PE20010492A1 - Procedimiento para la preparacion de adrenalina - Google Patents

Procedimiento para la preparacion de adrenalina

Info

Publication number
PE20010492A1
PE20010492A1 PE2000000817A PE0008172000A PE20010492A1 PE 20010492 A1 PE20010492 A1 PE 20010492A1 PE 2000000817 A PE2000000817 A PE 2000000817A PE 0008172000 A PE0008172000 A PE 0008172000A PE 20010492 A1 PE20010492 A1 PE 20010492A1
Authority
PE
Peru
Prior art keywords
stage
adrenaline
acidic
educt
methyl
Prior art date
Application number
PE2000000817A
Other languages
English (en)
Inventor
Franz Dietrich Klingler
Lienhard Wolter
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20010492A1 publication Critical patent/PE20010492A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE ADRENALINA CARACTERIZADO PORQUE EN UNA PRIMERA ETAPA ADRENALONA N-PROTEGIDA TAL COMO (3`,4'-DIHIDROXI-2-N-BENCIL-N-METIL-AMINO-ACETOFENONA), COMO EDUCTO, SE SOMETE A UNA HIDROGENACION ASIMETRICA A UNA TEMPERATURA DE 40°C A 70°C, A UNA PRESION DE 10*10(5) Pa HASTA 100*10(5)Pa CON [Rh(COD)Cl]2 COMO CATALIZADOR Y UN LIGANDO DE FOSFINA QUIRAL TAL COMO (2R,4R)-4-(DICICLOHEXILFOSFINO)-2-(DIFENILFOSFINO-METIL)-N-METILAMINOCARBONILPIRROLIDINA OPCIONALMENTE UNIDA A UN POLIMERO COMO SISTEMA CATALIZADOR, EN UN DISOLVENTE PROTICO TAL COMO METANOL, ETANOL, PROPANOL, ISOPROPANOL, AGUA, LA RELACION MOLAR DE EDUCTO A CATALIZADOR DE RODIO OSCILA ENTRE 500:1 Y 10000:1; POR UN TIEMPO DE REACCION DE 2 A 8 HORAS; EN UNA SEGUNDA ETAPA, SE PRECIPITA EN CONDICIONES BASICAS LA ADRENALINA N-PROTEGIDA RESULTANTE UTILIZANDOSE UNA BASE NITROGENADA, AMONIACO Y EN UNA TERCERA ETAPA SE SEPARA EL GRUPO PROTECTOR DE N EN CONDICIONES ACIDAS UTILIZANDOSE ACIDO SULFURICO, ACIDO CLORHIDRICO, ACIDO FOSFORICO SIENDO, EL pH DE 5 Y 6, A UNA TEMPERATURA DE 40°C A 80°C
PE2000000817A 1999-08-14 2000-08-11 Procedimiento para la preparacion de adrenalina PE20010492A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19938709A DE19938709C1 (de) 1999-08-14 1999-08-14 Verfahren zur Herstellung von Adrenalin

Publications (1)

Publication Number Publication Date
PE20010492A1 true PE20010492A1 (es) 2001-05-01

Family

ID=7918496

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000817A PE20010492A1 (es) 1999-08-14 2000-08-11 Procedimiento para la preparacion de adrenalina

Country Status (29)

