BR9909795A - Derivados de epotilona 12, 13-modificados - Google Patents

Derivados de epotilona 12, 13-modificados

Info

Publication number
BR9909795A
BR9909795A BR9909795-8A BR9909795A BR9909795A BR 9909795 A BR9909795 A BR 9909795A BR 9909795 A BR9909795 A BR 9909795A BR 9909795 A BR9909795 A BR 9909795A
Authority
BR
Brazil
Prior art keywords
modified
epothilone derivatives
derivatives
epothilone
epotylone
Prior art date
Application number
BR9909795-8A
Other languages
English (en)
Portuguese (pt)
Inventor
Gregory D Vite
Soong-Hoon Kim
Gerhard Hofle
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR9909795A publication Critical patent/BR9909795A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR9909795-8A 1998-04-21 1999-04-05 Derivados de epotilona 12, 13-modificados BR9909795A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8256498P 1998-04-21 1998-04-21
PCT/US1999/007475 WO1999054319A1 (en) 1998-04-21 1999-04-05 12,13-modified epothilone derivatives

Publications (1)

Publication Number Publication Date
BR9909795A true BR9909795A (pt) 2000-12-26

Family

ID=22171978

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909795-8A BR9909795A (pt) 1998-04-21 1999-04-05 Derivados de epotilona 12, 13-modificados

Country Status (17)

Country Link
US (2) US6380395B1 (enExample)
EP (3) EP1073647B1 (enExample)
JP (2) JP4476483B2 (enExample)
CN (1) CN1142923C (enExample)
AR (2) AR015007A1 (enExample)
AT (2) ATE340177T1 (enExample)
AU (2) AU748526B2 (enExample)
BR (1) BR9909795A (enExample)
CA (2) CA2329181C (enExample)
CY (2) CY1105836T1 (enExample)
DE (2) DE69933287T2 (enExample)
DK (3) DK1073648T3 (enExample)
ES (3) ES2400049T3 (enExample)
PE (1) PE20000460A1 (enExample)
PT (3) PT1073648E (enExample)
TR (1) TR200003036T2 (enExample)
WO (2) WO1999054319A1 (enExample)

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US6780620B1 (en) * 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
WO2000057874A1 (en) * 1999-03-29 2000-10-05 Bristol-Myers Squibb Co. A process for the preparation of aziridinyl epothilones from oxiranyl epothilones
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
CN1348370A (zh) 1999-04-15 2002-05-08 布里斯托尔-迈尔斯斯奎布公司 环状蛋白酪氨酸激酶抑制剂
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
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EE05301B1 (et) * 2001-01-25 2010-06-15 Bristol-Myers Squibb Company Meetod epotilooni analooge sisaldavate ravimvormide valmistamiseks ning nende kasutamine ravimi valmistamiseks
RU2003126171A (ru) * 2001-01-25 2005-02-27 Бристол-Маерс Сквибб Компани (Us) Парентеральный состав, содержащий аналоги эпотилона
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EE200300396A (et) 2001-02-20 2003-12-15 Bristol-Myers Squibb Company Epotilooni derivaatide kasutamine refraktaarsete kasvajate raviks
WO2002072085A1 (en) * 2001-03-14 2002-09-19 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
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WO2002098868A1 (en) 2001-06-01 2002-12-12 Bristol-Myers Squibb Company Epothilone derivatives
BR0212107A (pt) * 2001-08-23 2004-08-24 Novartis Ag Análogos da ciclopropil e da ciclobutil epotilona
WO2003026744A1 (en) * 2001-09-25 2003-04-03 Alcon, Inc. The use of epothilones and analogs in conjunction with ophthalmic surgery
TW200303202A (en) * 2002-02-15 2003-09-01 Bristol Myers Squibb Co Method of preparation of 21-amino epothilone derivatives
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
US7211593B2 (en) * 2002-03-12 2007-05-01 Bristol-Myers Squibb Co. C12-cyano epothilone derivatives
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AU2003243561A1 (en) * 2002-06-14 2003-12-31 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
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CN100553634C (zh) * 2002-10-11 2009-10-28 达纳-法伯癌症研究公司 用于治疗多发性骨髓瘤的埃坡霉素衍生物
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CN103893779A (zh) * 2005-08-19 2014-07-02 恩多塞特公司 多药物配体缀合物
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Also Published As

Publication number Publication date
EP1589017A2 (en) 2005-10-26
DE69933287D1 (de) 2006-11-02
PE20000460A1 (es) 2000-06-09
AU3382799A (en) 1999-11-08
DK1073647T3 (da) 2009-11-09
CY1105836T1 (el) 2011-02-02
WO1999054318A1 (en) 1999-10-28
DK1073648T3 (da) 2007-01-08
CN1142923C (zh) 2004-03-24
JP2002512238A (ja) 2002-04-23
ES2273484T3 (es) 2007-05-01
PT1073647E (pt) 2009-07-17
EP1073648A1 (en) 2001-02-07
CY1109593T1 (el) 2014-08-13
AU757733B2 (en) 2003-03-06
EP1589017A3 (en) 2009-04-22
CA2329181C (en) 2011-02-22
US6380395B1 (en) 2002-04-30
ES2327803T3 (es) 2009-11-03
JP4476483B2 (ja) 2010-06-09
AR015007A1 (es) 2001-04-11
CA2329181A1 (en) 1999-10-28
PT1073648E (pt) 2006-12-29
PT1589017E (pt) 2013-03-04
EP1073648B1 (en) 2006-09-20
EP1073647A4 (en) 2003-01-02
EP1073647B1 (en) 2009-07-08
AU748526B2 (en) 2002-06-06
ATE435861T1 (de) 2009-07-15
CA2323609A1 (en) 1999-10-28
TR200003036T2 (tr) 2001-01-22
DE69933287T2 (de) 2007-05-03
ATE340177T1 (de) 2006-10-15
WO1999054319A1 (en) 1999-10-28
DE69941083D1 (en) 2009-08-20
US6399638B1 (en) 2002-06-04
ES2400049T3 (es) 2013-04-05
CN1298398A (zh) 2001-06-06
JP2002512239A (ja) 2002-04-23
EP1073648A4 (en) 2003-01-02
AU3471699A (en) 1999-11-08
EP1589017B1 (en) 2012-12-05
EP1073647A1 (en) 2001-02-07
DK1589017T3 (da) 2013-03-18
AR015774A1 (es) 2001-05-16

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