ATE499352T1 - Verfahren zur herstellung von n- (diphenylmethyl)piperazinen - Google Patents
Verfahren zur herstellung von n- (diphenylmethyl)piperazinenInfo
- Publication number
- ATE499352T1 ATE499352T1 AT07022670T AT07022670T ATE499352T1 AT E499352 T1 ATE499352 T1 AT E499352T1 AT 07022670 T AT07022670 T AT 07022670T AT 07022670 T AT07022670 T AT 07022670T AT E499352 T1 ATE499352 T1 AT E499352T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazines
- diphenylmethyl
- producing
- levocetrizine
- cetirizine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 1
- 229960001803 cetirizine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NWVNXDKZIQLBNM-UHFFFAOYSA-N diphenylmethylpiperazine Chemical class C1CNCCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 NWVNXDKZIQLBNM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98952807P | 2007-11-21 | 2007-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE499352T1 true ATE499352T1 (de) | 2011-03-15 |
Family
ID=38884730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07022670T ATE499352T1 (de) | 2007-11-21 | 2007-11-22 | Verfahren zur herstellung von n- (diphenylmethyl)piperazinen |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2062881B1 (de) |
| AT (1) | ATE499352T1 (de) |
| DE (1) | DE602007012725D1 (de) |
| ES (1) | ES2361343T3 (de) |
| PL (1) | PL2062881T3 (de) |
| WO (1) | WO2009065622A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010057515A1 (en) * | 2008-11-21 | 2010-05-27 | Synthon B.V. | Levocetirizine by menthyl intermediate |
| WO2012101475A1 (en) | 2011-01-27 | 2012-08-02 | Jubilant Life Sciences Limited | An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate |
| DE102014220798A1 (de) | 2014-10-14 | 2016-04-14 | Scheuten S.À.R.L. | Hydrophil beschichtetes Isolierglas für Gewächshäuser |
| US12521395B2 (en) | 2019-11-08 | 2026-01-13 | Nerviano Medical Sciences S.R.L. | Gem-disubstituted heterocyclic compounds and their use as IDH inhibitors |
| CN117209453A (zh) * | 2023-08-24 | 2023-12-12 | 迪嘉药业集团股份有限公司 | 一种盐酸左西替利嗪中间体的制备及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1139113B (de) * | 1961-01-17 | 1962-11-08 | Basf Ag | Verfahren zur Herstellung von N-ª‰-Halogenalkylcarbaminsaeureestern |
| IT1140978B (it) * | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| FI75816C (fi) | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
| GB8827391D0 (en) | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| ATE170749T1 (de) | 1992-09-24 | 1998-09-15 | Sepracor Inc | Verwendung von (-) cetirizin zur behandlung allergischer rhinitis und und asthma |
| GB9305282D0 (en) | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| JP2002249487A (ja) * | 2001-02-22 | 2002-09-06 | Sumitomo Chem Co Ltd | ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。 |
| HU227074B1 (en) * | 2005-12-08 | 2010-06-28 | Egis Gyogyszergyar Nyrt | An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate |
-
2007
- 2007-11-22 AT AT07022670T patent/ATE499352T1/de not_active IP Right Cessation
- 2007-11-22 DE DE602007012725T patent/DE602007012725D1/de active Active
- 2007-11-22 PL PL07022670T patent/PL2062881T3/pl unknown
- 2007-11-22 EP EP07022670A patent/EP2062881B1/de not_active Not-in-force
- 2007-11-22 ES ES07022670T patent/ES2361343T3/es active Active
-
2008
- 2008-11-21 WO PCT/EP2008/009978 patent/WO2009065622A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009065622A1 (en) | 2009-05-28 |
| EP2062881A1 (de) | 2009-05-27 |
| DE602007012725D1 (de) | 2011-04-07 |
| PL2062881T3 (pl) | 2011-07-29 |
| EP2062881B1 (de) | 2011-02-23 |
| ES2361343T3 (es) | 2011-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |