PE20000460A1 - Derivados de epotilona 12,13-modificados - Google Patents

Derivados de epotilona 12,13-modificados

Info

Publication number
PE20000460A1
PE20000460A1 PE1999000331A PE00033199A PE20000460A1 PE 20000460 A1 PE20000460 A1 PE 20000460A1 PE 1999000331 A PE1999000331 A PE 1999000331A PE 00033199 A PE00033199 A PE 00033199A PE 20000460 A1 PE20000460 A1 PE 20000460A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
aryl
epotilone
derivatives
Prior art date
Application number
PE1999000331A
Other languages
English (en)
Spanish (es)
Inventor
Gregory D Vite
Soong-Hoon Kim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20000460A1 publication Critical patent/PE20000460A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PE1999000331A 1998-04-21 1999-04-20 Derivados de epotilona 12,13-modificados PE20000460A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8256498P 1998-04-21 1998-04-21

Publications (1)

Publication Number Publication Date
PE20000460A1 true PE20000460A1 (es) 2000-06-09

Family

ID=22171978

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000331A PE20000460A1 (es) 1998-04-21 1999-04-20 Derivados de epotilona 12,13-modificados

Country Status (17)

Country Link
US (2) US6380395B1 (enExample)
EP (3) EP1073648B1 (enExample)
JP (2) JP4476483B2 (enExample)
CN (1) CN1142923C (enExample)
AR (2) AR015774A1 (enExample)
AT (2) ATE435861T1 (enExample)
AU (2) AU748526B2 (enExample)
BR (1) BR9909795A (enExample)
CA (2) CA2323609A1 (enExample)
CY (2) CY1105836T1 (enExample)
DE (2) DE69933287T2 (enExample)
DK (3) DK1073647T3 (enExample)
ES (3) ES2327803T3 (enExample)
PE (1) PE20000460A1 (enExample)
PT (3) PT1073647E (enExample)
TR (1) TR200003036T2 (enExample)
WO (2) WO1999054319A1 (enExample)

Families Citing this family (85)

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BRPI0206509B8 (pt) * 2001-01-25 2021-05-25 R Pharm Us Operating Llc processo para formular, para administração parenteral, um análogo de epotilona, preparação farmacêutica, processo para formar uma composição farmacêutica para administração parental, composição farmacêutica e uso de um análogo de epotilona na preparação de uma composição farmacêutica para o tratamento de câncer
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MXPA03007423A (es) 2001-02-20 2003-11-18 Bristol Myers Squibb Co Derivados de epotilona para tratamiento de tumores refractarios.
CZ305799B6 (cs) * 2001-03-14 2016-03-23 Bristol-Myers Squibb Company Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
EP1392664A4 (en) * 2001-06-01 2005-01-26 Bristol Myers Squibb Co EPOTHILONE DERIVATIVES
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WO2003077903A1 (en) * 2002-03-12 2003-09-25 Bristol-Myers Squibb Company C12-cyano epothilone derivatives
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US7091193B2 (en) * 2002-10-09 2006-08-15 Kosan Biosciences Incorporated Therapeutic formulations
US20060094766A1 (en) * 2002-10-11 2006-05-04 Boris Lin Epothilone derivatives for the treatment of multiple myeloma
EP1567487A4 (en) 2002-11-15 2005-11-16 Bristol Myers Squibb Co OPEN-CHAINED, PROLYL-FROSTED MODULATORS OF ANDROGEN RECEPTOR FUNCTION
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Also Published As

Publication number Publication date
DK1073647T3 (da) 2009-11-09
CA2329181A1 (en) 1999-10-28
CN1298398A (zh) 2001-06-06
CY1109593T1 (el) 2014-08-13
AR015774A1 (es) 2001-05-16
ATE340177T1 (de) 2006-10-15
EP1073647A4 (en) 2003-01-02
EP1073648A4 (en) 2003-01-02
CA2329181C (en) 2011-02-22
JP2002512238A (ja) 2002-04-23
AU3382799A (en) 1999-11-08
PT1589017E (pt) 2013-03-04
DE69941083D1 (en) 2009-08-20
EP1589017B1 (en) 2012-12-05
EP1073647B1 (en) 2009-07-08
CY1105836T1 (el) 2011-02-02
AR015007A1 (es) 2001-04-11
AU3471699A (en) 1999-11-08
TR200003036T2 (tr) 2001-01-22
ATE435861T1 (de) 2009-07-15
CN1142923C (zh) 2004-03-24
ES2400049T3 (es) 2013-04-05
US6380395B1 (en) 2002-04-30
EP1073648A1 (en) 2001-02-07
US6399638B1 (en) 2002-06-04
DE69933287D1 (de) 2006-11-02
DK1589017T3 (da) 2013-03-18
EP1073648B1 (en) 2006-09-20
DK1073648T3 (da) 2007-01-08
ES2327803T3 (es) 2009-11-03
AU748526B2 (en) 2002-06-06
EP1589017A2 (en) 2005-10-26
CA2323609A1 (en) 1999-10-28
DE69933287T2 (de) 2007-05-03
ES2273484T3 (es) 2007-05-01
PT1073648E (pt) 2006-12-29
AU757733B2 (en) 2003-03-06
EP1073647A1 (en) 2001-02-07
PT1073647E (pt) 2009-07-17
BR9909795A (pt) 2000-12-26
JP2002512239A (ja) 2002-04-23
JP4476483B2 (ja) 2010-06-09
EP1589017A3 (en) 2009-04-22
WO1999054319A1 (en) 1999-10-28
WO1999054318A1 (en) 1999-10-28

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