AU7364998A - Antisense oligonucleotides specific for thymidylate synthase - Google Patents
Antisense oligonucleotides specific for thymidylate synthaseInfo
- Publication number
- AU7364998A AU7364998A AU73649/98A AU7364998A AU7364998A AU 7364998 A AU7364998 A AU 7364998A AU 73649/98 A AU73649/98 A AU 73649/98A AU 7364998 A AU7364998 A AU 7364998A AU 7364998 A AU7364998 A AU 7364998A
- Authority
- AU
- Australia
- Prior art keywords
- antisense oligonucleotides
- thymidylate synthase
- oligonucleotides specific
- specific
- thymidylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108020000948 Antisense Oligonucleotides Proteins 0.000 title 1
- 108010022394 Threonine synthase Proteins 0.000 title 1
- 102000005497 Thymidylate Synthase Human genes 0.000 title 1
- 239000000074 antisense oligonucleotide Substances 0.000 title 1
- 238000012230 antisense oligonucleotides Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01045—Thymidylate synthase (2.1.1.45)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4523097P | 1997-04-30 | 1997-04-30 | |
US60045230 | 1997-04-30 | ||
PCT/US1998/008722 WO1998049287A2 (en) | 1997-04-30 | 1998-04-30 | Antisense oligonucleotides specific for thymidylate synthase |
Publications (1)
Publication Number | Publication Date |
---|---|
AU7364998A true AU7364998A (en) | 1998-11-24 |
Family
ID=21936721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU73649/98A Abandoned AU7364998A (en) | 1997-04-30 | 1998-04-30 | Antisense oligonucleotides specific for thymidylate synthase |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU7364998A (en) |
WO (1) | WO1998049287A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE344835T1 (en) * | 1997-09-23 | 2006-11-15 | Sarissa Inc | ANTISENSE OLIGONUCLEOTIDES AGAINST THYMIDYLATE SYNTHASE |
US20060135450A1 (en) * | 2002-04-08 | 2006-06-22 | Sarissa Inc. | Combinations of antisense oligonucleotides directed against thymidylate synthase mrna and uses thereof |
US6087489A (en) * | 1998-06-02 | 2000-07-11 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of human thymidylate synthase expression |
WO2005093090A1 (en) * | 2004-03-26 | 2005-10-06 | Sarissa Inc. | Antisense oligonucleotides and uses thereof in improving cancer treatment strategies |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0619736A1 (en) * | 1991-12-31 | 1994-10-19 | Worcester Foundation For Biomedical Research, Inc. | Antiparasitic oligonucleotides active against drug resistant malaria |
US5652355A (en) * | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
-
1998
- 1998-04-30 WO PCT/US1998/008722 patent/WO1998049287A2/en active Application Filing
- 1998-04-30 AU AU73649/98A patent/AU7364998A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1998049287A3 (en) | 1999-02-04 |
WO1998049287A2 (en) | 1998-11-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |