BRPI0509910A - derivados do amino-ftalazina, o respectivo reparo e a sua aplicação em terapêutica - Google Patents

derivados do amino-ftalazina, o respectivo reparo e a sua aplicação em terapêutica

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Publication number
BRPI0509910A
BRPI0509910A BRPI0509910-2A BRPI0509910A BRPI0509910A BR PI0509910 A BRPI0509910 A BR PI0509910A BR PI0509910 A BRPI0509910 A BR PI0509910A BR PI0509910 A BRPI0509910 A BR PI0509910A
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Prior art keywords
alkylene
alkyl
aryl
heteroaryl
fluoroalkyl
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BRPI0509910-2A
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English (en)
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Jean Michel Augereau
Michel Geslin
Gilles Courtemanche
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Sanofi Aventis
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Publication of BRPI0509910A publication Critical patent/BRPI0509910A/pt

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

DERIVADOS DO AMINO-FTALAZINA, O RESPECTIVO PREPARO E A SUA APLICAçãO EM TERAPêUTICA. A invenção se refere aos derivados da 1-amino-flalazina, de fórmula geral (1), na qual A, B = C~ 1-4~-aíquileno eventualmente substituido; L = ligação simples ou C~ 1-2~-alquileno , -CH=CH- eventualmente substituídos ou -C=C- ou ciclo-prop-1 ,2-diila; R~ 1~ = adia ou heteroarila eventualmente substituidos; R~ 2~, R~ 3~ = H, C~ 1-3~-alquila, C~ 1-3~-fluoroalquila ou R~ 2~ e R~ 3~ formam juntos, com o átomo de carbono que os porta, um cicloprop-1.1-dilia; R~ 4~ = H, C~ 1-5~ -alquila, C~ 1-3~-fluoroalquila, C~ 3-6~-cicíoalquiia, C~ 3-6~-cicloalquila-C~ 1-3~-alquileno, C~ 1-3~-alquila-O-C~ 1-3~-alquiíeno, HO-C~ 1-3~-alquileno, C~ 1-3~-alquila-X-C~ 1-3~-alquileno no qual X = S, SO ou SO~ 2~, ou R~ 4~, R~a~R~b~N-C~ l-3~-alquileno, arila, arila-C~ 1-3~-alquileno, arila-O-, arila-O-Ci-3~-alquileno, arila-C~ 1-3~-alquileno-O-C~ 1-3~-alquileno, heteroarila ou heteroarila-C~ 1-3~-alquileno; R~ 5~ = H, halogênio, C~ 1-5~-alquila, C~ 1-3~-fluoroaíquila, C~ 1-5~ -alcóxi, C~ 1-3~-fluoroalcóxi, HO-C~ 1-3~-aíquileno-CN, C~ 1-3~-alquila-X no qual X = S, SO, SO~ 2~; ou R~ 5~ = R~ a~ R~ b~ N-, R~ a~ R~ b~N-C~ 1-3~ alquileno, arila, arila-C~ 1-3~ alquileno, arila-O- ou heteroarila; R~ 6~ H, halogênio, C~ 1-5~ alquila, C~ 1-3~ f1uoroalquiIa, C~ 1-5~-alcóxi, C~ 1-3~-Fluoroalcóxi, -CN, R~ a~ R~ b~ N, R~ a~R~ b~N C~ -1-3~-alquileno, adia ou heteroarila; R~ 7~ = H, halagênio, C~1-5~-alquila, C~1-3~-fluoroalquila, C~ 1-5~-alcóxi, C~ 1-3~-fluoroalcáxi. HO-C~ 1-3~-alquileno, -CN, C~ 1-3~-alquiia-X no qual X = S, SO ou SO~ 2~; no qual R~ 7~ = R~ a~R~ b~ N-, R~ a~R~ b~N C~-1-3~ alquileno, R~ a~ R~ b~NC(O)-, C~ 1-3~-alquila-C(O)-, arila, arila-O- ou heteroarlia; R~ 8~ = H, halogênio, C~ 1-3~-alquila, C~ 1-5~-alcóxi, C~ 1-3~-fluoroalcóxi, no estado de baseou de sal de adição a um ácido, assim como no estado de hidrato ou de solvato. Processo de preparo e aplicação em terapêutica.
BRPI0509910-2A 2004-04-13 2005-04-13 derivados do amino-ftalazina, o respectivo reparo e a sua aplicação em terapêutica BRPI0509910A (pt)

Applications Claiming Priority (2)

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FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique
PCT/FR2005/000889 WO2005103033A1 (fr) 2004-04-13 2005-04-13 Dérivés de la 1-amino-phthalazine, leur préparation, et leur application en thérapeutique

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BRPI0509910A true BRPI0509910A (pt) 2007-09-18

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US (1) US7423030B2 (pt)
EP (1) EP1737840B1 (pt)
JP (1) JP4918477B2 (pt)
KR (1) KR20070007361A (pt)
CN (1) CN1953972A (pt)
AR (1) AR049543A1 (pt)
AT (1) ATE372998T1 (pt)
AU (1) AU2005235766A1 (pt)
BR (1) BRPI0509910A (pt)
CA (1) CA2562100A1 (pt)
DE (1) DE602005002470T2 (pt)
DO (1) DOP2005000062A (pt)
FR (1) FR2868780B1 (pt)
GT (1) GT200500089A (pt)
IL (1) IL178402A0 (pt)
MA (1) MA28575B1 (pt)
MX (1) MXPA06011829A (pt)
NO (1) NO20065184L (pt)
PE (1) PE20060336A1 (pt)
RU (1) RU2006139952A (pt)
SV (1) SV2005002083A (pt)
TW (1) TW200607800A (pt)
UY (1) UY28855A1 (pt)
WO (1) WO2005103033A1 (pt)

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CN101083986A (zh) * 2004-09-20 2007-12-05 泽农医药公司 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
TW200626155A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
FR2891825B1 (fr) * 2005-10-12 2007-12-14 Sanofi Aventis Sa Derives de la 1-amino-isoquinoline, leur preparation et leur application en therapeutique
FR2891828B1 (fr) * 2005-10-12 2007-12-21 Sanofi Aventis Sa Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CN102482312A (zh) 2009-08-26 2012-05-30 赛诺菲 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
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WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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DE602005002470D1 (de) 2007-10-25
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FR2868780B1 (fr) 2008-10-17
UY28855A1 (es) 2005-11-30
TW200607800A (en) 2006-03-01
CN1953972A (zh) 2007-04-25
WO2005103033A1 (fr) 2005-11-03
FR2868780A1 (fr) 2005-10-14
NO20065184L (no) 2007-01-11
JP4918477B2 (ja) 2012-04-18
EP1737840A1 (fr) 2007-01-03
AU2005235766A1 (en) 2005-11-03
CA2562100A1 (fr) 2005-11-03
RU2006139952A (ru) 2008-05-20
MXPA06011829A (es) 2007-01-16
SV2005002083A (es) 2005-12-01
PE20060336A1 (es) 2006-05-15
JP2007532611A (ja) 2007-11-15
US7423030B2 (en) 2008-09-09
DE602005002470T2 (de) 2008-06-12
MA28575B1 (fr) 2007-05-02
KR20070007361A (ko) 2007-01-15
EP1737840B1 (fr) 2007-09-12
AR049543A1 (es) 2006-08-16
ATE372998T1 (de) 2007-09-15
US20070099895A1 (en) 2007-05-03

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