ATE478858T1 - Cyclische sulfone, die zur verwendung als bace- inhibitoren geeignet sind - Google Patents
Cyclische sulfone, die zur verwendung als bace- inhibitoren geeignet sindInfo
- Publication number
- ATE478858T1 ATE478858T1 AT07712220T AT07712220T ATE478858T1 AT E478858 T1 ATE478858 T1 AT E478858T1 AT 07712220 T AT07712220 T AT 07712220T AT 07712220 T AT07712220 T AT 07712220T AT E478858 T1 ATE478858 T1 AT E478858T1
- Authority
- AT
- Austria
- Prior art keywords
- bace inhibitors
- cyclic sulfones
- sulfones suitable
- medicaments
- cyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602951.6A GB0602951D0 (en) | 2006-02-14 | 2006-02-14 | Organic Compounds |
| PCT/EP2007/051454 WO2007093621A1 (en) | 2006-02-14 | 2007-02-14 | Cyclic sulfones useful as bace inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478858T1 true ATE478858T1 (de) | 2010-09-15 |
Family
ID=36141810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07712220T ATE478858T1 (de) | 2006-02-14 | 2007-02-14 | Cyclische sulfone, die zur verwendung als bace- inhibitoren geeignet sind |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090099207A1 (de) |
| EP (1) | EP1989194B1 (de) |
| JP (1) | JP2009526820A (de) |
| KR (1) | KR20080093049A (de) |
| CN (1) | CN101384580A (de) |
| AT (1) | ATE478858T1 (de) |
| AU (1) | AU2007216463A1 (de) |
| BR (1) | BRPI0707812A2 (de) |
| CA (1) | CA2637857A1 (de) |
| DE (1) | DE602007008691D1 (de) |
| GB (1) | GB0602951D0 (de) |
| RU (1) | RU2008136762A (de) |
| WO (1) | WO2007093621A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| AU2008290561A1 (en) * | 2007-08-23 | 2009-02-26 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as BACE inhibitors |
| WO2010003976A1 (en) * | 2008-07-10 | 2010-01-14 | Novartis Ag | Cyclic sulfones with aminobenzyl substitution useful as bace inhibitors |
| WO2011044185A2 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| US8557826B2 (en) | 2009-10-08 | 2013-10-15 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| US10202355B2 (en) | 2013-02-12 | 2019-02-12 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| CA2436526C (en) * | 2000-12-13 | 2010-10-19 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
-
2006
- 2006-02-14 GB GBGB0602951.6A patent/GB0602951D0/en not_active Ceased
-
2007
- 2007-02-14 CN CNA2007800055303A patent/CN101384580A/zh active Pending
- 2007-02-14 DE DE602007008691T patent/DE602007008691D1/de active Active
- 2007-02-14 CA CA002637857A patent/CA2637857A1/en not_active Abandoned
- 2007-02-14 BR BRPI0707812-9A patent/BRPI0707812A2/pt not_active Application Discontinuation
- 2007-02-14 RU RU2008136762/04A patent/RU2008136762A/ru not_active Application Discontinuation
- 2007-02-14 AT AT07712220T patent/ATE478858T1/de not_active IP Right Cessation
- 2007-02-14 US US12/279,388 patent/US20090099207A1/en not_active Abandoned
- 2007-02-14 JP JP2008554774A patent/JP2009526820A/ja active Pending
- 2007-02-14 EP EP07712220A patent/EP1989194B1/de not_active Not-in-force
- 2007-02-14 KR KR1020087019867A patent/KR20080093049A/ko not_active Application Discontinuation
- 2007-02-14 AU AU2007216463A patent/AU2007216463A1/en not_active Abandoned
- 2007-02-14 WO PCT/EP2007/051454 patent/WO2007093621A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US20090099207A1 (en) | 2009-04-16 |
| CA2637857A1 (en) | 2007-08-23 |
| GB0602951D0 (en) | 2006-03-29 |
| RU2008136762A (ru) | 2010-03-20 |
| JP2009526820A (ja) | 2009-07-23 |
| AU2007216463A1 (en) | 2007-08-23 |
| BRPI0707812A2 (pt) | 2011-05-10 |
| WO2007093621A1 (en) | 2007-08-23 |
| EP1989194B1 (de) | 2010-08-25 |
| EP1989194A1 (de) | 2008-11-12 |
| CN101384580A (zh) | 2009-03-11 |
| DE602007008691D1 (de) | 2010-10-07 |
| KR20080093049A (ko) | 2008-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |