NO20065184L - 1-amino-ftalazinderivater, deres fremstilling og terapeutiske anvendelse derav - Google Patents

1-amino-ftalazinderivater, deres fremstilling og terapeutiske anvendelse derav

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Publication number
NO20065184L
NO20065184L NO20065184A NO20065184A NO20065184L NO 20065184 L NO20065184 L NO 20065184L NO 20065184 A NO20065184 A NO 20065184A NO 20065184 A NO20065184 A NO 20065184A NO 20065184 L NO20065184 L NO 20065184L
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Prior art keywords
alkylene
aryl
alkyl
rarbn
heteroaryl
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NO20065184A
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English (en)
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Michel Geslin
Jean Michel Augereau
Gilles Courtemanche
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Sanofi Aventis
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Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20065184L publication Critical patent/NO20065184L/no

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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Det beskrives 1-aminoftalazinderivater med den generelle formel (I) der A, B = eventuelt substituert C1-4-alkylen; L = en enkelt binding eller C1-2-alkylen, eventuelt substituert -CH=CH-, eller -OC- eller cykloprop-l,2-diyl; R1 er eventuelt substituert aryl eller heteroaryl; R2, R3 = H, C1-3-alkyl, C1-3-fluoralkyl eller R2 og R3 sammen med karbonatomet som bærer dem danner en cykloprop-l,l-diyl; R4 = H, C1-5-alkyl, C1-3-fluoralkyl, C3-6-cykloalkyl, C3-6-cykloalkyl-C1-3-alkylen, C1-3-alkyl-O-C1-3-alkylen, HO-C1-3-alkylen, C1-3-alkyl-X-C1-3-alkylen der X = S, SO eller SO2; eller R4 = RaRbN-C1-3-alkylen, aryl, aryl-C1-3-alkylen, aryl-O-, aryl-O-C1-3-alkylen, aryl-C1-3-alkylen-O-C1-3-alkylen, heteroaryl eller heteroaryl-C1-3-alkylen; R5 = H, halogen, C1-5-alkyl, C1-3-fluor-alkyl, C1-5-alkoksy, C1-3-fluoralkoksy, HO-C1-3-alkylen, -CN, C1-3-alkyl-X-, der X = S, SO eller SO2; eller R5 = RaRbN-, RaRbN-C1--alkylen, aryl, aryl-C1-3-alkylen, aryl-O-eller heteroaryl; R6 = H, halogen, C1-5-alkyl, C1-3-fluoralkyl, C1-5-alkoksy, C1-3-fluor-alkoksy, -CN, RaRbN-, RaRbN-C1-3-alkylen, aryl eller heteroaryl; R7 = H, halogen, C1-5-alkyl, C1-3-fluoralkyl,C1-5-alkoksy, C1-3-fluoralkoksy, HO-C1-3-alkylen, -CN, C1-3-alkyl-X-, der X = S, SO eller SO2; eller R7, = RaRb,N-, RaRbN-C1-3-alkylen, RcRbNC(O)-, C1-3-alkyl-C(O)-, aryl, aryl-O- eller heteroaryl; R8 = H, halogen, C1-5-alkyl, C1-5-alkoksy, C1-3-fluoralkoksy; i form av base eller syreaddisjonssalt og i form av et hydrat eller et solvat. Det beskriver en fremgangsmåte for fremstilling bruk av oppfinnelsens derivater for terapeutiske formål.
NO20065184A 2004-04-13 2006-11-10 1-amino-ftalazinderivater, deres fremstilling og terapeutiske anvendelse derav NO20065184L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique
PCT/FR2005/000889 WO2005103033A1 (fr) 2004-04-13 2005-04-13 Dérivés de la 1-amino-phthalazine, leur préparation, et leur application en thérapeutique

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Publication Number Publication Date
NO20065184L true NO20065184L (no) 2007-01-11

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US (1) US7423030B2 (no)
EP (1) EP1737840B1 (no)
JP (1) JP4918477B2 (no)
KR (1) KR20070007361A (no)
CN (1) CN1953972A (no)
AR (1) AR049543A1 (no)
AT (1) ATE372998T1 (no)
AU (1) AU2005235766A1 (no)
BR (1) BRPI0509910A (no)
CA (1) CA2562100A1 (no)
DE (1) DE602005002470T2 (no)
DO (1) DOP2005000062A (no)
FR (1) FR2868780B1 (no)
GT (1) GT200500089A (no)
IL (1) IL178402A0 (no)
MA (1) MA28575B1 (no)
MX (1) MXPA06011829A (no)
NO (1) NO20065184L (no)
PE (1) PE20060336A1 (no)
RU (1) RU2006139952A (no)
SV (1) SV2005002083A (no)
TW (1) TW200607800A (no)
UY (1) UY28855A1 (no)
WO (1) WO2005103033A1 (no)

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CN101083992A (zh) * 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
EP2269610A3 (en) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
TW200626148A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
FR2891825B1 (fr) * 2005-10-12 2007-12-14 Sanofi Aventis Sa Derives de la 1-amino-isoquinoline, leur preparation et leur application en therapeutique
FR2891828B1 (fr) * 2005-10-12 2007-12-21 Sanofi Aventis Sa Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
BRPI0715160A2 (pt) 2006-08-08 2013-06-11 Sanofi Aventis imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US8785608B2 (en) 2009-08-26 2014-07-22 Sanofi Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
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US7423030B2 (en) 2008-09-09
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EP1737840B1 (fr) 2007-09-12
PE20060336A1 (es) 2006-05-15
AR049543A1 (es) 2006-08-16
KR20070007361A (ko) 2007-01-15
GT200500089A (es) 2005-10-31
BRPI0509910A (pt) 2007-09-18
SV2005002083A (es) 2005-12-01
WO2005103033A1 (fr) 2005-11-03
CA2562100A1 (fr) 2005-11-03
CN1953972A (zh) 2007-04-25
EP1737840A1 (fr) 2007-01-03
DOP2005000062A (es) 2006-10-15
DE602005002470D1 (de) 2007-10-25
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FR2868780A1 (fr) 2005-10-14
UY28855A1 (es) 2005-11-30
US20070099895A1 (en) 2007-05-03
FR2868780B1 (fr) 2008-10-17
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IL178402A0 (en) 2007-02-11
JP4918477B2 (ja) 2012-04-18
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ATE372998T1 (de) 2007-09-15
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