AR074833A1 - Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivos - Google Patents
Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivosInfo
- Publication number
- AR074833A1 AR074833A1 ARP090105021A ARP090105021A AR074833A1 AR 074833 A1 AR074833 A1 AR 074833A1 AR P090105021 A ARP090105021 A AR P090105021A AR P090105021 A ARP090105021 A AR P090105021A AR 074833 A1 AR074833 A1 AR 074833A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- antibacterial
- lipopeptidic
- grampositives
- infections
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos lipopéptidos, composiciones farmacéuticas de estos compuestos y los métodos de uso de estos compuestos como compuestos antibacterianos. Estos compuestos son particularmente útiles contra una variedad de bacterias, que incluyen cepas resistentes. Los compuestos son útiles como agentes antibacterianos contra Clostridium difficile. Reivindicación 1: Un compuesto caracterizado porque es de la fórmula (1) y sus sales farmacéuticamente aceptables, en donde R es -C(=O)A; A se selecciona de alquilo, alquenilo, cicloalquilo, arilo, heteroarilo, y NHRA; y RA se selecciona de alquilo y cicloalquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13987508P | 2008-12-22 | 2008-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074833A1 true AR074833A1 (es) | 2011-02-16 |
Family
ID=41718893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090105021A AR074833A1 (es) | 2008-12-22 | 2009-12-21 | Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivos |
Country Status (27)
Country | Link |
---|---|
US (3) | US8507647B2 (es) |
EP (2) | EP2674437A1 (es) |
JP (1) | JP5670914B2 (es) |
KR (1) | KR101717795B1 (es) |
CN (1) | CN102325787B (es) |
AR (1) | AR074833A1 (es) |
AU (1) | AU2009330245C1 (es) |
BR (1) | BRPI0923567A2 (es) |
CA (1) | CA2747965C (es) |
CY (1) | CY1114883T1 (es) |
DK (1) | DK2379580T3 (es) |
ES (1) | ES2442167T3 (es) |
HK (1) | HK1161886A1 (es) |
HR (1) | HRP20131170T1 (es) |
IL (1) | IL213638A0 (es) |
MX (1) | MX2011006803A (es) |
NZ (1) | NZ594019A (es) |
PL (1) | PL2379580T3 (es) |
PT (1) | PT2379580E (es) |
RS (1) | RS53152B (es) |
RU (1) | RU2512396C2 (es) |
SG (1) | SG172299A1 (es) |
SI (1) | SI2379580T1 (es) |
SM (1) | SMT201400037B (es) |
TW (1) | TWI444198B (es) |
WO (1) | WO2010075215A1 (es) |
ZA (1) | ZA201104693B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140037877A (ko) * | 2011-05-26 | 2014-03-27 | 큐비스트 파마슈티컬즈 인코포레이티드 | Cb-183,315 조성물 및 관련 방법 |
US10377699B2 (en) * | 2013-11-06 | 2019-08-13 | The University Of Hong Kong | Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue |
WO2015172047A1 (en) * | 2014-05-08 | 2015-11-12 | Merck Sharp & Dohme Corp. | Cyclic peptide compounds and related methods, salts and compositions |
US10647746B2 (en) | 2016-04-08 | 2020-05-12 | Versitech Limited | Antibacterial cyclic lipopeptides |
US11667674B2 (en) * | 2016-04-08 | 2023-06-06 | Versitech Limited | Antibacterial cyclic lipopeptides |
KR102388208B1 (ko) * | 2016-04-22 | 2022-04-18 | 아스트라제네카 아베 | 암을 치료하기 위한 거대 환형 mcl1 억제제 |
US10098890B2 (en) | 2016-10-29 | 2018-10-16 | Cipla Limited | Stable carfilzomib formulations |
IT201600127655A1 (it) * | 2016-12-16 | 2018-06-16 | Gnosis Spa | Processo per la purificazione di antibiotici lipopolipeptidici |
US10072045B1 (en) | 2017-06-26 | 2018-09-11 | Ramapo Pharmaceuticals, Inc. | Antibacterial lipopeptides and methods for their preparation and use |
US10526343B2 (en) | 2018-03-26 | 2020-01-07 | University Of Sharjah | Heterocyclic systems and pharmaceutical applications thereof |
RU2762182C1 (ru) * | 2020-12-08 | 2021-12-16 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
USRE32333E (en) | 1978-10-16 | 1987-01-20 | Eli Lilly And Company | A-21978 Antibiotics and process for their production |
USRE32455E (en) | 1978-10-16 | 1987-07-07 | Eli Lilly And Company | A-21978 antibiotics and process for their production |
DK163305C (da) | 1982-02-27 | 1992-08-03 | Beecham Group Plc | Analogifremgangsmaade til fremstilling af 1-normon-2-yl-heterocycliske forbindelser og mellemprodukter til anvendelse ved fremgangsmaaden |
IL68700A0 (en) * | 1982-05-21 | 1983-09-30 | Lilly Co Eli | Improvements relating to a-21978c cyclic peptide derivatives and their production |
US4482487A (en) * | 1982-05-21 | 1984-11-13 | Eli Lilly And Company | A-21978C cyclic peptides |
US4537717A (en) | 1982-05-21 | 1985-08-27 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
