PA8619401A1 - Proceso para la preparacion de inhibidores de tubulina - Google Patents

Proceso para la preparacion de inhibidores de tubulina

Info

Publication number
PA8619401A1
PA8619401A1 PA20048619401A PA8619401A PA8619401A1 PA 8619401 A1 PA8619401 A1 PA 8619401A1 PA 20048619401 A PA20048619401 A PA 20048619401A PA 8619401 A PA8619401 A PA 8619401A PA 8619401 A1 PA8619401 A1 PA 8619401A1
Authority
PA
Panama
Prior art keywords
preparation
tubulin inhibitors
rent
salt
triazolopirimidine
Prior art date
Application number
PA20048619401A
Other languages
English (en)
Inventor
Yanzhong Wu
Jean Schmid
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8619401A1 publication Critical patent/PA8619401A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN PROCESO PARA LA PREPARACION DE UNA SAL DEL ACIDO DICARBOXILICO DE 6-[FENIL8SUSTITUIDOS)]-TRIAZOLOPIRIMIDINA Y COMO UNA SAL HIDRATADA QUE TIENE LA FORMULA ESTRUCTURAL (I) EN LA CUAL: R1 ES CF3 O C2F5; R2 ES H O ALQUILO C1-C3; n ES UN NUMERO ENTERO DEE 2,3 O 4; X ES Cl O Br; R3 Y R4 SON CADA UNO INDEPENDIENTEMENTE H O ALQUILO C1-C3; EN DONDE LA LINEA PUNTEADA ES UN ENLACE OPCIONAL.
PA20048619401A 2003-12-08 2004-12-07 Proceso para la preparacion de inhibidores de tubulina PA8619401A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52793103P 2003-12-08 2003-12-08

Publications (1)

Publication Number Publication Date
PA8619401A1 true PA8619401A1 (es) 2005-08-04

Family

ID=34676796

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20048619401A PA8619401A1 (es) 2003-12-08 2004-12-07 Proceso para la preparacion de inhibidores de tubulina

Country Status (29)

Country Link
US (1) US7396835B2 (es)
EP (1) EP1692137B1 (es)
JP (1) JP2007513185A (es)
KR (1) KR20060094984A (es)
CN (1) CN1890245A (es)
AR (1) AR046939A1 (es)
AT (1) ATE356128T1 (es)
AU (1) AU2004297244A1 (es)
BR (1) BRPI0417422A (es)
CA (1) CA2546899A1 (es)
CO (1) CO5700827A2 (es)
CR (1) CR8435A (es)
DE (1) DE602004005239T2 (es)
DK (1) DK1692137T3 (es)
EC (1) ECSP066606A (es)
ES (1) ES2281850T3 (es)
GT (1) GT200400248A (es)
HK (1) HK1090377A1 (es)
IL (1) IL175775A0 (es)
MY (1) MY179926A (es)
NO (1) NO20062492L (es)
NZ (1) NZ547471A (es)
PA (1) PA8619401A1 (es)
PE (1) PE20050593A1 (es)
PL (1) PL1692137T3 (es)
RU (1) RU2006117023A (es)
TW (1) TW200522963A (es)
WO (1) WO2005056560A1 (es)
ZA (1) ZA200604680B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
TW200808730A (en) * 2006-06-09 2008-02-16 Wyeth Corp Process for synthesizing piperazine-piperidine compounds
WO2008084027A1 (de) * 2007-01-08 2008-07-17 Basf Se Verwendung von azolopyrimidinen zur bekämpfung von pflanzenpathogenen schadpilzen
US9649317B2 (en) 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
CN116178375B (zh) * 2023-02-24 2024-09-20 重庆文理学院 一种三唑并嘧啶化合物及其合成方法和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (es) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
WO1998041496A1 (en) 1997-03-18 1998-09-24 American Cyanamid Company Process for the preparation of arylmalonates
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US5986153A (en) 1997-09-30 1999-11-16 Phillips Petroleum Company Olefin color stabilization
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
CN100339378C (zh) * 1998-03-23 2007-09-26 巴斯福股份公司 杀真菌的6-(2-卤代-4-烷氧基苯基)-三唑并嘧啶
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
HUP0300798A3 (en) 2000-06-30 2006-02-28 Wyeth Corp Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them
ES2279452T3 (es) * 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
CN101193884A (zh) * 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法

Also Published As

Publication number Publication date
BRPI0417422A (pt) 2007-03-13
AU2004297244A1 (en) 2005-06-23
ES2281850T3 (es) 2007-10-01
MY179926A (en) 2020-11-19
EP1692137B1 (en) 2007-03-07
JP2007513185A (ja) 2007-05-24
EP1692137A1 (en) 2006-08-23
CN1890245A (zh) 2007-01-03
TW200522963A (en) 2005-07-16
ECSP066606A (es) 2006-10-25
DE602004005239D1 (de) 2007-04-19
DE602004005239T2 (de) 2007-12-20
ATE356128T1 (de) 2007-03-15
KR20060094984A (ko) 2006-08-30
NZ547471A (en) 2009-03-31
US20050124635A1 (en) 2005-06-09
CO5700827A2 (es) 2006-11-30
PL1692137T3 (pl) 2007-06-29
PE20050593A1 (es) 2005-09-27
RU2006117023A (ru) 2008-01-20
DK1692137T3 (da) 2007-04-30
NO20062492L (no) 2006-07-03
AR046939A1 (es) 2006-01-04
HK1090377A1 (en) 2006-12-22
IL175775A0 (en) 2006-09-05
ZA200604680B (en) 2009-04-29
US7396835B2 (en) 2008-07-08
CA2546899A1 (en) 2005-06-23
GT200400248A (es) 2005-09-14
WO2005056560A1 (en) 2005-06-23
CR8435A (es) 2007-06-08

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