SV2005002083A - Derivados de la 1-amino-ftalazina, su preparacion y aplicacion en terapeutica - Google Patents

Derivados de la 1-amino-ftalazina, su preparacion y aplicacion en terapeutica

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Publication number
SV2005002083A
SV2005002083A SV2005002083A SV2005002083A SV2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A SV 2005002083 A SV2005002083 A SV 2005002083A
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El Salvador
Prior art keywords
rent
aryl
alkylene
alquileno
rarbn
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SV2005002083A
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English (en)
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Jean Michel Augereau
Michel Geslin
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Sanofi Aventis
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Publication of SV2005002083A publication Critical patent/SV2005002083A/es

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Abstract

LA INVENCION SE REFIERE A DERIVADOS DE LA 1-AMINO-FTALAZINA, DE FORMULA GENERAL (I): VER FORMULA, EN DONDE A, B= ALQUILENO-C1-4 EVENTUALMENTE SUSTITUIDO; L= ENLACE SIMPLE O ALQUILENO-C1-2, -CH=CH- EVENTUALMENTE SUSTITUIDOS, O -C=C-, O CICLOPROP-1,2-DIILO; R1=ARILO O HETEROARILO EVENTUALMENTE SUSTITUIDOS; R2, R3=H, ALQUILO C1-C3, FLUOROALQUILO-C1-C3 O R2 Y R3 FORMAN JUNTOS, CON EL ATOMO DE CARBONO QUE LOS LLEVA, UN CICLOPROP-1,1-DIILO; R3=H, ALQUILO-C1-C5, FLUOROALQUILO-C1-C3, CICLOALQUILO-C3-6, CICLOALQUILO-C3-C6-ALQUILENO-C1-3, ALQUILO-C1-3-O-ALQUILENO-C1-3, HO-ALQUILENO-C1-3, ALQUILO-C1-3-X-ALQUILENO-C1-3 EN DONDE X=S, SO O SO2; O R4=RARBN-ALQUILENO-C1-3, ARILO, ARILO-ALQUILENO- C1-3, ARILO-O, ARILO-O-ALQUILENO-C1-3; ARILO-ALQUILENO-C1-3-O- ALQUILENO-C1-3, HETEROARILO O HETEROARILO-ALQUILENO-C1-3; R5=H, HALOGENO, ALQUILO-C1-5, FLUOROALQUILO-C1-3, ALCOXI-C1-5, FLUOROALCOXI-C1-3, HO-ALQUILENO-C1-3, HO-ALQUILENO-C1-3, -CN, ALQUILO-C1-3-X- EN DONDE X=S, SO O SO2; O R5=RARBN-, RARBN-ALQUILENO-C1-3, ARILO, ARILO-ALQUILENO-C1-3, ARILO-O- O HETEROARILO; R6=H, HALOGENO, ALQUILO-C1,5, FLUOROALQUILO-C1-3, ALCOXI-C1-5, FLUOROALCOXI-C1-3, -CN, RARBN-, RARBN-ALQUILENO-C1-3, ARILO O HETEROARILO; R7=H, HALOGENO, ALQUILO-C1,5, FLUOROALQUILO-C1-3, ALCOXI-C1-5, FLUOROALCOXI-C1-3, HO-ALQUILENO-C1-3, -CN, ALQUILO-C1-3-X-EN DONDE X=S, SO O SO2; O RARBN-, RARBN-ALQUILENO-C1-3, RARBNC(O)-, ALQUILO-C1-3-C(O)-, ARILO, ARILO- O HETEROARILO; R8=H, HALOGENO, ALQUILO-C1-5, ALCOXI-C1-5, FLUOROALCOXI-C1-3; EN EL ESTADO DE BASE O DE SAL DE ADICION DE UN ACIDO, COMO ASI TAMBIEN EN EL ESTADO DE HIDRATO O DE SOLVATO. PROCEDIMIENTO DE PREPARACION Y APLICACION EN TERAPEUTICA
SV2005002083A 2004-04-13 2005-04-13 Derivados de la 1-amino-ftalazina, su preparacion y aplicacion en terapeutica SV2005002083A (es)

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FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique

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US (1) US7423030B2 (es)
EP (1) EP1737840B1 (es)
JP (1) JP4918477B2 (es)
KR (1) KR20070007361A (es)
CN (1) CN1953972A (es)
AR (1) AR049543A1 (es)
AT (1) ATE372998T1 (es)
AU (1) AU2005235766A1 (es)
BR (1) BRPI0509910A (es)
CA (1) CA2562100A1 (es)
DE (1) DE602005002470T2 (es)
DO (1) DOP2005000062A (es)
FR (1) FR2868780B1 (es)
GT (1) GT200500089A (es)
IL (1) IL178402A0 (es)
MA (1) MA28575B1 (es)
MX (1) MXPA06011829A (es)
NO (1) NO20065184L (es)
PE (1) PE20060336A1 (es)
RU (1) RU2006139952A (es)
SV (1) SV2005002083A (es)
TW (1) TW200607800A (es)
UY (1) UY28855A1 (es)
WO (1) WO2005103033A1 (es)

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US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286790A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD)
AU2005286731A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
FR2891828B1 (fr) * 2005-10-12 2007-12-21 Sanofi Aventis Sa Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
FR2891825B1 (fr) * 2005-10-12 2007-12-14 Sanofi Aventis Sa Derives de la 1-amino-isoquinoline, leur preparation et leur application en therapeutique
RU2009108280A (ru) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
SG178880A1 (en) 2009-08-26 2012-04-27 Sanofi Sa Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
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WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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CA2562100A1 (fr) 2005-11-03
FR2868780B1 (fr) 2008-10-17
DE602005002470D1 (de) 2007-10-25
EP1737840A1 (fr) 2007-01-03
UY28855A1 (es) 2005-11-30
AR049543A1 (es) 2006-08-16
MA28575B1 (fr) 2007-05-02
BRPI0509910A (pt) 2007-09-18
ATE372998T1 (de) 2007-09-15
KR20070007361A (ko) 2007-01-15
WO2005103033A1 (fr) 2005-11-03
CN1953972A (zh) 2007-04-25
DOP2005000062A (es) 2006-10-15
IL178402A0 (en) 2007-02-11
MXPA06011829A (es) 2007-01-16
AU2005235766A1 (en) 2005-11-03
US7423030B2 (en) 2008-09-09
JP4918477B2 (ja) 2012-04-18
TW200607800A (en) 2006-03-01
GT200500089A (es) 2005-10-31
RU2006139952A (ru) 2008-05-20
NO20065184L (no) 2007-01-11
US20070099895A1 (en) 2007-05-03
EP1737840B1 (fr) 2007-09-12
FR2868780A1 (fr) 2005-10-14
JP2007532611A (ja) 2007-11-15
DE602005002470T2 (de) 2008-06-12

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