BR0315800A - Derivados de imidazopiridina, seu processo de preparação e as composições farmacêuticas que os contêm - Google Patents

Derivados de imidazopiridina, seu processo de preparação e as composições farmacêuticas que os contêm

Info

Publication number
BR0315800A
BR0315800A BR0315800-4A BR0315800A BR0315800A BR 0315800 A BR0315800 A BR 0315800A BR 0315800 A BR0315800 A BR 0315800A BR 0315800 A BR0315800 A BR 0315800A
Authority
BR
Brazil
Prior art keywords
group
alkyl
optionally substituted
atom
hydrogen
Prior art date
Application number
BR0315800-4A
Other languages
English (en)
Inventor
Sylvain Rault
Jean-Charles Lancelot
Marina Kopp
Daniel Henri Caignard
Bruno Pfeiffer
Pierre Renard
Jean-Guy Bizot-Espiard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0315800A publication Critical patent/BR0315800A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE IMIDAZOPIRIDINA, SEU PROCESSO DE PREPARAçãO E AS COMPOSIçõES FARMACêUTICAS QUE OS CONTêM". A presente invenção refere-se a compostos de fórmula (I): na qual R¬ 1¬ representa um átomo de hidrogênio, de halogênio, um grupamento alquila, polialogenoalquila, ciano, nitro, hidroxicarbonila, alcoxicarbonila, aminocarbonila, alquilaminocarbonila, ou dialquilaminocarbonila , R¬ 2¬ representa um átomo de hidrogênio, um grupamento alquila, arila eventualmente substituída, heteroarila eventualmente substituída ou um grupamento R¬ 20¬C(X)- com: R¬ 20¬ representando um grupamento alquila, alcóxi, amino, alquilamino, dialquilamino, arila eventualmente substituída ou heteroarila eventualmente substituída, X representando um átomo de oxigênio, de enxofre, ou um grupamento NR¬ 21¬ no qual R¬ 21¬ representa um átomo de hidrogênio ou um grupamento alquila, R¬ 3¬ representa um átomo de hidrogênio, ou um grupamento alquila, n representa um número inteiro compreendido inclusivamente entre 1 e 6, a representação R¬ 1¬ significa: seus enantiómeros, diaestereoisómeros, assim como seus sais de adição a um ácido ou a uma base farmaceuticamente aceitável.
BR0315800-4A 2002-11-05 2003-11-04 Derivados de imidazopiridina, seu processo de preparação e as composições farmacêuticas que os contêm BR0315800A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0213802A FR2846656B1 (fr) 2002-11-05 2002-11-05 Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2003/003277 WO2004043957A1 (fr) 2002-11-05 2003-11-04 Derives d’imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0315800A true BR0315800A (pt) 2005-09-20

Family

ID=32104440

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315800-4A BR0315800A (pt) 2002-11-05 2003-11-04 Derivados de imidazopiridina, seu processo de preparação e as composições farmacêuticas que os contêm

Country Status (27)

