PT1073647E - Derivados de 12,13-ciclopropano-epotilona - Google Patents
Derivados de 12,13-ciclopropano-epotilona Download PDFInfo
- Publication number
- PT1073647E PT1073647E PT99915273T PT99915273T PT1073647E PT 1073647 E PT1073647 E PT 1073647E PT 99915273 T PT99915273 T PT 99915273T PT 99915273 T PT99915273 T PT 99915273T PT 1073647 E PT1073647 E PT 1073647E
- Authority
- PT
- Portugal
- Prior art keywords
- epothilone derivatives
- cyclopropane
- cyclopropane epothilone
- derivatives
- epothilone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8256498P | 1998-04-21 | 1998-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1073647E true PT1073647E (pt) | 2009-07-17 |
Family
ID=22171978
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT50152362T PT1589017E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados na posição 12,13 |
PT99915273T PT1073647E (pt) | 1998-04-21 | 1999-04-05 | Derivados de 12,13-ciclopropano-epotilona |
PT99916383T PT1073648E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados em 12, 13 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT50152362T PT1589017E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados na posição 12,13 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99916383T PT1073648E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados em 12, 13 |
Country Status (17)
Country | Link |
---|---|
US (2) | US6380395B1 (pt) |
EP (3) | EP1073648B1 (pt) |
JP (2) | JP4476483B2 (pt) |
CN (1) | CN1142923C (pt) |
AR (2) | AR015774A1 (pt) |
AT (2) | ATE340177T1 (pt) |
AU (2) | AU748526B2 (pt) |
BR (1) | BR9909795A (pt) |
CA (2) | CA2323609A1 (pt) |
CY (2) | CY1105836T1 (pt) |
DE (2) | DE69933287T2 (pt) |
DK (3) | DK1073648T3 (pt) |
ES (3) | ES2400049T3 (pt) |
PE (1) | PE20000460A1 (pt) |
PT (3) | PT1589017E (pt) |
TR (1) | TR200003036T2 (pt) |
WO (2) | WO1999054319A1 (pt) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1386922B1 (en) | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
DE19826988A1 (de) | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
US6303342B1 (en) | 1998-11-20 | 2001-10-16 | Kason Biosciences, Inc. | Recombinant methods and materials for producing epothilones C and D |
ID29061A (id) * | 1998-12-02 | 2001-07-26 | Pfizer Prod Inc | METODE DAN KOMPOSISI UNTUK MEMPERBAIKI STABILITAS KONFORMASI SUATU PROTEIN DARI KELUARGA p53 |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
CA2368658A1 (en) * | 1999-03-29 | 2000-10-05 | Soong-Hoon Kim | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
EP2308833A3 (en) | 1999-04-15 | 2011-09-28 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
EP1414384A4 (en) | 2000-10-13 | 2005-07-27 | Univ Mississippi | SYNTHESIS OF EPOTHILONES AND RELATED ANALOGS |
WO2002058699A1 (en) | 2001-01-25 | 2002-08-01 | Bristol-Myers Squibb Company | Pharmaceutical forms of epothilones for oral administration |
IL156580A0 (en) * | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog |
ES2304240T3 (es) * | 2001-01-25 | 2008-10-01 | Bristol-Myers Squibb Company | Procedimientos para la preparacion de preparaciones farmaceuticas que contienen analogos de epotilona para el tratamiento de cancer. |
AU2002245296B2 (en) * | 2001-01-25 | 2006-12-21 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
BR0207487A (pt) | 2001-02-20 | 2004-08-10 | Brystol Myers Squibb Company | Método de tratamento de tumores em mamìferos e uso de compostos de epotilona |
BR0207316A (pt) | 2001-02-20 | 2004-02-10 | Bristol Myers Squibb Co | Derivados de epotilona para o tratamento de tumores refratários |
RU2321400C2 (ru) * | 2001-03-14 | 2008-04-10 | Бристол-Маерс Сквибб Компани | Композиция аналога эпотилона в сочетании с химиотерапевтическими агентами для лечения рака |
EP1389209B1 (en) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
JP2004532888A (ja) | 2001-06-01 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | エポチロン誘導体 |
WO2003018002A2 (en) * | 2001-08-23 | 2003-03-06 | Novartis Ag | Cyclopropyl and cyclobutyl epothilone analogs |
WO2003026744A1 (en) * | 2001-09-25 | 2003-04-03 | Alcon, Inc. | The use of epothilones and analogs in conjunction with ophthalmic surgery |
TW200303202A (en) * | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
WO2003077903A1 (en) * | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
AU2003218110A1 (en) | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
TW200403994A (en) | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
TW200400191A (en) | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
US7910594B2 (en) * | 2002-05-15 | 2011-03-22 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
