CO5560543A2 - Derivados de indeno [1,2-c] isoquinolina y metodos para usar los mismos - Google Patents
Derivados de indeno [1,2-c] isoquinolina y metodos para usar los mismosInfo
- Publication number
- CO5560543A2 CO5560543A2 CO04016685A CO04016685A CO5560543A2 CO 5560543 A2 CO5560543 A2 CO 5560543A2 CO 04016685 A CO04016685 A CO 04016685A CO 04016685 A CO04016685 A CO 04016685A CO 5560543 A2 CO5560543 A2 CO 5560543A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- isoquinoline
- same
- indeno
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
1.- Un compuesto de la fórmula y sales farmacéuticamente aceptables e hidratos del mismo,Donde:R5 es NH O S;R6 es -H O C1-C4 alquil;X es -C(O)-, -CH2, -CH(halo)-, -CH(OH) (CH2)n-, CH(OH)-arileno-, -O-, -NH-, -S- o -CH(NR11R12)-, donde n es un entero de 0-5;R11 y R12 son independientemente -hidrogeno o -C1-C9 alquil, o N, R11 y R12 tomados juntos forman una amina heterocíclica;R1, R2, R3, R4, R7, R8, R9 y R10 son independientemente -hidrógeno, -halo, -hidroxy, -O-(C1-C5 alquil), -C1-C10 alquil, -haloalquil, -C2C10 alquenil, -C3-C8 carbociclo, -aril, -NH2, -alquilamino, -C(O)OH, -C(O)O(C1-C5 alquil), OC(O)(C1-C5 alquil), NO2 o -A-B;donde A es -SO2-, -SO2NH-, -NHCO-, -NHCONH-, -O-, CO-, -OC(O)-, -C(O)O-, -CONH-, CON(C1-C4 alquil)-, NH-, -CH2-, -S- O -C(S)-;B es -C1-C10 alquil, -C2-C10 alquenil, -heterociclo, -C3-C8 carbociclo, -aril, -NZ1Z2, -alquilamino, aminodialquil, -alquilheterociclo, -arilamido, C(O)OH, -C(O)O-(C1-C5 alquil) O -C(O)O-fenil, donde ninguno de los cuales están no-sustituidos o sustituidos con uno o mas de -O-(C1-C5 alquil), halo, -haloalquil, -alcanol, -alquilamino, -hidroxi, -NO2, -NH2, -aminoalquil, -aminodialquil, -amina heterocíclica, -C1-C10 alquil, -C2-C10 alquenil, -C2-C10 alquinil, -aril, -benzil, -alquilamido, alquilcarboxi, -C1-C5 alquileno-C(O)O-C1-C5 alquil o grupos -C1-C5 alquileno-OC(O)-C1-C5 alquil; y Z1 y Z2 son independientemente -H o -C1-C10 alquil, los cuales están no-sustituidos o sustituidos con uno o mas de -halo, -OH o -N(Z3) (Z4), donde Z3 y Z4 son independientemente, -H o -C1-C5 alquil, donde están no-sustituidos o sustituidos con uno o mas de -halo, -hidroxi o -NH2; O N, Z3 y Z4 tomados juntos forman una amina heterocíclica sustituida o no sustituida, o N, Z1 y Z2 tomados juntos forman una amina heterocíclica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/944,524 US20030096833A1 (en) | 2001-08-31 | 2001-08-31 | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5560543A2 true CO5560543A2 (es) | 2005-09-30 |
Family
ID=25481570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04016685A CO5560543A2 (es) | 2001-08-31 | 2004-02-25 | Derivados de indeno [1,2-c] isoquinolina y metodos para usar los mismos |
Country Status (20)
Country | Link |
---|---|
US (3) | US20030096833A1 (es) |
EP (2) | EP1420785B1 (es) |
JP (1) | JP2005502681A (es) |
KR (1) | KR100922825B1 (es) |
CN (2) | CN1880306A (es) |
AT (1) | ATE465733T1 (es) |
AU (1) | AU2002329920B2 (es) |
BR (1) | BR0212225A (es) |
CA (1) | CA2457534A1 (es) |
CO (1) | CO5560543A2 (es) |
DE (1) | DE60236170D1 (es) |
EC (1) | ECSP044997A (es) |
ES (1) | ES2345436T3 (es) |
IL (1) | IL160437A0 (es) |
MX (1) | MXPA04001887A (es) |
NO (1) | NO20040845L (es) |
NZ (1) | NZ531218A (es) |
RU (1) | RU2300523C2 (es) |
WO (1) | WO2003020700A2 (es) |
ZA (1) | ZA200401376B (es) |
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US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
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JP2007525526A (ja) * | 2004-02-26 | 2007-09-06 | イノテック ファーマシューティカルズ コーポレイション | 四環系ラクタム誘導体およびその使用 |
EP1722797A4 (en) * | 2004-02-26 | 2008-03-19 | Inotek Pharmaceuticals Corp | ISOCHINOLINE DERIVATIVES AND METHOD FOR THE APPLICATION THEREOF |
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US20060019980A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceutical, Corp. | Methods for treating or preventing erectile dysfunction or urinary incontinence |
JP2008531563A (ja) * | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | 四環スルホンアミド化合物およびこれらの使用法 |
US7381722B2 (en) * | 2005-02-25 | 2008-06-03 | Inotek Pharmaceuticals Corporation | Tetracyclic amino and carboxamido compounds and methods of use thereof |
AU2006219022A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline Compounds and methods of use thereof |
KR20080039508A (ko) * | 2005-08-24 | 2008-05-07 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체 및 이의 사용 방법 |
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CA2629530C (en) | 2005-11-14 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | N-substituted indenoisoquinolines and syntheses thereof |
CA2677046A1 (en) * | 2007-02-28 | 2008-09-04 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
CA2788213A1 (en) | 2010-01-27 | 2011-08-04 | Purdue Research Foundation | Substituted norindenoisoquinolines, syntheses thereof, and methods of use |
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WO2012024437A1 (en) | 2010-08-17 | 2012-02-23 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
WO2012162513A2 (en) * | 2011-05-25 | 2012-11-29 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors |
US9682990B2 (en) | 2011-05-25 | 2017-06-20 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
US8912213B2 (en) | 2012-04-13 | 2014-12-16 | Purdue Research Foundation | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors |
US8686146B2 (en) | 2012-07-13 | 2014-04-01 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
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-
2001
- 2001-08-31 US US09/944,524 patent/US20030096833A1/en not_active Abandoned
-
2002
- 2002-08-30 EP EP02766175A patent/EP1420785B1/en not_active Expired - Lifetime
- 2002-08-30 ES ES02766175T patent/ES2345436T3/es not_active Expired - Lifetime
- 2002-08-30 RU RU2004109141/04A patent/RU2300523C2/ru not_active IP Right Cessation
- 2002-08-30 NZ NZ531218A patent/NZ531218A/en not_active IP Right Cessation
- 2002-08-30 CA CA002457534A patent/CA2457534A1/en not_active Abandoned
- 2002-08-30 AT AT02766175T patent/ATE465733T1/de not_active IP Right Cessation
- 2002-08-30 CN CNA2006100924325A patent/CN1880306A/zh active Pending
- 2002-08-30 BR BR0212225-1A patent/BR0212225A/pt not_active IP Right Cessation
- 2002-08-30 MX MXPA04001887A patent/MXPA04001887A/es active IP Right Grant
- 2002-08-30 DE DE60236170T patent/DE60236170D1/de not_active Expired - Lifetime
- 2002-08-30 US US10/233,198 patent/US6828319B2/en not_active Expired - Fee Related
- 2002-08-30 WO PCT/US2002/027585 patent/WO2003020700A2/en active Application Filing
- 2002-08-30 AU AU2002329920A patent/AU2002329920B2/en not_active Ceased
- 2002-08-30 EP EP10152431A patent/EP2174659A1/en not_active Withdrawn
- 2002-08-30 JP JP2003524971A patent/JP2005502681A/ja active Pending
- 2002-08-30 IL IL16043702A patent/IL160437A0/xx unknown
- 2002-08-30 KR KR1020047002771A patent/KR100922825B1/ko not_active IP Right Cessation
- 2002-08-30 CN CNB028213254A patent/CN100503574C/zh not_active Expired - Fee Related
-
2004
- 2004-02-19 ZA ZA200401376A patent/ZA200401376B/en unknown
- 2004-02-25 CO CO04016685A patent/CO5560543A2/es not_active Application Discontinuation
- 2004-02-26 NO NO20040845A patent/NO20040845L/no unknown
- 2004-02-27 EC EC2004004997A patent/ECSP044997A/es unknown
-
2008
- 2008-06-16 US US12/140,120 patent/US20080262016A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ZA200401376B (en) | 2004-11-19 |
RU2300523C2 (ru) | 2007-06-10 |
KR20040044486A (ko) | 2004-05-28 |
CA2457534A1 (en) | 2003-03-13 |
ATE465733T1 (de) | 2010-05-15 |
US20030171392A1 (en) | 2003-09-11 |
CN1880306A (zh) | 2006-12-20 |
US20080262016A1 (en) | 2008-10-23 |
ECSP044997A (es) | 2004-04-28 |
BR0212225A (pt) | 2005-01-18 |
CN100503574C (zh) | 2009-06-24 |
EP1420785A2 (en) | 2004-05-26 |
WO2003020700A2 (en) | 2003-03-13 |
KR100922825B1 (ko) | 2009-10-21 |
DE60236170D1 (de) | 2010-06-10 |
WO2003020700A3 (en) | 2004-02-12 |
CN1575172A (zh) | 2005-02-02 |
JP2005502681A (ja) | 2005-01-27 |
US20030096833A1 (en) | 2003-05-22 |
RU2004109141A (ru) | 2005-03-27 |
US6828319B2 (en) | 2004-12-07 |
AU2002329920B2 (en) | 2008-07-31 |
EP1420785B1 (en) | 2010-04-28 |
MXPA04001887A (es) | 2005-03-07 |
NZ531218A (en) | 2006-02-24 |
EP2174659A1 (en) | 2010-04-14 |
IL160437A0 (en) | 2004-07-25 |
EP1420785A4 (en) | 2005-10-19 |
ES2345436T3 (es) | 2010-09-23 |
NO20040845L (no) | 2004-04-01 |
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