Country Link
US (1) US6218575B1 (es)
EP (1) EP1210318B1 (es)
JP (1) JP4594576B2 (es)
KR (1) KR100666841B1 (es)
CN (1) CN1179939C (es)
AR (1) AR025105A1 (es)
AT (1) ATE253549T1 (es)
AU (1) AU766721B2 (es)
BR (1) BR0013146B1 (es)
CA (1) CA2381246C (es)
CO (1) CO5190670A1 (es)
CZ (1) CZ300938B6 (es)
DE (2) DE19938709C1 (es)
DK (1) DK1210318T3 (es)
EA (1) EA004052B1 (es)
ES (1) ES2209975T3 (es)
HK (1) HK1048627B (es)
HU (1) HU224529B1 (es)
IL (2) IL147703A0 (es)
MX (1) MXPA02001140A (es)
NZ (1) NZ517369A (es)
PE (1) PE20010492A1 (es)
PL (1) PL200340B1 (es)
PT (1) PT1210318E (es)
TR (1) TR200200403T2 (es)
TW (1) TWI256948B (es)
UY (1) UY26283A1 (es)
WO (1) WO2001012583A1 (es)
ZA (1) ZA200201220B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579627A (zh) * 2003-08-05 2005-02-16 中国科学院大连化学物理研究所 一种手性配体金属络合物催化体系及制法和应用
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
DE102004033313A1 (de) * 2004-07-08 2006-01-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Enantiomeren 3-hydroxy-3-phenyl-propylaminen
JP4834333B2 (ja) * 2005-06-27 2011-12-14 アルプス薬品工業株式会社 光学活性ベンジルアミン誘導体の製造方法
WO2007145203A1 (ja) * 2006-06-13 2007-12-21 Daiichi Fine Chemical Co., Ltd. 光学活性２－アミノ－１－（４－フルオロフェニル）エタノール
WO2009004593A2 (en) * 2007-07-03 2009-01-08 Wockhardt Research Centre Processes for the preparation of epinephrine
US8436181B2 (en) 2007-09-06 2013-05-07 Nippon Soda Co., Ltd. Production process of optically active 3-quinuclidinol derivative
CN101983186B (zh) * 2008-04-07 2013-12-11 日本曹达株式会社 钌化合物和光学活性氨基醇化合物的制造方法
CN101906457B (zh) * 2010-08-05 2013-03-20 福州大学 一种生物不对称转化制备r－肾上腺素的方法
CN106397229B (zh) * 2016-08-30 2018-06-29 蚌埠丰原医药科技发展有限公司 一种制备（r）-4-（2-（苄基（甲基）氨基）-羟乙基）苯-1,2-二醇的方法
IT201800004492A1 (it) * 2018-04-13 2019-10-13 Procedimento per la sintesi di beta-amminoalcoli otticamente attivi
EP3725765A1 (en) * 2019-04-18 2020-10-21 Edmond Pharma S.R.L. A process for the preparation of enantiomerically pure norepinephrine
CN117003651B (zh) * 2023-09-28 2024-01-02 广东嘉博制药有限公司 一种l-肾上腺素的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE524717C (de) * 1927-10-30 1931-05-11 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Aminoalkoholen der aromatischen Reihe
EP0251164B1 (en) * 1986-06-25 1992-12-16 Kazuo Achiwa New chiral phosphinopyrrolidine compounds and their use for asymetric synthesis of optically active compounds
JP2617329B2 (ja) * 1988-02-24 1997-06-04 富士薬品工業株式会社 光学活性なアミノアルコールの製造法
JP2816555B2 (ja) * 1988-03-07 1998-10-27 富士薬品工業株式会社 新規なホスフイノピロリジン化合物およびそれを用いる不斉合成法
DE19902229C2 (de) * 1999-01-21 2000-11-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von L-Phenylephrinhydrochlorid

Also Published As

Publication number Publication date
TWI256948B (en) 2006-06-21
EP1210318B1 (de) 2003-11-05
ATE253549T1 (de) 2003-11-15
AU7272200A (en) 2001-03-13
EA004052B1 (ru) 2003-12-25
BR0013146A (pt) 2002-04-30
HK1048627A1 (en) 2003-04-11
HK1048627B (zh) 2005-04-22
AR025105A1 (es) 2002-11-06
NZ517369A (en) 2003-10-31
ES2209975T3 (es) 2004-07-01
KR100666841B1 (ko) 2007-01-11
DE19938709C1 (de) 2001-01-18
HUP0203201A2 (hu) 2003-01-28
BR0013146B1 (pt) 2011-01-25
CA2381246C (en) 2009-11-10
ZA200201220B (en) 2002-11-27
CZ2002514A3 (cs) 2002-05-15
CN1368949A (zh) 2002-09-11
KR20020022099A (ko) 2002-03-23
TR200200403T2 (tr) 2002-05-21
MXPA02001140A (es) 2002-10-31
JP2003507357A (ja) 2003-02-25
PL353394A1 (en) 2003-11-17
CO5190670A1 (es) 2002-08-29
JP4594576B2 (ja) 2010-12-08
CZ300938B6 (cs) 2009-09-16
EA200200205A1 (ru) 2002-08-29
CA2381246A1 (en) 2001-02-22
HUP0203201A3 (en) 2003-12-29
WO2001012583A1 (de) 2001-02-22
IL147703A (en) 2006-10-31
DE50004356D1 (de) 2003-12-11
US6218575B1 (en) 2001-04-17
CN1179939C (zh) 2004-12-15
DK1210318T3 (da) 2003-12-01
HU224529B1 (hu) 2005-10-28
PT1210318E (pt) 2004-03-31
EP1210318A1 (de) 2002-06-05
UY26283A1 (es) 2001-03-16
AU766721B2 (en) 2003-10-23
IL147703A0 (en) 2002-08-14
PL200340B1 (pl) 2008-12-31

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