AU748526B2 - 12,13-modified epothilone derivatives - Google Patents

12,13-modified epothilone derivatives Download PDF

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Publication number
AU748526B2
AU748526B2 AU34716/99A AU3471699A AU748526B2 AU 748526 B2 AU748526 B2 AU 748526B2 AU 34716/99 A AU34716/99 A AU 34716/99A AU 3471699 A AU3471699 A AU 3471699A AU 748526 B2 AU748526 B2 AU 748526B2
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AU
Australia
Prior art keywords
alkyl
methyl
group
compound
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU34716/99A
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English (en)
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AU3471699A (en
Inventor
Gerhard Hofle
Soong-Hoon Kim Kim
Gregory D. Vite
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU3471699A publication Critical patent/AU3471699A/en
Application granted granted Critical
Publication of AU748526B2 publication Critical patent/AU748526B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU34716/99A 1998-04-21 1999-04-05 12,13-modified epothilone derivatives Ceased AU748526B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8256498P 1998-04-21 1998-04-21
US60/082564 1998-04-21
PCT/US1999/007475 WO1999054319A1 (en) 1998-04-21 1999-04-05 12,13-modified epothilone derivatives

Publications (2)

Publication Number Publication Date
AU3471699A AU3471699A (en) 1999-11-08
AU748526B2 true AU748526B2 (en) 2002-06-06

Family

ID=22171978

Family Applications (2)

Application Number Title Priority Date Filing Date
AU33827/99A Ceased AU757733B2 (en) 1998-04-21 1999-04-05 12,13-cyclopropane epothilone derivatives
AU34716/99A Ceased AU748526B2 (en) 1998-04-21 1999-04-05 12,13-modified epothilone derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU33827/99A Ceased AU757733B2 (en) 1998-04-21 1999-04-05 12,13-cyclopropane epothilone derivatives

Country Status (17)

Country Link
US (2) US6399638B1 (enExample)
EP (3) EP1073648B1 (enExample)
JP (2) JP4476483B2 (enExample)
CN (1) CN1142923C (enExample)
AR (2) AR015774A1 (enExample)
AT (2) ATE435861T1 (enExample)
AU (2) AU757733B2 (enExample)
BR (1) BR9909795A (enExample)
CA (2) CA2329181C (enExample)
CY (2) CY1105836T1 (enExample)
DE (2) DE69933287T2 (enExample)
DK (3) DK1073648T3 (enExample)
ES (3) ES2327803T3 (enExample)
PE (1) PE20000460A1 (enExample)
PT (3) PT1073647E (enExample)
TR (1) TR200003036T2 (enExample)
WO (2) WO1999054318A1 (enExample)

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AU2003218107A1 (en) * 2002-03-12 2003-09-29 Bristol-Myers Squibb Company C12-cyano epothilone derivatives
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Also Published As

Publication number Publication date
ATE340177T1 (de) 2006-10-15
ES2273484T3 (es) 2007-05-01
EP1073648A4 (en) 2003-01-02
EP1073648B1 (en) 2006-09-20
AU757733B2 (en) 2003-03-06
DK1073648T3 (da) 2007-01-08
AU3471699A (en) 1999-11-08
EP1073647B1 (en) 2009-07-08
DE69933287D1 (de) 2006-11-02
CY1109593T1 (el) 2014-08-13
DK1589017T3 (da) 2013-03-18
EP1073648A1 (en) 2001-02-07
JP2002512238A (ja) 2002-04-23
EP1073647A4 (en) 2003-01-02
WO1999054318A1 (en) 1999-10-28
AR015774A1 (es) 2001-05-16
EP1073647A1 (en) 2001-02-07
BR9909795A (pt) 2000-12-26
US6399638B1 (en) 2002-06-04
JP4476483B2 (ja) 2010-06-09
WO1999054319A1 (en) 1999-10-28
EP1589017B1 (en) 2012-12-05
PE20000460A1 (es) 2000-06-09
AU3382799A (en) 1999-11-08
CY1105836T1 (el) 2011-02-02
PT1073647E (pt) 2009-07-17
CA2329181A1 (en) 1999-10-28
EP1589017A3 (en) 2009-04-22
CA2323609A1 (en) 1999-10-28
US6380395B1 (en) 2002-04-30
CA2329181C (en) 2011-02-22
DK1073647T3 (da) 2009-11-09
DE69941083D1 (en) 2009-08-20
PT1589017E (pt) 2013-03-04
PT1073648E (pt) 2006-12-29
CN1298398A (zh) 2001-06-06
TR200003036T2 (tr) 2001-01-22
AR015007A1 (es) 2001-04-11
ES2327803T3 (es) 2009-11-03
DE69933287T2 (de) 2007-05-03
CN1142923C (zh) 2004-03-24
JP2002512239A (ja) 2002-04-23
ES2400049T3 (es) 2013-04-05
EP1589017A2 (en) 2005-10-26
ATE435861T1 (de) 2009-07-15

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