AR095706A1 - Indazoles sustituidos con heteroarilo - Google Patents
Indazoles sustituidos con heteroariloInfo
- Publication number
- AR095706A1 AR095706A1 ARP140101319A ARP140101319A AR095706A1 AR 095706 A1 AR095706 A1 AR 095706A1 AR P140101319 A ARP140101319 A AR P140101319A AR P140101319 A ARP140101319 A AR P140101319A AR 095706 A1 AR095706 A1 AR 095706A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- alkylene
- haloalkoxy
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de la fórmula (1) que son inhibidores de Bub1 quinasa; procesos para su producción y su uso en fármacos para enfermedades hiperproliferativas (tumores hematológicos y tumores sólidos). Reivindicación 1: Un compuesto de la fórmula (1) en donde: T es CH, N; V es CH, N; Y es CR⁶, N; R¹ es hidrógeno, halógeno, alquilo C₁₋₃; R² / R³ son en forma independiente entre sí hidrógeno, halógeno, ciano, hidroxi, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, alcoxi C₁₋₆; R⁴ es en forma independiente hidrógeno, hidroxi, halógeno, ciano, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, alcoxi C₁₋₆, -O-(alquilen C₂₋₄)-O-C(O)-(alquilo C₁₋₄), haloalcoxi C₁₋₆, -C(O)OR⁹, -C(O)-(alquilo C₁₋₆), -C(O)NR¹⁰R¹¹, cicloalquilo C₃₋₇, -S(O)₂NH-(cicloalquilo C₃₋₆), -S(O)₂NR¹⁰R¹¹, heteroarilo que está opcionalmente sustituido en forma independiente una o más veces con ciano, alquilo C₁₋₄, haloalquilo C₁₋₄, haloalcoxi C₁₋₄, donde dos de R², R³, (R⁴)ₙ, cuando están posicionados en posición orto entre sí, pueden formar junto con los dos átomos de carbono a los cuales están unidos, un anillo heterocíclico de 5, 6 ó 7 miembros que contiene 1 ó 2 heteroátomos seleccionados entre O ó N, y que opcionalmente contiene un enlace doble adicional y/o que está opcionalmente sustituido con un grupo oxo (=O) y/o un grupo alquilo C₁₋₄; n es 0, 1, 2 o 3; R⁶ es (a) hidrógeno; (b) hidroxi; (c) ciano; (d) alcoxi C₁₋₆ opcionalmente sustituido en forma independiente una o más veces con (d1) OH, (d2) -O-(alquilo C₁₋₆), (d3) -C(O)OR⁹, (d4) -C(O)NR¹⁰R¹¹, (d5) -NR¹²R¹³, (d6) -S-(alquilo C₁₋₆), (d7) -S(O)-(alquilo C₁₋₆), (d8) -S(O)₂-(alquilo C₁₋₆), (d9) -S(O)₂NR¹⁰R¹¹, (d10) heterociclilo, que está opcionalmente sustituido con -C(O)OR⁹ u oxo (=O), (d11) heteroarilo, que está opcionalmente sustituido en forma independiente una o más veces con ciano, alquilo C₁₋₄, haloalquilo C₁₋₄, haloalcoxi C₁₋₄, -C(O)OR⁹, -C(O)NR¹⁰R¹¹, -(alquilen C₁₋₄)-O-(alquilo C₁₋₄), (e) un resto de fórmula (2), donde el * es el punto de unión, (f) cicloalcoxi C₃₋₇, (g) haloalcoxi C₁₋₆, (h) -O-(alquilen C₂₋₆)-O-(alquilo C₁₋₆) que está opcionalmente sustituido con hidroxi, (i) -NR¹²R¹³, (j) -NHS(O)₂-(alquilo C₁₋₆), (k) -NHS(O)₂-(haloalquilo C₁₋₆); R⁷ es (a) hidrógeno, (b) alquilo C₁₋₄, que está opcionalmente sustituido con heteroarilo, (c) haloalquilo C₁₋₄, (d) hidroxialquilo C₂₋₄, (e) -CH₂-heteroarilo, donde el heteroarilo está opcionalmente sustituido en forma independiente una o más veces con hidroxi, halógeno, ciano, alquilo C₁₋₆ alquenilo C₂₋₆, alquinilo C₂₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, -(alquilen C₁₋₆)-O-(alquilo C₁₋₆), NR¹²R¹³, -C(O)OR⁹, -C(O)-(alquilo C₁₋₆), -C(O)NR¹⁰R¹¹, cicloalquilo C₃₋₇, -S(O)₂NH-(cicloalquilo C₃₋₆), -S(O)₂NR¹⁰R¹¹, (f) -bencilo, donde el anillo fenilo está opcionalmente sustituido en forma independiente una o más veces con halógeno, alquilo C₁₋₄, haloalquilo C₁₋₄, alcoxi C₁₋₄, haloalcoxi C₁₋₄, ciano, C(O)OR⁹, (g) -C(O)-(alquilo C₁₋₆), (h) -C(O)-(alquilen C₁₋₆)-O-(alquilo C₁₋₆), (i) -C(O)-(alquilen C₁₋₆)-O-(alquilen C₂₋₆)-O-(alquilo C₁₋₆), (j) -C(O)-heterociclilo, (k) un resto de fórmula (3), donde el * es el punto de unión; R⁸ es (a) heteroarilo de 5 miembros, (b) heteroarilo de 6 miembros seleccionado entre (b1) piridin-2-ilo, (b2) piridin-3-ilo, (b3) pirazin-2-ilo, (b4) piridazin-3-ilo, (b5) piridazin-4-ilo, (b6) pirimidin-2-ilo, (b7) pirimidin-4-ilo, (b8) pirimidin-5-ilo, (b9) 1,3,5-triazin-2-ilo, (b10) 1,2,4-triazin-3-ilo, (b11) 