PE20231081A1 - Derivados de quinoxalina como farmacos contra el cancer - Google Patents
Derivados de quinoxalina como farmacos contra el cancerInfo
- Publication number
- PE20231081A1 PE20231081A1 PE2022002989A PE2022002989A PE20231081A1 PE 20231081 A1 PE20231081 A1 PE 20231081A1 PE 2022002989 A PE2022002989 A PE 2022002989A PE 2022002989 A PE2022002989 A PE 2022002989A PE 20231081 A1 PE20231081 A1 PE 20231081A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- against cancer
- quinoxaline derivatives
- drugs against
- fluoroalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Refiere a compuestos derivados de azaquinolona de Formula (I), o una sal farmaceuticamente aceptable de estos, en donde R1 se selecciona independientemente de H, alquilo C1-4, cicloalquilo C3-6, fluoroalquilo C1-4 y alquiloxi C1-4; R2 se selecciona de H, halo, alquilo C1-4 y fluoroalquilo C1-4; R3 es H o alquilo C1-4 y R4 es halo o alquilo C1-4. Dichos compuestos se seleccionan del grupo de 6-fluoro-5-[4-[(5-fluoro-2-metil-3-oxo-4H-quinoxalin-6-il)metil]piperazin-1-il]-N-metilpiridin-2-carboxamida. Asimismo, refiere a una composicion farmaceutica comprendida por un compuesto de azaquinolona, o una sal del mismo, junto a un diluyente, excipiente o portador inerte farmaceuticamente aceptable; y a su uso en medicina contra el cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063044095P | 2020-06-25 | 2020-06-25 | |
| US202063120351P | 2020-12-02 | 2020-12-02 | |
| PCT/EP2021/067304 WO2021260092A1 (en) | 2020-06-25 | 2021-06-24 | Quinoxaline derivatives as anti-cancer drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231081A1 true PE20231081A1 (es) | 2023-07-17 |
Family
ID=76662494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022002989A PE20231081A1 (es) | 2020-06-25 | 2021-06-24 | Derivados de quinoxalina como farmacos contra el cancer |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US11795158B2 (es) |
| EP (1) | EP4172152A1 (es) |
| JP (1) | JP2023532257A (es) |
| KR (1) | KR20230026450A (es) |
| CN (1) | CN115768760A (es) |
| AU (1) | AU2021295423B2 (es) |
| BR (1) | BR112022025435A2 (es) |
| CA (1) | CA3186996A1 (es) |
| CL (1) | CL2022003711A1 (es) |
| CO (1) | CO2023000186A2 (es) |
| CR (1) | CR20230024A (es) |
| DO (1) | DOP2022000288A (es) |
| EC (1) | ECSP23005059A (es) |
| IL (1) | IL299123A (es) |
| MX (1) | MX2022015435A (es) |
| PE (1) | PE20231081A1 (es) |
| SA (1) | SA522441701B1 (es) |
| TW (1) | TW202218664A (es) |
| UY (1) | UY39296A (es) |
| WO (1) | WO2021260092A1 (es) |
| ZA (1) | ZA202300924B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220040173A1 (en) * | 2020-08-04 | 2022-02-10 | Astrazeneca Ab | Methods of delaying pain progression and treating prostate cancer |
| US11591331B2 (en) | 2021-04-19 | 2023-02-28 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
| CN115702156A (zh) * | 2021-04-23 | 2023-02-14 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
| KR20240012437A (ko) | 2021-05-24 | 2024-01-29 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 질소 함유 헤테로사이클릭 화합물, 이의 제조 방법 및 의학에서 이의 응용 |
