999-07-14
AU693818B2 (en) 1998-07-09
ES2113040T3 (es) 1998-04-16
AU8024494A (en) 1995-06-15
IL111921A0 (en) 1995-03-15
SK279950B6 (sk) 1999-06-11
JP3963490B2 (ja) 2007-08-22
PL180022B1 (pl) 2000-12-29
HRP940950B1 (en) 1998-12-31
MY113302A (en) 2002-01-31
CZ288078B6 (cs) 2001-04-11
FI945776A (fi) 1995-06-11
PL306198A1 (en) 1995-06-12
EP0657448B1 (de) 1998-03-04
BG61947B1 (bg) 1998-10-30
NO944786D0 (no) 1994-12-09
RO113345B1 (ro) 1998-06-30
JPH07196621A (ja) 1995-08-01
HUT72058A (en) 1996-03-28
DK0657448T3 (da) 1998-12-21
LV11470B (en) 1996-12-20
EP0657448A1 (de) 1995-06-14
DE4342186A1 (de) 1995-06-14
BG99248A (en) 1995-09-29
YU48865B (sh) 2002-08-12
YU71694A (sh) 1996-10-18
DE59405376D1 (de) 1998-04-09
EE03215B1 (et) 1999-08-16
CN1109877A (zh) 1995-10-11
HU220597B1 (hu) 2002-03-28
RU94043645A (ru) 1996-10-27
ATE163645T1 (de) 1998-03-15
SV1994000071A (es) 1995-07-29
RU2138483C1 (ru) 1999-09-27
HRP940950A2 (en) 1997-02-28
KR950018008A (ko) 1995-07-22
NZ270086A (en) 1996-02-27
NO944786L (no) 1995-06-12
UA41323C2 (uk) 2001-09-17
SI0657448T1 (en) 1998-06-30
NO307180B1 (no) 2000-02-21
US5639886A (en) 1997-06-17
CA2137523A1 (en) 1995-06-11
CA2137523C (en) 2007-05-22
ZA949830B (en) 1995-08-22
GR3026383T3 (en) 1998-06-30
CO4180607A1 (es) 1995-06-07
LV11470A (lv) 1996-08-20
FI945776A0 (fi) 1994-12-08
SK151494A3 (en) 1995-07-11
CZ310594A3 (en) 1995-09-13
HU9403553D0 (en) 1995-02-28

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