OA11400A - Solid oral dosage form comprising a combination ofmetformin and glibenclamide. - Google Patents
Solid oral dosage form comprising a combination ofmetformin and glibenclamide. Download PDFInfo
- Publication number
- OA11400A OA11400A OA1200000076A OA1200000076A OA11400A OA 11400 A OA11400 A OA 11400A OA 1200000076 A OA1200000076 A OA 1200000076A OA 1200000076 A OA1200000076 A OA 1200000076A OA 11400 A OA11400 A OA 11400A
- Authority
- OA
- OAPI
- Prior art keywords
- glibenclamide
- dosage form
- oral dosage
- metformin
- solid oral
- Prior art date
Links
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 229960004580 glibenclamide Drugs 0.000 title claims abstract description 24
- 239000007787 solid Substances 0.000 title claims description 13
- 239000006186 oral dosage form Substances 0.000 title claims description 12
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229960003105 metformin Drugs 0.000 claims abstract description 26
- 239000002245 particle Substances 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims description 29
- 239000008187 granular material Substances 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005550 wet granulation Methods 0.000 claims description 2
- 238000009472 formulation Methods 0.000 description 16
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 10
- 229960004329 metformin hydrochloride Drugs 0.000 description 9
- 238000012360 testing method Methods 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
- 229920002785 Croscarmellose sodium Polymers 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 229960001681 croscarmellose sodium Drugs 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 4
- 239000008108 microcrystalline cellulose Substances 0.000 description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 description 4
- -1 such ashydrochloride Chemical compound 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000011260 co-administration Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000013066 combination product Substances 0.000 description 2
- 229940127555 combination product Drugs 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 229940127017 oral antidiabetic Drugs 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 101100114828 Drosophila melanogaster Orai gene Proteins 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 229940127003 anti-diabetic drug Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229960005168 croscarmellose Drugs 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229950005627 embonate Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004110 gluconeogenesis Effects 0.000 description 1
- 229940095884 glucophage Drugs 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98401781A EP0974356B1 (en) | 1998-07-15 | 1998-07-15 | Tablets comprising a combination of metformin and glibenclamide |
Publications (1)
Publication Number | Publication Date |
---|---|
OA11400A true OA11400A (en) | 2004-04-08 |
Family
ID=8235441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA1200000076A OA11400A (en) | 1998-07-15 | 2000-03-15 | Solid oral dosage form comprising a combination ofmetformin and glibenclamide. |
Country Status (27)
Country | Link |
---|---|
US (2) | US6303146B1 (pt) |
EP (4) | EP0974356B1 (pt) |
JP (2) | JP2002520371A (pt) |
KR (2) | KR100478347B1 (pt) |
CN (2) | CN1146427C (pt) |
AP (1) | AP1450A (pt) |
AR (2) | AR013052A1 (pt) |
AT (1) | ATE250418T1 (pt) |
AU (2) | AU753604B2 (pt) |
BR (1) | BR9906600A (pt) |
CA (1) | CA2303537C (pt) |
DE (1) | DE69818444T2 (pt) |
DK (1) | DK0974356T3 (pt) |
DZ (1) | DZ2846A1 (pt) |
ES (1) | ES2206868T3 (pt) |
ID (1) | ID25784A (pt) |
MA (1) | MA24930A1 (pt) |
MY (1) | MY129552A (pt) |
NZ (1) | NZ503248A (pt) |
OA (1) | OA11400A (pt) |
PT (1) | PT974356E (pt) |
RU (2) | RU2226396C2 (pt) |
SI (1) | SI0974356T1 (pt) |
TW (2) | TW555560B (pt) |
UY (1) | UY25611A1 (pt) |
WO (1) | WO2000003742A2 (pt) |
ZA (1) | ZA200001159B (pt) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
HU229352B1 (en) | 1999-11-03 | 2013-11-28 | Bristol Myers Squibb Co | Medicament comprising the combination of metformin and glyburide |
US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
US20010036479A1 (en) | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
FR2816840B1 (fr) | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
FR2816841B1 (fr) * | 2000-11-22 | 2004-02-06 | Lipha | Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation |
CA2434169C (en) * | 2001-01-12 | 2011-03-15 | Sun Pharmaceutical Industries Limited | Spaced drug delivery system |
FR2825023B1 (fr) * | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
US7767249B2 (en) * | 2001-06-07 | 2010-08-03 | Hewlett-Packard Development Company, L.P. | Preparation of nanoparticles |
US20050271737A1 (en) * | 2001-06-07 | 2005-12-08 | Chinea Vanessa I | Application of a bioactive agent to a substrate |
US8206753B2 (en) * | 2001-06-20 | 2012-06-26 | Metaproteomics, Llc | Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes |
US7879869B2 (en) | 2001-07-30 | 2011-02-01 | Mitsubishi Tanabe Pharma Corporation | Drugs for ameliorating postcibal hyperglycemia |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
ITFI20010230A1 (it) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
DK1482919T3 (da) * | 2002-01-25 | 2007-07-30 | Silanes Sa De Cv Lab | Farmaceutisk sammensætning til blodsukkerkontrol hos patienter med type 2 diabetes |
SI1476138T1 (sl) * | 2002-02-21 | 2012-07-31 | Valeant Internat Barbados Srl | Formulacije s prirejenim sproščanjem vsaj ene oblike tramadola |
US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
US20030219482A1 (en) * | 2002-03-21 | 2003-11-27 | Chaudhari Sunil Sudhakar | Multiparticulate compositions for once-a-day administration |
CA2480824A1 (fr) | 2002-04-09 | 2003-10-16 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline |
ES2320438T7 (es) | 2002-04-09 | 2013-02-14 | Flamel Technologies | Formulación farmaceútica oral de suspensión acuosa de microcápsulas que permiten la liberación modificada de principio(s) activo(s) |
WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
US7445796B2 (en) * | 2002-08-19 | 2008-11-04 | L. Perrigo Company | Pharmaceutically active particles of a monomodal particle size distribution and method |
US20060002998A1 (en) * | 2002-11-15 | 2006-01-05 | Anupam Trehan | Pharmaceutical dosage forms of biguanide-sulfonylurea combinations |
FR2853831A1 (fr) * | 2003-03-05 | 2004-10-22 | Usv Ltd | Forme posologique solide a usage oral de metformine et de glyburide et son procede de preparation |
US7662366B2 (en) * | 2003-04-15 | 2010-02-16 | Chugai Seiyaku Kabushiki Kaisha | Method of preventing β cell disruption in pancreatic Langerhans' islets |
US20060121108A1 (en) * | 2004-12-02 | 2006-06-08 | Prasad C K | System and method for producing a directly compressible, high-potency formulation of metformin hydrochloride |
CN100341495C (zh) * | 2004-12-29 | 2007-10-10 | 三九医药股份有限公司 | 格列本脲固体分散体、口服组合物及其制备方法 |
KR100760430B1 (ko) * | 2004-12-31 | 2007-10-04 | 한미약품 주식회사 | 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법 |
PE20061245A1 (es) * | 2005-03-30 | 2007-01-06 | Generex Pharm Inc | Composiciones para la transmision transmucosa oral de la metformina |
