SI0910633T1 - Hibridni gen poliketid-sintaze 1 - Google Patents

Hibridni gen poliketid-sintaze 1

Info

Publication number
SI0910633T1
SI0910633T1 SI9730793T SI9730793T SI0910633T1 SI 0910633 T1 SI0910633 T1 SI 0910633T1 SI 9730793 T SI9730793 T SI 9730793T SI 9730793 T SI9730793 T SI 9730793T SI 0910633 T1 SI0910633 T1 SI 0910633T1
Authority
SI
Slovenia
Prior art keywords
gene
polyketide synthase
hybrid polyketide
hybrid
synthase
Prior art date
Application number
SI9730793T
Other languages
English (en)
Inventor
Peter Francis Leadlay
James Staunton
Jesus Cortes
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Publication of SI0910633T1 publication Critical patent/SI0910633T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI9730793T 1996-07-05 1997-07-04 Hibridni gen poliketid-sintaze 1 SI0910633T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis
EP97930631A EP0910633B1 (en) 1996-07-05 1997-07-04 Hybrid polyketide synthase I gene
PCT/GB1997/001819 WO1998001546A2 (en) 1996-07-05 1997-07-04 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
SI0910633T1 true SI0910633T1 (sl) 2010-04-30

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730793T SI0910633T1 (sl) 1996-07-05 1997-07-04 Hibridni gen poliketid-sintaze 1

Country Status (28)

