DE602007008691D1 - Cyclische sulfone, die zur verwendung als bace-inhibitoren geeignet sind - Google Patents
Cyclische sulfone, die zur verwendung als bace-inhibitoren geeignet sindInfo
- Publication number
- DE602007008691D1 DE602007008691D1 DE602007008691T DE602007008691T DE602007008691D1 DE 602007008691 D1 DE602007008691 D1 DE 602007008691D1 DE 602007008691 T DE602007008691 T DE 602007008691T DE 602007008691 T DE602007008691 T DE 602007008691T DE 602007008691 D1 DE602007008691 D1 DE 602007008691D1
- Authority
- DE
- Germany
- Prior art keywords
- bace inhibitors
- cyclic sulphones
- medicaments
- sulphones
- cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602951.6A GB0602951D0 (en) | 2006-02-14 | 2006-02-14 | Organic Compounds |
| PCT/EP2007/051454 WO2007093621A1 (en) | 2006-02-14 | 2007-02-14 | Cyclic sulfones useful as bace inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007008691D1 true DE602007008691D1 (de) | 2010-10-07 |
Family
ID=36141810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007008691T Active DE602007008691D1 (de) | 2006-02-14 | 2007-02-14 | Cyclische sulfone, die zur verwendung als bace-inhibitoren geeignet sind |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090099207A1 (de) |
| EP (1) | EP1989194B1 (de) |
| JP (1) | JP2009526820A (de) |
| KR (1) | KR20080093049A (de) |
| CN (1) | CN101384580A (de) |
| AT (1) | ATE478858T1 (de) |
| AU (1) | AU2007216463A1 (de) |
| BR (1) | BRPI0707812A2 (de) |
| CA (1) | CA2637857A1 (de) |
| DE (1) | DE602007008691D1 (de) |
| GB (1) | GB0602951D0 (de) |
| RU (1) | RU2008136762A (de) |
| WO (1) | WO2007093621A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| KR20100061805A (ko) * | 2007-08-23 | 2010-06-09 | 노파르티스 아게 | Ｂａｃｅ 억제제로서 유용한 아미노벤질-치환된 시클릭 술폰 |
| JP2011527311A (ja) * | 2008-07-10 | 2011-10-27 | ノバルティス アーゲー | Ｂａｃｅ阻害薬として有用なアミノベンジル置換環状スルホン誘導体 |
| EP2485590B1 (de) | 2009-10-08 | 2015-01-07 | Merck Sharp & Dohme Corp. | Heterozyklische pentafluorsulfur-imin-verbindungen als bace-1-hemmer sowie zusammensetzungen damit und ihre verwendung |
| WO2011044187A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| WO2011044185A2 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| CN104995176B (zh) | 2013-02-12 | 2019-02-22 | 巴克老龄化研究所 | 调节bace所介导的app加工的乙内酰脲 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| KR100869061B1 (ko) * | 2000-12-13 | 2008-11-17 | 와이어쓰 | 베타 아밀로이드 생성의 헤테로고리 술폰아미드 저해제 |
-
2006
- 2006-02-14 GB GBGB0602951.6A patent/GB0602951D0/en not_active Ceased
-
2007
- 2007-02-14 KR KR1020087019867A patent/KR20080093049A/ko not_active Application Discontinuation
- 2007-02-14 CA CA002637857A patent/CA2637857A1/en not_active Abandoned
- 2007-02-14 EP EP07712220A patent/EP1989194B1/de not_active Not-in-force
- 2007-02-14 RU RU2008136762/04A patent/RU2008136762A/ru not_active Application Discontinuation
- 2007-02-14 US US12/279,388 patent/US20090099207A1/en not_active Abandoned
- 2007-02-14 AU AU2007216463A patent/AU2007216463A1/en not_active Abandoned
- 2007-02-14 BR BRPI0707812-9A patent/BRPI0707812A2/pt not_active Application Discontinuation
- 2007-02-14 JP JP2008554774A patent/JP2009526820A/ja active Pending
- 2007-02-14 CN CNA2007800055303A patent/CN101384580A/zh active Pending
- 2007-02-14 WO PCT/EP2007/051454 patent/WO2007093621A1/en active Application Filing
- 2007-02-14 DE DE602007008691T patent/DE602007008691D1/de active Active
- 2007-02-14 AT AT07712220T patent/ATE478858T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20090099207A1 (en) | 2009-04-16 |
| CA2637857A1 (en) | 2007-08-23 |
| JP2009526820A (ja) | 2009-07-23 |
| AU2007216463A1 (en) | 2007-08-23 |
| WO2007093621A1 (en) | 2007-08-23 |
| CN101384580A (zh) | 2009-03-11 |
| EP1989194B1 (de) | 2010-08-25 |
| KR20080093049A (ko) | 2008-10-17 |
| EP1989194A1 (de) | 2008-11-12 |
| GB0602951D0 (en) | 2006-03-29 |
| BRPI0707812A2 (pt) | 2011-05-10 |
| ATE478858T1 (de) | 2010-09-15 |
| RU2008136762A (ru) | 2010-03-20 |
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