DK0910633T3 - Hybrid polyketidsyntase I-gen - Google Patents
Hybrid polyketidsyntase I-genInfo
- Publication number
- DK0910633T3 DK0910633T3 DK97930631.3T DK97930631T DK0910633T3 DK 0910633 T3 DK0910633 T3 DK 0910633T3 DK 97930631 T DK97930631 T DK 97930631T DK 0910633 T3 DK0910633 T3 DK 0910633T3
- Authority
- DK
- Denmark
- Prior art keywords
- gene
- polyketide synthase
- hybrid polyketide
- hybrid
- synthase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9614189.0A GB9614189D0 (en) | 1996-07-05 | 1996-07-05 | Polyketides and their synthesis |
US2418896P | 1996-08-19 | 1996-08-19 | |
GBGB9710962.3A GB9710962D0 (en) | 1997-05-28 | 1997-05-28 | Polyketides and their synthesis |
PCT/GB1997/001819 WO1998001546A2 (en) | 1996-07-05 | 1997-07-04 | Polyketides and their synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0910633T3 true DK0910633T3 (da) | 2010-03-29 |
Family
ID=27268361
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97930626T DK0909327T3 (da) | 1996-07-05 | 1997-07-04 | Erythromyciner og fremgangsmåder til deres fremstilling |
DK97930631.3T DK0910633T3 (da) | 1996-07-05 | 1997-07-04 | Hybrid polyketidsyntase I-gen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97930626T DK0909327T3 (da) | 1996-07-05 | 1997-07-04 | Erythromyciner og fremgangsmåder til deres fremstilling |
Country Status (28)
Country | Link |
---|---|
EP (3) | EP0909327B1 (da) |
JP (2) | JP2000511063A (da) |
KR (1) | KR20000023579A (da) |
CN (1) | CN1179046C (da) |
AP (1) | AP1029A (da) |
AT (2) | ATE296893T1 (da) |
AU (2) | AU731301B2 (da) |
BG (1) | BG103133A (da) |
BR (1) | BR9710209A (da) |
CA (2) | CA2259463A1 (da) |
DE (2) | DE69733416T2 (da) |
DK (2) | DK0909327T3 (da) |
EA (1) | EA001744B1 (da) |
EE (1) | EE03976B1 (da) |
ES (2) | ES2337424T3 (da) |
GB (1) | GB2331518B (da) |
GE (1) | GEP20012348B (da) |
IL (1) | IL127916A0 (da) |
IS (1) | IS4940A (da) |
NO (1) | NO990012L (da) |
NZ (1) | NZ333861A (da) |
OA (1) | OA10952A (da) |
PL (1) | PL331285A1 (da) |
PT (1) | PT909327E (da) |
SI (1) | SI0910633T1 (da) |
SK (1) | SK182498A3 (da) |
TR (1) | TR199900006T2 (da) |
WO (2) | WO1998001546A2 (da) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US6063561A (en) * | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US6558942B1 (en) | 1994-05-06 | 2003-05-06 | The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US6500960B1 (en) | 1995-07-06 | 2002-12-31 | Stanford University (Board Of Trustees Of The Leland Stanford Junior University) | Method to produce novel polyketides |
US6927057B2 (en) | 1993-09-20 | 2005-08-09 | Kosan Biosciences | Macrolide analogs |
US20030170725A1 (en) | 1993-09-20 | 2003-09-11 | Chaitan Khosla | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
ATE286133T1 (de) | 1995-07-06 | 2005-01-15 | Univ Leland Stanford Junior | Zellfreie synthese von polyketiden |
US6600029B1 (en) | 1995-12-19 | 2003-07-29 | Regents Of The University Of Minnesota | Metabolic engineering of polyhydroxyalkanoate monomer synthases |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
US6399789B1 (en) | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
US6503741B1 (en) | 1998-05-28 | 2003-01-07 | Kosan Biosciences, Inc. | Polyketide synthase genes from Streptomyces venezuelae |
JP2008169226A (ja) * | 1997-04-30 | 2008-07-24 | Kosan Biosciences Inc | 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー |
CA2288030A1 (en) | 1997-04-30 | 1998-11-05 | Kosan Biosciences, Inc. | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold |
US6902913B2 (en) | 1997-04-30 | 2005-06-07 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6117659A (en) * | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
CA2294616A1 (en) | 1997-07-10 | 1999-01-21 | Kosan Biosciences, Inc. | Production of polyketides in plants |
AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
JP2002508968A (ja) * | 1998-01-14 | 2002-03-26 | グラクソ グループ リミテッド | ポリケチドおよびその合成 |
EP1082439A2 (en) * | 1998-05-28 | 2001-03-14 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
GB9814006D0 (en) | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
AU765821B2 (en) | 1998-07-02 | 2003-10-02 | Board Of Regents Of The Leland Stanford Junior University, The | Methods for making polyketides |
GB9814622D0 (en) * | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
WO2000024907A2 (en) | 1998-10-28 | 2000-05-04 | Kosan Biosciences, Inc. | Library of novel "unnatural" natural products |
HUP0104192A3 (en) | 1998-11-03 | 2003-12-29 | Pfizer Prod Inc | Novel macrolide antibiotics |
US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
BR9916969A (pt) | 1999-01-27 | 2001-11-06 | Pfizer Prod Inc | Antibióticos cetólidos |
US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
EP1153124A2 (en) * | 1999-02-09 | 2001-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to mediate polyketide synthase module effectiveness |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6458771B1 (en) | 1999-04-16 | 2002-10-01 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
WO2000063224A2 (en) | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
IL145739A0 (en) | 1999-05-24 | 2002-07-25 | Pfizer Prod Inc | 13-methyl-erythromycin derivatives |
GB9912563D0 (en) * | 1999-05-28 | 1999-07-28 | Biotica Tech Ltd | Polyketides and their synthesis |
AU2748701A (en) * | 1999-10-29 | 2001-06-06 | Kosan Biosciences, Inc. | Rapamycin analogs |
EP1101769A3 (en) | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Nitrogen containing erythromycin derivatives |
EP1255763A2 (en) | 2000-02-18 | 2002-11-13 | Kosan Biosciences, Inc. | Motilide compounds |
EP1146051A3 (en) * | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Erythromycin A derivatives |
CA2405958C (en) | 2000-04-13 | 2011-08-09 | Biotica Technology Limited | Hybrid glycosylated products and their production and use |
JP4765032B2 (ja) | 2002-02-19 | 2011-09-07 | ダウ・アグロサイエンス・エル・エル・シー | 新規スピノシンを産生するポリケチド合成酵素 |
JP2005532809A (ja) | 2002-07-16 | 2005-11-04 | バイオチカ テクノロジー リミテッド | ポリケチド、及び他の天然物の製造 |
DK200201957A (da) | 2002-12-20 | 2003-01-20 | Alpharma Aps | 10-substituted erythromycin ketolides and methods of making |
GB0230217D0 (en) * | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
PL1638529T3 (pl) | 2003-06-16 | 2017-03-31 | Andrx Pharmaceuticals, Llc. | Kompozycja doustna o przedłużonym uwalnianiu |
GB0327720D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
CN102224242B (zh) | 2008-09-24 | 2014-09-24 | 中国科学院上海有机化学研究所 | 新基因簇 |
GB0904540D0 (en) | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
CN101519637B (zh) * | 2009-04-07 | 2011-06-15 | 华东理工大学 | 一种红色糖多孢菌及其发酵生产红霉素的方法 |
GB0914589D0 (en) | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
EP2533784B1 (en) | 2010-02-09 | 2015-04-22 | Neurovive Pharmaceutical AB | Sanglifehrin based compounds |
WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
WO2013172782A1 (en) * | 2012-05-16 | 2013-11-21 | Nanyang Technological University | A polyketide synthase construct and its use in the preparation of polyketides |
US10533016B2 (en) | 2015-01-09 | 2020-01-14 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
US10907188B2 (en) | 2016-04-12 | 2021-02-02 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
WO2018020272A1 (en) | 2016-07-29 | 2018-02-01 | Isomerase Therapeutics Limited | Novel methods |
CA3042231A1 (en) | 2016-10-28 | 2018-05-03 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
US20190264184A1 (en) * | 2016-10-28 | 2019-08-29 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
AU2018225390B2 (en) | 2017-02-22 | 2021-07-22 | ISR Immune System Regulation Holding AB (publ) | Novel immune stimulating macrolides |
JP7100653B2 (ja) | 2017-02-22 | 2022-07-13 | アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ(パブル) | 新規な免疫刺激マクロライド |
US20210040134A1 (en) | 2018-03-23 | 2021-02-11 | ISR Immune System Regulation Holding AB (publ) | Combinations of macrolide compounds and immune checkpoint inhibitors |
BR112021014479A2 (pt) | 2019-01-22 | 2021-10-13 | Aeovian Pharmaceuticals, Inc. | Moduladores de mtorc e seus usos |
TW202132315A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ras 抑制劑 |
JP2022553859A (ja) | 2019-11-04 | 2022-12-26 | レボリューション メディシンズ インコーポレイテッド | Ras阻害剤 |
BR112022008565A2 (pt) | 2019-11-04 | 2022-08-09 | Revolution Medicines Inc | Composto, composição farmacêutica, conjugado, métodos para tratar câncer e um distúrbio relativo à proteína ras |
EP4214209A1 (en) | 2020-09-15 | 2023-07-26 | Revolution Medicines, Inc. | Indole derivatives as ras inhibitors in the treatment of cancer |
KR20240014756A (ko) | 2022-07-26 | 2024-02-02 | 강원대학교산학협력단 | 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법 |
CN117288869B (zh) * | 2023-11-24 | 2024-02-09 | 中国医学科学院医药生物技术研究所 | 一种原料药中对甲苯磺酸酯类杂质的检测方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
WO1993013663A1 (en) * | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
EP0725778B1 (en) * | 1993-09-20 | 2001-09-26 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
-
1997
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 EP EP97930626A patent/EP0909327B1/en not_active Expired - Lifetime
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 EP EP97930631A patent/EP0910633B1/en not_active Expired - Lifetime
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 EE EEP199900014A patent/EE03976B1/xx not_active IP Right Cessation
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en active Application Filing
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 EP EP09178121A patent/EP2182067A3/en not_active Withdrawn
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Application Discontinuation
-
1999
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Application Discontinuation
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown
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