DOP2005000062A - Derivados de la 1-amino-ftalazina, su preparacion y su aplicación en terapeutica - Google Patents

Derivados de la 1-amino-ftalazina, su preparacion y su aplicación en terapeutica

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Publication number
DOP2005000062A
DOP2005000062A DO2005000062A DO2005000062A DOP2005000062A DO P2005000062 A DOP2005000062 A DO P2005000062A DO 2005000062 A DO2005000062 A DO 2005000062A DO 2005000062 A DO2005000062 A DO 2005000062A DO P2005000062 A DOP2005000062 A DO P2005000062A
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Dominican Republic
Prior art keywords
alkylene
aryl
alkyl
rarbn
heteroaryl
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DO2005000062A
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English (en)
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Jean Michel Augereau
Geslin Michel
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Sanofi Aventis
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Publication of DOP2005000062A publication Critical patent/DOP2005000062A/es

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

La invención se refiere a derivados de la 1-aminoftalazina, de fórmula general (I): en donde A, B = alquileno-Cl-4, eventualmente sustituido; L = enlace simple o alquileno-C1-2, -CH=CH- eventualmente sustituidos, o -C=C-, o cicloprop-l,2-diilo; R1 = arilo o heteroarilo eventualmente sustituidos; R2, R3= H, alquilo C l-3, fluoroalquilo-C1-3 o R2 y R3 forman juntos, con el àtomo de carbono que los lleva, un cicloprop-l,1-diilo; R4 = H, alquilo-C1-5, fluroalquilo-C1-3, cicloalquilo-C3-6, cicloalquilo-C3-6-alquileno-C1-3, alquilo-C,1-3-0-alquileno-Cl-3, HO-alquileno-C1-3, alquilo-Cl-3-X-alquileno-Cl-3 en donde X = S, SO o S02; o R4, = RaRbN-alquileno-Cl-3, arilo, arilo-alquilenoCl-3, arilo-O, arilo-O-alquileno-C1-3; arilo-alquileno-Cl-3-Oalquileno-Cl-3, heteroarilo o heteroarilo-alquileno-C1-3; R5 = H, halógeno, alquilo-C1-5, fluoroalquilo-Cl-3, alcoxi-Cl-5, fluoroalcoxi-C1-3, HO-alquileno-C1-3, -CN, alquilo-C1-3-X- en donde X = S, SO o S02; o R5 = RaRbN-, RaRbN-alquileno-C1-3, arilo, arilo-alquileno-C1-3, arilo-O- o heteroarilo; R6 = H, halógeno, alquilo-C1-5, fluoroalquilo-C1-3, alcoxi-C1-5, fluoroalcoxi-C1-3, -CN, RaRbN-, RaRbN-alquileno-C1-3, arilo o heteroarilo; R7 = H, halógeno, alquilo-C1,5, fluoroalquilo-C1-3, alcoxi-Cl-5, fluoroalcoxi-C1-3, HO-alquileno-Cl-3, -CN, alquiloCl-3-X- en donde X = S, SO o SO2; o RaRbN-, RaRbN-alquileno-C, 3, RaRbNC(0)-, alquilo-C1-3-C (0) -, arilo, arilo-O- o heteroarilo; RB = H, halógeno, alquilo-C1-5, alcoxi-C1-5, fluoroalcoxi-C1-3; en el estado de base o de sal de adición de un acido, como asi tambien en el estado de hidrato o de solvato. Procedimiento de preparacibn y aplicación en terapeutica.
DO2005000062A 2004-04-13 2005-04-13 Derivados de la 1-amino-ftalazina, su preparacion y su aplicación en terapeutica DOP2005000062A (es)

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FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique

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US (1) US7423030B2 (es)
EP (1) EP1737840B1 (es)
JP (1) JP4918477B2 (es)
KR (1) KR20070007361A (es)
CN (1) CN1953972A (es)
AR (1) AR049543A1 (es)
AT (1) ATE372998T1 (es)
AU (1) AU2005235766A1 (es)
BR (1) BRPI0509910A (es)
CA (1) CA2562100A1 (es)
DE (1) DE602005002470T2 (es)
DO (1) DOP2005000062A (es)
FR (1) FR2868780B1 (es)
GT (1) GT200500089A (es)
IL (1) IL178402A0 (es)
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NO (1) NO20065184L (es)
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RU (1) RU2006139952A (es)
SV (1) SV2005002083A (es)
TW (1) TW200607800A (es)
UY (1) UY28855A1 (es)
WO (1) WO2005103033A1 (es)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CN101083986A (zh) * 2004-09-20 2007-12-05 泽农医药公司 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
TW200626155A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
FR2891825B1 (fr) * 2005-10-12 2007-12-14 Sanofi Aventis Sa Derives de la 1-amino-isoquinoline, leur preparation et leur application en therapeutique
FR2891828B1 (fr) * 2005-10-12 2007-12-21 Sanofi Aventis Sa Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CN102482312A (zh) 2009-08-26 2012-05-30 赛诺菲 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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EP2683698B1 (de) 2011-03-08 2017-10-04 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
GB201311953D0 (en) * 2013-07-03 2013-08-14 Redx Pharma Ltd Compounds
EA030631B1 (ru) 2013-07-31 2018-09-28 Новартис Аг 1,4-дизамещенные аналоги пиридазинхинолина и способы лечения состояний, связанных с smn-дефицитом
KR102507847B1 (ko) * 2016-10-28 2023-03-08 서울대학교병원 페닐 프탈라진 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물
JP2024529839A (ja) * 2021-06-29 2024-08-14 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター
WO2023088856A1 (en) * 2021-11-17 2023-05-25 F. Hoffmann-La Roche Ag Heterocyclic nlrp3 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
DE1005072B (de) * 1955-08-02 1957-03-28 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von basisch substiuierten heterocyclischen Verbindungen
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
JP2005532368A (ja) * 2002-06-12 2005-10-27 アボット・ラボラトリーズ メラニン濃縮ホルモン受容体の拮抗薬

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FR2868780B1 (fr) 2008-10-17
UY28855A1 (es) 2005-11-30
TW200607800A (en) 2006-03-01
CN1953972A (zh) 2007-04-25
WO2005103033A1 (fr) 2005-11-03
FR2868780A1 (fr) 2005-10-14
NO20065184L (no) 2007-01-11
JP4918477B2 (ja) 2012-04-18
EP1737840A1 (fr) 2007-01-03
AU2005235766A1 (en) 2005-11-03
CA2562100A1 (fr) 2005-11-03
RU2006139952A (ru) 2008-05-20
MXPA06011829A (es) 2007-01-16
SV2005002083A (es) 2005-12-01
PE20060336A1 (es) 2006-05-15
JP2007532611A (ja) 2007-11-15
US7423030B2 (en) 2008-09-09
DE602005002470T2 (de) 2008-06-12
MA28575B1 (fr) 2007-05-02
KR20070007361A (ko) 2007-01-15
EP1737840B1 (fr) 2007-09-12
AR049543A1 (es) 2006-08-16
ATE372998T1 (de) 2007-09-15
US20070099895A1 (en) 2007-05-03
BRPI0509910A (pt) 2007-09-18

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