PE20000106A1 - Composiciones insolubles para controlar la glucosa en la sangre - Google Patents

Composiciones insolubles para controlar la glucosa en la sangre

Info

Publication number
PE20000106A1
PE20000106A1 PE1998001271A PE00127198A PE20000106A1 PE 20000106 A1 PE20000106 A1 PE 20000106A1 PE 1998001271 A PE1998001271 A PE 1998001271A PE 00127198 A PE00127198 A PE 00127198A PE 20000106 A1 PE20000106 A1 PE 20000106A1
Authority
PE
Peru
Prior art keywords
protein
insulin
acillated
derived
analogue
Prior art date
Application number
PE1998001271A
Other languages
English (en)
Inventor
Mark Laurence Brader
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20000106A1 publication Critical patent/PE20000106A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Abstract

SE REFIERE A UNA COMPOSICION INSOLUBLE QUE COMPRENDE a)UNA PROTEINA SELECCIONADA DE INSULINA, ANALOGO DE INSULINA, PROINSULINA, b)PROTEINA DERIVADA SELECCIONADA DE INSULINA DERIVADA, ANALOGO DE INSULINA DERIVADA, PROINSULINA DERIVADA, c)COMPLEJANTE, d)ESTABILIZADOR DE HEXAMERO, e)CATION METALICO DIVALENTE. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)UNA PROTEINA, b)UNA PROTEINA ACILADA CON UN ACIDO GRASO SATURADO DE CADENA RECTA O CADENA RAMIFICADA, TAL COMO DESTHR(B30)-ANALOGO DE INSULINA HUMANA ACILADA CON ACIDO GRASO, LYS B28, PROB29-ANALOGO DE INSULINA HUMANA ACILADA CON ACIDO GRASO, ASPB28-ANALOGO DE INSULINA HUMANA ACILADA CON ACIDO GRASO, c)PROTAMINA, d)PRESERVANTE FENOLICO COMO FENOL, m-CRESOL, CLOROCRESOL, ENTRE OTROS, e)ZINC. LA PROPORCION ENTRE LA PROTEINA Y LA PROTEINA ACILADA ES DE 1:9 A 9:1. LA INSULINA PUEDE SER UN MICROCRISTAL DE MORFOLOGIA SIMILAR A UN BASTON, MORFOLOGIA IRREGULAR, PRECIPITADO AMORFO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION.
PE1998001271A 1997-12-23 1998-12-22 Composiciones insolubles para controlar la glucosa en la sangre PE20000106A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6860197P 1997-12-23 1997-12-23
US8885998P 1998-06-11 1998-06-11
US10994098P 1998-11-25 1998-11-25

Publications (1)

Publication Number Publication Date
PE20000106A1 true PE20000106A1 (es) 2000-02-09

Family

ID=27371371

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001271A PE20000106A1 (es) 1997-12-23 1998-12-22 Composiciones insolubles para controlar la glucosa en la sangre

Country Status (24)

Country Link
US (2) US6531448B1 (es)
EP (1) EP0925792B1 (es)
JP (1) JP2001526225A (es)
KR (1) KR20010024799A (es)
CN (1) CN1284876A (es)
AR (1) AR019807A1 (es)
AT (1) ATE264690T1 (es)
AU (1) AU2008899A (es)
BR (1) BR9814471A (es)
CA (1) CA2315300A1 (es)
CO (1) CO4970787A1 (es)
DE (1) DE69823319D1 (es)
DZ (1) DZ2691A1 (es)
EA (1) EA003394B1 (es)
HR (1) HRP20000427A2 (es)
HU (1) HUP0100243A3 (es)
ID (1) ID25476A (es)
IL (1) IL136724A0 (es)
NO (1) NO20003269L (es)
NZ (1) NZ505091A (es)
PE (1) PE20000106A1 (es)
PL (1) PL341300A1 (es)
TR (1) TR200001935T2 (es)
WO (1) WO1999032116A1 (es)

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Also Published As

Publication number Publication date
BR9814471A (pt) 2000-10-10
DZ2691A1 (fr) 2003-03-29
US20030144181A1 (en) 2003-07-31
EA200000708A1 (ru) 2000-12-25
EA003394B1 (ru) 2003-04-24
ID25476A (id) 2000-10-05
HRP20000427A2 (en) 2001-06-30
US6531448B1 (en) 2003-03-11
NZ505091A (en) 2002-11-26
ATE264690T1 (de) 2004-05-15
WO1999032116A1 (en) 1999-07-01
DE69823319D1 (de) 2004-05-27
AR019807A1 (es) 2002-03-20
CO4970787A1 (es) 2000-11-07
EP0925792A2 (en) 1999-06-30
NO20003269L (no) 2000-08-23
EP0925792B1 (en) 2004-04-21
CA2315300A1 (en) 1999-07-01
NO20003269D0 (no) 2000-06-22
HUP0100243A3 (en) 2001-09-28
EP0925792A3 (en) 2001-09-12
TR200001935T2 (tr) 2000-12-21
KR20010024799A (ko) 2001-03-26
JP2001526225A (ja) 2001-12-18
IL136724A0 (en) 2001-06-14
PL341300A1 (en) 2001-04-09
CN1284876A (zh) 2001-02-21
HUP0100243A2 (hu) 2001-08-28
AU2008899A (en) 1999-07-12

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