WO2003105828A1 (en) * | 2002-06-14 | 2003-12-24 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
US7256178B2 (en) * | 2002-07-31 | 2007-08-14 | Eisai Co., Ltd. | Physiologically active substances |
CA2494259A1 (en) * | 2002-08-02 | 2004-02-19 | Novartis Ag | Epothilone derivatives |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DK1506203T3 (da) | 2002-08-23 | 2007-05-14 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
MXPA05003006A (es) | 2002-09-23 | 2005-06-22 | Squibb Bristol Myers Co | Metodos para la preparacion, aislamiento y purificacion de epotilona b y estructuras cristalinas de rayos x y de epotilona b. |
US7091193B2 (en) * | 2002-10-09 | 2006-08-15 | Kosan Biosciences Incorporated | Therapeutic formulations |
CA2501610C (en) * | 2002-10-11 | 2012-01-03 | Dana-Farber Cancer Institute Inc | Epothilone derivatives for the treatment of multiple myeloma |
WO2004045518A2 (en) | 2002-11-15 | 2004-06-03 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
CA2512867C (en) | 2003-01-27 | 2014-08-26 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
KR20060122819A (ko) * | 2003-10-09 | 2006-11-30 | 코산 바이오사이언시즈, 인코포레이티드 | 치료학적 제형 |
US20050148543A1 (en) * | 2003-10-09 | 2005-07-07 | Michael Sherrill | Therapeutic formulations |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
US10675326B2 (en) | 2004-10-07 | 2020-06-09 | The Board Of Trustees Of The University Of Illinois | Compositions comprising cupredoxins for treating cancer |
EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
BRPI0518286A2 (pt) * | 2004-11-18 | 2008-11-11 | Bristol Myers Squibb Co | microesfera com revestimento entÉrico contendo ixabepilona e sua preparaÇço |
WO2007086879A2 (en) | 2005-02-11 | 2007-08-02 | University Of Southern California | Method of expressing proteins with disulfide bridges |
CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
CA2617660C (en) * | 2005-08-19 | 2014-03-25 | Endocyte, Inc. | Multi-drug ligand conjugates |
US20080280937A1 (en) * | 2005-08-19 | 2008-11-13 | Christopher Paul Leamon | Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives |
EP2029156A4 (en) | 2006-05-01 | 2010-07-21 | Univ Southern California | POLY THERAPY FOR TREATING CANCER |
CN101535300B (zh) | 2006-05-16 | 2014-05-28 | 埃格拉医疗公司 | Iap bir域结合化合物 |
AR061181A1 (es) * | 2006-05-25 | 2008-08-13 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
PE20080102A1 (es) * | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
WO2008070666A2 (en) | 2006-12-04 | 2008-06-12 | The Board Of Trustees Of The University Of Illinois | Compositions and methods to treat cancer with cpg rich dna and cupredoxins |
WO2008098216A2 (en) | 2007-02-08 | 2008-08-14 | The Board Of Trustees Of The University Of Illinois | Compositions and methods to prevent cancer with cupredoxins |
WO2008101231A2 (en) * | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
EP2139523B1 (en) * | 2007-03-14 | 2014-10-22 | Endocyte, Inc. | Conjugates of folate and tubulysin for targeted drug delivery |
US8143415B2 (en) * | 2007-05-25 | 2012-03-27 | Bristol-Myers Squibb Company | Processes for making epothilone compounds and analogs |
AU2008268432B2 (en) * | 2007-06-25 | 2015-01-15 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
EP2209374B1 (en) | 2007-10-25 | 2014-12-03 | Endocyte, Inc. | Tubulysins and processes for preparing |
WO2009146152A2 (en) * | 2008-04-04 | 2009-12-03 | Emory University | Non-myelosuppressive compounds, pharmaceutical compositions thereof, and methods of treatment |
AU2009240538B2 (en) * | 2008-04-24 | 2014-08-07 | Bristol-Myers Squibb Company | Use of Epothilone D in treating Tau-associated diseases including Alzheimer's disease |
WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
EP2534170B1 (en) | 2010-02-12 | 2017-04-19 | Pharmascience Inc. | Iap bir domain binding compounds |
MX2012013100A (es) | 2010-05-18 | 2013-01-22 | Cerulean Pharma Inc | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. |
US8846006B2 (en) | 2011-01-20 | 2014-09-30 | Board Of Regents, The University Of Texas System | MRI markers, delivery and extraction systems, and methods of manufacture and use thereof |
CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
IN2015DN04147A (pt) | 2012-10-16 | 2015-10-16 | Endocyte Inc | |
WO2014075391A1 (zh) | 2012-11-17 | 2014-05-22 | 北京市丰硕维康技术开发有限责任公司 | 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物 |
WO2017066606A1 (en) * | 2015-10-16 | 2017-04-20 | William Marsh Rice University | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
DE59610712D1 (de) | 1995-11-17 | 2003-10-16 | Biotechnolog Forschung Gmbh | Epothilonderivate, herstellung und verwendung |
DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
NZ334821A (en) | 1996-08-30 | 2000-12-22 | Novartis Ag | Method for producing epothilones |
DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
CZ303422B6 (cs) | 1996-11-18 | 2012-09-05 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilon C, zpusob jeho výroby a jeho použití jako cytostatik a prostredku pro ochranu rostlin |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
EP1386922B1 (en) | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
WO1998038192A1 (de) | 1997-02-25 | 1998-09-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Seitenkettenmodifizierte epothilone |
DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
DE59805900D1 (de) | 1997-04-18 | 2002-11-14 | Studiengesellschaft Kohle Mbh | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
PT1001951E (pt) | 1997-07-16 | 2003-02-28 | Schering Ag | Derivados de tiazolo, processo para a sua preparacao e utilizacao |
DE59814067D1 (de) | 1997-08-09 | 2007-09-06 | Bayer Schering Pharma Ag | Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
KR100669174B1 (ko) | 1998-02-05 | 2007-01-17 | 노파르티스 아게 | 유기화합물 함유 조성물 |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
MXPA00008365A (es) | 1998-02-25 | 2002-11-07 | Sloan Kettering Inst Cancer | Sintesis de epotilonas, intermediarios y analogos de las mismas. |
WO2000000485A1 (de) | 1998-06-30 | 2000-01-06 | Schering Aktiengesellschaft | Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung |
US6303342B1 (en) | 1998-11-20 | 2001-10-16 | Kason Biosciences, Inc. | Recombinant methods and materials for producing epothilones C and D |
EP1140944B1 (en) | 1998-12-22 | 2003-08-27 | Novartis AG | Epothilone derivatives and their use as antitumor agents |
EA009206B1 (ru) | 1999-02-18 | 2007-12-28 | Шеринг Акциенгезельшафт | Производные 16-галогенэпотилона и их фармацевтическое использование |
US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
AR023792A1 (es) | 1999-04-30 | 2002-09-04 | Bayer Schering Pharma Ag | Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos |
-
1999
- 1999-03-29 US US09/280,192 patent/US6380395B1/en not_active Expired - Lifetime
- 1999-03-29 US US09/280,191 patent/US6399638B1/en not_active Expired - Lifetime
- 1999-04-05 AU AU34716/99A patent/AU748526B2/en not_active Ceased
- 1999-04-05 JP JP2000544658A patent/JP4476483B2/ja not_active Expired - Fee Related
- 1999-04-05 DK DK99916383T patent/DK1073648T3/da active
- 1999-04-05 EP EP99916383A patent/EP1073648B1/en not_active Expired - Lifetime
- 1999-04-05 ES ES05015236T patent/ES2400049T3/es not_active Expired - Lifetime
- 1999-04-05 CA CA002323609A patent/CA2323609A1/en not_active Abandoned
- 1999-04-05 CA CA2329181A patent/CA2329181C/en not_active Expired - Fee Related
- 1999-04-05 CN CNB998052663A patent/CN1142923C/zh not_active Expired - Fee Related
- 1999-04-05 DE DE69933287T patent/DE69933287T2/de not_active Expired - Lifetime
- 1999-04-05 ES ES99915273T patent/ES2327803T3/es not_active Expired - Lifetime
- 1999-04-05 EP EP99915273A patent/EP1073647B1/en not_active Expired - Lifetime
- 1999-04-05 TR TR2000/03036T patent/TR200003036T2/xx unknown
- 1999-04-05 PT PT50152362T patent/PT1589017E/pt unknown
- 1999-04-05 JP JP2000544657A patent/JP2002512238A/ja active Pending
- 1999-04-05 PT PT99915273T patent/PT1073647E/pt unknown
- 1999-04-05 WO PCT/US1999/007475 patent/WO1999054319A1/en active IP Right Grant
- 1999-04-05 ES ES99916383T patent/ES2273484T3/es not_active Expired - Lifetime
- 1999-04-05 AT AT99916383T patent/ATE340177T1/de active
- 1999-04-05 EP EP05015236A patent/EP1589017B1/en not_active Expired - Lifetime
- 1999-04-05 BR BR9909795-8A patent/BR9909795A/pt not_active IP Right Cessation
- 1999-04-05 AU AU33827/99A patent/AU757733B2/en not_active Ceased
- 1999-04-05 DK DK99915273T patent/DK1073647T3/da active
- 1999-04-05 WO PCT/US1999/007448 patent/WO1999054318A1/en active IP Right Grant
- 1999-04-05 DE DE69941083T patent/DE69941083D1/de not_active Expired - Lifetime
- 1999-04-05 AT AT99915273T patent/ATE435861T1/de active
- 1999-04-05 DK DK05015236.2T patent/DK1589017T3/da active
- 1999-04-05 PT PT99916383T patent/PT1073648E/pt unknown
- 1999-04-20 PE PE1999000331A patent/PE20000460A1/es not_active Application Discontinuation
- 1999-04-21 AR ARP990101834A patent/AR015774A1/es unknown
- 1999-04-21 AR ARP990101833A patent/AR015007A1/es unknown
-
2006
- 2006-12-08 CY CY20061101766T patent/CY1105836T1/el unknown
-
2009
- 2009-09-01 CY CY20091100911T patent/CY1109593T1/el unknown
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