MX2022011240A - Azálidos de urea inmunomoduladores. - Google Patents
Azálidos de urea inmunomoduladores.Info
- Publication number
- MX2022011240A MX2022011240A MX2022011240A MX2022011240A MX2022011240A MX 2022011240 A MX2022011240 A MX 2022011240A MX 2022011240 A MX2022011240 A MX 2022011240A MX 2022011240 A MX2022011240 A MX 2022011240A MX 2022011240 A MX2022011240 A MX 2022011240A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- immunomodulating
- formula
- azalides
- urea
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000026278 immune system disease Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Formula 1. En la presente se definen compuestos inmunomoduladores de Fórmula (1) en donde R, R0, R1, R2, R3 y W son tal como se define en la presente, estereoisómeros de estos y sales farmacéuticamente aceptables de estos; y composiciones que comprenden dichos compuestos. La invención también incluye métodos para tratar una enfermedad o trastorno inflamatorio y/o inmunológico en un animal al administrar una cantidad terapéuticamente efectiva de un compuesto 10 de la Fórmula (1), estereoisómero de este y una sal farmacéuticamente aceptable de este; o uso de dicho compuesto de Fórmula (1) para preparar un medicamento para tratar una enfermedad o trastorno inflamatorio y/o inmunológico en un animal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062988492P | 2020-03-12 | 2020-03-12 | |
PCT/US2021/021897 WO2021183758A1 (en) | 2020-03-12 | 2021-03-11 | Immunomodulating urea azalides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011240A true MX2022011240A (es) | 2022-12-15 |
Family
ID=75278424
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011242A MX2022011242A (es) | 2020-03-12 | 2021-03-11 | Inmunomodulación de o-het/aril azálidos. |
MX2022011240A MX2022011240A (es) | 2020-03-12 | 2021-03-11 | Azálidos de urea inmunomoduladores. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011242A MX2022011242A (es) | 2020-03-12 | 2021-03-11 | Inmunomodulación de o-het/aril azálidos. |
Country Status (13)
Country | Link |
---|---|
US (5) | US11771677B2 (es) |
EP (2) | EP4118092A1 (es) |
JP (2) | JP2023517673A (es) |
KR (1) | KR20220156570A (es) |
CN (2) | CN115461353A (es) |
AR (1) | AR121554A1 (es) |
AU (2) | AU2021232959B2 (es) |
BR (2) | BR112022017779A2 (es) |
CA (2) | CA3175087A1 (es) |
MX (2) | MX2022011242A (es) |
TW (1) | TWI830987B (es) |
WO (4) | WO2021183754A1 (es) |
ZA (1) | ZA202209530B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023038852A1 (en) | 2021-09-07 | 2023-03-16 | Zoetis Services Llc | Immunomodulating azalides |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60003586T2 (de) * | 2000-01-27 | 2004-01-08 | Pfizer Products Inc., Groton | Antibiotische azalid-zusammensetzungen |
ITMI20040124A1 (it) * | 2004-01-29 | 2004-04-29 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria |
WO2007129646A1 (ja) | 2006-05-01 | 2007-11-15 | Taisho Pharmaceutical Co., Ltd. | マクロライド誘導体 |
JP2010535776A (ja) | 2007-08-10 | 2010-11-25 | ワイズセラピューティックス株式会社 | ロキシスロマイシン又はその誘導体の投与による免疫応答の調節 |
EP2271656A1 (en) * | 2008-04-23 | 2011-01-12 | Glaxo Group Limited | 2'-o,3'-n-bridged macrolides |
US20130045939A1 (en) | 2010-03-19 | 2013-02-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid macrolide derivatives and their uses |
WO2013148874A1 (en) * | 2012-03-27 | 2013-10-03 | Burnet Michael W | Anti-inflammatory macrolides |
CA2908620A1 (en) | 2013-04-10 | 2014-10-16 | Probiotic Pharmaceuticals Aps | Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect |
GB201608236D0 (en) * | 2016-05-11 | 2016-06-22 | Fidelta D O O | Seco macrolide compounds |
-
2021
- 2021-03-11 BR BR112022017779A patent/BR112022017779A2/pt unknown
- 2021-03-11 CA CA3175087A patent/CA3175087A1/en active Pending
- 2021-03-11 KR KR1020227035193A patent/KR20220156570A/ko active Search and Examination
- 2021-03-11 WO PCT/US2021/021889 patent/WO2021183754A1/en active Application Filing
- 2021-03-11 US US17/198,863 patent/US11771677B2/en active Active
- 2021-03-11 US US17/801,328 patent/US20230137567A1/en active Pending
- 2021-03-11 CA CA3175114A patent/CA3175114A1/en active Pending
- 2021-03-11 CN CN202180030710.7A patent/CN115461353A/zh active Pending
- 2021-03-11 US US17/801,340 patent/US20230136177A1/en active Pending
- 2021-03-11 WO PCT/US2021/021897 patent/WO2021183758A1/en active Application Filing
- 2021-03-11 WO PCT/US2021/021906 patent/WO2021183762A1/en unknown
- 2021-03-11 EP EP21716891.3A patent/EP4118092A1/en active Pending
- 2021-03-11 MX MX2022011242A patent/MX2022011242A/es unknown
- 2021-03-11 WO PCT/US2021/021900 patent/WO2021183759A1/en active Application Filing
- 2021-03-11 AU AU2021232959A patent/AU2021232959B2/en active Active
- 2021-03-11 TW TW110108700A patent/TWI830987B/zh active
- 2021-03-11 AU AU2021233895A patent/AU2021233895A1/en active Pending
- 2021-03-11 AR ARP210100621A patent/AR121554A1/es unknown
- 2021-03-11 MX MX2022011240A patent/MX2022011240A/es unknown
- 2021-03-11 JP JP2022554774A patent/JP2023517673A/ja active Pending
- 2021-03-11 EP EP21715446.7A patent/EP4118091A1/en active Pending
- 2021-03-11 US US17/801,337 patent/US20230129438A1/en active Pending
- 2021-03-11 JP JP2022554776A patent/JP2023517674A/ja active Pending
- 2021-03-11 BR BR112022017015A patent/BR112022017015A2/pt unknown
- 2021-03-11 CN CN202180029670.4A patent/CN115461352A/zh active Pending
-
2022
- 2022-08-25 ZA ZA2022/09530A patent/ZA202209530B/en unknown
-
2023
- 2023-08-17 US US18/451,243 patent/US20230390237A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2021232959A1 (en) | 2022-09-15 |
JP2023517674A (ja) | 2023-04-26 |
WO2021183758A1 (en) | 2021-09-16 |
CN115461353A (zh) | 2022-12-09 |
US11771677B2 (en) | 2023-10-03 |
AU2021233895A1 (en) | 2022-09-29 |
TW202200158A (zh) | 2022-01-01 |
MX2022011242A (es) | 2022-12-15 |
TWI830987B (zh) | 2024-02-01 |
JP2023517673A (ja) | 2023-04-26 |
US20230136177A1 (en) | 2023-05-04 |
EP4118092A1 (en) | 2023-01-18 |
CN115461352A (zh) | 2022-12-09 |
US20230390237A1 (en) | 2023-12-07 |
US20230137567A1 (en) | 2023-05-04 |
AR121554A1 (es) | 2022-06-15 |
WO2021183762A1 (en) | 2021-09-16 |
WO2021183754A1 (en) | 2021-09-16 |
CA3175087A1 (en) | 2021-09-16 |
US20210290591A1 (en) | 2021-09-23 |
WO2021183759A1 (en) | 2021-09-16 |
US20230129438A1 (en) | 2023-04-27 |
AU2021232959B2 (en) | 2023-09-07 |
EP4118091A1 (en) | 2023-01-18 |
BR112022017015A2 (pt) | 2022-11-16 |
BR112022017779A2 (pt) | 2022-11-29 |
ZA202209530B (en) | 2024-02-28 |
KR20220156570A (ko) | 2022-11-25 |
CA3175114A1 (en) | 2021-09-16 |
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