PE20020756A1 - Imidazotriazinonas sustituidas como inhibidores de la fosfodiesterasa pde 2 - Google Patents

Imidazotriazinonas sustituidas como inhibidores de la fosfodiesterasa pde 2

Info

Publication number
PE20020756A1
PE20020756A1 PE2001001277A PE2001001277A PE20020756A1 PE 20020756 A1 PE20020756 A1 PE 20020756A1 PE 2001001277 A PE2001001277 A PE 2001001277A PE 2001001277 A PE2001001277 A PE 2001001277A PE 20020756 A1 PE20020756 A1 PE 20020756A1
Authority
PE
Peru
Prior art keywords
ilo
alkyl
substituted
imidazotriazinones
inhibitors
Prior art date
Application number
PE2001001277A
Other languages
English (en)
Inventor
Ulrich Niewohner
Dagmar Schaus
Gerhard Konig
Der Staay Franz-Josef Van
Karl-Heinz Schlemmer
Rolf Grosser
Rudy Schreiber
Frank-Gerhard Bos
Martin Hendrix
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20020756A1 publication Critical patent/PE20020756A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A IMIDAZOTRIAZINONAS SUSTITUIDOS DE FORMULA I DONDE R1 ES FENILO, NAFTILO, QUINOLILO, ISOQUINOLINILO OPCIONALMENTE SUSTITUIDOS POR ALQUILO C1-C4, ALCOXI C1-C4, HALOGENO, CIANO, NHCOR8, NHSO2R9, SO2NR10R11, SO2R12, NR13R14; R8, R10, R11, R13, R14 SON H, ALQUILO C1-C4; R9 Y R12 SON ALQUILO C1-C4, R10 Y R11 JUNTO A N O R13 Y R14 JUNTO A N FORMAN EL RESTO AZETIDIN-1-ILO; PIRROL-1-ILO, PIPERIDIN-1-ILO, AZEPIN-1-ILO, 4-METILPIPERAZIN-1-ILO, MORFOLIN-1-ILO; R2 Y R3 SON H, F; R4 ES ALQUILO C1-C4, R5 ES ALQUILO C1-C3; R6 ES H, METILO; R7 ES FENILO, TIOFENO, FURANILO OPCIONALMENTE SUSTITUIDO CON HIDROXIMETANODIILO; M ES ALCANODIILO C2-C5, ALQUENODIILO C2-C5, ALQUINODIILO C2-C5. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE PDE2 QUE CONDUCE A UN AUMENTO DIFERENCIADO DE GMPc Y PUEDEN SER UTILES PARA LA MEJORA DE LA CAPACIDAD DE CONCENTRACION, APRENDIZAJE, MEMORIA, PERCEPCION, TRASTORNO CONSECUENCIA DE LA DEMENCIA
PE2001001277A 2000-12-21 2001-12-20 Imidazotriazinonas sustituidas como inhibidores de la fosfodiesterasa pde 2 PE20020756A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10064105A DE10064105A1 (de) 2000-12-21 2000-12-21 Neue Substituierte Imidazotriazinone

Publications (1)

Publication Number Publication Date
PE20020756A1 true PE20020756A1 (es) 2002-10-02

Family

ID=7668333

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001277A PE20020756A1 (es) 2000-12-21 2001-12-20 Imidazotriazinonas sustituidas como inhibidores de la fosfodiesterasa pde 2

Country Status (15)

Country Link
US (1) US6573263B2 (es)
EP (1) EP1347978B1 (es)
JP (1) JP2004525098A (es)
AR (1) AR034423A1 (es)
AU (1) AU2002216087A1 (es)
CA (1) CA2431965A1 (es)
DE (2) DE10064105A1 (es)
DO (1) DOP2001000297A (es)
ES (1) ES2248228T3 (es)
GT (1) GT200100254A (es)
HN (1) HN2001000281A (es)
PE (1) PE20020756A1 (es)
SV (1) SV2002000776A (es)
UY (1) UY27080A1 (es)
WO (1) WO2002050078A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087605B2 (en) 2001-06-01 2006-08-08 Bayer Aktiengesellschaft 5-Ethyl-imidazotriazinones
GB0113342D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 1
DE60320529T2 (de) * 2002-02-04 2009-06-10 F. Hoffmann-La Roche Ag Chinolinderivate als npy antagonisten
CA2489251A1 (en) * 2002-07-05 2004-01-15 F. Hoffmann-La Roche Ag Quinazoline derivatives
CA2493712A1 (en) * 2002-08-07 2004-02-19 F. Hoffmann-La Roche Ag Aminothiazole derivatives as npy5 receptor inhibitors
JP2006219374A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
UA115057C2 (uk) 2012-04-25 2017-09-11 Такеда Фармасьютікал Компані Лімітед Азотвмісна гетероциклічна сполука
EP2873669A4 (en) * 2012-07-13 2015-11-25 Takeda Pharmaceutical HETEROCYCLIC COMPOUND
WO2014142255A1 (ja) 2013-03-14 2014-09-18 武田薬品工業株式会社 複素環化合物
JP6411342B2 (ja) 2013-07-03 2018-10-24 武田薬品工業株式会社 アミド化合物
JP6427491B2 (ja) 2013-07-03 2018-11-21 武田薬品工業株式会社 複素環化合物
EP3087060B1 (en) 2013-12-23 2020-05-13 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
US9849132B2 (en) 2014-01-08 2017-12-26 Intra-Cellular Therapies, Inc. Products and pharmaceutical compositions
MA50375A (fr) 2014-04-23 2021-05-26 Dart Neuroscience Cayman Ltd Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2
TWI568737B (zh) 2014-11-05 2017-02-01 達特神經科學（開曼）有限責任公司 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物
US10105349B2 (en) 2014-12-06 2018-10-23 Intra-Cellular Therapies, Inc. Organic compounds
KR102557603B1 (ko) 2014-12-06 2023-07-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
EP3285581B1 (en) 2015-03-26 2021-08-11 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
US10195201B2 (en) 2015-05-05 2019-02-05 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as PDE2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
EP3313852B1 (en) 2015-06-25 2021-01-20 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2019101970A1 (en) 2017-11-23 2019-05-31 Oslo University Hospital Hf Treatment of tachycardia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK109578A (da) 1977-03-25 1978-09-26 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af heterocycliske forbindelser
DE19541264A1 (de) 1995-11-06 1997-05-07 Bayer Ag Purin-6-on-derivate
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
HU230154B1 (hu) * 1997-11-12 2015-09-28 Bayer Intellectual Property Gmbh Eljárás 2-es helyzetben fenil-szubszituenst hordozó imidazo-triazinon-származékok előállítására
DE19827640A1 (de) 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
DE19838705A1 (de) 1998-08-26 2000-03-02 Bayer Ag Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one

Also Published As

Publication number Publication date
CA2431965A1 (en) 2002-06-27
WO2002050078A1 (de) 2002-06-27
EP1347978B1 (de) 2005-08-31
SV2002000776A (es) 2002-12-02
DOP2001000297A (es) 2003-08-15
JP2004525098A (ja) 2004-08-19
AU2002216087A1 (en) 2002-07-01
UY27080A1 (es) 2002-07-31
EP1347978A1 (de) 2003-10-01
AR034423A1 (es) 2004-02-25
HN2001000281A (es) 2003-02-04
US6573263B2 (en) 2003-06-03
GT200100254A (es) 2002-08-19
DE10064105A1 (de) 2002-06-27
US20020198377A1 (en) 2002-12-26
ES2248228T3 (es) 2006-03-16
DE50107316D1 (de) 2005-10-06

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