PE20050593A1 - Proceso para la preparacion de una sal del acido dicarboxilico de 6-[fenil(sustituido)-triazolopirimidina como inhibidores de tubulina - Google Patents
Proceso para la preparacion de una sal del acido dicarboxilico de 6-[fenil(sustituido)-triazolopirimidina como inhibidores de tubulinaInfo
- Publication number
- PE20050593A1 PE20050593A1 PE2004001201A PE2004001201A PE20050593A1 PE 20050593 A1 PE20050593 A1 PE 20050593A1 PE 2004001201 A PE2004001201 A PE 2004001201A PE 2004001201 A PE2004001201 A PE 2004001201A PE 20050593 A1 PE20050593 A1 PE 20050593A1
- Authority
- PE
- Peru
- Prior art keywords
- salt
- triazolopyrimidine
- phenyl
- alkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UN PROCESO PARA LA PREPARACION DE UNA SAL DEL ACIDO DICARBOXILICO DE 6-[FENIL(SUSTITUIDO)-TRIAZOLOPIRIMIDINA Y COMO UNA SAL HIDRATADA QUE TIENE LA FORMULA I EN LA CUAL R1 ES CF3, C2F5; R2 ES H, ALQUILO C1-C6;n ES UN NUMERO ENTERO DE 2 A 4; X ES Cl, Br; R3 Y R4 SON H, ALQUILO C1-C3; R3 Y R4 TOMADOS JUNTO CON EL ATOMO DE N AL CUAL CADA UNO ESTA UNIDO FORMAN UN ANILLO HETEROCICLICO SATURADO DE 4 A 6 MIEMBROS CON 1 A 2 ATOMOS DE NITROGENO Y 0 A 1 ATOMOS DE O, S OPCIONALMENTE SUSTITUIDOS CON R5; R5 ES ALQUILO C1-C3 DONDE LA LINEA PUNTEADA ES UN ENLACE OPCIONAL. EL PROCESO COMPRENDE: a) HACER REACCIONAR UN ESTER DEL ACIDO MALONICO DE FORMULA II DONDE R6 Y R7 SON ALQUILO C1-C3 CON 3-AMINO 1,2,4-TRIAZOL EN PRESENCIA DE UNA BASE DE TRIALQUILAMINA Y CALENTAMIENTO DE 130°C A 170°C DURANTE 1 A 6 HORAS, DILUYENDO CON TOLUENO Y ENFRIANDO DE 130°C HASTA 20°C AGREGANDO AL MENOS DOS EQUIVALENTES DE HIDROXIDO DE METAL ALCALINO ACUOSO (MOH) Y AISLANDO UNA SAL DIMETALICA; b) HALOGENAR LA SAL DIMETALICA CON UN REACTIVO HALOGENANTE POX3 DONDE X ES Br, Cl PARA OBTENER UN PRODUCTO HALOGENADO; c) HACER REACCIONAR EL PRODUCTO HALOGENADO CON UNA AMINA EN UN SOLVENTE APROTICO DE 20°C A 30°C PARA OBTENER EL PRODUCTO AMINA; d) HACER REACCIONAR UN HIDRURO DE METAL ALCALINO CON AMINOALCOHOL HO-(CH2)n-NR3R4 DURANTE 30min EN TETRAHIDROFURANO PARA OBTENER 6-[FENIL(SUSTITUIDO)-TRIAZOLOPIRIMIDINA Y e) REACCIONAR CON AGUA Y ACIDO CARBOXILICO AGREGANDO UN SOLVENTE PARA OBTENER LA SAL RESPECTIVA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52793103P | 2003-12-08 | 2003-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050593A1 true PE20050593A1 (es) | 2005-09-27 |
Family
ID=34676796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004001201A PE20050593A1 (es) | 2003-12-08 | 2004-12-07 | Proceso para la preparacion de una sal del acido dicarboxilico de 6-[fenil(sustituido)-triazolopirimidina como inhibidores de tubulina |
Country Status (29)
Country | Link |
---|---|
US (1) | US7396835B2 (es) |
EP (1) | EP1692137B1 (es) |
JP (1) | JP2007513185A (es) |
KR (1) | KR20060094984A (es) |
CN (1) | CN1890245A (es) |
AR (1) | AR046939A1 (es) |
AT (1) | ATE356128T1 (es) |
AU (1) | AU2004297244A1 (es) |
BR (1) | BRPI0417422A (es) |
CA (1) | CA2546899A1 (es) |
CO (1) | CO5700827A2 (es) |
CR (1) | CR8435A (es) |
DE (1) | DE602004005239T2 (es) |
DK (1) | DK1692137T3 (es) |
EC (1) | ECSP066606A (es) |
ES (1) | ES2281850T3 (es) |
GT (1) | GT200400248A (es) |
HK (1) | HK1090377A1 (es) |
IL (1) | IL175775A0 (es) |
MY (1) | MY179926A (es) |
NO (1) | NO20062492L (es) |
NZ (1) | NZ547471A (es) |
PA (1) | PA8619401A1 (es) |
PE (1) | PE20050593A1 (es) |
PL (1) | PL1692137T3 (es) |
RU (1) | RU2006117023A (es) |
TW (1) | TW200522963A (es) |
WO (1) | WO2005056560A1 (es) |
ZA (1) | ZA200604680B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US7419982B2 (en) * | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
TW200808730A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Process for synthesizing piperazine-piperidine compounds |
US20100056371A1 (en) * | 2007-01-08 | 2010-03-04 | Basf Se | Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi |
EP2903436B1 (en) | 2012-09-19 | 2019-07-17 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
EP3758696A4 (en) | 2018-03-02 | 2021-12-08 | The Trustees of the University of Pennsylvania | [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AND USE OF THESE IN THE STABILIZATION OF MICROTUBULES |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593996A (en) | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
TW224044B (es) | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
JP2794510B2 (ja) | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
IL108731A (en) | 1993-03-04 | 1997-03-18 | Shell Int Research | 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES |
IL108747A (en) | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
RU2147584C1 (ru) | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
US5817663A (en) | 1996-10-07 | 1998-10-06 | American Cyanamid Company | Pentafluorophenylazolopyrimidines |
ATE231485T1 (de) | 1997-03-18 | 2003-02-15 | Basf Ag | Verfahren zur herstellung von arylmalonaten |
US5750766A (en) | 1997-03-18 | 1998-05-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
US5948783A (en) | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
TWI252231B (en) | 1997-04-14 | 2006-04-01 | American Cyanamid Co | Fungicidal trifluorophenyl-triazolopyrimidines |
TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6117876A (en) * | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
US5994360A (en) | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
US5986153A (en) | 1997-09-30 | 1999-11-16 | Phillips Petroleum Company | Olefin color stabilization |
US6020338A (en) | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
US5981534A (en) | 1998-09-25 | 1999-11-09 | American Cyanamid Company | Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines |
DK1066291T3 (da) * | 1998-03-23 | 2005-09-19 | Basf Ag | Svampedræbende 6-(2-halogen-4-alkoxyphenyl)-triazolopyrimidiner |
JP2000103790A (ja) | 1998-09-25 | 2000-04-11 | American Cyanamid Co | 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類 |
US5986135A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6242451B1 (en) | 1998-09-25 | 2001-06-05 | Klaus-Juergen Pees | Fungicidal trihalophenyl-triazolopyrimidines |
US5985883A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trichlorophenyl-triazolopyrimidines |
EA006483B1 (ru) | 2000-06-30 | 2005-12-29 | Уайт | Замещенные триазолопиримидины в качестве противораковых средств |
CA2539252A1 (en) * | 2003-09-24 | 2005-04-07 | Wyeth Holdings Corporation | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents |
CN101193884A (zh) * | 2005-06-13 | 2008-06-04 | 惠氏公司 | 微管蛋白抑制剂和其制备方法 |
-
2004
- 2004-12-02 MY MYPI20044999A patent/MY179926A/en unknown
- 2004-12-03 GT GT200400248A patent/GT200400248A/es unknown
- 2004-12-03 TW TW093137287A patent/TW200522963A/zh unknown
- 2004-12-07 KR KR1020067012134A patent/KR20060094984A/ko not_active Application Discontinuation
- 2004-12-07 CA CA002546899A patent/CA2546899A1/en not_active Abandoned
- 2004-12-07 BR BRPI0417422-4A patent/BRPI0417422A/pt not_active IP Right Cessation
- 2004-12-07 ES ES04813203T patent/ES2281850T3/es active Active
- 2004-12-07 DE DE602004005239T patent/DE602004005239T2/de not_active Expired - Fee Related
- 2004-12-07 DK DK04813203T patent/DK1692137T3/da active
- 2004-12-07 AT AT04813203T patent/ATE356128T1/de not_active IP Right Cessation
- 2004-12-07 CN CNA2004800362897A patent/CN1890245A/zh active Pending
- 2004-12-07 WO PCT/US2004/040854 patent/WO2005056560A1/en active IP Right Grant
- 2004-12-07 PA PA20048619401A patent/PA8619401A1/es unknown
- 2004-12-07 RU RU2006117023/04A patent/RU2006117023A/ru not_active Application Discontinuation
- 2004-12-07 AR ARP040104569A patent/AR046939A1/es not_active Application Discontinuation
- 2004-12-07 PL PL04813203T patent/PL1692137T3/pl unknown
- 2004-12-07 AU AU2004297244A patent/AU2004297244A1/en not_active Withdrawn
- 2004-12-07 JP JP2006542867A patent/JP2007513185A/ja not_active Withdrawn
- 2004-12-07 NZ NZ547471A patent/NZ547471A/en unknown
- 2004-12-07 EP EP04813203A patent/EP1692137B1/en active Active
- 2004-12-07 PE PE2004001201A patent/PE20050593A1/es not_active Application Discontinuation
- 2004-12-08 US US11/007,839 patent/US7396835B2/en not_active Expired - Fee Related
-
2006
- 2006-05-18 IL IL175775A patent/IL175775A0/en unknown
- 2006-05-31 NO NO20062492A patent/NO20062492L/no not_active Application Discontinuation
- 2006-06-05 EC EC2006006606A patent/ECSP066606A/es unknown
- 2006-06-06 CR CR8435A patent/CR8435A/es not_active Application Discontinuation
- 2006-06-07 ZA ZA200604680A patent/ZA200604680B/xx unknown
- 2006-06-08 CO CO06055468A patent/CO5700827A2/es not_active Application Discontinuation
- 2006-11-02 HK HK06112063A patent/HK1090377A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR046939A1 (es) | 2006-01-04 |
KR20060094984A (ko) | 2006-08-30 |
ATE356128T1 (de) | 2007-03-15 |
CA2546899A1 (en) | 2005-06-23 |
PA8619401A1 (es) | 2005-08-04 |
CO5700827A2 (es) | 2006-11-30 |
ZA200604680B (en) | 2009-04-29 |
BRPI0417422A (pt) | 2007-03-13 |
NZ547471A (en) | 2009-03-31 |
IL175775A0 (en) | 2006-09-05 |
DE602004005239T2 (de) | 2007-12-20 |
DK1692137T3 (da) | 2007-04-30 |
NO20062492L (no) | 2006-07-03 |
CN1890245A (zh) | 2007-01-03 |
EP1692137B1 (en) | 2007-03-07 |
EP1692137A1 (en) | 2006-08-23 |
JP2007513185A (ja) | 2007-05-24 |
WO2005056560A1 (en) | 2005-06-23 |
MY179926A (en) | 2020-11-19 |
ECSP066606A (es) | 2006-10-25 |
RU2006117023A (ru) | 2008-01-20 |
HK1090377A1 (en) | 2006-12-22 |
PL1692137T3 (pl) | 2007-06-29 |
TW200522963A (en) | 2005-07-16 |
US20050124635A1 (en) | 2005-06-09 |
DE602004005239D1 (de) | 2007-04-19 |
ES2281850T3 (es) | 2007-10-01 |
AU2004297244A1 (en) | 2005-06-23 |
CR8435A (es) | 2007-06-08 |
GT200400248A (es) | 2005-09-14 |
US7396835B2 (en) | 2008-07-08 |
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