AR034423A1 - Imidazotriazinonas sustituidas, un procedimiento para su preparacion, medicamentos y el uso de dichas imidazotriazinonas para la preparacion de medicamentos - Google Patents
Imidazotriazinonas sustituidas, un procedimiento para su preparacion, medicamentos y el uso de dichas imidazotriazinonas para la preparacion de medicamentosInfo
- Publication number
- AR034423A1 AR034423A1 ARP010105704A ARP010105704A AR034423A1 AR 034423 A1 AR034423 A1 AR 034423A1 AR P010105704 A ARP010105704 A AR P010105704A AR P010105704 A ARP010105704 A AR P010105704A AR 034423 A1 AR034423 A1 AR 034423A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- preparation
- imidazotriazinones
- methyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Imidazotriazinonas sustituidas, que comprenden compuestos de fórmula general (1) en la que: R1 significa fenilo, naftilo, quinolinilo o isoquinolinilo, que pueden estar sustituidos hasta tres veces de forma idéntica o diferente por radicales seleccionados del grupo constituido por alquilo C1-4, alcoxi C1-4, halógeno, ciano, -NHCOR8, -NHSO2R9, -SO2NR10R11, -SO2R12 y -NR13R14, en la que, R8, R10, R11, R13 y R14 son independientemente entre sí hidrógeno o alquilo C1-4, y R9 y R12 son independientemente entre sí alquilo C1-4, o R10 y R11 junto con el átomo de nitrógeno vecino forman un radical azetidin-1-ilo, pirrol-1-ilo, piperid-1-ilo, azepin-1-ilo, 4-metil-piperazin-1-ilo o morfolin-1-ilo; o R13 y R14 junto con el átomo de nitrógeno vecino forman un radical azetidin-1-ilo, pirroli-1-ilo, piperid-1-ilo, azepin-1-ilo, 4-metil-piperazin-1-ilo o morfolin-1-ilo; R2 y R3 significan independientemente entre sí hidrógeno o flúor; R4 significa alquilo C1-4; R5 significa alquilo C1-3; R6 significa hidrógeno o metilo; R7 significa fenilo, tiofeno, furanilo, que puede estar sustituido hasta tres veces de forma idéntica o diferente por radicales seleccionados del grupo constituido por alquilo C1-4, alcoxi C1-4, halógeno y ciano o cicloalquilo C5-8; L significa carbonilo o hidroximetanodiilo; y M significa alcanodiilo C2-5, alquenodiilo C2-5 o alquinodiilo C2-5; y sus sales fisiológicamente aceptables; procedimiento para su preparación, medicamentos y el uso de dichos compuestos para la preparación de medicamentos especialmente para la mejora de la percepción, la capacidad de concentración, la capacidad de aprendizaje y/o la capacidad de memoria.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10064105A DE10064105A1 (de) | 2000-12-21 | 2000-12-21 | Neue Substituierte Imidazotriazinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034423A1 true AR034423A1 (es) | 2004-02-25 |
Family
ID=7668333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105704A AR034423A1 (es) | 2000-12-21 | 2001-12-07 | Imidazotriazinonas sustituidas, un procedimiento para su preparacion, medicamentos y el uso de dichas imidazotriazinonas para la preparacion de medicamentos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6573263B2 (es) |
| EP (1) | EP1347978B1 (es) |
| JP (1) | JP2004525098A (es) |
| AR (1) | AR034423A1 (es) |
| AU (1) | AU2002216087A1 (es) |
| CA (1) | CA2431965A1 (es) |
| DE (2) | DE10064105A1 (es) |
| DO (1) | DOP2001000297A (es) |
| ES (1) | ES2248228T3 (es) |
| GT (1) | GT200100254A (es) |
| HN (1) | HN2001000281A (es) |
| PE (1) | PE20020756A1 (es) |
| SV (1) | SV2002000776A (es) |
| UY (1) | UY27080A1 (es) |
| WO (1) | WO2002050078A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087605B2 (en) | 2001-06-01 | 2006-08-08 | Bayer Aktiengesellschaft | 5-Ethyl-imidazotriazinones |
| GB0113342D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel Heterocycles 1 |
| RU2298002C2 (ru) * | 2002-02-04 | 2007-04-27 | Ф. Хоффманн-Ля Рош Аг | Производные хинолина в качестве антагонистов npy |
| WO2004005265A1 (en) * | 2002-07-05 | 2004-01-15 | F. Hoffmann-La Roche Ag | Quinazoline derivatives |
| MXPA05001328A (es) * | 2002-08-07 | 2005-04-28 | Hoffmann La Roche | Derivados de tiazol. |
| JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体 |
| NZ631258A (en) | 2012-04-25 | 2016-11-25 | Takeda Pharmaceuticals Co | Nitrogenated heterocyclic compound |
| US9527841B2 (en) | 2012-07-13 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Substituted pyrido[2,3-b]pyrazines as phosphodiesterase 2A inhibitors |
| EP2975031A4 (en) | 2013-03-14 | 2017-04-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JP6411342B2 (ja) | 2013-07-03 | 2018-10-24 | 武田薬品工業株式会社 | アミド化合物 |
| JP6427491B2 (ja) | 2013-07-03 | 2018-11-21 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3087060B1 (en) | 2013-12-23 | 2020-05-13 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as pde2 inhibitors |
| US9849132B2 (en) | 2014-01-08 | 2017-12-26 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
| ES2759246T3 (es) | 2014-04-23 | 2020-05-08 | Dart Neuroscience Cayman Ltd | Compuestos de[1,2,4]triazolo[1,5-a]pirimidinilo-7-il sustituidos como inhibidores de PDE2 |
| WO2016073424A1 (en) | 2014-11-05 | 2016-05-12 | Dart Neuroscience, Llc | Substituted 5-methyl-[1, 2, 4] triazolo [1,5-a) pyrimidin-2-amine compounds as pde2 inhibitors |
| CA2969597C (en) | 2014-12-06 | 2023-10-24 | Intra-Cellular Therapies, Inc. | 1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors |
| WO2016090380A1 (en) | 2014-12-06 | 2016-06-09 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| EP3285581B1 (en) | 2015-03-26 | 2021-08-11 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as pde2 inhibitors |
| US10195201B2 (en) | 2015-05-05 | 2019-02-05 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as PDE2 inhibitors |
| WO2016183741A1 (en) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Pyrimidinone amide compounds as pde2 inhibitors |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| US10647727B2 (en) | 2015-06-25 | 2020-05-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| EP3713572A1 (en) | 2017-11-23 | 2020-09-30 | Oslo University Hospital HF | Treatment of tachycardia |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK109578A (da) | 1977-03-25 | 1978-09-26 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af heterocycliske forbindelser |
| DE19541264A1 (de) | 1995-11-06 | 1997-05-07 | Bayer Ag | Purin-6-on-derivate |
| DE19709877A1 (de) | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
| PT1049695E (pt) * | 1997-11-12 | 2002-07-31 | Bayer Ag | Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase |
| DE19827640A1 (de) * | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| DE19838705A1 (de) | 1998-08-26 | 2000-03-02 | Bayer Ag | Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one |
-
2000
- 2000-12-21 DE DE10064105A patent/DE10064105A1/de not_active Withdrawn
-
2001
- 2001-11-30 DO DO2001000297A patent/DOP2001000297A/es unknown
- 2001-12-07 AR ARP010105704A patent/AR034423A1/es unknown
- 2001-12-10 DE DE50107316T patent/DE50107316D1/de not_active Expired - Fee Related
- 2001-12-10 ES ES01271375T patent/ES2248228T3/es not_active Expired - Lifetime
- 2001-12-10 WO PCT/EP2001/014450 patent/WO2002050078A1/de active IP Right Grant
- 2001-12-10 JP JP2002551971A patent/JP2004525098A/ja active Pending
- 2001-12-10 EP EP01271375A patent/EP1347978B1/de not_active Expired - Lifetime
- 2001-12-10 AU AU2002216087A patent/AU2002216087A1/en not_active Abandoned
- 2001-12-10 CA CA002431965A patent/CA2431965A1/en not_active Abandoned
- 2001-12-18 UY UY27080A patent/UY27080A1/es not_active Application Discontinuation
- 2001-12-19 GT GT200100254A patent/GT200100254A/es unknown
- 2001-12-19 HN HN2001000281A patent/HN2001000281A/es unknown
- 2001-12-20 SV SV2001000776A patent/SV2002000776A/es unknown
- 2001-12-20 PE PE2001001277A patent/PE20020756A1/es not_active Application Discontinuation
- 2001-12-21 US US10/026,310 patent/US6573263B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1347978B1 (de) | 2005-08-31 |
| HN2001000281A (es) | 2003-02-04 |
| DE10064105A1 (de) | 2002-06-27 |
| ES2248228T3 (es) | 2006-03-16 |
| UY27080A1 (es) | 2002-07-31 |
| US20020198377A1 (en) | 2002-12-26 |
| WO2002050078A1 (de) | 2002-06-27 |
| DE50107316D1 (de) | 2005-10-06 |
| EP1347978A1 (de) | 2003-10-01 |
| US6573263B2 (en) | 2003-06-03 |
| JP2004525098A (ja) | 2004-08-19 |
| SV2002000776A (es) | 2002-12-02 |
| PE20020756A1 (es) | 2002-10-02 |
| DOP2001000297A (es) | 2003-08-15 |
| CA2431965A1 (en) | 2002-06-27 |
| GT200100254A (es) | 2002-08-19 |
| AU2002216087A1 (en) | 2002-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |