PE20121152A1 - Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion - Google Patents

Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Info

Publication number
PE20121152A1
PE20121152A1 PE2012000296A PE2012000296A PE20121152A1 PE 20121152 A1 PE20121152 A1 PE 20121152A1 PE 2012000296 A PE2012000296 A PE 2012000296A PE 2012000296 A PE2012000296 A PE 2012000296A PE 20121152 A1 PE20121152 A1 PE 20121152A1
Authority
PE
Peru
Prior art keywords
amino
alkyl
pyrazoles
substitute
manufacturing
Prior art date
Application number
PE2012000296A
Other languages
English (en)
Inventor
Kristen Bjergarde
Mark Dodson
Jacques Mauger
Anil Nair
Marcel Patek
Michel Tabart
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20121152A1 publication Critical patent/PE20121152A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE Ar-L-A ES II; X1, X2, X3 Y X4 SON CADA UNO CR'5; R'5 ES H, F; A ES FENILO, PIRIDILO SUSTITUIDO O NO CON F, Cl, SF5, ALQUILO C1-C6, ENTRE OTROS; L ES NH-CO-NH, O-CO-NH; R1 ES H; X ES O, NH; R3 ES H, ALQUILO C1-C6; R4a ES H, ALQUILO C1-C4; R4b ES H, ALQUILO C1-C4; R5 ES H, HALOGENO. SON COMPUESTOS PREFERIDOS: TRIFLUOROACETATO DE 4-[(3-{[(2-FLUOROFENIL)CARBAMOIL]AMINO}BENCIL)AMINO]-1H-PIRAZOL-3-CARBOXAMIDA; TRIFLUOROACETATO DE 4-{[3-({[2-FLUORO-3-(TRIFLUOROMETIL)FENIL]CARBAMOIL}AMINO)BENCIL]AMINO}-1H-PIRAZOL-3-CARBOXAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE KDR (RECEPTOR CON DOMINIO DE INSERCION QUINASA) Y TIE2 (TIROSINA QUINASA ESPECIFICO DE CELULAS ENDOTELIALES) UTILES EN EL TRATAMIENTO DE CANCER
PE2012000296A 2006-11-10 2007-11-09 Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion PE20121152A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0609812A FR2908409B1 (fr) 2006-11-10 2006-11-10 Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
PE20121152A1 true PE20121152A1 (es) 2012-09-07

Family

ID=38169388

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2012000296A PE20121152A1 (es) 2006-11-10 2007-11-09 Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion
PE2007001548A PE20081162A1 (es) 2006-11-10 2007-11-09 Pirazoles sustituidos, composiciones que los contienen, procedimientos de fabricacion y utilizacion

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2007001548A PE20081162A1 (es) 2006-11-10 2007-11-09 Pirazoles sustituidos, composiciones que los contienen, procedimientos de fabricacion y utilizacion

Country Status (40)

Country Link
US (3) US7989439B2 (es)
EP (1) EP2091920B1 (es)
JP (1) JP5538893B2 (es)
KR (1) KR20090083456A (es)
CN (1) CN101553473B (es)
AR (1) AR063638A1 (es)
AU (1) AU2007327423B2 (es)
BR (1) BRPI0718999A2 (es)
CA (1) CA2667846A1 (es)
CL (1) CL2007003251A1 (es)
CO (1) CO6190516A2 (es)
CR (1) CR10749A (es)
CY (1) CY1116000T1 (es)
DK (1) DK2091920T3 (es)
DO (1) DOP2009000088A (es)
EA (1) EA019454B1 (es)
EC (1) ECSP099312A (es)
ES (1) ES2528385T3 (es)
FR (1) FR2908409B1 (es)
HK (1) HK1137988A1 (es)
HN (1) HN2009000856A (es)
HR (1) HRP20150070T1 (es)
IL (1) IL198328A0 (es)
MA (1) MA30972B1 (es)
MX (1) MX2009004983A (es)
MY (1) MY147502A (es)
NI (1) NI200900078A (es)
NO (1) NO20091990L (es)
NZ (1) NZ576709A (es)
PE (2) PE20121152A1 (es)
PL (1) PL2091920T3 (es)
PT (1) PT2091920E (es)
SI (1) SI2091920T1 (es)
SV (1) SV2009003253A (es)
TN (1) TN2009000155A1 (es)
TW (1) TW200829556A (es)
UA (1) UA97965C2 (es)
UY (1) UY30707A1 (es)
WO (1) WO2008065282A2 (es)
ZA (1) ZA200903560B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858323B2 (en) * 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
FR2947546B1 (fr) 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique
TWI532725B (zh) * 2010-01-26 2016-05-11 賽諾菲阿凡提斯公司 經氧取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
TWI523844B (zh) * 2011-01-26 2016-03-01 賽諾菲公司 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
CN102432639B (zh) * 2011-09-30 2013-11-06 山东大学 1-(2-羟基-3-(苯氨基)丙基)-3-二茂铁基-1h-吡唑-5-甲酸乙酯化合物及其应用
ES2625944T3 (es) 2012-11-02 2017-07-21 Pfizer Inc. Inhibidores de tirosina cinasa de Bruton
CA2976766A1 (en) * 2015-03-25 2016-09-29 Novartis Ag Formylated n-heterocyclic derivatives as fgfr4 inhibitors
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
CA2445357A1 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Pyrazole derived kinase inhibitors
CN1809557B (zh) * 2003-04-16 2012-07-04 阿斯利康(瑞典)有限公司 化合物
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
PL2256106T3 (pl) * 2003-07-22 2015-08-31 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
EP1781653A1 (en) * 2004-07-05 2007-05-09 Astex Therapeutics Limited 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
WO2006018662A2 (en) * 2004-08-16 2006-02-23 Prosidion Limited Aryl urea derivatives for treating obesity
JP2008526723A (ja) * 2004-12-30 2008-07-24 アステックス、セラピューティックス、リミテッド Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体
US20080161355A1 (en) * 2005-01-21 2008-07-03 Astex Therapeutics Limited Combinations of Pyrazole Kinase Inhibitors and Further Antitumor Agents
AR052559A1 (es) * 2005-01-21 2007-03-21 Astex Therapeutics Ltd Derivados de pirazol para inhibir cdk's y gsk's
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
FR2947546B1 (fr) * 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
PE20081162A1 (es) 2008-10-02
WO2008065282A3 (fr) 2008-07-31
CL2007003251A1 (es) 2009-08-07
CR10749A (es) 2009-07-23
US8420824B2 (en) 2013-04-16
AU2007327423B2 (en) 2012-09-06
IL198328A0 (en) 2010-02-17
TN2009000155A1 (fr) 2010-10-18
CY1116000T1 (el) 2017-01-25
NI200900078A (es) 2010-01-27
AU2007327423A1 (en) 2008-06-05
TW200829556A (en) 2008-07-16
HK1137988A1 (en) 2010-08-13
NZ576709A (en) 2011-08-26
HN2009000856A (es) 2011-10-19
EP2091920A2 (fr) 2009-08-26
EP2091920B1 (fr) 2014-10-22
EA200970472A1 (ru) 2009-10-30
DK2091920T3 (en) 2015-01-26
CA2667846A1 (fr) 2008-06-05
PL2091920T3 (pl) 2015-04-30
ZA200903560B (en) 2010-08-25
SV2009003253A (es) 2009-10-27
MA30972B1 (fr) 2009-12-01
US20110237641A1 (en) 2011-09-29
HRP20150070T1 (hr) 2015-02-27
MY147502A (en) 2012-12-14
NO20091990L (no) 2009-06-02
JP5538893B2 (ja) 2014-07-02
CN101553473B (zh) 2013-06-05
ES2528385T3 (es) 2015-02-09
WO2008065282A2 (fr) 2008-06-05
BRPI0718999A2 (pt) 2014-02-25
EA019454B1 (ru) 2014-03-31
CO6190516A2 (es) 2010-08-19
DOP2009000088A (es) 2013-06-15
UA97965C2 (ru) 2012-04-10
US20090291984A1 (en) 2009-11-26
PT2091920E (pt) 2015-02-05
FR2908409A1 (fr) 2008-05-16
ECSP099312A (es) 2009-06-30
SI2091920T1 (sl) 2015-02-27
JP2010509297A (ja) 2010-03-25
AR063638A1 (es) 2009-02-04
MX2009004983A (es) 2009-05-22
US7989439B2 (en) 2011-08-02
FR2908409B1 (fr) 2009-01-09
UY30707A1 (es) 2008-07-03
US8410286B2 (en) 2013-04-02
US20110237801A1 (en) 2011-09-29
KR20090083456A (ko) 2009-08-03
CN101553473A (zh) 2009-10-07

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