1,2,4-triazin-5-ilo, (b12) 1,2,4-triazin-6-ilo, (c) fenilo, donde dicho heteroarilo de 5 miembros o heteroarilo de 6 miembros o fenilo está opcionalmente sustituido en forma independiente una o más veces con halógeno, hidroxi, ciano, alquilo C₁₋₆, hidroxialquilo C₁₋₆, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, -(CH₂)-O-(alquilo C₁₋₆), etoximetilo, -(alquilen C₂₋₆)-O-(alquilo C₁₋₆), -C(O)OR⁹, -C(O)NR¹⁰R¹¹, -NR¹²R¹³; R⁹ es (a) hidrógeno, (b) alquilo C₁₋₄ que está opcionalmente sustituido con hidroxi; R¹⁰, R¹¹ son en forma independiente entre sí hidrógeno, alquilo C₁₋₄, hidroxialquilo C₂₋₄, o junto con el átomo de nitrógeno al cual están unidos forman un anillo heterocíclico de 4 - 6 miembros que opcionalmente contiene un heteroátomo adicional seleccionado entre el grupo que consiste en O, S o N, y que está opcionalmente sustituido con 1 - 2 átomos de flúor o -C(O)OR⁹; R¹²,R¹³ son en forma independiente entre sí hidrógeno, alquilo C₁₋₄, hidroxialquilo C₂₋₄, -C(O)-(alquilo C₁₋₆), -C(O)-(alquilen C₁₋₆)-O-(alquilo C₁₋₆), -C(O)H, -C(O)OR⁹, o junto con el átomo de nitrógeno al cual están unidos forman un anillo heterocíclico de 4 - 6 miembros que opcionalmente contiene un heteroátomo adicional seleccionado entre el grupo que consiste en O, S o N, y que está opcionalmente sustituido con un grupo oxo (=O); o un N-óxido, una sal, un tautómero o un estereoisómero de dicho compuesto, o una sal de dicho N-óxido, tautómero o estereoisómero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13160520 | 2013-03-21 |
Publications (1)
Publication Number | Publication Date |
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AR095706A1 true AR095706A1 (es) | 2015-11-04 |
Family
ID=47901890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140101319A AR095706A1 (es) | 2013-03-21 | 2014-03-21 | Indazoles sustituidos con heteroarilo |
Country Status (10)
Country | Link |
---|---|
US (1) | US20160046610A1 (es) |
EP (1) | EP2976336A1 (es) |
JP (1) | JP2016514718A (es) |
CN (1) | CN105209455A (es) |
AR (1) | AR095706A1 (es) |
CA (1) | CA2907592A1 (es) |
HK (1) | HK1218750A1 (es) |
TW (1) | TW201514166A (es) |
UY (1) | UY35500A (es) |
WO (1) | WO2014147203A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
WO2013092512A1 (en) | 2011-12-21 | 2013-06-27 | Bayer Intellectual Property Gmbh | Substituted benzylpyrazoles |
WO2014147204A1 (en) * | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted indazoles |
CA2907730A1 (en) * | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
JP2016525075A (ja) | 2013-06-21 | 2016-08-22 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロアリール置換ピラゾール類 |
EP3010904A1 (en) | 2013-06-21 | 2016-04-27 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
WO2015063003A1 (en) | 2013-10-30 | 2015-05-07 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
HUE050761T2 (hu) | 2014-01-01 | 2021-01-28 | Medivation Tech Llc | Vegyületek és alkalmazási eljárások |
WO2015193339A1 (en) | 2014-06-17 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones |
EP3194378A1 (en) * | 2014-09-19 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles |
CN107001331A (zh) | 2014-09-19 | 2017-08-01 | 拜耳制药股份公司 | 作为bub1抑制剂的苄基取代的吲唑 |
MX2017009831A (es) * | 2015-01-28 | 2017-11-02 | Bayer Pharma AG | Derivados de 4h-pirrol[3,2-c]piridin-4-ona. |
CN107922389A (zh) | 2015-06-17 | 2018-04-17 | 拜耳制药股份公司 | 3‑氨基‑1,5,6,7‑四氢‑4h‑吲哚‑4‑酮 |
JP2019504826A (ja) * | 2015-12-16 | 2019-02-21 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロ−1,5,6,7−テトラヒドロ−4h−インドール−4−オン類 |
WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
WO2017157992A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders |
WO2017157991A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases |
WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
WO2018158175A1 (en) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combination of bub1 inhibitors |
WO2018206547A1 (en) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and atr inhibitors |
WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
US20230364070A1 (en) | 2020-09-23 | 2023-11-16 | Scorpion Therapeutics, Inc. | Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer |
WO2022072645A2 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
TW202229282A (zh) | 2020-09-30 | 2022-08-01 | 美商史考皮恩治療有限公司 | 治療癌症之方法 |
EP4225445A2 (en) | 2020-10-09 | 2023-08-16 | Scorpion Therapeutics, Inc. | Heterocyclic inhibitors of egfr and/or her2, for use in the treatment of cancer |
WO2022094271A1 (en) | 2020-10-30 | 2022-05-05 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
WO2022098992A1 (en) | 2020-11-05 | 2022-05-12 | Scorpion Therapeutics, Inc. | Use of macrocyclic compounds in methods of treating cancer |
WO2022197913A1 (en) | 2021-03-18 | 2022-09-22 | Scorpion Therapeutics, Inc. | Bicyclic derivatives which can be used to treat cancer |
WO2023173083A1 (en) | 2022-03-11 | 2023-09-14 | Scorpion Therapeutics, Inc. | Tetrahydroindole derivatives as egfr and/or her2 inhibtors useful for the treatment of cancer |
EP4293019A1 (en) * | 2022-06-13 | 2023-12-20 | Netherlands Translational Research Center Holding B.V. | 4-substituted (1h-benzo[d]imidazol-2-yl)-1h-pyrazoles as bub1 inhibitors useful for treating cancers |
Family Cites Families (12)
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US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US6837294B2 (en) * | 2003-02-10 | 2005-01-04 | Zipshade Industrial (B.V.I.) Corp. | Pull down, push up, shade assembly |
EP2336122B1 (en) * | 2005-07-26 | 2014-05-14 | Vertex Pharmaceuticals Inc. | 1-pyrimidinyl- or 1-pyridinyl-2-amino benzimidazole derivatives and related compounds as inhibitors of protein kinases for the treatment of cancer |
JP2010111624A (ja) * | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ttk阻害作用を有するインダゾール誘導体 |
US20130178475A1 (en) * | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
WO2012139930A1 (en) * | 2011-04-11 | 2012-10-18 | Nerviano Medical Sciences S.R.L. | Pyrazolyl-pyrimidine derivatives as kinase inhibitors |
UA111754C2 (uk) * | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
WO2013092512A1 (en) | 2011-12-21 | 2013-06-27 | Bayer Intellectual Property Gmbh | Substituted benzylpyrazoles |
DE102012200352A1 (de) * | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
WO2013167698A1 (en) | 2012-05-11 | 2013-11-14 | Bayer Pharma Aktiengesellschaft | Substituted cycloalkenopyrazoles as bub1 inhibitors for the treatment of cancer |
CA2907730A1 (en) * | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
WO2014147204A1 (en) * | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted indazoles |
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2014
- 2014-03-20 JP JP2016503668A patent/JP2016514718A/ja active Pending
- 2014-03-20 EP EP14714196.4A patent/EP2976336A1/en not_active Withdrawn
- 2014-03-20 CA CA2907592A patent/CA2907592A1/en not_active Abandoned
- 2014-03-20 US US14/778,975 patent/US20160046610A1/en not_active Abandoned
- 2014-03-20 WO PCT/EP2014/055657 patent/WO2014147203A1/en active Application Filing
- 2014-03-20 CN CN201480029308.7A patent/CN105209455A/zh active Pending
- 2014-03-21 TW TW103110770A patent/TW201514166A/zh unknown
- 2014-03-21 AR ARP140101319A patent/AR095706A1/es unknown
- 2014-03-24 UY UY0001035500A patent/UY35500A/es not_active Application Discontinuation
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2016
- 2016-06-13 HK HK16106728.8A patent/HK1218750A1/zh unknown
Also Published As
Publication number | Publication date |
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CA2907592A1 (en) | 2014-09-25 |
EP2976336A1 (en) | 2016-01-27 |
UY35500A (es) | 2014-10-31 |
JP2016514718A (ja) | 2016-05-23 |
WO2014147203A1 (en) | 2014-09-25 |
US20160046610A1 (en) | 2016-02-18 |
CN105209455A (zh) | 2015-12-30 |
HK1218750A1 (zh) | 2017-03-10 |
TW201514166A (zh) | 2015-04-16 |
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