US4396543A (en) * | 1982-05-21 | 1983-08-02 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
US4524135A (en) * | 1982-05-21 | 1985-06-18 | Eli Lilly And Company | A-21978C cyclic peptides |
USRE32310E (en) * | 1982-05-21 | 1986-12-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
USRE32311E (en) * | 1982-05-21 | 1986-12-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
US4399067A (en) * | 1982-05-21 | 1983-08-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
ZA857759B (en) | 1984-10-09 | 1987-05-27 | Lilly Co Eli | Process for the production of a-21978c derivatives |
ZA883887B (en) * | 1987-06-10 | 1990-02-28 | Lilly Co Eli | Chromatographic purification process |
US5039660A (en) | 1988-03-02 | 1991-08-13 | Endocon, Inc. | Partially fused peptide pellet |
EP0460882B1 (en) * | 1990-06-07 | 1996-07-24 | Eli Lilly And Company | Lipopeptide deacylase |
WO1995005384A1 (en) | 1993-08-13 | 1995-02-23 | Smithkline Beecham Plc | Derivatives of monic acids a and c having antibacterial, antimycoplasmatical, antifungal and herbicidal activity |
DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
KR100545506B1 (ko) | 1996-03-08 | 2006-10-04 | 아스테라스 세이야쿠 가부시키가이샤 | 환상 리포펩티드 물질의 탈아실화 방법 |
DE19807972A1 (de) * | 1998-02-25 | 1999-08-26 | Hoechst Marion Roussel De Gmbh | Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung |
EP1674107B8 (en) * | 1998-09-25 | 2017-01-25 | Cubist Pharmaceuticals LLC | Use of daptomycin |
JP2003520353A (ja) | 1999-11-03 | 2003-07-02 | ザ ウィタカー コーポレーション | マルチファイバアレー用光電子モジュール |
BR0017028A (pt) * | 1999-12-15 | 2003-01-07 | Cubist Pharm Inc | Lipopepìdeos como agentes antibacterianos |
WO2001044272A2 (en) * | 1999-12-15 | 2001-06-21 | Cubist Pharmaceuticals, Inc. | Daptomycin analogs as antibacterial agents |
WO2001044274A1 (en) | 1999-12-15 | 2001-06-21 | Cubist Pharmaceuticals, Inc. | Lipopeptides as antibacterial agents |
US20060014674A1 (en) * | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
IL160171A0 (en) | 2001-08-06 | 2004-07-25 | Cubist Pharm Inc | Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
CA2587848A1 (en) | 2004-11-12 | 2006-10-19 | Cubist Pharmaceuticals, Inc. | Antiinfective lipopeptides |
-
2009
- 2009-12-18 BR BRPI0923567A patent/BRPI0923567A2/pt not_active Application Discontinuation
- 2009-12-18 AU AU2009330245A patent/AU2009330245C1/en not_active Ceased
- 2009-12-18 RU RU2011130278/04A patent/RU2512396C2/ru not_active IP Right Cessation
- 2009-12-18 US US12/641,465 patent/US8507647B2/en active Active
- 2009-12-18 EP EP13183732.0A patent/EP2674437A1/en not_active Withdrawn
- 2009-12-18 NZ NZ594019A patent/NZ594019A/xx not_active IP Right Cessation
- 2009-12-18 CA CA2747965A patent/CA2747965C/en not_active Expired - Fee Related
- 2009-12-18 PT PT97958763T patent/PT2379580E/pt unknown
- 2009-12-18 KR KR1020117017003A patent/KR101717795B1/ko active IP Right Grant
- 2009-12-18 ES ES09795876.3T patent/ES2442167T3/es active Active
- 2009-12-18 DK DK09795876.3T patent/DK2379580T3/da active
- 2009-12-18 SI SI200930815T patent/SI2379580T1/sl unknown
- 2009-12-18 MX MX2011006803A patent/MX2011006803A/es active IP Right Grant
- 2009-12-18 SG SG2011045440A patent/SG172299A1/en unknown
- 2009-12-18 WO PCT/US2009/068747 patent/WO2010075215A1/en active Application Filing
- 2009-12-18 EP EP09795876.3A patent/EP2379580B1/en active Active
- 2009-12-18 CN CN200980157145.XA patent/CN102325787B/zh not_active Expired - Fee Related
- 2009-12-18 RS RS20140021A patent/RS53152B/en unknown
- 2009-12-18 PL PL09795876T patent/PL2379580T3/pl unknown
- 2009-12-18 JP JP2011543601A patent/JP5670914B2/ja not_active Expired - Fee Related
- 2009-12-21 TW TW098143962A patent/TWI444198B/zh not_active IP Right Cessation
- 2009-12-21 AR ARP090105021A patent/AR074833A1/es unknown
-
2011
- 2011-06-19 IL IL213638A patent/IL213638A0/en unknown
- 2011-06-24 ZA ZA2011/04693A patent/ZA201104693B/en unknown
-
2012
- 2012-03-09 HK HK12102426.6A patent/HK1161886A1/xx not_active IP Right Cessation
-
2013
- 2013-06-12 US US13/916,402 patent/US20140073558A1/en not_active Abandoned
- 2013-12-10 HR HRP20131170AT patent/HRP20131170T1/hr unknown
-
2014
- 2014-01-09 CY CY20141100015T patent/CY1114883T1/el unknown
- 2014-03-28 SM SM201400037T patent/SMT201400037B/xx unknown
-
2015
- 2015-08-04 US US14/818,123 patent/US20150337013A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |