EE03976B1 - Erütromütsiinid ja nende valmistamise meetod - Google Patents
Erütromütsiinid ja nende valmistamise meetodInfo
- Publication number
- EE03976B1 EE03976B1 EEP199900014A EE9900014A EE03976B1 EE 03976 B1 EE03976 B1 EE 03976B1 EE P199900014 A EEP199900014 A EE P199900014A EE 9900014 A EE9900014 A EE 9900014A EE 03976 B1 EE03976 B1 EE 03976B1
- Authority
- EE
- Estonia
- Prior art keywords
- erythromycins
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9614189.0A GB9614189D0 (en) | 1996-07-05 | 1996-07-05 | Polyketides and their synthesis |
US2418896P | 1996-08-19 | 1996-08-19 | |
GBGB9710962.3A GB9710962D0 (en) | 1997-05-28 | 1997-05-28 | Polyketides and their synthesis |
PCT/GB1997/001810 WO1998001571A2 (en) | 1996-07-05 | 1997-07-04 | Erythromycins and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9900014A EE9900014A (et) | 1999-08-16 |
EE03976B1 true EE03976B1 (et) | 2003-02-17 |
Family
ID=27268361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP199900014A EE03976B1 (et) | 1996-07-05 | 1997-07-04 | Erütromütsiinid ja nende valmistamise meetod |
Country Status (28)
Country | Link |
---|---|
EP (3) | EP0910633B1 (xx) |
JP (2) | JP4173551B2 (xx) |
KR (1) | KR20000023579A (xx) |
CN (1) | CN1179046C (xx) |
AP (1) | AP1029A (xx) |
AT (2) | ATE296893T1 (xx) |
AU (2) | AU731654B2 (xx) |
BG (1) | BG103133A (xx) |
BR (1) | BR9710209A (xx) |
CA (2) | CA2259420C (xx) |
DE (2) | DE69739688D1 (xx) |
DK (2) | DK0910633T3 (xx) |
EA (1) | EA001744B1 (xx) |
EE (1) | EE03976B1 (xx) |
ES (2) | ES2337424T3 (xx) |
GB (1) | GB2331518B (xx) |
GE (1) | GEP20012348B (xx) |
IL (1) | IL127916A0 (xx) |
IS (1) | IS4940A (xx) |
NO (1) | NO990012L (xx) |
NZ (1) | NZ333861A (xx) |
OA (1) | OA10952A (xx) |
PL (1) | PL331285A1 (xx) |
PT (1) | PT909327E (xx) |
SI (1) | SI0910633T1 (xx) |
SK (1) | SK182498A3 (xx) |
TR (1) | TR199900006T2 (xx) |
WO (2) | WO1998001546A2 (xx) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US6063561A (en) * | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US6927057B2 (en) | 1993-09-20 | 2005-08-09 | Kosan Biosciences | Macrolide analogs |
US6558942B1 (en) | 1994-05-06 | 2003-05-06 | The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US20030170725A1 (en) | 1993-09-20 | 2003-09-11 | Chaitan Khosla | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US6500960B1 (en) | 1995-07-06 | 2002-12-31 | Stanford University (Board Of Trustees Of The Leland Stanford Junior University) | Method to produce novel polyketides |
US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
AU706445B2 (en) | 1995-07-06 | 1999-06-17 | Brown University Research Foundation | Cell-free synthesis of polyketides |
US6600029B1 (en) | 1995-12-19 | 2003-07-29 | Regents Of The University Of Minnesota | Metabolic engineering of polyhydroxyalkanoate monomer synthases |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
US6399789B1 (en) | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
US6117659A (en) * | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6902913B2 (en) | 1997-04-30 | 2005-06-07 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6503741B1 (en) | 1998-05-28 | 2003-01-07 | Kosan Biosciences, Inc. | Polyketide synthase genes from Streptomyces venezuelae |
JP2008169226A (ja) * | 1997-04-30 | 2008-07-24 | Kosan Biosciences Inc | 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー |
CA2288030A1 (en) | 1997-04-30 | 1998-11-05 | Kosan Biosciences, Inc. | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold |
CN1188520C (zh) | 1997-07-10 | 2005-02-09 | 高山生物科学股份有限公司 | 在植物中生产聚酮化合物 |
AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
EP1045912A1 (en) * | 1998-01-14 | 2000-10-25 | Glaxo Group Limited | Polyketides and their synthesis |
CA2328427A1 (en) * | 1998-05-28 | 1999-12-02 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
GB9814006D0 (en) * | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
AU765821B2 (en) | 1998-07-02 | 2003-10-02 | Board Of Regents Of The Leland Stanford Junior University, The | Methods for making polyketides |
GB9814622D0 (en) * | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
JP2002528467A (ja) | 1998-10-28 | 2002-09-03 | コーサン バイオサイエンシーズ, インコーポレイテッド | 新規な「不自然な(unnatural)」天然生成物のライブラリ |
TR200200436T2 (tr) | 1998-11-03 | 2002-06-21 | Pfizer Inc. | Yeni makrolit antibiyotikler |
US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
BR9916969A (pt) | 1999-01-27 | 2001-11-06 | Pfizer Prod Inc | Antibióticos cetólidos |
US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
WO2000047724A2 (en) * | 1999-02-09 | 2000-08-17 | Board Of Trustees Of The Leland Stanford Junior University | Methods to mediate polyketide synthase module effectiveness |
KR100710605B1 (ko) | 1999-04-16 | 2007-04-24 | 코산 바이오사이언시즈, 인코포레이티드 | 매크롤라이드 항감염제 |
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6399582B1 (en) | 1999-04-16 | 2002-06-04 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
AU3832100A (en) | 1999-05-24 | 2000-12-12 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
GB9912563D0 (en) * | 1999-05-28 | 1999-07-28 | Biotica Tech Ltd | Polyketides and their synthesis |
WO2001034816A1 (en) * | 1999-10-29 | 2001-05-17 | Kosan Biosciences, Inc. | Rapamycin analogs |
EP1101769A3 (en) | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Nitrogen containing erythromycin derivatives |
CA2399198A1 (en) | 2000-02-18 | 2001-08-23 | Christopher Carreras | Motilide compounds |
EP1146051A3 (en) * | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Erythromycin A derivatives |
EP1278881B1 (en) | 2000-04-13 | 2009-12-30 | Biotica Technology Limited | Hybrid glycosylated products and their production and use |
KR101016561B1 (ko) | 2002-02-19 | 2011-02-22 | 다우 아그로사이언시즈 엘엘씨 | 신규한 스피노신 생산 폴리케타이드 신타제 |
EP1655372A3 (en) | 2002-07-16 | 2008-01-16 | Biotica Technology Limited | Production of polyketides and other natural products |
DK200201957A (da) * | 2002-12-20 | 2003-01-20 | Alpharma Aps | 10-substituted erythromycin ketolides and methods of making |
GB0230217D0 (en) * | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
EP1638529B1 (en) | 2003-06-16 | 2016-08-10 | ANDRX Pharmaceuticals, LLC. | Oral extended-release composition |
GB0327720D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
US8962329B2 (en) | 2008-09-24 | 2015-02-24 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Gene cluster |
GB0904540D0 (en) | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
CN101519637B (zh) * | 2009-04-07 | 2011-06-15 | 华东理工大学 | 一种红色糖多孢菌及其发酵生产红霉素的方法 |
GB0914589D0 (en) | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
BR112012019866A8 (pt) | 2010-02-09 | 2017-12-26 | Biotica Tech Limited | Composto, uso do mesmo, composição farmacêutica, e, processo para preparar um composto |
WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
WO2013172782A1 (en) * | 2012-05-16 | 2013-11-21 | Nanyang Technological University | A polyketide synthase construct and its use in the preparation of polyketides |
EP4289950A3 (en) | 2015-01-09 | 2024-01-24 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
MA44680A (fr) | 2016-04-12 | 2019-02-20 | Warp Drive Bio Inc | Compositions et procédés pour la production de composés |
US11781128B2 (en) | 2016-07-29 | 2023-10-10 | Isomerase Therapeutics Limited | Methods for producing hybrid polyketide synthase genes and polyketides |
EP3532055A4 (en) * | 2016-10-28 | 2020-10-21 | Ginkgo Bioworks Inc. | COMPOSITIONS AND PROCESSES FOR THE PRODUCTION OF COMPOUNDS |
WO2018081592A2 (en) | 2016-10-28 | 2018-05-03 | Warp Drive Bio, Inc. | Compositions and methods for the production of compounds |
CA3053874A1 (en) | 2017-02-22 | 2018-08-30 | Immune System Regulation Holding Ab | Novel immune stimulating macrolides |
AU2018225390B2 (en) | 2017-02-22 | 2021-07-22 | ISR Immune System Regulation Holding AB (publ) | Novel immune stimulating macrolides |
CA3094747A1 (en) | 2018-03-23 | 2019-09-26 | ISR Immune System Regulation Holding AB (publ) | Combinations of macrolide compounds and immune checkpoint inhibitors |
EP3914245A4 (en) | 2019-01-22 | 2022-08-24 | Aeovian Pharmaceuticals, Inc. | MTORC MODULATORS AND THEIR USES |
JP2022553858A (ja) | 2019-11-04 | 2022-12-26 | レボリューション メディシンズ インコーポレイテッド | Ras阻害剤 |
MX2022005360A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
CR20220240A (es) | 2019-11-04 | 2022-08-03 | Revolution Medicines Inc | Inhibidores de ras |
JP2023541916A (ja) | 2020-09-15 | 2023-10-04 | レボリューション メディシンズ インコーポレイテッド | がんの治療における、ras阻害剤としてのインドール誘導体 |
KR20240014756A (ko) | 2022-07-26 | 2024-02-02 | 강원대학교산학협력단 | 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법 |
CN117288869B (zh) * | 2023-11-24 | 2024-02-09 | 中国医学科学院医药生物技术研究所 | 一种原料药中对甲苯磺酸酯类杂质的检测方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993013663A1 (en) * | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
DK0725778T3 (da) * | 1993-09-20 | 2001-12-17 | Univ Leland Stanford Junior | Rekombinant produktion af hidtil ukendte polyketider |
-
1997
- 1997-07-04 EP EP97930631A patent/EP0910633B1/en not_active Expired - Lifetime
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en active Application Filing
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Application Discontinuation
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 EP EP97930626A patent/EP0909327B1/en not_active Expired - Lifetime
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 EE EEP199900014A patent/EE03976B1/xx not_active IP Right Cessation
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 EP EP09178121A patent/EP2182067A3/en not_active Withdrawn
-
1999
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Application Discontinuation
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown
Also Published As
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