PE20030431A1 - DERIVADOS QUINUCLIDINAS COMO AGONISTAS DEL RECEPTOR NICOTINICO DE LA ACETILCOLINA TIPO a7 - Google Patents

DERIVADOS QUINUCLIDINAS COMO AGONISTAS DEL RECEPTOR NICOTINICO DE LA ACETILCOLINA TIPO a7

Info

Publication number
PE20030431A1
PE20030431A1 PE2002000470A PE2002000470A PE20030431A1 PE 20030431 A1 PE20030431 A1 PE 20030431A1 PE 2002000470 A PE2002000470 A PE 2002000470A PE 2002000470 A PE2002000470 A PE 2002000470A PE 20030431 A1 PE20030431 A1 PE 20030431A1
Authority
PE
Peru
Prior art keywords
alkyl
agonists
carboxamide
pyridine
oct
Prior art date
Application number
PE2002000470A
Other languages
English (en)
Inventor
Groppi
Donn G Wishka
Steven C Reitz
David W Piotrowski
Original Assignee
Pharmacia And Upjohn Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia And Upjohn Company Llc filed Critical Pharmacia And Upjohn Company Llc
Publication of PE20030431A1 publication Critical patent/PE20030431A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A HETEROARILOS MULTICICLICOS SUSTITUIDOS CON QUINUCLIDINAS DE FORMULA I DONDE W ES EL GRUPO a, GRUPO b, ENTRE OTROS; X ES O, S; R1 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R2 ES H, ALQUILO, ALQUILO HALOGENADO, ENTRE OTROS; Z---Z'----Z'' SON N(R4)-C(R3)=C(R3), N=C(R3)-C(R15)2, ENTRE OTROS; J, L, M Y Q SON N, C(R6); R3 ES UNA MOLECULA CENTRAL H, F, Br, ALQUILO, ALQUENILO, ENTRE OTROS; R4 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R15 ES UNA MOLECULA CENTRAL. SON COMPUESTOS PREFERIDOS N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-2,3-DIHIDROFURO[2,3-c]PIRIDINA-5-CARBOXAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]FURO[3,2-c]PIRIDINA-2-CARBOXAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-7-CLOROFURO-[2,3-c]PIRIDINA-5-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS ACTUAN SOBRE RECEPTORES Ò7 NICOTINICOS DE LA ACETILCOLINA UTIL PARA EL TRATAMIENTO DE ALZHEIMER, NEURODEGENERACION
PE2002000470A 2001-06-12 2002-06-05 DERIVADOS QUINUCLIDINAS COMO AGONISTAS DEL RECEPTOR NICOTINICO DE LA ACETILCOLINA TIPO a7 PE20030431A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US29770801P 2001-06-12 2001-06-12
US29771101P 2001-06-12 2001-06-12
US29770901P 2001-06-12 2001-06-12
US29771001P 2001-06-12 2001-06-12
US29771201P 2001-06-12 2001-06-12
US32859601P 2001-10-11 2001-10-11
US37349502P 2002-04-18 2002-04-18

Publications (1)

Publication Number Publication Date
PE20030431A1 true PE20030431A1 (es) 2003-05-26

Family

ID=27569623

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000470A PE20030431A1 (es) 2001-06-12 2002-06-05 DERIVADOS QUINUCLIDINAS COMO AGONISTAS DEL RECEPTOR NICOTINICO DE LA ACETILCOLINA TIPO a7

Country Status (17)

Country Link
US (1) US7067515B2 (es)
EP (1) EP1406901A1 (es)
JP (1) JP2004537532A (es)
KR (1) KR20040018266A (es)
CN (1) CN1511154A (es)
AR (1) AR036040A1 (es)
BR (1) BR0210384A (es)
CA (1) CA2445467A1 (es)
CO (1) CO5540302A2 (es)
CZ (1) CZ20033377A3 (es)
EA (1) EA200301216A1 (es)
IL (1) IL159344A0 (es)
MX (1) MXPA03011484A (es)
NO (1) NO20035522D0 (es)
PE (1) PE20030431A1 (es)
PL (1) PL367311A1 (es)
WO (1) WO2002100857A1 (es)

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BR0210384A (pt) 2004-06-29
IL159344A0 (en) 2004-06-01
EP1406901A1 (en) 2004-04-14
CO5540302A2 (es) 2005-07-29
US20030045540A1 (en) 2003-03-06
NO20035522D0 (no) 2003-12-11
CN1511154A (zh) 2004-07-07
AR036040A1 (es) 2004-08-04
WO2002100857A1 (en) 2002-12-19
US7067515B2 (en) 2006-06-27
CA2445467A1 (en) 2002-12-19
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