DE602007012725D1 - Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen - Google Patents

Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen

Info

Publication number
DE602007012725D1
DE602007012725D1 DE602007012725T DE602007012725T DE602007012725D1 DE 602007012725 D1 DE602007012725 D1 DE 602007012725D1 DE 602007012725 T DE602007012725 T DE 602007012725T DE 602007012725 T DE602007012725 T DE 602007012725T DE 602007012725 D1 DE602007012725 D1 DE 602007012725D1
Authority
DE
Germany
Prior art keywords
piperazines
diphenylmethyl
preparation
levocetrizine
cetirizine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007012725T
Other languages
English (en)
Inventor
Jie Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthon BV
Original Assignee
Synthon BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon BV filed Critical Synthon BV
Publication of DE602007012725D1 publication Critical patent/DE602007012725D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602007012725T 2007-11-21 2007-11-22 Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen Active DE602007012725D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98952807P 2007-11-21 2007-11-21

Publications (1)

Publication Number Publication Date
DE602007012725D1 true DE602007012725D1 (de) 2011-04-07

Family

ID=38884730

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007012725T Active DE602007012725D1 (de) 2007-11-21 2007-11-22 Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen

Country Status (6)

Country Link
EP (1) EP2062881B1 (de)
AT (1) ATE499352T1 (de)
DE (1) DE602007012725D1 (de)
ES (1) ES2361343T3 (de)
PL (1) PL2062881T3 (de)
WO (1) WO2009065622A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010057515A1 (en) * 2008-11-21 2010-05-27 Synthon B.V. Levocetirizine by menthyl intermediate
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
DE102014220798A1 (de) 2014-10-14 2016-04-14 Scheuten S.À.R.L. Hydrophil beschichtetes Isolierglas für Gewächshäuser
JP2022554364A (ja) 2019-11-08 2022-12-28 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ｇｅｍ－二置換複素環式化合物及びＩＤＨ阻害剤としてのその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1139113B (de) * 1961-01-17 1962-11-08 Basf Ag Verfahren zur Herstellung von N-ª‰-Halogenalkylcarbaminsaeureestern
IT1140978B (it) * 1980-05-23 1986-10-10 Selvi & C Spa 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche
FI75816C (fi) 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.
GB8827391D0 (en) 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
EP0950412A3 (de) 1992-09-24 2001-05-16 Sepracor, Inc. Zusammensetzungen zur Behandlung von allergischen Krankheiten unter Verwendung von (-) Cetirizin
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
JP2002249487A (ja) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
HU227074B1 (en) * 2005-12-08 2010-06-28 Egis Gyogyszergyar Nyrt An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate

Also Published As

Publication number Publication date
EP2062881A1 (de) 2009-05-27
PL2062881T3 (pl) 2011-07-29
EP2062881B1 (de) 2011-02-23
ES2361343T3 (es) 2011-06-16
ATE499352T1 (de) 2011-03-15
WO2009065622A1 (en) 2009-05-28

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