DE3586355T2 - Heilmittel fuer wunden. - Google Patents

Heilmittel fuer wunden.

Info

Publication number
DE3586355T2
DE3586355T2 DE8585905980T DE3586355T DE3586355T2 DE 3586355 T2 DE3586355 T2 DE 3586355T2 DE 8585905980 T DE8585905980 T DE 8585905980T DE 3586355 T DE3586355 T DE 3586355T DE 3586355 T2 DE3586355 T2 DE 3586355T2
Authority
DE
Germany
Prior art keywords
wounds
cells
substance
medicine
capillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585905980T
Other languages
English (en)
Other versions
DE3586355D1 (de
Inventor
R Knighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota filed Critical University of Minnesota
Application granted granted Critical
Publication of DE3586355D1 publication Critical patent/DE3586355D1/de
Publication of DE3586355T2 publication Critical patent/DE3586355T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
DE8585905980T 1984-11-29 1985-11-08 Heilmittel fuer wunden. Expired - Lifetime DE3586355T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67647184A 1984-11-29 1984-11-29
US78620685A 1985-10-10 1985-10-10
PCT/US1985/002205 WO1986003122A1 (en) 1984-11-29 1985-11-08 Wound healing agents

Publications (2)

Publication Number Publication Date
DE3586355D1 DE3586355D1 (de) 1992-08-20
DE3586355T2 true DE3586355T2 (de) 1993-01-14

Family

ID=27101561

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19853590594 Ceased DE3590594T1 (de) 1984-11-29 1985-11-08
DE8585905980T Expired - Lifetime DE3586355T2 (de) 1984-11-29 1985-11-08 Heilmittel fuer wunden.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19853590594 Ceased DE3590594T1 (de) 1984-11-29 1985-11-08

Country Status (16)

Country Link
EP (2) EP0383363A3 (de)
AT (1) ATE78167T1 (de)
AU (1) AU596954B2 (de)
CA (1) CA1261259A (de)
CH (1) CH673774A5 (de)
DE (2) DE3590594T1 (de)
DK (1) DK165169C (de)
FI (1) FI85219C (de)
GB (1) GB2248777B (de)
HU (1) HUT42329A (de)
IE (1) IE57894B1 (de)
IL (1) IL77096A (de)
NL (1) NL8520384A (de)
NO (1) NO170194C (de)
SE (1) SE8603228L (de)
WO (1) WO1986003122A1 (de)

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US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US5498600A (en) * 1984-10-12 1996-03-12 Zymogenetics, Inc. Biologically active mosaic proteins
EP0487116B1 (de) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen
US5045633A (en) * 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
IL84911A (en) * 1987-12-22 1993-04-04 Yissum Res Dev Co Processes for the preparation of collagen products, and pharmaceutical compositions containing the same
US5814602A (en) * 1988-03-17 1998-09-29 Novo Nordisk A/S Heparin-binding proteins
US4900541A (en) * 1988-05-06 1990-02-13 Govier William C Sunscreen composition
IT1217938B (it) * 1988-06-28 1990-03-30 Girolamo Sirchia Procedimento per la preparazione e la conservazione di concentrati eritrocitari e piastrinici
US5599558A (en) * 1989-09-15 1997-02-04 Curative Technologies, Inc. Selecting amounts of platelet releasate for efficacious treatment of tissue
IL95641A0 (en) * 1989-09-15 1991-06-30 Curative Tech Inc Preparation of a platelet releasate product
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6197325B1 (en) * 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
WO1992009301A1 (en) * 1990-11-27 1992-06-11 The American National Red Cross Tissue sealant and growth factor containing compositions that promote accelerated wound healing
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
FR2691911B1 (fr) * 1992-06-05 1994-11-25 Delmas Olivier Dispositif permettant l'obtention d'un surnageant de thrombocytes activés, procédé mettant en Óoeuvre le dispositif et surnageant obtenu.
FR2696095B1 (fr) * 1992-09-30 1994-11-25 Inoteb Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application.
EP0637450A3 (de) * 1993-08-04 1995-04-05 Collagen Corp Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe.
WO1995015763A1 (en) * 1993-12-08 1995-06-15 Universite De Montreal Process for the preparation of serum and platelet growth factors extract
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
JPH11505713A (ja) * 1995-05-24 1999-05-25 セルファクターズ ピーエルシー 細胞分化剤
CA2222506C (en) * 1995-06-06 2007-07-24 Quantic Biomedical Partners Device and method for concentrating plasma
US5834418A (en) * 1996-03-20 1998-11-10 Theratechnologies, Inc. Process for the preparation of platelet growth factors extract
US6120520A (en) 1997-05-27 2000-09-19 Angiotrax, Inc. Apparatus and methods for stimulating revascularization and/or tissue growth
US6051008A (en) 1996-12-02 2000-04-18 Angiotrax, Inc. Apparatus having stabilization members for percutaneously performing surgery and methods of use
US6102926A (en) 1996-12-02 2000-08-15 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use
US6117444A (en) * 1997-04-10 2000-09-12 Brigham & Women's Hospital Polyethylene glycol/microfibrillar collagen composite serves as a resorbable hemostatic agent
AT407484B (de) 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US6524568B2 (en) 1998-06-22 2003-02-25 Cytomedix, Inc. Enriched platelet wound healant
CA2301794C (en) * 1998-06-22 2004-05-18 Autologous Wound Therapy, Inc. Improved enriched platelet wound healant
US6432119B1 (en) 1999-03-17 2002-08-13 Angiotrax, Inc. Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
EP1507543A4 (de) 2002-05-09 2006-07-26 Cambridgemed Inc Pharmazeutische zusammensetzung zur behandlung von wunden mit blutplasma oder serum
CN1327905C (zh) 2002-09-10 2007-07-25 美国国家红十字会 止血敷料
DE112004002847T5 (de) * 2004-05-05 2007-04-05 Synthes Gmbh Verwendung von Blutplättchen oder blutblättchenreichem Plasma (PRP)
US8529958B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20090075891A1 (en) 2007-08-06 2009-03-19 Macphee Martin Methods and dressings for sealing internal injuries
EP3886879A4 (de) 2018-11-30 2022-12-07 Cellphire Inc. Thrombozyten als freisetzungsmittel
KR20220016092A (ko) 2019-05-03 2022-02-08 셀파이어, 인크. 혈액 생성물을 생산하기 위한 물질 및 방법
US20210299179A1 (en) 2020-02-04 2021-09-30 Cellphire, Inc. Methods of treating congenital hemophilia with anti-fibrinolytic loaded platelets
AU2020334903B2 (en) 2019-08-16 2023-12-21 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent

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Publication number Priority date Publication date Assignee Title
GB1195061A (en) * 1966-05-27 1970-06-17 Fmc Corp Coated Structures and Methods of Forming Them.
FR2472385A1 (fr) * 1979-12-27 1981-07-03 Sederma Sa Nouveaux extraits biologiques utilisables en cosmetologie, et procedes d'obtention de ces extraits
FR2533438B2 (fr) * 1979-12-27 1986-03-07 Sederma Sarl Utilisation en cosmetologie des facteurs de croissance et d'extraits biologiques contenant ceux-ci
DE3110560A1 (de) * 1981-03-18 1982-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben"
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor

Also Published As

Publication number Publication date
IE852810L (en) 1986-05-29
IL77096A (en) 1993-01-31
DK357386A (da) 1986-07-28
FI863087A0 (fi) 1986-07-28
AU5094985A (en) 1986-06-18
NO862964L (no) 1986-07-23
FI85219C (fi) 1992-03-25
EP0202298B1 (de) 1992-07-15
ATE78167T1 (de) 1992-08-15
GB2248777A (en) 1992-04-22
FI85219B (fi) 1991-12-13
DK165169C (da) 1993-03-01
GB8617658D0 (en) 1986-08-28
NL8520384A (nl) 1986-10-01
WO1986003122A1 (en) 1986-06-05
EP0383363A3 (de) 1990-10-03
DK165169B (da) 1992-10-19
NO170194B (no) 1992-06-15
GB2248777B (en) 1993-06-30
DK357386D0 (da) 1986-07-28
NO862964D0 (no) 1986-07-23
SE8603228D0 (sv) 1986-07-25
HUT42329A (en) 1987-07-28
EP0202298A1 (de) 1986-11-26
CA1261259A (en) 1989-09-26
DE3590594T1 (de) 1987-01-29
SE8603228L (sv) 1986-07-25
NO170194C (no) 1992-09-23
AU596954B2 (en) 1990-05-24
CH673774A5 (de) 1990-04-12
EP0383363A2 (de) 1990-08-22
EP0202298A4 (de) 1988-07-04
IE57894B1 (en) 1993-05-05
DE3586355D1 (de) 1992-08-20
FI863087A (fi) 1986-07-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: REGENTS OF THE UNIVERSITY OF MINNESOTA, ST. PAUL,