DOP2009000088A - Pirazoles sustituidos que presentan actividad anticancerígena - Google Patents

Pirazoles sustituidos que presentan actividad anticancerígena

Info

Publication number
DOP2009000088A
DOP2009000088A DO2009000088A DO2009000088A DOP2009000088A DO P2009000088 A DOP2009000088 A DO P2009000088A DO 2009000088 A DO2009000088 A DO 2009000088A DO 2009000088 A DO2009000088 A DO 2009000088A DO P2009000088 A DOP2009000088 A DO P2009000088A
Authority
DO
Dominican Republic
Prior art keywords
pirazols
replaced
target activity
presenting anti
presenting
Prior art date
Application number
DO2009000088A
Other languages
English (en)
Inventor
Kirsten Bjergarde
Mark Dodson
Jacques Mauger
Anil Nair
Marcel Patek
Michel Tabart
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of DOP2009000088A publication Critical patent/DOP2009000088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere principalmente a compuestos químicos nuevos, particulamente a pirazoles sustituidos.
DO2009000088A 2006-11-10 2009-04-23 Pirazoles sustituidos que presentan actividad anticancerígena DOP2009000088A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0609812A FR2908409B1 (fr) 2006-11-10 2006-11-10 Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
DOP2009000088A true DOP2009000088A (es) 2013-06-15

Family

ID=38169388

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2009000088A DOP2009000088A (es) 2006-11-10 2009-04-23 Pirazoles sustituidos que presentan actividad anticancerígena

Country Status (40)

Country Link
US (3) US7989439B2 (es)
EP (1) EP2091920B1 (es)
JP (1) JP5538893B2 (es)
KR (1) KR20090083456A (es)
CN (1) CN101553473B (es)
AR (1) AR063638A1 (es)
AU (1) AU2007327423B2 (es)
BR (1) BRPI0718999A2 (es)
CA (1) CA2667846A1 (es)
CL (1) CL2007003251A1 (es)
CO (1) CO6190516A2 (es)
CR (1) CR10749A (es)
CY (1) CY1116000T1 (es)
DK (1) DK2091920T3 (es)
DO (1) DOP2009000088A (es)
EA (1) EA019454B1 (es)
EC (1) ECSP099312A (es)
ES (1) ES2528385T3 (es)
FR (1) FR2908409B1 (es)
HK (1) HK1137988A1 (es)
HN (1) HN2009000856A (es)
HR (1) HRP20150070T1 (es)
IL (1) IL198328A0 (es)
MA (1) MA30972B1 (es)
MX (1) MX2009004983A (es)
MY (1) MY147502A (es)
NI (1) NI200900078A (es)
NO (1) NO20091990L (es)
NZ (1) NZ576709A (es)
PE (2) PE20121152A1 (es)
PL (1) PL2091920T3 (es)
PT (1) PT2091920E (es)
SI (1) SI2091920T1 (es)
SV (1) SV2009003253A (es)
TN (1) TN2009000155A1 (es)
TW (1) TW200829556A (es)
UA (1) UA97965C2 (es)
UY (1) UY30707A1 (es)
WO (1) WO2008065282A2 (es)
ZA (1) ZA200903560B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858323B2 (en) * 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
FR2947546B1 (fr) * 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique
AR079967A1 (es) * 2010-01-26 2012-02-29 Sanofi Aventis Derivados de acido 3-heteroaroilamino-propionico sustituidos con oxigeno y su uso como productos farmaceuticos
TWI523844B (zh) 2011-01-26 2016-03-01 賽諾菲公司 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
CN102432639B (zh) * 2011-09-30 2013-11-06 山东大学 1-(2-羟基-3-(苯氨基)丙基)-3-二茂铁基-1h-吡唑-5-甲酸乙酯化合物及其应用
JP6178861B2 (ja) 2012-11-02 2017-08-09 ファイザー・インク ブルトン型チロシンキナーゼ阻害剤
JP6695353B2 (ja) * 2015-03-25 2020-05-20 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としてのホルミル化ｎ−複素環式誘導体
CN107619388A (zh) 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
MXPA03009847A (es) * 2001-04-27 2004-02-12 Vertex Pharma Inhibidores de cinasa derivados de pirazol.
EP1613619B1 (en) * 2003-04-16 2008-03-26 AstraZeneca AB Quinazoline derivatives for treatment of cancer
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
PL1651612T3 (pl) * 2003-07-22 2012-09-28 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
WO2006003440A1 (en) * 2004-07-05 2006-01-12 Astex Therapeutics Limited 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
JP2008509982A (ja) * 2004-08-16 2008-04-03 プロシディオン・リミテッド アリール尿素誘導体
US20100160324A1 (en) * 2004-12-30 2010-06-24 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
AR052660A1 (es) * 2005-01-21 2007-03-28 Astex Therapeutics Ltd Derivados de pirazol para inhibir la cdk's y gsk's
BRPI0606319A2 (pt) * 2005-01-21 2009-06-16 Astex Therapeutics Ltd compostos farmacêuticos
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
FR2947546B1 (fr) * 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
BRPI0718999A2 (pt) 2014-02-25
CN101553473A (zh) 2009-10-07
WO2008065282A2 (fr) 2008-06-05
AR063638A1 (es) 2009-02-04
PE20081162A1 (es) 2008-10-02
WO2008065282A3 (fr) 2008-07-31
MA30972B1 (fr) 2009-12-01
UA97965C2 (ru) 2012-04-10
MX2009004983A (es) 2009-05-22
HN2009000856A (es) 2011-10-19
US20110237801A1 (en) 2011-09-29
HK1137988A1 (en) 2010-08-13
US8410286B2 (en) 2013-04-02
JP5538893B2 (ja) 2014-07-02
KR20090083456A (ko) 2009-08-03
ECSP099312A (es) 2009-06-30
HRP20150070T1 (hr) 2015-02-27
UY30707A1 (es) 2008-07-03
FR2908409B1 (fr) 2009-01-09
US8420824B2 (en) 2013-04-16
CY1116000T1 (el) 2017-01-25
ES2528385T3 (es) 2015-02-09
PL2091920T3 (pl) 2015-04-30
PT2091920E (pt) 2015-02-05
MY147502A (en) 2012-12-14
CR10749A (es) 2009-07-23
CO6190516A2 (es) 2010-08-19
SI2091920T1 (sl) 2015-02-27
DK2091920T3 (en) 2015-01-26
US7989439B2 (en) 2011-08-02
PE20121152A1 (es) 2012-09-07
NZ576709A (en) 2011-08-26
EP2091920A2 (fr) 2009-08-26
AU2007327423A1 (en) 2008-06-05
NI200900078A (es) 2010-01-27
EP2091920B1 (fr) 2014-10-22
US20090291984A1 (en) 2009-11-26
TW200829556A (en) 2008-07-16
CL2007003251A1 (es) 2009-08-07
FR2908409A1 (fr) 2008-05-16
NO20091990L (no) 2009-06-02
US20110237641A1 (en) 2011-09-29
SV2009003253A (es) 2009-10-27
TN2009000155A1 (fr) 2010-10-18
CA2667846A1 (fr) 2008-06-05
CN101553473B (zh) 2013-06-05
AU2007327423B2 (en) 2012-09-06
ZA200903560B (en) 2010-08-25
JP2010509297A (ja) 2010-03-25
EA200970472A1 (ru) 2009-10-30
IL198328A0 (en) 2010-02-17
EA019454B1 (ru) 2014-03-31

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