Country Link
EP (3) EP2182067A3 (sl)
JP (2) JP2000511063A (sl)
KR (1) KR20000023579A (sl)
CN (1) CN1179046C (sl)
AP (1) AP1029A (sl)
AT (2) ATE296893T1 (sl)
AU (2) AU731654B2 (sl)
BG (1) BG103133A (sl)
BR (1) BR9710209A (sl)
CA (2) CA2259420C (sl)
DE (2) DE69739688D1 (sl)
DK (2) DK0909327T3 (sl)
EA (1) EA001744B1 (sl)
EE (1) EE03976B1 (sl)
ES (2) ES2337424T3 (sl)
GB (1) GB2331518B (sl)
GE (1) GEP20012348B (sl)
IL (1) IL127916A0 (sl)
IS (1) IS4940A (sl)
NO (1) NO990012L (sl)
NZ (1) NZ333861A (sl)
OA (1) OA10952A (sl)
PL (1) PL331285A1 (sl)
PT (1) PT909327E (sl)
SI (1) SI0910633T1 (sl)
SK (1) SK182498A3 (sl)
TR (1) TR199900006T2 (sl)
WO (2) WO1998001571A2 (sl)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6080555A (en) 1995-07-06 2000-06-27 Stanford University Synthesis of polyketides from diketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6117659A (en) * 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
JP2008169226A (ja) * 1997-04-30 2008-07-24 Kosan Biosciences Inc 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
IL132590A0 (en) 1997-04-30 2001-03-19 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US6262340B1 (en) 1997-07-10 2001-07-17 Kosan Biosciences, Inc. Production of polyketides in plants
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AU2066799A (en) * 1998-01-14 1999-08-02 Glaxo Group Limited Polyketides and their synthesis
EP1082439A2 (en) * 1998-05-28 2001-03-14 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6265202B1 (en) * 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
US6221641B1 (en) 1998-07-02 2001-04-24 Leland Stanford Junior University Method for making polyketides
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
AU1447700A (en) 1998-10-28 2000-05-15 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
TR200200435T2 (tr) 1998-11-03 2002-07-22 Pfizer Products Inc. Yeni makrolit antibiyotikler.
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
HUP0105190A3 (en) 1999-01-27 2003-03-28 Pfizer Prod Inc Ketolide antibiotics, medicaments containing them and their use
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6753173B1 (en) 1999-02-09 2004-06-22 Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
KR100710605B1 (ko) 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
JP2003500414A (ja) 1999-05-24 2003-01-07 ファイザー・プロダクツ・インク １３−メチルエリスロマイシン誘導体
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
AU2748701A (en) 1999-10-29 2001-06-06 Kosan Biosciences, Inc. Rapamycin analogs
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
WO2001060833A2 (en) 2000-02-18 2001-08-23 Kosan Biosciences, Inc. Motilide compounds
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
DK1278881T3 (da) 2000-04-13 2010-05-10 Biotica Tech Ltd Glycosylerede hybrid-produkter og deres fremstilling og anvendelse
ES2375714T3 (es) * 2002-02-19 2012-03-05 Dow Agrosciences Llc Nuevas poliquétido-sintetasas productoras de espinosina.
EP1655372A3 (en) 2002-07-16 2008-01-16 Biotica Technology Limited Production of polyketides and other natural products
DK200201957A (da) 2002-12-20 2003-01-20 Alpharma Aps 10-substituted erythromycin ketolides and methods of making
GB0230217D0 (en) * 2002-12-27 2003-02-05 Biotica Tech Ltd Borrelidin-producing polyketide synthase and its uses
CA2673334C (en) 2003-06-16 2013-11-12 Andrx Pharmaceuticals, Llc Oral extended-release composition
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP2342335B1 (en) 2008-09-24 2015-09-16 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
CN101519637B (zh) * 2009-04-07 2011-06-15 华东理工大学 一种红色糖多孢菌及其发酵生产红霉素的方法
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
ES2541853T3 (es) 2010-02-09 2015-07-27 Neurovive Pharmaceutical Ab Compuestos basados en sangliferina
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
GB201118334D0 (en) 2011-10-24 2011-12-07 Biotica Tech Ltd Novel dosage form
WO2013172782A1 (en) * 2012-05-16 2013-11-21 Nanyang Technological University A polyketide synthase construct and its use in the preparation of polyketides
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
JP7187318B2 (ja) 2016-04-12 2022-12-12 ギンゴー バイオワークス， インコーポレイテッド 組換え異種ｌａｌを発現する宿主細胞、及び化合物の生産のための方法
EP3960857A1 (en) 2016-07-29 2022-03-02 Isomerase Therapeutics Limited Novel methods
KR20190099396A (ko) 2016-10-28 2019-08-27 징코 바이오웍스, 인크. 화합물의 생산을 위한 조성물 및 방법
JP2019533470A (ja) * 2016-10-28 2019-11-21 ギンゴー バイオワークス， インコーポレイテッド 化合物の生産のための組成物および方法
WO2018153960A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
JP7100652B2 (ja) 2017-02-22 2022-07-13 アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） 新規免疫刺激マクロライド
US20210040134A1 (en) 2018-03-23 2021-02-11 ISR Immune System Regulation Holding AB (publ) Combinations of macrolide compounds and immune checkpoint inhibitors
GB2586764B (en) 2019-01-22 2022-02-09 Aeovian Pharmaceuticals Inc MTORC modulators and uses thereof
CN114867735A (zh) 2019-11-04 2022-08-05 锐新医药公司 Ras抑制剂
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
CN115873020A (zh) 2019-11-04 2023-03-31 锐新医药公司 Ras抑制剂
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer
KR20240014756A (ko) 2022-07-26 2024-02-02 강원대학교산학협력단 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
CN117288869B (zh) * 2023-11-24 2024-02-09 中国医学科学院医药生物技术研究所 一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
DE69434408T2 (de) * 1993-09-20 2006-03-16 The Leland Stanford Junior University, Palo Alto Recombinante Herstellung aromatischer Polyketiden
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides

Also Published As

Publication number Publication date
AU731301B2 (en) 2001-03-29
PL331285A1 (en) 1999-07-05
WO1998001546A3 (en) 1998-04-09
CA2259463A1 (en) 1998-01-15
DK0909327T3 (da) 2005-09-26
EP0910633B1 (en) 2009-12-09
CA2259420C (en) 2007-09-18
EA001744B1 (ru) 2001-08-27
JP2000511063A (ja) 2000-08-29
EE03976B1 (et) 2003-02-17
GB9900156D0 (en) 1999-02-24
DE69733416D1 (de) 2005-07-07
WO1998001546A2 (en) 1998-01-15
BG103133A (en) 2000-04-28
PT909327E (pt) 2005-10-31
JP4173551B2 (ja) 2008-10-29
AP1029A (en) 2001-12-11
EP0909327A2 (en) 1999-04-21
CN1179046C (zh) 2004-12-08
ES2244001T3 (es) 2005-12-01
BR9710209A (pt) 2000-01-11
KR20000023579A (ko) 2000-04-25
GB2331518B (en) 2001-03-14
DE69739688D1 (de) 2010-01-21
IS4940A (is) 1999-01-04
IL127916A0 (en) 1999-11-30
WO1998001571A3 (en) 1998-02-19
TR199900006T2 (xx) 1999-04-21
ES2337424T3 (es) 2010-04-23
DE69733416T2 (de) 2006-04-27
AP9901444A0 (en) 1999-03-31
NO990012L (no) 1999-02-23
EP2182067A3 (en) 2010-07-14
NO990012D0 (no) 1999-01-04
AU3450997A (en) 1998-02-02
AU731654B2 (en) 2001-04-05
ATE451455T1 (de) 2009-12-15
CA2259420A1 (en) 1998-01-15
EE9900014A (et) 1999-08-16
EP0909327B1 (en) 2005-06-01
NZ333861A (en) 2000-08-25
GEP20012348B (en) 2001-01-25
OA10952A (en) 2002-02-25
ATE296893T1 (de) 2005-06-15
WO1998001571A2 (en) 1998-01-15
AU3451497A (en) 1998-02-02
GB2331518A (en) 1999-05-26
EA199900087A1 (ru) 1999-08-26
DK0910633T3 (da) 2010-03-29
SK182498A3 (en) 2000-05-16
EP0910633A2 (en) 1999-04-28
CN1229438A (zh) 1999-09-22
JP2000516450A (ja) 2000-12-12
EP2182067A2 (en) 2010-05-05

Similar Documents

Publication Publication Date Title
SI0910633T1 (sl) Hibridni gen poliketid-sintaze 1
AUPN958296A0 (en) Novel acc synthase genes from pineapple
AU9023798A (en) Mdm2-specific antisense oligonucleotides
AU5259498A (en) Antisense oligonucleotides
EP0974661A4 (en) GERANYL DIPHOSPHATE SYNTHESIS GENES
AU3652297A (en) Gene encoding hyaluronan synthase
AU6229098A (en) Cancer-associated genes
AU3758199A (en) Peptides for efficient gene transfer
IL136679A0 (en) Grafted copolymers as gene carriers
AU4173497A (en) Monocot seed gene expression system
AU6417799A (en) Matrix-remodeling genes
AU3981799A (en) Method for identifying genes
AU8234798A (en) Categorising nucleic acid
AU2750197A (en) Dna replication-regulating genes
EP1038957A4 (en) GENE TSA305
AU7364998A (en) Antisense oligonucleotides specific for thymidylate synthase
AU4513599A (en) Nucleotide sequence
EP1086244A4 (en) METHOD FOR DETECTING THE GENES OF RESTRICTION ENZYMES
AUPP058797A0 (en) Novel gene
AU2685499A (en) Cyclopropane-fatty-acyl-phospholipid synthase
GB9810997D0 (en) Genes & enzymes
AU1996397A (en) Novel ACC synthase genes from pineapple
DE59909194D1 (en) Aminoalkyl-3,4-dihydrochinolin-derivate als no synthase inhibitoren
GB9724828D0 (en) Gene
AUPN960396A0 (en) Novel acc synthase genes