PE20130191A1 - Combinaciones que contienen 2, 3-dihidroimidazo[1, 2-c]quinazolina sustituida - Google Patents

Combinaciones que contienen 2, 3-dihidroimidazo[1, 2-c]quinazolina sustituida

Info

Publication number
PE20130191A1
PE20130191A1 PE2012002028A PE2012002028A PE20130191A1 PE 20130191 A1 PE20130191 A1 PE 20130191A1 PE 2012002028 A PE2012002028 A PE 2012002028A PE 2012002028 A PE2012002028 A PE 2012002028A PE 20130191 A1 PE20130191 A1 PE 20130191A1
Authority
PE
Peru
Prior art keywords
dihydroimidazo
quinazoline
halogen
substitute
combinations containing
Prior art date
Application number
PE2012002028A
Other languages
English (en)
Inventor
Ningshu Liu
Andrea Hagerbarth
Katja Haike
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44144895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130191(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20130191A1 publication Critical patent/PE20130191A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

SE REFIERE A UNA COMBINACION DE: I) UNO O MAS COMPUESTOS 2,3-DIHIDROIMIDAZO[1,2-C]QUINAZOLINA DE FORMULA (A1) DONDE: X ES NH O CR5R6; Y1 ES CR3 O N; EL ENLACE Y2----Y3 ES UNA UNION SIMPLE O DOBLE; Z1, Z2, Z3 Y Z4 SON INDEPENDIENTEMENTE CH, CR2 O N; R1 ES ARILO OPCIONALMENTE CON 1 A 3 SUSTITUYENTES, ENTRE OTROS; R3 ES H, HALOGENO, ENTRE OTROS; R5 ES H O ALQUILO C1-C6; R6 ES HALOGENO, H, ENTRE OTROS; II) UNO O MAS COMPUESTOS N-(2-ARILAMINO)ARILSULFONAMIDA DE FORMULA (B), DONDE G ES METILO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; Rº ES H, HALOGENO, ENTRE OTROS; X ES F, Cl O METILO; Y ES I, Br, Cl, ENTRE OTROS; Z ES H O F; Y III) UNO O MAS AGENTES FARMACEUTICO ADICIONALES. DICHA COMBINACION ES UTIL PARA EL TRATAMIENTO DE CANCER PANCREATICO, CARCINOMA DE HEPATOCITOS, CANCER DE MAMA
PE2012002028A 2010-04-16 2011-04-14 Combinaciones que contienen 2, 3-dihidroimidazo[1, 2-c]quinazolina sustituida PE20130191A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10160109 2010-04-16

Publications (1)

Publication Number Publication Date
PE20130191A1 true PE20130191A1 (es) 2013-02-21

Family

ID=44144895

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012002028A PE20130191A1 (es) 2010-04-16 2011-04-14 Combinaciones que contienen 2, 3-dihidroimidazo[1, 2-c]quinazolina sustituida

Country Status (24)

Country Link
US (1) US20130184270A1 (es)
EP (1) EP2558126A2 (es)
JP (1) JP5886271B2 (es)
KR (1) KR20130098155A (es)
CN (1) CN102958540B (es)
AU (1) AU2011240003A1 (es)
BR (1) BR112012026480A2 (es)
CA (1) CA2796253A1 (es)
CL (1) CL2012002887A1 (es)
CO (1) CO6620036A2 (es)
CR (1) CR20120524A (es)
CU (1) CU20120150A7 (es)
DO (1) DOP2012000269A (es)
EA (1) EA201201414A8 (es)
EC (1) ECSP12012261A (es)
HK (1) HK1182937A1 (es)
IL (1) IL222356A0 (es)
MA (1) MA34158B1 (es)
MX (1) MX2012012064A (es)
PE (1) PE20130191A1 (es)
SG (1) SG184550A1 (es)
TN (1) TN2012000493A1 (es)
WO (1) WO2011128407A2 (es)
ZA (1) ZA201208616B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2168583A1 (en) 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma
UA113280C2 (xx) 2010-11-11 2017-01-10 АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
EP2508525A1 (en) 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
JO3733B1 (ar) * 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
WO2014160034A1 (en) * 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Aldehyde dehydrogenase-1 modulators and methods of use thereof
EA031493B9 (ru) 2013-04-08 2019-12-18 Байер Фарма Акциенгезельшафт Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл)
WO2015082376A2 (en) * 2013-12-03 2015-06-11 Bayer Pharma Aktiengesellschaft Use of pi3k-inhibitors
CN107683138A (zh) * 2015-03-09 2018-02-09 拜耳制药股份公司 取代的2,3‑二氢咪唑并[1,2‑c]喹唑啉类化合物的用途
AU2016231259A1 (en) * 2015-03-09 2017-09-21 Bayer Healthcare Pharmaceuticals Inc. Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations
JP6935415B2 (ja) * 2016-03-08 2021-09-15 バイエル ファーマ アクチエンゲゼルシャフト ２−アミノ−Ｎ−［７−メトキシ−２，３−ジヒドロイミダゾ−［１，２−ｃ］キナゾリン−５−イル］ピリミジン−５−カルボキサミド類
WO2019002068A1 (en) 2017-06-28 2019-01-03 Bayer Consumer Care Ag COMBINATION OF A PI3K INHIBITOR AND AN ANDROGEN RECEPTOR ANTAGONIST
EP3723754A4 (en) 2017-12-13 2021-05-19 Merck Sharp & Dohme Corp. IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
RU2326881C9 (ru) * 2002-09-30 2009-04-10 Байер Фармасьютикалс Корпорейшн Конденсированные производные азолпиримидина, обладающие свойствами ингибитора фосфатидилинозитол-3-киназы (pi3k)
JP4323793B2 (ja) 2002-12-16 2009-09-02 キヤノン株式会社 ズームレンズ及びそれを有する光学機器
DE102004064002B4 (de) 2004-08-04 2019-05-09 Continental Automotive Gmbh System zum Überwachen einer Sensorvorrichtung
PT1912636E (pt) 2005-07-21 2014-07-24 Ardea Biosciences Inc Inibidores de n-(arilamino)-sulfonamida de mek
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
AR064106A1 (es) 2006-12-05 2009-03-11 Bayer Schering Pharma Ag Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
KR20110014149A (ko) * 2008-04-14 2011-02-10 아디아 바이오사이언스즈 인크. 조성물 및 이것의 제조 및 사용 방법
EP2168583A1 (en) * 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma

Also Published As

Publication number Publication date
EA201201414A1 (ru) 2013-04-30
KR20130098155A (ko) 2013-09-04
DOP2012000269A (es) 2012-12-15
EP2558126A2 (en) 2013-02-20
CA2796253A1 (en) 2011-10-20
JP5886271B2 (ja) 2016-03-16
MX2012012064A (es) 2012-12-17
CU20120150A7 (es) 2013-02-26
MA34158B1 (fr) 2013-04-03
US20130184270A1 (en) 2013-07-18
CL2012002887A1 (es) 2013-01-18
CO6620036A2 (es) 2013-02-15
WO2011128407A2 (en) 2011-10-20
CN102958540B (zh) 2015-09-02
IL222356A0 (en) 2012-12-31
WO2011128407A3 (en) 2012-02-23
CN102958540A (zh) 2013-03-06
SG184550A1 (en) 2012-11-29
WO2011128407A9 (en) 2011-12-22
BR112012026480A2 (pt) 2016-08-16
ECSP12012261A (es) 2012-11-30
HK1182937A1 (en) 2013-12-13
JP2013525293A (ja) 2013-06-20
EA201201414A8 (ru) 2013-12-30
ZA201208616B (en) 2015-08-26
AU2011240003A1 (en) 2012-11-08
TN2012000493A1 (en) 2014-04-01
CR20120524A (es) 2013-01-09

Similar Documents

Publication Publication Date Title
PE20130191A1 (es) Combinaciones que contienen 2, 3-dihidroimidazo[1, 2-c]quinazolina sustituida
PE20180462A1 (es) Moduladores cot y metodos de uso de los mismos
CU20120101A7 (es) Derivados de triazolopirazinas sustituidas como inhibidores del receptor c-met o hgf para tratar el cáncer
NI200900040A (es) Derivados de quinazolinona 5-substituidos como agentes antitumorales.
CY1119499T1 (el) Ενωσεις 6,7-διυδροπυραζολο[1,5-α]πυραζιν-4(5η)-ονης και η χρηση τους ως αρνητικοι αλλοστερικοι τροποποιητες των υποδοχεων mglur2
PE20090900A1 (es) Derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol como inhibidores del receptor del factor de creciemiento de hepatocitos (met), su procedimiento de preparacion y una composicion farmaceutica que los contiene
EA200971081A1 (ru) Пуриновые производные и их применение в качестве модуляторов толл-подобного рецептора 7
EA201200049A1 (ru) 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17
CY1117147T1 (el) Παραγωγα [1,2,3]τριαζολο[4,5-d]πυριμιδiνης ως αγωνιστες του κaνναβινοειδους υποδοχεα 2
PE20091561A1 (es) Compuestos inhibidores de raf y metodos para su uso
CU24517B1 (es) Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos
PE20150684A1 (es) Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr)
PE20140961A1 (es) Inhibidores macrociclicos de serina proteasas de hepatitis c
TW201129565A (en) Tricyclic heterocyclic compounds, compositions and methods of use thereof
EA201692542A1 (ru) Индановые и индолиновые производные и их применение в качестве активаторов растворимой гуанилатциклазы
EA202090860A1 (ru) Аналоги тиадиазола и способы лечения состояний, связанных с дефицитом smn
EA201171062A1 (ru) Алкиламидные соединения и их применение
GT200800158A (es) Pirazolquinolonas como potentes inhibidores de parp
DOP2011000076A (es) Derivados de heteroaril amidas y su uso como activadores de glucoquinasa
EA201071234A1 (ru) Производные изохинолинона в качестве nk3 антагонистов
CL2012001072A1 (es) Compuestos derivados de feniletinilo, moduladores alostericos positivos del receptor de glutamato (mglur5); procedimiento de preparacion; composicion farmaceutica; y uso para tratar esquizofrenia o enfermedades cognitivas.
AR078278A1 (es) Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
CR11098A (es) Compuestos de pirido [2,3-d] pirimidina-7-ona como inhibidores de p13k-alfa para el tratamiento del cancer
AR047531A1 (es) Derivados 1h-tieno(2,3-c)pirazol utiles como inhibidores de quinasa
EA201792374A1 (ru) Азабензимидазолы и их применение в качестве модуляторов рецептора ampa

Legal Events

Date Code Title Description
FD Application declared void or lapsed