BRPI0417422A - processo para a preparação de um sal de ácido 6 - [(substituìdo) fenil] - triazolopirimidina dicarboxìlico - Google Patents
processo para a preparação de um sal de ácido 6 - [(substituìdo) fenil] - triazolopirimidina dicarboxìlicoInfo
- Publication number
- BRPI0417422A BRPI0417422A BRPI0417422-4A BRPI0417422A BRPI0417422A BR PI0417422 A BRPI0417422 A BR PI0417422A BR PI0417422 A BRPI0417422 A BR PI0417422A BR PI0417422 A BRPI0417422 A BR PI0417422A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- acid salt
- phenyl
- preparation
- dicarboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE UM SAL DE áCIDO 6¢(SUBSTITUìDO)FENIL!-TRIAZOLOPIRIMIDINA DICARBOXìLICO". A presente invenção se refere a um processo para a preparação de sal de ácido 6-¢(substituído)fenil!triazolopirimidina dicarboxílico e como um sal hidratado dotado de fórmula estrutural (I) Onde: R¬ 1¬ é CF~ 3~ OU C~ 2~F~ 5~; R¬ 2¬ é H ou alquila C~ 1~-C~ 3~; n é um número inteiro de 2, 3, ou 4; X é C1 ou Br R¬ 3¬ e R¬ 4¬ são cada um dos quais independentemente H ou alquila C~ 1~-C~ 3~; ou R¬ 3¬ e R¬ 4¬ quando opcionalmente obtidos juntos com um átomo de nitrogênio ao qual cada um é fixado a partir de um anel heterocíclico saturado de 4 a 6 membros dotado de 1-2 átomos de nitrogênio e de 0-1 átomos de oxigênio ou 0-1 átomos de enxofre, e opcionalmente substituído com R¬ 5¬; R¬ 5¬ é alquila C~ 1~-C~ 3~; onde a linha pontilhada é uma ligação opcional.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52793103P | 2003-12-08 | 2003-12-08 | |
PCT/US2004/040854 WO2005056560A1 (en) | 2003-12-08 | 2004-12-07 | Process for the preparation of tubulin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417422A true BRPI0417422A (pt) | 2007-03-13 |
Family
ID=34676796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417422-4A BRPI0417422A (pt) | 2003-12-08 | 2004-12-07 | processo para a preparação de um sal de ácido 6 - [(substituìdo) fenil] - triazolopirimidina dicarboxìlico |
Country Status (29)
Country | Link |
---|---|
US (1) | US7396835B2 (pt) |
EP (1) | EP1692137B1 (pt) |
JP (1) | JP2007513185A (pt) |
KR (1) | KR20060094984A (pt) |
CN (1) | CN1890245A (pt) |
AR (1) | AR046939A1 (pt) |
AT (1) | ATE356128T1 (pt) |
AU (1) | AU2004297244A1 (pt) |
BR (1) | BRPI0417422A (pt) |
CA (1) | CA2546899A1 (pt) |
CO (1) | CO5700827A2 (pt) |
CR (1) | CR8435A (pt) |
DE (1) | DE602004005239T2 (pt) |
DK (1) | DK1692137T3 (pt) |
EC (1) | ECSP066606A (pt) |
ES (1) | ES2281850T3 (pt) |
GT (1) | GT200400248A (pt) |
HK (1) | HK1090377A1 (pt) |
IL (1) | IL175775A0 (pt) |
MY (1) | MY179926A (pt) |
NO (1) | NO20062492L (pt) |
NZ (1) | NZ547471A (pt) |
PA (1) | PA8619401A1 (pt) |
PE (1) | PE20050593A1 (pt) |
PL (1) | PL1692137T3 (pt) |
RU (1) | RU2006117023A (pt) |
TW (1) | TW200522963A (pt) |
WO (1) | WO2005056560A1 (pt) |
ZA (1) | ZA200604680B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US7419982B2 (en) * | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
TW200808730A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Process for synthesizing piperazine-piperidine compounds |
WO2008084027A1 (de) * | 2007-01-08 | 2008-07-17 | Basf Se | Verwendung von azolopyrimidinen zur bekämpfung von pflanzenpathogenen schadpilzen |
US9649317B2 (en) | 2012-09-19 | 2017-05-16 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
WO2019169111A1 (en) | 2018-03-02 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules |
CN116178375B (zh) * | 2023-02-24 | 2024-09-20 | 重庆文理学院 | 一种三唑并嘧啶化合物及其合成方法和应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW224044B (pt) | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
US5593996A (en) | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
JP2794510B2 (ja) | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
IL108747A (en) | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
IL108731A (en) | 1993-03-04 | 1997-03-18 | Shell Int Research | 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES |
RU2147584C1 (ru) | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
US5817663A (en) | 1996-10-07 | 1998-10-06 | American Cyanamid Company | Pentafluorophenylazolopyrimidines |
US5750766A (en) | 1997-03-18 | 1998-05-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
WO1998041496A1 (en) | 1997-03-18 | 1998-09-24 | American Cyanamid Company | Process for the preparation of arylmalonates |
US6117876A (en) * | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
TWI252231B (en) | 1997-04-14 | 2006-04-01 | American Cyanamid Co | Fungicidal trifluorophenyl-triazolopyrimidines |
US5948783A (en) | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US5994360A (en) | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
US5986153A (en) | 1997-09-30 | 1999-11-16 | Phillips Petroleum Company | Olefin color stabilization |
US6020338A (en) | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
CN100339378C (zh) * | 1998-03-23 | 2007-09-26 | 巴斯福股份公司 | 杀真菌的6-(2-卤代-4-烷氧基苯基)-三唑并嘧啶 |
US5981534A (en) | 1998-09-25 | 1999-11-09 | American Cyanamid Company | Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines |
US5985883A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trichlorophenyl-triazolopyrimidines |
JP2000103790A (ja) | 1998-09-25 | 2000-04-11 | American Cyanamid Co | 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類 |
US5986135A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6242451B1 (en) | 1998-09-25 | 2001-06-05 | Klaus-Juergen Pees | Fungicidal trihalophenyl-triazolopyrimidines |
HUP0300798A3 (en) | 2000-06-30 | 2006-02-28 | Wyeth Corp | Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them |
ES2279452T3 (es) * | 2003-09-24 | 2007-08-16 | Wyeth Holdings Corporation | 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos. |
CN101193884A (zh) * | 2005-06-13 | 2008-06-04 | 惠氏公司 | 微管蛋白抑制剂和其制备方法 |
-
2004
- 2004-12-02 MY MYPI20044999A patent/MY179926A/en unknown
- 2004-12-03 GT GT200400248A patent/GT200400248A/es unknown
- 2004-12-03 TW TW093137287A patent/TW200522963A/zh unknown
- 2004-12-07 AR ARP040104569A patent/AR046939A1/es not_active Application Discontinuation
- 2004-12-07 EP EP04813203A patent/EP1692137B1/en active Active
- 2004-12-07 PL PL04813203T patent/PL1692137T3/pl unknown
- 2004-12-07 BR BRPI0417422-4A patent/BRPI0417422A/pt not_active IP Right Cessation
- 2004-12-07 CN CNA2004800362897A patent/CN1890245A/zh active Pending
- 2004-12-07 JP JP2006542867A patent/JP2007513185A/ja not_active Withdrawn
- 2004-12-07 AU AU2004297244A patent/AU2004297244A1/en not_active Withdrawn
- 2004-12-07 DK DK04813203T patent/DK1692137T3/da active
- 2004-12-07 RU RU2006117023/04A patent/RU2006117023A/ru not_active Application Discontinuation
- 2004-12-07 AT AT04813203T patent/ATE356128T1/de not_active IP Right Cessation
- 2004-12-07 NZ NZ547471A patent/NZ547471A/en unknown
- 2004-12-07 ES ES04813203T patent/ES2281850T3/es active Active
- 2004-12-07 KR KR1020067012134A patent/KR20060094984A/ko not_active Application Discontinuation
- 2004-12-07 PA PA20048619401A patent/PA8619401A1/es unknown
- 2004-12-07 PE PE2004001201A patent/PE20050593A1/es not_active Application Discontinuation
- 2004-12-07 WO PCT/US2004/040854 patent/WO2005056560A1/en active IP Right Grant
- 2004-12-07 CA CA002546899A patent/CA2546899A1/en not_active Abandoned
- 2004-12-07 DE DE602004005239T patent/DE602004005239T2/de not_active Expired - Fee Related
- 2004-12-08 US US11/007,839 patent/US7396835B2/en not_active Expired - Fee Related
-
2006
- 2006-05-18 IL IL175775A patent/IL175775A0/en unknown
- 2006-05-31 NO NO20062492A patent/NO20062492L/no not_active Application Discontinuation
- 2006-06-05 EC EC2006006606A patent/ECSP066606A/es unknown
- 2006-06-06 CR CR8435A patent/CR8435A/es not_active Application Discontinuation
- 2006-06-07 ZA ZA200604680A patent/ZA200604680B/xx unknown
- 2006-06-08 CO CO06055468A patent/CO5700827A2/es not_active Application Discontinuation
- 2006-11-02 HK HK06112063A patent/HK1090377A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2004297244A1 (en) | 2005-06-23 |
ES2281850T3 (es) | 2007-10-01 |
MY179926A (en) | 2020-11-19 |
EP1692137B1 (en) | 2007-03-07 |
JP2007513185A (ja) | 2007-05-24 |
EP1692137A1 (en) | 2006-08-23 |
CN1890245A (zh) | 2007-01-03 |
TW200522963A (en) | 2005-07-16 |
ECSP066606A (es) | 2006-10-25 |
DE602004005239D1 (de) | 2007-04-19 |
DE602004005239T2 (de) | 2007-12-20 |
ATE356128T1 (de) | 2007-03-15 |
KR20060094984A (ko) | 2006-08-30 |
NZ547471A (en) | 2009-03-31 |
US20050124635A1 (en) | 2005-06-09 |
CO5700827A2 (es) | 2006-11-30 |
PL1692137T3 (pl) | 2007-06-29 |
PE20050593A1 (es) | 2005-09-27 |
RU2006117023A (ru) | 2008-01-20 |
DK1692137T3 (da) | 2007-04-30 |
NO20062492L (no) | 2006-07-03 |
AR046939A1 (es) | 2006-01-04 |
HK1090377A1 (en) | 2006-12-22 |
IL175775A0 (en) | 2006-09-05 |
ZA200604680B (en) | 2009-04-29 |
US7396835B2 (en) | 2008-07-08 |
CA2546899A1 (en) | 2005-06-23 |
GT200400248A (es) | 2005-09-14 |
PA8619401A1 (es) | 2005-08-04 |
WO2005056560A1 (en) | 2005-06-23 |
CR8435A (es) | 2007-06-08 |
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Legal Events
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B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: PARA QUE A PETICAO NO 20090072583/RJ DE 28.07.09 SEJA ATENDIDA, APRESENTAR PROCURACAO ORIGINAL, OUCOPIA AUTENTICADA, DANDO PODERES PARA DESISTIR DO PEDIDO. |
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B15G | Petition not considered as such [chapter 15.7 patent gazette] |
Free format text: DESCONHECIDA A PETICAO NO 020090072583/RJ DE 28/07/2009, EM VIRTUDE DO DISPOSTO NO ARTIGO 219 INCISO II DA LPI 9279/96. |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A. E 7A. ANUIDADE(S). |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 6A E 7A ANUIDADES. |