DK1278881T3 - Glycosylerede hybrid-produkter og deres fremstilling og anvendelse - Google Patents

Glycosylerede hybrid-produkter og deres fremstilling og anvendelse

Info

Publication number
DK1278881T3
DK1278881T3 DK01921617.5T DK01921617T DK1278881T3 DK 1278881 T3 DK1278881 T3 DK 1278881T3 DK 01921617 T DK01921617 T DK 01921617T DK 1278881 T3 DK1278881 T3 DK 1278881T3
Authority
DK
Denmark
Prior art keywords
polyketides
polyketide
glycosylated
ability
preparation
Prior art date
Application number
DK01921617.5T
Other languages
English (en)
Inventor
Peter Francis Leadlay
James Staunton
Sabine Gaisser
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0009207.2A external-priority patent/GB0009207D0/en
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of DK1278881T3 publication Critical patent/DK1278881T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK01921617.5T 2000-04-13 2001-04-17 Glycosylerede hybrid-produkter og deres fremstilling og anvendelse DK1278881T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0009207.2A GB0009207D0 (en) 2000-04-13 2000-04-13 Hybrid glycosylated products and their production and use
US69421800A 2000-10-23 2000-10-23
PCT/GB2001/001743 WO2001079520A1 (en) 2000-04-13 2001-04-17 Hybrid glycosylated products and their production and use

Publications (1)

Publication Number Publication Date
DK1278881T3 true DK1278881T3 (da) 2010-05-10

Family

ID=26244108

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01921617.5T DK1278881T3 (da) 2000-04-13 2001-04-17 Glycosylerede hybrid-produkter og deres fremstilling og anvendelse

Country Status (10)

Country Link
US (1) US7482137B2 (da)
EP (1) EP1278881B1 (da)
JP (1) JP5037771B2 (da)
AT (1) ATE453719T1 (da)
AU (2) AU2001248588B2 (da)
CA (1) CA2405958C (da)
DE (1) DE60140936D1 (da)
DK (1) DK1278881T3 (da)
ES (1) ES2338212T3 (da)
WO (1) WO2001079520A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128680D0 (en) * 2001-11-29 2002-01-23 Biotica Tech Ltd Hybrid glycosylated products and their production and use
EP1655372A3 (en) 2002-07-16 2008-01-16 Biotica Technology Limited Production of polyketides and other natural products
EP2388333A3 (en) * 2003-06-19 2012-04-04 Evolva SA A method of producing a low molecular weight organic compound in a cell
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
WO2006003456A2 (en) * 2004-07-07 2006-01-12 Isis Innovation Limited Glycosylation of antibiotics
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
JP5196856B2 (ja) * 2007-05-14 2013-05-15 キヤノン株式会社 プローブセット、プローブ担体及び検査方法
US8962329B2 (en) 2008-09-24 2015-02-24 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Gene cluster
CN103849591B (zh) * 2012-12-05 2017-07-07 中国科学院上海有机化学研究所 一种泰乐菌素产生菌、遗传改造方法及其应用
CN103215282B (zh) * 2013-04-09 2016-08-03 中国科学院上海有机化学研究所 越野他汀的生物合成基因簇及其应用
WO2016074221A1 (zh) * 2014-11-14 2016-05-19 浙江海正药业股份有限公司 多杀菌素异源表达菌株及其构建方法和应用
CA3053874A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
AU2018225390B2 (en) 2017-02-22 2021-07-22 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating macrolides
CA3053993A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating compound
US10919927B2 (en) 2017-02-22 2021-02-16 ISR Immune System Regulation Holding AB (publ) Immune stimulating macrolide
CN107226830B (zh) * 2017-05-02 2019-12-10 北京理工大学 一种乙基多杀菌素的化学合成方法
CA3094747A1 (en) 2018-03-23 2019-09-26 ISR Immune System Regulation Holding AB (publ) Combinations of macrolide compounds and immune checkpoint inhibitors
EP3914245A4 (en) 2019-01-22 2022-08-24 Aeovian Pharmaceuticals, Inc. MTORC MODULATORS AND THEIR USES

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598805A (en) 1970-02-26 1971-08-10 Abbott Lab Erythromycin ester derivatives
US3697547A (en) * 1970-12-18 1972-10-10 Abbott Lab Erythronolide b derivatives
EP0056291B1 (en) * 1981-01-09 1986-01-08 Pierrel S.p.A. Novel semisynthetic macrolidic antibiotics, microbiological processes for their preparation and related microorganism, novel intermediate compounds for their preparation and related pharmaceutical compositions containing them
US4423148A (en) * 1982-07-02 1983-12-27 Eli Lilly And Company Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
WO1993013663A1 (en) 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
SE9201544L (sv) * 1991-05-31 1992-12-01 Ciba Geigy Ag Saett att framstaella glykosyltransferaser
GB2256197B (en) * 1991-05-31 1995-11-22 Ciba Geigy Ag Yeast as host for expression of heterologous glycosyl transferase enzymes
WO1993010248A1 (en) * 1991-11-14 1993-05-27 Novo Nordisk A/S A PROCESS FOR EXPRESSING GENES IN $i(BACILLUS LICHENIFORMIS)
DK0725778T3 (da) 1993-09-20 2001-12-17 Univ Leland Stanford Junior Rekombinant produktion af hidtil ukendte polyketider
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5834251A (en) 1994-12-30 1998-11-10 Alko Group Ltd. Methods of modifying carbohydrate moieties
US5998194A (en) 1995-12-21 1999-12-07 Abbott Laboratories Polyketide-associated sugar biosynthesis genes
EP0910633B1 (en) 1996-07-05 2009-12-09 Biotica Technology Limited Hybrid polyketide synthase I gene
US5871983A (en) 1996-09-13 1999-02-16 Eli Lilly And Company Glucosyltransferase gene GTFE from amycolatopsis orientalis
CA2288030A1 (en) * 1997-04-30 1998-11-05 Kosan Biosciences, Inc. Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
JP2001511349A (ja) 1997-07-25 2001-08-14 ヘキスト・マリオン・ルセル Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子
ZA989885B (en) 1997-10-31 1999-05-05 Abbott Lab Use of macrolides for the treatment of cancer and macular degeneration
GB9814006D0 (en) 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
WO2000004044A1 (en) 1998-07-14 2000-01-27 Princeton University Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same

Also Published As

Publication number Publication date
JP5037771B2 (ja) 2012-10-03
US7482137B2 (en) 2009-01-27
ES2338212T3 (es) 2010-05-05
ATE453719T1 (de) 2010-01-15
JP2003530857A (ja) 2003-10-21
CA2405958C (en) 2011-08-09
DE60140936D1 (de) 2010-02-11
WO2001079520A1 (en) 2001-10-25
AU4858801A (en) 2001-10-30
EP1278881B1 (en) 2009-12-30
CA2405958A1 (en) 2001-10-25
AU2001248588B2 (en) 2006-02-02
US20070092944A1 (en) 2007-04-26
EP1278881A1 (en) 2003-01-29

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