PE20220485A1 - Conjugados peptidicos de agentes dirigidos a microtubulos como terapeuticos - Google Patents

Conjugados peptidicos de agentes dirigidos a microtubulos como terapeuticos

Info

Publication number
PE20220485A1
PE20220485A1 PE2022000038A PE2022000038A PE20220485A1 PE 20220485 A1 PE20220485 A1 PE 20220485A1 PE 2022000038 A PE2022000038 A PE 2022000038A PE 2022000038 A PE2022000038 A PE 2022000038A PE 20220485 A1 PE20220485 A1 PE 20220485A1
Authority
PE
Peru
Prior art keywords
targeting agents
microtubule
peptide conjugates
therapeutics
alkyl
Prior art date
Application number
PE2022000038A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Richard Marshall
Johanna Marie Csengery
Robert John Maguire
Robert A Volkmann
Original Assignee
Cybrexa 3 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cybrexa 3 Inc filed Critical Cybrexa 3 Inc
Publication of PE20220485A1 publication Critical patent/PE20220485A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PE2022000038A 2019-07-10 2020-07-09 Conjugados peptidicos de agentes dirigidos a microtubulos como terapeuticos PE20220485A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962872638P 2019-07-10 2019-07-10
US202063041324P 2020-06-19 2020-06-19
PCT/US2020/041348 WO2021007402A1 (en) 2019-07-10 2020-07-09 Peptide conjugates of microtubule-targeting agents as therapeutics

Publications (1)

Publication Number Publication Date
PE20220485A1 true PE20220485A1 (es) 2022-04-04

Family

ID=71944331

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022000038A PE20220485A1 (es) 2019-07-10 2020-07-09 Conjugados peptidicos de agentes dirigidos a microtubulos como terapeuticos

Country Status (19)

Country Link
US (2) US11555019B2 (https=)
EP (1) EP3996749A1 (https=)
JP (1) JP7675060B2 (https=)
KR (1) KR20220051332A (https=)
CN (1) CN114302744B (https=)
AU (1) AU2020311925A1 (https=)
BR (1) BR112022000297A2 (https=)
CA (1) CA3146385A1 (https=)
CL (1) CL2022000043A1 (https=)
CO (1) CO2022001315A2 (https=)
CR (1) CR20220057A (https=)
EC (1) ECSP22010121A (https=)
IL (1) IL289659B1 (https=)
MX (1) MX2022000450A (https=)
MY (1) MY209459A (https=)
PE (1) PE20220485A1 (https=)
PH (1) PH12022550037A1 (https=)
TW (1) TW202116356A (https=)
WO (1) WO2021007402A1 (https=)

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KR20200121800A (ko) 2018-01-05 2020-10-26 싸이브렉사 1, 인크. 산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법
TW202116356A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩三號公司 作為治療劑之微管靶向藥劑之肽結合物
CN114341162B (zh) 2019-07-10 2025-10-17 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
US20240093250A1 (en) 2021-01-08 2024-03-21 Cybrexa 2, Inc. Process for preparing a conjugate linking moiety
JP2024542212A (ja) * 2021-11-17 2024-11-13 サイブレクサ 4,インコーポレイテッド 治療薬としてのペプチドチューブリン阻害剤のペプチドコンジュゲート

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CN114341162B (zh) 2019-07-10 2025-10-17 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
TW202116356A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩三號公司 作為治療劑之微管靶向藥劑之肽結合物
US20240093250A1 (en) 2021-01-08 2024-03-21 Cybrexa 2, Inc. Process for preparing a conjugate linking moiety
CN117897175A (zh) 2021-04-29 2024-04-16 美商斯布雷克萨二号公司 拓扑异构酶i抑制剂的肽缀合物的给药方案
JP2024542212A (ja) 2021-11-17 2024-11-13 サイブレクサ 4,インコーポレイテッド 治療薬としてのペプチドチューブリン阻害剤のペプチドコンジュゲート

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