US8529537B2 (en) * | 2005-08-05 | 2013-09-10 | Kimberly-Clark Worldwide, Inc. | Absorbent article with enclosures |
MXPA05009633A (es) * | 2005-09-08 | 2007-03-07 | Silanes Sa De Cv Lab | Composicion farmaceutica estable de glimepirida de liberacion inmediata y metformina de liberacion prolongada. |
CA2654661C (en) | 2006-06-26 | 2012-10-23 | Amgen Inc. | Compositions comprising modified lcat and use thereof for treating atherosclerosis |
WO2008062273A2 (en) * | 2006-11-20 | 2008-05-29 | Cadila Pharmaceuticals Limited | Solid oral dosage form having antidiabetic drug combination |
MY159203A (en) | 2007-07-19 | 2016-12-30 | Takeda Pharmaceuticals Co | Solid preparation comprising alogliptin and metformin hydrochloride |
MX348799B (es) | 2007-07-26 | 2017-06-29 | Amgen Inc | Enzimas aciltransferasa de lecitina-colesterol, modificadas. |
US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
WO2011135106A1 (es) * | 2010-04-26 | 2011-11-03 | Smart Pharma Solutions, S.L | Granulado altamente dispersable para la preparación de formulaciones de sustancias activas de altas dosis y procedimiento de obtención del mismo |
RU2451506C1 (ru) | 2011-06-02 | 2012-05-27 | Сергей Юрьевич Лешков | Комбинация для лечения сахарного диабета и его осложнений |
AU2012347540A1 (en) | 2011-12-08 | 2014-06-26 | Amgen Inc. | Agonistic human LCAT antigen binding proteins and their use in therapy |
CN104127424A (zh) * | 2014-07-30 | 2014-11-05 | 沈阳药科大学 | 格列本脲衍生物及其制备方法和应用 |
CN105030793A (zh) * | 2015-08-25 | 2015-11-11 | 瑞阳制药有限公司 | 二甲双胍格列本脲胶囊及其制备方法 |
WO2019070109A1 (es) * | 2017-10-03 | 2019-04-11 | Infinite Clinical Research International, S.A. De C.V. | Triconjugado para el tratamiento de diabetes mellitus |
KR102484756B1 (ko) * | 2020-11-13 | 2023-01-06 | 한국생산기술연구원 | 용해성 증대 및 취급용이성을 갖는 파우더 배지의 과립화 방법 |
CN113143940A (zh) * | 2020-12-30 | 2021-07-23 | 成都恒瑞制药有限公司 | 一种抗糖尿病药物组合物的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE362704C (de) * | 1921-08-09 | 1922-11-02 | Naamlooze Vennootschap Interna | Vorrichtung zum Senken einer Last, insbesondere eines Rettungsbootes |
US3174901A (en) | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
DE2348334C2 (de) | 1973-09-26 | 1982-11-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs |
US4060634A (en) * | 1973-09-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Rapidly resorbable glibenclamide |
US4916163A (en) | 1985-06-04 | 1990-04-10 | The Upjohn Company | Spray-dried lactose formulation of micronized glyburide |
DE3833439A1 (de) | 1988-10-01 | 1991-09-12 | Hoechst Ag | Verfahren zur mikronisierung von glibenclamid |
DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
IT1276130B1 (it) * | 1995-11-14 | 1997-10-27 | Gentili Ist Spa | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
IL133142A0 (en) | 1997-06-18 | 2001-03-19 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
US6544564B1 (en) * | 2001-11-27 | 2003-04-08 | Michael Donald Farley | Cytotoxic pharmaceutical composition |
-
1998
- 1998-07-15 DE DE69818444T patent/DE69818444T2/de not_active Revoked
- 1998-07-15 ES ES98401781T patent/ES2206868T3/es not_active Expired - Lifetime
- 1998-07-15 PT PT98401781T patent/PT974356E/pt unknown
- 1998-07-15 DK DK98401781T patent/DK0974356T3/da active
- 1998-07-15 SI SI9830517T patent/SI0974356T1/xx unknown
- 1998-07-15 AT AT98401781T patent/ATE250418T1/de not_active IP Right Cessation
- 1998-07-15 EP EP98401781A patent/EP0974356B1/en not_active Revoked
-
1999
- 1999-07-12 RU RU2000109583/15A patent/RU2226396C2/ru active
- 1999-07-12 NZ NZ503248A patent/NZ503248A/xx not_active IP Right Cessation
- 1999-07-12 AU AU54179/99A patent/AU753604B2/en not_active Expired
