PT909327E - Eritromicinas e processo para a sua preparacao - Google Patents

Eritromicinas e processo para a sua preparacao

Info

Publication number
PT909327E
PT909327E PT97930626T PT97930626T PT909327E PT 909327 E PT909327 E PT 909327E PT 97930626 T PT97930626 T PT 97930626T PT 97930626 T PT97930626 T PT 97930626T PT 909327 E PT909327 E PT 909327E
Authority
PT
Portugal
Prior art keywords
erythromycines
preparation
Prior art date
Application number
PT97930626T
Other languages
English (en)
Inventor
Leadlay Peter Francis
Staunton James
Cortes Jesus
Pacey Michael Stephen
Original Assignee
Pfizer
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Pfizer, Biotica Tech Ltd filed Critical Pfizer
Publication of PT909327E publication Critical patent/PT909327E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT97930626T 1996-07-05 1997-07-04 Eritromicinas e processo para a sua preparacao PT909327E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
PT909327E true PT909327E (pt) 2005-10-31

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97930626T PT909327E (pt) 1996-07-05 1997-07-04 Eritromicinas e processo para a sua preparacao

Country Status (28)

Country Link
EP (3) EP0909327B1 (pt)
JP (2) JP2000511063A (pt)
KR (1) KR20000023579A (pt)
CN (1) CN1179046C (pt)
AP (1) AP1029A (pt)
AT (2) ATE451455T1 (pt)
AU (2) AU731654B2 (pt)
BG (1) BG103133A (pt)
BR (1) BR9710209A (pt)
CA (2) CA2259463A1 (pt)
DE (2) DE69733416T2 (pt)
DK (2) DK0910633T3 (pt)
EA (1) EA001744B1 (pt)
EE (1) EE03976B1 (pt)
ES (2) ES2337424T3 (pt)
GB (1) GB2331518B (pt)
GE (1) GEP20012348B (pt)
IL (1) IL127916A0 (pt)
IS (1) IS4940A (pt)
NO (1) NO990012L (pt)
NZ (1) NZ333861A (pt)
OA (1) OA10952A (pt)
PL (1) PL331285A1 (pt)
PT (1) PT909327E (pt)
SI (1) SI0910633T1 (pt)
SK (1) SK182498A3 (pt)
TR (1) TR199900006T2 (pt)
WO (2) WO1998001546A2 (pt)

Families Citing this family (76)

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US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
WO1997002358A1 (en) 1995-07-06 1997-01-23 The Leland Stanford Junior University Cell-free synthesis of polyketides
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6117659A (en) 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
JP2008169226A (ja) * 1997-04-30 2008-07-24 Kosan Biosciences Inc 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
AU744751C (en) 1997-07-10 2005-11-24 Kosan Biosciences, Inc. Production of polyketides in plants
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US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
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AU765821B2 (en) 1998-07-02 2003-10-02 Board Of Regents Of The Leland Stanford Junior University, The Methods for making polyketides
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CA2349338C (en) 1998-11-03 2005-12-06 Pfizer Products Inc. Novel macrolide antibiotics
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
BR9916969A (pt) 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
JP2002536014A (ja) * 1999-02-09 2002-10-29 ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ ポリケチドシンターゼモジュールの有効性を媒介する方法
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
AU4354900A (en) 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
ES2272273T3 (es) 1999-04-16 2007-05-01 Kosan Biosciences, Inc. Agentes antiinfecciosos macrolidos.
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
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GB0230217D0 (en) * 2002-12-27 2003-02-05 Biotica Tech Ltd Borrelidin-producing polyketide synthase and its uses
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GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
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US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
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WO2013172782A1 (en) * 2012-05-16 2013-11-21 Nanyang Technological University A polyketide synthase construct and its use in the preparation of polyketides
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EP3491132B1 (en) 2016-07-29 2021-09-08 Isomerase Therapeutics Limited Methods and constructs for producing hybrid polyketides (pks) of a type 1 modular pks or hybrid modular non ribosomal peptides (nrps)
AU2017350898A1 (en) * 2016-10-28 2019-06-13 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
US11479797B2 (en) 2016-10-28 2022-10-25 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
JP7100652B2 (ja) 2017-02-22 2022-07-13 アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） 新規免疫刺激マクロライド
WO2018153960A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
EP3768277A1 (en) 2018-03-23 2021-01-27 Isr Immune System Regulation Holding Ab (Publ) Combinations of macrolide compounds and immune checkpoint inhibitors
EA202191983A1 (ru) 2019-01-22 2021-12-01 Аеовиан Фармасьютикалз, Инк. МОДУЛЯТОРЫ mTORC И ИХ ПРИМЕНЕНИЕ
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JP2022553859A (ja) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド Ｒａｓ阻害剤
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
KR20240014756A (ko) 2022-07-26 2024-02-02 강원대학교산학협력단 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
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WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
ES2240259T3 (es) * 1993-09-20 2005-10-16 The Leland Stanford Junior University Produccion recombinante de poliquetidos aromaticos.

Also Published As

Publication number Publication date
EP0909327B1 (en) 2005-06-01
GB9900156D0 (en) 1999-02-24
BR9710209A (pt) 2000-01-11
WO1998001571A2 (en) 1998-01-15
CN1229438A (zh) 1999-09-22
WO1998001546A2 (en) 1998-01-15
GEP20012348B (en) 2001-01-25
JP4173551B2 (ja) 2008-10-29
EE9900014A (et) 1999-08-16
ES2244001T3 (es) 2005-12-01
DE69739688D1 (de) 2010-01-21
EA001744B1 (ru) 2001-08-27
IL127916A0 (en) 1999-11-30
GB2331518B (en) 2001-03-14
SI0910633T1 (sl) 2010-04-30
EP0910633A2 (en) 1999-04-28
EE03976B1 (et) 2003-02-17
DE69733416T2 (de) 2006-04-27
CA2259420C (en) 2007-09-18
CA2259420A1 (en) 1998-01-15
AU3451497A (en) 1998-02-02
EP0909327A2 (en) 1999-04-21
EA199900087A1 (ru) 1999-08-26
NZ333861A (en) 2000-08-25
BG103133A (en) 2000-04-28
EP2182067A3 (en) 2010-07-14
NO990012D0 (no) 1999-01-04
AU731654B2 (en) 2001-04-05
GB2331518A (en) 1999-05-26
AP1029A (en) 2001-12-11
JP2000511063A (ja) 2000-08-29
AU3450997A (en) 1998-02-02
DK0910633T3 (da) 2010-03-29
NO990012L (no) 1999-02-23
TR199900006T2 (xx) 1999-04-21
EP0910633B1 (en) 2009-12-09
CN1179046C (zh) 2004-12-08
IS4940A (is) 1999-01-04
DK0909327T3 (da) 2005-09-26
EP2182067A2 (en) 2010-05-05
JP2000516450A (ja) 2000-12-12
CA2259463A1 (en) 1998-01-15
SK182498A3 (en) 2000-05-16
PL331285A1 (en) 1999-07-05
DE69733416D1 (de) 2005-07-07
WO1998001571A3 (en) 1998-02-19
OA10952A (en) 2002-02-25
AP9901444A0 (en) 1999-03-31
KR20000023579A (ko) 2000-04-25
ES2337424T3 (es) 2010-04-23
AU731301B2 (en) 2001-03-29
ATE296893T1 (de) 2005-06-15
ATE451455T1 (de) 2009-12-15
WO1998001546A3 (en) 1998-04-09

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