DE602006009698D1 - Verfahren zur herstellung von expoxybutanol-zwischenprodukten - Google Patents

Verfahren zur herstellung von expoxybutanol-zwischenprodukten

Info

Publication number
DE602006009698D1
DE602006009698D1 DE602006009698T DE602006009698T DE602006009698D1 DE 602006009698 D1 DE602006009698 D1 DE 602006009698D1 DE 602006009698 T DE602006009698 T DE 602006009698T DE 602006009698 T DE602006009698 T DE 602006009698T DE 602006009698 D1 DE602006009698 D1 DE 602006009698D1
Authority
DE
Germany
Prior art keywords
formula
expoxybutanol
preparing
intermediate products
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006009698T
Other languages
English (en)
Inventor
Marc Muller
Lin Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Publication of DE602006009698D1 publication Critical patent/DE602006009698D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
DE602006009698T 2005-12-01 2006-11-29 Verfahren zur herstellung von expoxybutanol-zwischenprodukten Active DE602006009698D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05026163 2005-12-01
PCT/CH2006/000671 WO2007062542A2 (en) 2005-12-01 2006-11-29 Process for the manufacture of epoxybutanol intermediates

Publications (1)

Publication Number Publication Date
DE602006009698D1 true DE602006009698D1 (de) 2009-11-19

Family

ID=36178579

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006009698T Active DE602006009698D1 (de) 2005-12-01 2006-11-29 Verfahren zur herstellung von expoxybutanol-zwischenprodukten

Country Status (19)

Country Link
US (2) US7816537B2 (de)
EP (2) EP2133345A1 (de)
JP (1) JP5329969B2 (de)
KR (1) KR101191682B1 (de)
CN (1) CN101321522B (de)
AT (1) ATE444747T1 (de)
AU (2) AU2006319657B2 (de)
BR (1) BRPI0619120B1 (de)
CA (2) CA2711852C (de)
CY (1) CY1110588T1 (de)
DE (1) DE602006009698D1 (de)
DK (1) DK1954264T3 (de)
ES (1) ES2333258T3 (de)
HR (1) HRP20090675T1 (de)
PL (1) PL1954264T3 (de)
PT (1) PT1954264E (de)
SI (1) SI1954264T1 (de)
WO (1) WO2007062542A2 (de)
ZA (1) ZA200804218B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10023600B2 (en) 2009-09-21 2018-07-17 Gilead Sciences, Inc. Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs
SG186830A1 (en) 2010-07-22 2013-02-28 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections
WO2014023623A1 (en) 2012-08-07 2014-02-13 Basilea Pharmaceutica Ag Process for the manufacture of isavuconazole or ravuconazole
WO2015150947A1 (en) 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
TWI698444B (zh) 2014-10-29 2020-07-11 美商基利科學股份有限公司 製備核糖苷的方法
BR112018005048B8 (pt) 2015-09-16 2021-03-23 Gilead Sciences Inc uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
AU2018235754B2 (en) 2017-03-14 2021-04-08 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
ES2938859T3 (es) 2017-05-01 2023-04-17 Gilead Sciences Inc Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato
CN111093627B (zh) 2017-07-11 2024-03-08 吉利德科学公司 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
ES2915582T3 (es) 2017-08-10 2022-06-23 Sumitomo Chemical Co Método para producir un compuesto de alcohol epoxi
CN118766947A (zh) 2020-01-27 2024-10-15 吉利德科学公司 用于治疗SARS CoV-2感染的方法
WO2021183750A2 (en) 2020-03-12 2021-09-16 Gilead Sciences, Inc. Methods of preparing 1'-cyano nucleosides
KR20220164784A (ko) 2020-04-06 2022-12-13 길리애드 사이언시즈, 인코포레이티드 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
CN115666570A (zh) 2020-05-29 2023-01-31 吉利德科学公司 瑞德西韦治疗方法
EP4172160A2 (de) 2020-06-24 2023-05-03 Gilead Sciences, Inc. 1'-cyanonukleosidanaloga und verwendungen davon
CA3190702A1 (en) 2020-08-27 2022-03-03 Elaine Bunyan Compounds and methods for treatment of viral infections
TW202400185A (zh) 2022-03-02 2024-01-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
CN115536643A (zh) * 2022-12-05 2022-12-30 南京桦冠生物技术有限公司 一种艾沙康唑类药物关键中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
AU2931399A (en) 1998-03-06 1999-09-20 F. Hoffmann-La Roche Ag 3-(4-(4-cyanophenyl)thiazol-2-y))-1-(1h-1,2,4-triazol-1-yl) -butan-2-ol derivatives having antifungal activity
US6133485A (en) 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
US6391903B1 (en) 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
US6884892B2 (en) 2002-06-20 2005-04-26 Sumitomo Chemical Company, Limited Production methods of epoxytriazole derivative and intermediate therefor
JP4627413B2 (ja) * 2003-05-06 2011-02-09 三井化学株式会社 １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法

Also Published As

Publication number Publication date
ATE444747T1 (de) 2009-10-15
CA2629092A1 (en) 2007-06-07
PL1954264T3 (pl) 2010-02-26
AU2006319657B2 (en) 2010-08-12
EP2133345A1 (de) 2009-12-16
BRPI0619120B1 (pt) 2023-10-10
CA2711852C (en) 2011-10-04
ES2333258T3 (es) 2010-02-18
AU2006319657A1 (en) 2007-06-07
HRP20090675T1 (hr) 2010-01-31
JP5329969B2 (ja) 2013-10-30
AU2010203301A1 (en) 2010-08-12
US20090299073A1 (en) 2009-12-03
CA2629092C (en) 2012-01-03
CN101321522B (zh) 2012-05-30
AU2010203301B2 (en) 2012-06-21
PT1954264E (pt) 2009-12-23
EP1954264A2 (de) 2008-08-13
US20110021794A1 (en) 2011-01-27
CN101321522A (zh) 2008-12-10
BRPI0619120A2 (pt) 2011-09-13
KR20080075014A (ko) 2008-08-13
JP2009517413A (ja) 2009-04-30
ZA200804218B (en) 2009-01-28
US7816537B2 (en) 2010-10-19
KR101191682B1 (ko) 2012-10-16
EP1954264B1 (de) 2009-10-07
SI1954264T1 (sl) 2010-01-29
WO2007062542A3 (en) 2007-11-01
US8076494B2 (en) 2011-12-13
CA2711852A1 (en) 2007-06-07
WO2007062542A2 (en) 2007-06-07
CY1110588T1 (el) 2015-04-29
DK1954264T3 (da) 2010-01-11

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Legal Events

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8364 No opposition during term of opposition