OA10952A - Erythromycins and process for their preparation - Google Patents

Erythromycins and process for their preparation Download PDF

Info

Publication number
OA10952A
OA10952A OA9900002A OA9900002A OA10952A OA 10952 A OA10952 A OA 10952A OA 9900002 A OA9900002 A OA 9900002A OA 9900002 A OA9900002 A OA 9900002A OA 10952 A OA10952 A OA 10952A
Authority
OA
OAPI
Prior art keywords
plasmid
compound
alkyl
erythraea
group
Prior art date
Application number
OA9900002A
Other languages
English (en)
Inventor
Peter Francis Leadlay
James Staunton
Jesus Cortes
Michael Stephen Pacey
Original Assignee
Biotica Tech Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd
Publication of OA10952A publication Critical patent/OA10952A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
OA9900002A 1996-07-05 1999-01-04 Erythromycins and process for their preparation OA10952A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
OA10952A true OA10952A (en) 2002-02-25

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900002A OA10952A (en) 1996-07-05 1999-01-04 Erythromycins and process for their preparation

Country Status (28)

Country Link
EP (3) EP0910633B1 (xx)
JP (2) JP2000511063A (xx)
KR (1) KR20000023579A (xx)
CN (1) CN1179046C (xx)
AP (1) AP1029A (xx)
AT (2) ATE451455T1 (xx)
AU (2) AU731301B2 (xx)
BG (1) BG103133A (xx)
BR (1) BR9710209A (xx)
CA (2) CA2259420C (xx)
DE (2) DE69733416T2 (xx)
DK (2) DK0909327T3 (xx)
EA (1) EA001744B1 (xx)
EE (1) EE03976B1 (xx)
ES (2) ES2244001T3 (xx)
GB (1) GB2331518B (xx)
GE (1) GEP20012348B (xx)
IL (1) IL127916A0 (xx)
IS (1) IS4940A (xx)
NO (1) NO990012L (xx)
NZ (1) NZ333861A (xx)
OA (1) OA10952A (xx)
PL (1) PL331285A1 (xx)
PT (1) PT909327E (xx)
SI (1) SI0910633T1 (xx)
SK (1) SK182498A3 (xx)
TR (1) TR199900006T2 (xx)
WO (2) WO1998001571A2 (xx)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
WO1998049315A2 (en) 1997-04-30 1998-11-05 Kosan Biosciences, Inc. Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
EP1493814A1 (en) 1995-07-06 2005-01-05 The Leland Stanford Junior University Cell-free synthesis of polyketides
WO1997022711A1 (en) 1995-12-19 1997-06-26 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6117659A (en) * 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
JP2008169226A (ja) * 1997-04-30 2008-07-24 Kosan Biosciences Inc 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
JP2001509379A (ja) 1997-07-10 2001-07-24 コーサン バイオサイエンシーズ， インコーポレイテッド 植物におけるポリケチドの産生
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1045912A1 (en) * 1998-01-14 2000-10-25 Glaxo Group Limited Polyketides and their synthesis
JP2002516090A (ja) * 1998-05-28 2002-06-04 コーサン バイオサイエンシーズ， インコーポレイテッド 組換えナルボノライドポリケチドシンターゼ
US6265202B1 (en) * 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
WO2000001838A2 (en) * 1998-07-02 2000-01-13 The Board Of Regents Of The Leland Stanford Junior University Methods for making polyketides
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
WO2000024907A2 (en) 1998-10-28 2000-05-04 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
JP4043191B2 (ja) 1998-11-03 2008-02-06 ファイザー・プロダクツ・インク 新規なマクロライド抗生物質
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
HUP0105190A3 (en) 1999-01-27 2003-03-28 Pfizer Prod Inc Ketolide antibiotics, medicaments containing them and their use
CA2359801A1 (en) 1999-02-09 2000-08-17 Rajesh S. Gokhale Methods to mediate polyketide synthase module effectiveness
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6458771B1 (en) 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
CN1351608A (zh) 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
EP1244800B1 (en) * 1999-10-29 2007-03-14 Kosan Biosciences, Inc. Rapamycin analogs
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
EP1255763A2 (en) 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Motilide compounds
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
WO2001079520A1 (en) 2000-04-13 2001-10-25 Biotica Technology Limited Hybrid glycosylated products and their production and use
ES2375714T3 (es) * 2002-02-19 2012-03-05 Dow Agrosciences Llc Nuevas poliquétido-sintetasas productoras de espinosina.
WO2004007709A2 (en) 2002-07-16 2004-01-22 Biotica Technology Limited Production of polyketides
DK200201957A (da) 2002-12-20 2003-01-20 Alpharma Aps 10-substituted erythromycin ketolides and methods of making
GB0230217D0 (en) * 2002-12-27 2003-02-05 Biotica Tech Ltd Borrelidin-producing polyketide synthase and its uses
PL1638529T3 (pl) 2003-06-16 2017-03-31 Andrx Pharmaceuticals, Llc. Kompozycja doustna o przedłużonym uwalnianiu
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP2342335B1 (en) 2008-09-24 2015-09-16 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
CN101519637B (zh) * 2009-04-07 2011-06-15 华东理工大学 一种红色糖多孢菌及其发酵生产红霉素的方法
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098809A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
GB201118334D0 (en) 2011-10-24 2011-12-07 Biotica Tech Ltd Novel dosage form
WO2013172782A1 (en) * 2012-05-16 2013-11-21 Nanyang Technological University A polyketide synthase construct and its use in the preparation of polyketides
WO2016112295A1 (en) 2015-01-09 2016-07-14 Warp Drive Bio, Inc. Compounds that participate in cooperative binding and uses thereof
US10907188B2 (en) 2016-04-12 2021-02-02 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
AU2017303863B2 (en) 2016-07-29 2022-12-15 Isomerase Therapeutics Limited Novel methods
AU2017350898A1 (en) * 2016-10-28 2019-06-13 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
US11479797B2 (en) 2016-10-28 2022-10-25 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
WO2018153959A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
CN110741011A (zh) 2017-02-22 2020-01-31 免疫系统调节控股有限公司 新型免疫刺激大环内酯
JP2021523930A (ja) 2018-03-23 2021-09-09 アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） マクロライド化合物と免疫チェックポイント阻害剤との組み合わせ
BR112021014479A2 (pt) 2019-01-22 2021-10-13 Aeovian Pharmaceuticals, Inc. Moduladores de mtorc e seus usos
WO2021091956A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
JP2022553857A (ja) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド Ｒａｓ阻害剤
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer
KR20240014756A (ko) 2022-07-26 2024-02-02 강원대학교산학협력단 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
CN117288869B (zh) * 2023-11-24 2024-02-09 中国医学科学院医药生物技术研究所 一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
DE69434408T2 (de) * 1993-09-20 2006-03-16 The Leland Stanford Junior University, Palo Alto Recombinante Herstellung aromatischer Polyketiden

Also Published As

Publication number Publication date
IL127916A0 (en) 1999-11-30
NO990012D0 (no) 1999-01-04
EE9900014A (et) 1999-08-16
WO1998001571A3 (en) 1998-02-19
JP4173551B2 (ja) 2008-10-29
WO1998001546A3 (en) 1998-04-09
DE69733416D1 (de) 2005-07-07
CN1179046C (zh) 2004-12-08
WO1998001546A2 (en) 1998-01-15
DE69739688D1 (de) 2010-01-21
SI0910633T1 (sl) 2010-04-30
GB9900156D0 (en) 1999-02-24
ES2244001T3 (es) 2005-12-01
EP0909327B1 (en) 2005-06-01
AP1029A (en) 2001-12-11
SK182498A3 (en) 2000-05-16
JP2000516450A (ja) 2000-12-12
EA199900087A1 (ru) 1999-08-26
TR199900006T2 (xx) 1999-04-21
AU731654B2 (en) 2001-04-05
DK0909327T3 (da) 2005-09-26
BR9710209A (pt) 2000-01-11
ATE451455T1 (de) 2009-12-15
BG103133A (en) 2000-04-28
CA2259420A1 (en) 1998-01-15
PT909327E (pt) 2005-10-31
PL331285A1 (en) 1999-07-05
CA2259463A1 (en) 1998-01-15
GEP20012348B (en) 2001-01-25
EP2182067A2 (en) 2010-05-05
CN1229438A (zh) 1999-09-22
KR20000023579A (ko) 2000-04-25
AP9901444A0 (en) 1999-03-31
AU731301B2 (en) 2001-03-29
EP0909327A2 (en) 1999-04-21
AU3450997A (en) 1998-02-02
CA2259420C (en) 2007-09-18
NO990012L (no) 1999-02-23
ATE296893T1 (de) 2005-06-15
ES2337424T3 (es) 2010-04-23
GB2331518A (en) 1999-05-26
DE69733416T2 (de) 2006-04-27
JP2000511063A (ja) 2000-08-29
DK0910633T3 (da) 2010-03-29
EP0910633B1 (en) 2009-12-09
EE03976B1 (et) 2003-02-17
NZ333861A (en) 2000-08-25
EP2182067A3 (en) 2010-07-14
IS4940A (is) 1999-01-04
EA001744B1 (ru) 2001-08-27
WO1998001571A2 (en) 1998-01-15
GB2331518B (en) 2001-03-14
AU3451497A (en) 1998-02-02
EP0910633A2 (en) 1999-04-28

Similar Documents

Publication Publication Date Title
EP0909327B1 (en) Erythromycins and process for their preparation
US6271255B1 (en) Erythromycins and process for their preparation
US6472371B1 (en) Macrolides
EP1244800B1 (en) Rapamycin analogs
US6825171B2 (en) Erythromycin derivatives
KR20010071684A (ko) 폴리케타이드 및 그들의 합성방법
AU2003217591B2 (en) Novel spinosyn-producing polyketide synthases
US7807418B2 (en) Method for producing hybrid polyketide synthases
EP1602727A2 (en) Novel erythromycins and process for their preparation
CZ437598A3 (cs) Erythromyciny, způsoby jejich výroby, farmaceutická kompozice na jejich bázi, způsob léčení a použití
JP2009213479A (ja) ポリケチド類及びそれらの合成
HRP20000474A2 (en) Polyketides and their synthesis
MXPA00006604A (en) Novel macrolides
MXPA01010817A (en) 13-methyl-erythromycin derivatives