Country Link
US (1) US7098220B2 (pt)
EP (1) EP1558612B1 (pt)
JP (1) JP2006508111A (pt)
KR (1) KR100717488B1 (pt)
CN (1) CN100335480C (pt)
AR (1) AR041882A1 (pt)
AT (1) ATE337317T1 (pt)
AU (1) AU2003292323A1 (pt)
BR (1) BR0315800A (pt)
CA (1) CA2504008A1 (pt)
CY (1) CY1105752T1 (pt)
DE (1) DE60307875T2 (pt)
DK (1) DK1558612T3 (pt)
EA (1) EA008446B1 (pt)
ES (1) ES2271653T3 (pt)
FR (1) FR2846656B1 (pt)
HK (1) HK1081964A1 (pt)
MA (1) MA27411A1 (pt)
MX (1) MXPA05004791A (pt)
MY (1) MY135191A (pt)
NO (1) NO20052710L (pt)
NZ (1) NZ539599A (pt)
PL (1) PL375373A1 (pt)
PT (1) PT1558612E (pt)
UA (1) UA80579C2 (pt)
WO (1) WO2004043957A1 (pt)
ZA (1) ZA200503234B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1754483A1 (en) 2005-08-18 2007-02-21 Merck Sante Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them
FR2903695B1 (fr) 2006-07-13 2008-10-24 Merck Sante Soc Par Actions Si Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2008016730A2 (en) * 2006-08-02 2008-02-07 Targeted Molecular Diagnostics, Llc Compositions and methods for reducing cellular fat
US8163505B2 (en) 2007-05-22 2012-04-24 The Penn State Research Foundation Methods using PBK1 for identifying agents that treat metabolic disorders
WO2010030360A1 (en) * 2008-09-11 2010-03-18 Arena Pharmaceuticals, Inc. 3H-IMIDAZO[4,5-b]PYRIDIN-5-OL DERIVATIVES USEFUL IN THE TREATMENT OF GPR81 RECEPTOR DISORDERS
MX2011003239A (es) * 2008-09-26 2011-04-28 Merck Sharp & Dohme Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos.
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP5557845B2 (ja) * 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
WO2010103040A1 (en) 2009-03-10 2010-09-16 INSERM (Institut National de la Santé et de la Recherche Médicale) 5'-adenosine monophosphate-activated protein kinase (ampk) activators for treating pulmonary hypertension
AU2010317842A1 (en) 2009-11-16 2012-07-12 Mellitech [1,5]-diazocin derivatives
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2811025C (en) * 2010-09-10 2018-07-17 Shionogi & Co., Ltd. Hetero ring-fused imidazole derivative having ampk activating effect
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2906040B1 (en) * 2012-08-22 2021-02-17 Merck Sharp & Dohme Corp. Novel benzimidazole tetrahydropyran derivatives
WO2014145852A2 (en) 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
ES2749103T3 (es) 2014-09-12 2020-03-19 Knopp Biosciences Llc Benzoimidazol-1,2-ilamidas como activadores del canal Kv7
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707984B1 (fr) * 1993-07-23 1995-09-01 Adir Nouvelles pipérazines substituées, leur procédé de préparation et les compositions les contenant.
KR100571690B1 (ko) * 1996-12-11 2006-04-18 아벤티스 파마슈티칼스 인크. [1S-[1a,2b,3b,4a(S*)]]-4-[[3-아미노-4-[[1-[3-클로로-2-티에닐)메틸]프로필]아미노]-2-피리디닐]아미노]-N-에틸-2,3-디하이드록시사이클로펜탄카복스아미드, 이의 제조방법 및 이의 디하이드로클로라이드 염의 제조방법
AU760020B2 (en) * 1998-08-31 2003-05-08 Merck & Co., Inc. Novel angiogenesis inhibitors
US6271241B1 (en) * 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors

Also Published As

Publication number Publication date
CN100335480C (zh) 2007-09-05
DE60307875D1 (de) 2006-10-05
HK1081964A1 (en) 2006-05-26
MA27411A1 (fr) 2005-06-01
FR2846656B1 (fr) 2004-12-24
EA200500717A1 (ru) 2005-10-27
DE60307875T2 (de) 2007-04-12
US20060069117A1 (en) 2006-03-30
CN1711261A (zh) 2005-12-21
EP1558612B1 (fr) 2006-08-23
UA80579C2 (en) 2007-10-10
NZ539599A (en) 2007-06-29
US7098220B2 (en) 2006-08-29
PT1558612E (pt) 2006-12-29
EP1558612A1 (fr) 2005-08-03
NO20052710L (no) 2005-06-06
CA2504008A1 (fr) 2004-05-27
ZA200503234B (en) 2006-06-28
AU2003292323A1 (en) 2004-06-03
WO2004043957A1 (fr) 2004-05-27
ES2271653T3 (es) 2007-04-16
PL375373A1 (en) 2005-11-28
KR100717488B1 (ko) 2007-05-14
KR20050084663A (ko) 2005-08-26
JP2006508111A (ja) 2006-03-09
FR2846656A1 (fr) 2004-05-07
MXPA05004791A (es) 2005-07-22
ATE337317T1 (de) 2006-09-15
AR041882A1 (es) 2005-06-01
CY1105752T1 (el) 2010-12-22
DK1558612T3 (da) 2006-12-27
MY135191A (en) 2008-02-29
EA008446B1 (ru) 2007-06-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. E 7A.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010.