| JP2024522736A (ja) * | 2021-06-16 | 2024-06-21 | リペア セラピューティクス インコーポレイテッド | がん治療のためのｐａｒｐ阻害剤と組み合わせたａｔｒ阻害剤の使用 |
| WO2022271547A1 (en) | 2021-06-21 | 2022-12-29 | Tesaro, Inc. | Combination treatment of cancer with a parp inhibitor and a lipophilic statin |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046158A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 氮杂喹啉酮类化合物及其医药用途 |
| WO2023046149A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 喹喔啉类化合物及其医药用途 |
| EP4410791A1 (en) * | 2021-09-30 | 2024-08-07 | Xizang Haisco Pharmaceutical Co., Ltd. | Bicyclic derivative parp inhibitor and use thereof |
| WO2023051716A1 (zh) * | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 杂芳基衍生物parp抑制剂及其用途 |
| JP2024535393A (ja) | 2021-10-01 | 2024-09-30 | シンセラ， インコーポレイテッド | アゼチジン及びピロリジンｐａｒｐ１阻害剤及びその使用 |
| AU2022390101A1 (en) | 2021-11-19 | 2024-06-06 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Selective parp1 inhibitor and application thereof |
| AU2022422276A1 (en) * | 2021-12-21 | 2024-08-01 | Astrazeneca Ab | Methods of treating brain tumours and neuroblastomas |
| AU2023206690A1 (en) * | 2022-01-13 | 2024-08-29 | Acerand Therapeutics (Hong Kong) Limited | Piperazino ring-containing derivative, pharmaceutically acceptable salt thereof, preparation method therefor, and application thereof |
| CN118434725A (zh) * | 2022-01-20 | 2024-08-02 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| AU2023209820B2 (en) | 2022-01-21 | 2024-10-10 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| KR20240139604A (ko) * | 2022-01-27 | 2024-09-23 | 신테라, 인크. | Parp1 저해제 및 이의 용도 |
| AU2023212785A1 (en) * | 2022-01-28 | 2024-08-15 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023201338A1 (en) | 2022-04-15 | 2023-10-19 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a parp inhibitor |
| WO2023207284A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Piperazine derivatives as parp1 inhibitiors |
| WO2023212219A1 (en) | 2022-04-28 | 2023-11-02 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| WO2023217045A1 (zh) * | 2022-05-07 | 2023-11-16 | 南京明德新药研发有限公司 | 选择性抑制parp1的氟代喹喔啉酮衍生物 |
| WO2023227052A1 (zh) * | 2022-05-25 | 2023-11-30 | 西藏海思科制药有限公司 | 双环衍生物parp抑制剂及其用途 |
| CN118076597A (zh) * | 2022-06-02 | 2024-05-24 | 成都苑东生物制药股份有限公司 | 一种氮杂喹啉酮类衍生物、其制备方法及用途 |
| WO2023242302A1 (en) | 2022-06-15 | 2023-12-21 | Astrazeneca Ab | Combination therapy for treating cancer |
| CN115919859B (zh) * | 2022-07-14 | 2024-01-05 | 四川海思科制药有限公司 | 一种杂芳基衍生物的药物组合物及其在医药上的应用 |
| CN117658983A (zh) * | 2022-09-01 | 2024-03-08 | 浙江文达医药科技有限公司 | 选择性parp1抑制剂 |
| CN118119629A (zh) * | 2022-09-30 | 2024-05-31 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| US20240174669A1 (en) * | 2022-10-06 | 2024-05-30 | Xinthera, Inc. | Crystalline forms of a parp1 inhibitor |
| WO2024083218A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 取代四氢吡啶类化合物及其用途 |
| WO2024121753A1 (en) | 2022-12-06 | 2024-06-13 | Astrazeneca Ab | Polq inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9701075A (es) | 1994-08-12 | 1998-03-31 | Myriad Genetics Inc | Mutaciones en vivo y polimorfismos en el gen de susceptibilidad al cancer de pecho y ovario enlazado con 17q. |
