AR111414A1 - Derivados de heteroarilcarboxamida como inhibidores de la calicreína plasmática - Google Patents
Derivados de heteroarilcarboxamida como inhibidores de la calicreína plasmáticaInfo
- Publication number
- AR111414A1 AR111414A1 ARP180101024A ARP180101024A AR111414A1 AR 111414 A1 AR111414 A1 AR 111414A1 AR P180101024 A ARP180101024 A AR P180101024A AR P180101024 A ARP180101024 A AR P180101024A AR 111414 A1 AR111414 A1 AR 111414A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- ring system
- heteroarilcarboxamida
- calicreine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado por la fórmula (1), en donde A se selecciona del grupo A-G¹ que consiste en N y CH; T se selecciona del grupo T-G¹ que consiste en N, C-H, C₁₋₄-alquilo, C-CHF₂, C-CF₃ y C-OCH₃; R¹ se selecciona del grupo R¹-G¹ que consiste en C₁₋₃-alquilo; R² se selecciona del grupo R²-G¹ que consiste en un sistema de anillos bicíclicos espiro o fusionados que consiste en 1 átomo de N y 5 a 6 átomos de C como miembros del anillo, en donde el sistema de anillos se une mediante el átomo de N al anillo heteroaromático monocíclico en la fórmula (1) y en donde el sistema de anillos se sustituye opcionalmente con un sustituyente seleccionado del grupo que consiste en F, C₁₋₃-alquilo, CF₃, CN, HO-C₁₋₃-alquil- y C₁₋₃-alquiloxi- y en donde el sistema de anillos además se sustituye opcionalmente con un sustituyente seleccionado del grupo que consiste en F y CH₃; y R³ se selecciona del grupo R³-G¹ que consiste en H, CH₃, CHF₂ o CF₃; o una sal de aquel.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17167549 | 2017-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111414A1 true AR111414A1 (es) | 2019-07-10 |
Family
ID=58606127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101024A AR111414A1 (es) | 2017-04-21 | 2018-04-20 | Derivados de heteroarilcarboxamida como inhibidores de la calicreína plasmática |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10501440B2 (es) |
| EP (1) | EP3612523B1 (es) |
| JP (1) | JP7175914B2 (es) |
| CN (1) | CN110546146B (es) |
| AR (1) | AR111414A1 (es) |
| TW (1) | TW201902887A (es) |
| WO (1) | WO2018192866A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12091399B2 (en) | 2018-10-10 | 2024-09-17 | Boehringer Ingelheim International Gmbh | Phenyltetrazole derivatives as plasma kallikrein inhibitors |
| TW202144331A (zh) * | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| TW202144330A (zh) * | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| WO2021198534A1 (en) | 2020-04-04 | 2021-10-07 | Oxurion NV | Plasma kallikrein inhibitors for use in the treatment of coronaviral disease |
| WO2023144030A1 (en) | 2022-01-31 | 2023-08-03 | Oxurion NV | Plasma kallikrein inhibitor therapy for anti-vegf sensitization |
| WO2023148016A1 (en) | 2022-02-04 | 2023-08-10 | Oxurion NV | Biomarker for plasma kallikrein inhibitor therapy response |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013011107A1 (de) | 2011-07-21 | 2013-01-24 | Thyssenkrupp System Engineering Gmbh | Vorrichtung und verfahren zum stoppen und/oder ausrichten von transportgütern auf einer fördereinrichtung und fördereinrichtung |
| WO2013111108A1 (en) * | 2012-01-27 | 2013-08-01 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| PL2999697T3 (pl) | 2013-05-23 | 2017-09-29 | Kalvista Pharmaceuticals Limited | Pochodne heterocykliczne |
| EP3368524B1 (en) | 2015-10-27 | 2021-08-18 | Boehringer Ingelheim International GmbH | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
-
2018
- 2018-04-16 JP JP2019556654A patent/JP7175914B2/ja active Active
- 2018-04-16 EP EP18719794.2A patent/EP3612523B1/en active Active
- 2018-04-16 WO PCT/EP2018/059633 patent/WO2018192866A1/en active Application Filing
- 2018-04-16 US US15/953,523 patent/US10501440B2/en active Active
- 2018-04-16 CN CN201880026013.2A patent/CN110546146B/zh active Active
- 2018-04-20 AR ARP180101024A patent/AR111414A1/es unknown
- 2018-04-20 TW TW107113453A patent/TW201902887A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10501440B2 (en) | 2019-12-10 |
| CN110546146A (zh) | 2019-12-06 |
| JP2020517619A (ja) | 2020-06-18 |
| WO2018192866A1 (en) | 2018-10-25 |
| TW201902887A (zh) | 2019-01-16 |
| CN110546146B (zh) | 2023-02-21 |
| US20180305339A1 (en) | 2018-10-25 |
| EP3612523A1 (en) | 2020-02-26 |
| EP3612523B1 (en) | 2021-06-09 |
| JP7175914B2 (ja) | 2022-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |