EE03976B1 - Erütromütsiinid ja nende valmistamise meetod - Google Patents

Erütromütsiinid ja nende valmistamise meetod

Info

Publication number
EE03976B1
EE03976B1 EEP199900014A EE9900014A EE03976B1 EE 03976 B1 EE03976 B1 EE 03976B1 EE P199900014 A EEP199900014 A EE P199900014A EE 9900014 A EE9900014 A EE 9900014A EE 03976 B1 EE03976 B1 EE 03976B1
Authority
EE
Estonia
Prior art keywords
erythromycins
preparation
Prior art date
Application number
EEP199900014A
Other languages
English (en)
Estonian (et)
Other versions
EE9900014A (et
Inventor
Francis Leadlay Peter
Stephen Pacey Michael
Staunton James
Cortes Jesus
Original Assignee
Biotica Technology Limited
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Technology Limited, Pfizer Inc. filed Critical Biotica Technology Limited
Publication of EE9900014A publication Critical patent/EE9900014A/xx
Publication of EE03976B1 publication Critical patent/EE03976B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EEP199900014A 1996-07-05 1997-07-04 Erütromütsiinid ja nende valmistamise meetod EE03976B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (en) 1996-07-05 1997-07-04 Erythromycins and process for their preparation

Publications (2)

Publication Number Publication Date
EE9900014A EE9900014A (et) 1999-08-16
EE03976B1 true EE03976B1 (et) 2003-02-17

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900014A EE03976B1 (et) 1996-07-05 1997-07-04 Erütromütsiinid ja nende valmistamise meetod

Country Status (28)

Country Link
EP (3) EP0910633B1 (xx)
JP (2) JP4173551B2 (xx)
KR (1) KR20000023579A (xx)
CN (1) CN1179046C (xx)
AP (1) AP1029A (xx)
AT (2) ATE296893T1 (xx)
AU (2) AU731654B2 (xx)
BG (1) BG103133A (xx)
BR (1) BR9710209A (xx)
CA (2) CA2259420C (xx)
DE (2) DE69739688D1 (xx)
DK (2) DK0910633T3 (xx)
EA (1) EA001744B1 (xx)
EE (1) EE03976B1 (xx)
ES (2) ES2337424T3 (xx)
GB (1) GB2331518B (xx)
GE (1) GEP20012348B (xx)
IL (1) IL127916A0 (xx)
IS (1) IS4940A (xx)
NO (1) NO990012L (xx)
NZ (1) NZ333861A (xx)
OA (1) OA10952A (xx)
PL (1) PL331285A1 (xx)
PT (1) PT909327E (xx)
SI (1) SI0910633T1 (xx)
SK (1) SK182498A3 (xx)
TR (1) TR199900006T2 (xx)
WO (2) WO1998001546A2 (xx)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
AU706445B2 (en) 1995-07-06 1999-06-17 Brown University Research Foundation Cell-free synthesis of polyketides
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6117659A (en) * 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
JP2008169226A (ja) * 1997-04-30 2008-07-24 Kosan Biosciences Inc 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
CA2288030A1 (en) 1997-04-30 1998-11-05 Kosan Biosciences, Inc. Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
CN1188520C (zh) 1997-07-10 2005-02-09 高山生物科学股份有限公司 在植物中生产聚酮化合物
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1045912A1 (en) * 1998-01-14 2000-10-25 Glaxo Group Limited Polyketides and their synthesis
CA2328427A1 (en) * 1998-05-28 1999-12-02 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
AU765821B2 (en) 1998-07-02 2003-10-02 Board Of Regents Of The Leland Stanford Junior University, The Methods for making polyketides
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
JP2002528467A (ja) 1998-10-28 2002-09-03 コーサン バイオサイエンシーズ， インコーポレイテッド 新規な「不自然な（ｕｎｎａｔｕｒａｌ）」天然生成物のライブラリ
TR200200436T2 (tr) 1998-11-03 2002-06-21 Pfizer Inc. Yeni makrolit antibiyotikler
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
BR9916969A (pt) 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
WO2000047724A2 (en) * 1999-02-09 2000-08-17 Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
KR100710605B1 (ko) 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
AU3832100A (en) 1999-05-24 2000-12-12 Pfizer Products Inc. 13-methyl-erythromycin derivatives
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
WO2001034816A1 (en) * 1999-10-29 2001-05-17 Kosan Biosciences, Inc. Rapamycin analogs
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
CA2399198A1 (en) 2000-02-18 2001-08-23 Christopher Carreras Motilide compounds
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
EP1278881B1 (en) 2000-04-13 2009-12-30 Biotica Technology Limited Hybrid glycosylated products and their production and use
KR101016561B1 (ko) 2002-02-19 2011-02-22 다우 아그로사이언시즈 엘엘씨 신규한 스피노신 생산 폴리케타이드 신타제
EP1655372A3 (en) 2002-07-16 2008-01-16 Biotica Technology Limited Production of polyketides and other natural products
DK200201957A (da) * 2002-12-20 2003-01-20 Alpharma Aps 10-substituted erythromycin ketolides and methods of making
GB0230217D0 (en) * 2002-12-27 2003-02-05 Biotica Tech Ltd Borrelidin-producing polyketide synthase and its uses
EP1638529B1 (en) 2003-06-16 2016-08-10 ANDRX Pharmaceuticals, LLC. Oral extended-release composition
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
US8962329B2 (en) 2008-09-24 2015-02-24 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Gene cluster
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
CN101519637B (zh) * 2009-04-07 2011-06-15 华东理工大学 一种红色糖多孢菌及其发酵生产红霉素的方法
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
BR112012019866A8 (pt) 2010-02-09 2017-12-26 Biotica Tech Limited Composto, uso do mesmo, composição farmacêutica, e, processo para preparar um composto
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
GB201118334D0 (en) 2011-10-24 2011-12-07 Biotica Tech Ltd Novel dosage form
WO2013172782A1 (en) * 2012-05-16 2013-11-21 Nanyang Technological University A polyketide synthase construct and its use in the preparation of polyketides
EP4289950A3 (en) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
MA44680A (fr) 2016-04-12 2019-02-20 Warp Drive Bio Inc Compositions et procédés pour la production de composés
US11781128B2 (en) 2016-07-29 2023-10-10 Isomerase Therapeutics Limited Methods for producing hybrid polyketide synthase genes and polyketides
EP3532055A4 (en) * 2016-10-28 2020-10-21 Ginkgo Bioworks Inc. COMPOSITIONS AND PROCESSES FOR THE PRODUCTION OF COMPOUNDS
WO2018081592A2 (en) 2016-10-28 2018-05-03 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
CA3053874A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
AU2018225390B2 (en) 2017-02-22 2021-07-22 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating macrolides
CA3094747A1 (en) 2018-03-23 2019-09-26 ISR Immune System Regulation Holding AB (publ) Combinations of macrolide compounds and immune checkpoint inhibitors
EP3914245A4 (en) 2019-01-22 2022-08-24 Aeovian Pharmaceuticals, Inc. MTORC MODULATORS AND THEIR USES
JP2022553858A (ja) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド Ｒａｓ阻害剤
MX2022005360A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
CR20220240A (es) 2019-11-04 2022-08-03 Revolution Medicines Inc Inhibidores de ras
JP2023541916A (ja) 2020-09-15 2023-10-04 レボリューション メディシンズ インコーポレイテッド がんの治療における、ｒａｓ阻害剤としてのインドール誘導体
KR20240014756A (ko) 2022-07-26 2024-02-02 강원대학교산학협력단 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
CN117288869B (zh) * 2023-11-24 2024-02-09 中国医学科学院医药生物技术研究所 一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
DK0725778T3 (da) * 1993-09-20 2001-12-17 Univ Leland Stanford Junior Rekombinant produktion af hidtil ukendte polyketider

Also Published As

Publication number Publication date
CA2259463A1 (en) 1998-01-15
ATE296893T1 (de) 2005-06-15
CN1179046C (zh) 2004-12-08
GB9900156D0 (en) 1999-02-24
EP2182067A3 (en) 2010-07-14
DE69739688D1 (de) 2010-01-21
PT909327E (pt) 2005-10-31
ES2337424T3 (es) 2010-04-23
SI0910633T1 (sl) 2010-04-30
KR20000023579A (ko) 2000-04-25
DK0910633T3 (da) 2010-03-29
NZ333861A (en) 2000-08-25
AU731654B2 (en) 2001-04-05
JP4173551B2 (ja) 2008-10-29
NO990012L (no) 1999-02-23
EP0909327B1 (en) 2005-06-01
CN1229438A (zh) 1999-09-22
JP2000516450A (ja) 2000-12-12
EP0910633B1 (en) 2009-12-09
AU3450997A (en) 1998-02-02
AU3451497A (en) 1998-02-02
EP0910633A2 (en) 1999-04-28
PL331285A1 (en) 1999-07-05
WO1998001546A2 (en) 1998-01-15
AP1029A (en) 2001-12-11
CA2259420C (en) 2007-09-18
IL127916A0 (en) 1999-11-30
GB2331518B (en) 2001-03-14
TR199900006T2 (xx) 1999-04-21
ATE451455T1 (de) 2009-12-15
EP0909327A2 (en) 1999-04-21
GB2331518A (en) 1999-05-26
IS4940A (is) 1999-01-04
WO1998001571A3 (en) 1998-02-19
EE9900014A (et) 1999-08-16
DK0909327T3 (da) 2005-09-26
DE69733416T2 (de) 2006-04-27
NO990012D0 (no) 1999-01-04
BR9710209A (pt) 2000-01-11
EP2182067A2 (en) 2010-05-05
DE69733416D1 (de) 2005-07-07
SK182498A3 (en) 2000-05-16
EA199900087A1 (ru) 1999-08-26
CA2259420A1 (en) 1998-01-15
AP9901444A0 (en) 1999-03-31
OA10952A (en) 2002-02-25
AU731301B2 (en) 2001-03-29
EA001744B1 (ru) 2001-08-27
ES2244001T3 (es) 2005-12-01
GEP20012348B (en) 2001-01-25
WO1998001571A2 (en) 1998-01-15
WO1998001546A3 (en) 1998-04-09
BG103133A (en) 2000-04-28
JP2000511063A (ja) 2000-08-29

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