| CA2196795C (en) | 1994-08-12 | 2001-04-03 | Mark H. Skolnick | Method for diagnosing a predisposition for breast and ovarian cancer |
| PL1633724T3 (pl) | 2003-03-12 | 2011-10-31 | Kudos Pharm Ltd | Pochodne ftalazynonu |
| JP5525447B2 (ja) | 2007-10-26 | 2014-06-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのキノリノン誘導体 |
| CN102341394B (zh) | 2009-01-23 | 2015-04-15 | 武田药品工业株式会社 | 聚(adp-核糖)聚合酶(parp)抑制剂 |
| EP3312177B1 (en) | 2015-06-09 | 2021-04-14 | Onconic Therapeutics Inc. | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
| JOP20220008A1 (ar) | 2019-07-19 | 2023-01-30 | Astrazeneca Ab | مثبطات parp1 |
-
2021
- 2021-06-22 US US17/354,322 patent/US11795158B2/en active Active
- 2021-06-24 IL IL299123A patent/IL299123A/en unknown
- 2021-06-24 CR CR20230024A patent/CR20230024A/es unknown
- 2021-06-24 CN CN202180043057.8A patent/CN115768760A/zh active Pending
- 2021-06-24 BR BR112022025435A patent/BR112022025435A2/pt unknown
- 2021-06-24 KR KR1020237001972A patent/KR20230026450A/ko active Search and Examination
- 2021-06-24 JP JP2022579869A patent/JP2023532257A/ja active Pending
- 2021-06-24 EP EP21735690.6A patent/EP4172152A1/en active Pending
- 2021-06-24 WO PCT/EP2021/067304 patent/WO2021260092A1/en active Application Filing
- 2021-06-24 MX MX2022015435A patent/MX2022015435A/es unknown
- 2021-06-24 CA CA3186996A patent/CA3186996A1/en active Pending
- 2021-06-24 PE PE2022002989A patent/PE20231081A1/es unknown
- 2021-06-24 AU AU2021295423A patent/AU2021295423B2/en active Active
- 2021-06-25 UY UY0001039296A patent/UY39296A/es unknown
- 2021-06-25 TW TW110123282A patent/TW202218664A/zh unknown
-
2022
- 2022-12-11 SA SA522441701A patent/SA522441701B1/ar unknown
- 2022-12-14 DO DO2022000288A patent/DOP2022000288A/es unknown
- 2022-12-22 CL CL2022003711A patent/CL2022003711A1/es unknown
-
2023
- 2023-01-10 CO CONC2023/0000186A patent/CO2023000186A2/es unknown
- 2023-01-20 ZA ZA2023/00924A patent/ZA202300924B/en unknown
- 2023-01-23 EC ECSENADI20235059A patent/ECSP23005059A/es unknown
- 2023-09-14 US US18/467,185 patent/US20240010631A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL299123A (en) | 2023-02-01 |
| BR112022025435A2 (pt) | 2023-01-24 |
| CO2023000186A2 (es) | 2023-04-17 |
| WO2021260092A1 (en) | 2021-12-30 |
| DOP2022000288A (es) | 2023-01-15 |
| US20220009901A1 (en) | 2022-01-13 |
| US20240010631A1 (en) | 2024-01-11 |
| CL2022003711A1 (es) | 2023-06-23 |
| EP4172152A1 (en) | 2023-05-03 |
| KR20230026450A (ko) | 2023-02-24 |
| CA3186996A1 (en) | 2021-12-30 |
| AU2021295423A1 (en) | 2023-02-16 |
| ZA202300924B (en) | 2024-09-25 |
| JP2023532257A (ja) | 2023-07-27 |
| ECSP23005059A (es) | 2023-02-28 |
| CN115768760A (zh) | 2023-03-07 |
| UY39296A (es) | 2021-12-31 |
| MX2022015435A (es) | 2023-02-09 |
| TW202218664A (zh) | 2022-05-16 |
| CR20230024A (es) | 2023-03-01 |
| US11795158B2 (en) | 2023-10-24 |
| SA522441701B1 (ar) | 2024-08-11 |
| AU2021295423B2 (en) | 2024-05-02 |
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