AR015774A1 - Derivados de epotilona 12,13-modificados y sus sales - Google Patents

Derivados de epotilona 12,13-modificados y sus sales

Info

Publication number
AR015774A1
AR015774A1 ARP990101834A ARP990101834A AR015774A1 AR 015774 A1 AR015774 A1 AR 015774A1 AR P990101834 A ARP990101834 A AR P990101834A AR P990101834 A ARP990101834 A AR P990101834A AR 015774 A1 AR015774 A1 AR 015774A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
group
aryl
heterocycle
Prior art date
Application number
ARP990101834A
Other languages
English (en)
Spanish (es)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR015774A1 publication Critical patent/AR015774A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ARP990101834A 1998-04-21 1999-04-21 Derivados de epotilona 12,13-modificados y sus sales AR015774A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8256498P 1998-04-21 1998-04-21

Publications (1)

Publication Number Publication Date
AR015774A1 true AR015774A1 (es) 2001-05-16

Family

ID=22171978

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990101834A AR015774A1 (es) 1998-04-21 1999-04-21 Derivados de epotilona 12,13-modificados y sus sales
ARP990101833A AR015007A1 (es) 1998-04-21 1999-04-21 Compuestos de 12,13-ciclopropano epotilona y sales, solvatos e hidratos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP990101833A AR015007A1 (es) 1998-04-21 1999-04-21 Compuestos de 12,13-ciclopropano epotilona y sales, solvatos e hidratos de los mismos

Country Status (17)

Country Link
US (2) US6380395B1 (enExample)
EP (3) EP1073648B1 (enExample)
JP (2) JP4476483B2 (enExample)
CN (1) CN1142923C (enExample)
AR (2) AR015774A1 (enExample)
AT (2) ATE435861T1 (enExample)
AU (2) AU748526B2 (enExample)
BR (1) BR9909795A (enExample)
CA (2) CA2323609A1 (enExample)
CY (2) CY1105836T1 (enExample)
DE (2) DE69933287T2 (enExample)
DK (3) DK1073647T3 (enExample)
ES (3) ES2327803T3 (enExample)
PE (1) PE20000460A1 (enExample)
PT (3) PT1073647E (enExample)
TR (1) TR200003036T2 (enExample)
WO (2) WO1999054319A1 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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CA2425828A1 (en) 2000-10-13 2002-04-18 The University Of Mississippi Synthesis of epothilones and related analogs
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BRPI0206509B8 (pt) * 2001-01-25 2021-05-25 R Pharm Us Operating Llc processo para formular, para administração parenteral, um análogo de epotilona, preparação farmacêutica, processo para formar uma composição farmacêutica para administração parental, composição farmacêutica e uso de um análogo de epotilona na preparação de uma composição farmacêutica para o tratamento de câncer
CA2438610A1 (en) 2001-02-20 2002-08-29 Francis Y. F. Lee Treatment of refractory tumors using epothilone derivatives
MXPA03007423A (es) 2001-02-20 2003-11-18 Bristol Myers Squibb Co Derivados de epotilona para tratamiento de tumores refractarios.
CZ305799B6 (cs) * 2001-03-14 2016-03-23 Bristol-Myers Squibb Company Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
EP1392664A4 (en) * 2001-06-01 2005-01-26 Bristol Myers Squibb Co EPOTHILONE DERIVATIVES
WO2003018002A2 (en) * 2001-08-23 2003-03-06 Novartis Ag Cyclopropyl and cyclobutyl epothilone analogs
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WO2003077903A1 (en) * 2002-03-12 2003-09-25 Bristol-Myers Squibb Company C12-cyano epothilone derivatives
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Also Published As

Publication number Publication date
DK1073647T3 (da) 2009-11-09
CA2329181A1 (en) 1999-10-28
CN1298398A (zh) 2001-06-06
CY1109593T1 (el) 2014-08-13
PE20000460A1 (es) 2000-06-09
ATE340177T1 (de) 2006-10-15
EP1073647A4 (en) 2003-01-02
EP1073648A4 (en) 2003-01-02
CA2329181C (en) 2011-02-22
JP2002512238A (ja) 2002-04-23
AU3382799A (en) 1999-11-08
PT1589017E (pt) 2013-03-04
DE69941083D1 (en) 2009-08-20
EP1589017B1 (en) 2012-12-05
EP1073647B1 (en) 2009-07-08
CY1105836T1 (el) 2011-02-02
AR015007A1 (es) 2001-04-11
AU3471699A (en) 1999-11-08
TR200003036T2 (tr) 2001-01-22
ATE435861T1 (de) 2009-07-15
CN1142923C (zh) 2004-03-24
ES2400049T3 (es) 2013-04-05
US6380395B1 (en) 2002-04-30
EP1073648A1 (en) 2001-02-07
US6399638B1 (en) 2002-06-04
DE69933287D1 (de) 2006-11-02
DK1589017T3 (da) 2013-03-18
EP1073648B1 (en) 2006-09-20
DK1073648T3 (da) 2007-01-08
ES2327803T3 (es) 2009-11-03
AU748526B2 (en) 2002-06-06
EP1589017A2 (en) 2005-10-26
CA2323609A1 (en) 1999-10-28
DE69933287T2 (de) 2007-05-03
ES2273484T3 (es) 2007-05-01
PT1073648E (pt) 2006-12-29
AU757733B2 (en) 2003-03-06
EP1073647A1 (en) 2001-02-07
PT1073647E (pt) 2009-07-17
BR9909795A (pt) 2000-12-26
JP2002512239A (ja) 2002-04-23
JP4476483B2 (ja) 2010-06-09
EP1589017A3 (en) 2009-04-22
WO1999054319A1 (en) 1999-10-28
WO1999054318A1 (en) 1999-10-28

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