- 1999-07-12 WO PCT/EP1999/005571 patent/WO2000003742A2/en active IP Right Grant
- 1999-07-12 CN CNB998013625A patent/CN1146427C/zh not_active Expired - Lifetime
- 1999-07-12 RU RU2003126257/15A patent/RU2286788C2/ru active
- 1999-07-12 EP EP10185329A patent/EP2269613A3/en not_active Ceased
- 1999-07-12 EP EP04008415A patent/EP1435240A3/en not_active Ceased
- 1999-07-12 EP EP99940114A patent/EP1011684A2/en not_active Ceased
- 1999-07-12 CA CA002303537A patent/CA2303537C/en not_active Expired - Lifetime
- 1999-07-12 BR BR9906600-9A patent/BR9906600A/pt not_active Application Discontinuation
- 1999-07-12 JP JP2000559876A patent/JP2002520371A/ja active Pending
- 1999-07-12 KR KR10-2000-7002714A patent/KR100478347B1/ko not_active IP Right Cessation
- 1999-07-12 ID IDW20000482D patent/ID25784A/id unknown
- 1999-07-12 KR KR10-2004-7005583A patent/KR20040053177A/ko active Search and Examination
- 1999-07-12 CN CNA031092314A patent/CN1486698A/zh active Pending
- 1999-07-12 AP APAP/P/2000/001757A patent/AP1450A/en active
- 1999-07-13 MA MA25681A patent/MA24930A1/fr unknown
- 1999-07-14 TW TW088111959A patent/TW555560B/zh not_active IP Right Cessation
- 1999-07-14 US US09/353,141 patent/US6303146B1/en not_active Expired - Lifetime
- 1999-07-14 MY MYPI99002968A patent/MY129552A/en unknown
- 1999-07-14 DZ DZ990146A patent/DZ2846A1/xx active
- 1999-07-14 TW TW092113257A patent/TWI245632B/zh not_active IP Right Cessation
- 1999-07-15 UY UY25611A patent/UY25611A1/es not_active Application Discontinuation
- 1999-07-15 AR ARP990103470A patent/AR013052A1/es not_active Application Discontinuation
-
2000
- 2000-03-07 ZA ZA200001159A patent/ZA200001159B/xx unknown
- 2000-03-15 OA OA1200000076A patent/OA11400A/en unknown
-
2002
- 2002-12-27 US US10/329,426 patent/USRE38629E1/en not_active Expired - Lifetime
-
2003
- 2003-03-31 JP JP2003094873A patent/JP2003292443A/ja active Pending
- 2003-11-11 AU AU2003261560A patent/AU2003261560A1/en not_active Abandoned
-
2008
- 2008-04-07 AR ARP080101435A patent/AR065970A2/es not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
OA11400A (en) | Solid oral dosage form comprising a combination ofmetformin and glibenclamide. | |
EP0305051B1 (en) | Orally sustained-release acetaminophen formulation and process to obtain it | |
EP1275391B1 (en) | Pharmaceutical compositions containing irbesartan and a diuretic | |
EP0173210B1 (de) | Pellet-Zubereitung | |
US7732492B2 (en) | Nateglinide-containing preparation | |
US20070014854A1 (en) | Novel granulation process | |
DE20220415U1 (de) | Tamsulosin-Tabletten | |
EP1793801A1 (en) | Novel granulation process and granulate produced therefrom | |
US20070014864A1 (en) | Novel pharmaceutical granulate | |
AU2014295100B2 (en) | Antitubercular composition comprising rifampicin, isoniazid, ethambutol and pyrazinamide and its process of preparation. | |
WO2006109175A2 (en) | Solid dosage form of an antidiabetic drug | |
GR1009644B (el) | Φαρμακευτικο σκευασμα που περιλαμβανει βιλνταγλιπτινη και μετφορμινη και μεθοδος για την παρασκευη αυτου | |
EP2179725A1 (en) | Pharmaceutical composition comprising levetiracetam | |
JP2000516601A (ja) | 水溶性化合物及びセルロースを含有する粒状物 | |
CN112022827B (zh) | 一种盐酸赛庚啶快速释放药物制剂及其制备方法 | |
OA12714A (en) | Solid oral dosage form comprising a combination ofmetformin and glibenclamide. | |
WO2004069229A1 (en) | Dual release anti-diabetic drugs and process of production thereof | |
JPH0119364B2 (pt) | ||
WO2004091587A1 (en) | Multiple release anti-diabetic drugs and process of production thereof | |
CN114712359A (zh) | 一种马来酸阿伐曲泊帕药物制剂及其制备方法和应用 | |
MXPA00002568A (en) | Solid oral dosage form comprising a combination of metformin and glibenclamide |