JP7675060B2 - 治療薬としての微小管標的化剤のペプチドコンジュゲート - Google Patents

治療薬としての微小管標的化剤のペプチドコンジュゲート Download PDF

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JP7675060B2
JP7675060B2 JP2022501186A JP2022501186A JP7675060B2 JP 7675060 B2 JP7675060 B2 JP 7675060B2 JP 2022501186 A JP2022501186 A JP 2022501186A JP 2022501186 A JP2022501186 A JP 2022501186A JP 7675060 B2 JP7675060 B2 JP 7675060B2
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cancer
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JPWO2021007402A5 (https=
JP2022541747A5 (https=
JP2022541747A (ja
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リチャード マーシャル，ダニエル
マリー チェンゲリー，ヨハンナ
ジョン マグワイア，ロバート
エイ ボークマン，ロバート
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Cybrexa 3 Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022501186A 2019-07-10 2020-07-09 治療薬としての微小管標的化剤のペプチドコンジュゲート Active JP7675060B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962872638P 2019-07-10 2019-07-10
US62/872,638 2019-07-10
US202063041324P 2020-06-19 2020-06-19
US63/041,324 2020-06-19
PCT/US2020/041348 WO2021007402A1 (en) 2019-07-10 2020-07-09 Peptide conjugates of microtubule-targeting agents as therapeutics

Publications (4)

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JP2022541747A JP2022541747A (ja) 2022-09-27
JPWO2021007402A5 JPWO2021007402A5 (https=) 2023-07-18
JP2022541747A5 JP2022541747A5 (https=) 2023-07-18
JP7675060B2 true JP7675060B2 (ja) 2025-05-12

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US (2) US11555019B2 (https=)
EP (1) EP3996749A1 (https=)
JP (1) JP7675060B2 (https=)
KR (1) KR20220051332A (https=)
CN (1) CN114302744B (https=)
AU (1) AU2020311925A1 (https=)
BR (1) BR112022000297A2 (https=)
CA (1) CA3146385A1 (https=)
CL (1) CL2022000043A1 (https=)
CO (1) CO2022001315A2 (https=)
CR (1) CR20220057A (https=)
EC (1) ECSP22010121A (https=)
IL (1) IL289659B1 (https=)
MX (1) MX2022000450A (https=)
MY (1) MY209459A (https=)
PE (1) PE20220485A1 (https=)
PH (1) PH12022550037A1 (https=)
TW (1) TW202116356A (https=)
WO (1) WO2021007402A1 (https=)

Families Citing this family (5)

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KR20200121800A (ko) 2018-01-05 2020-10-26 싸이브렉사 1, 인크. 산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법
TW202116356A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩三號公司 作為治療劑之微管靶向藥劑之肽結合物
CN114341162B (zh) 2019-07-10 2025-10-17 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
US20240093250A1 (en) 2021-01-08 2024-03-21 Cybrexa 2, Inc. Process for preparing a conjugate linking moiety
JP2024542212A (ja) * 2021-11-17 2024-11-13 サイブレクサ ４，インコーポレイテッド 治療薬としてのペプチドチューブリン阻害剤のペプチドコンジュゲート

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