OA10952A - Erythromycins and process for their preparation - Google Patents

Erythromycins and process for their preparation Download PDF

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Publication number
OA10952A
OA10952A OA9900002A OA9900002A OA10952A OA 10952 A OA10952 A OA 10952A OA 9900002 A OA9900002 A OA 9900002A OA 9900002 A OA9900002 A OA 9900002A OA 10952 A OA10952 A OA 10952A
Authority
OA
OAPI
Prior art keywords
plasmid
compound
alkyl
erythraea
group
Prior art date
Application number
OA9900002A
Other languages
English (en)
Inventor
Peter Francis Leadlay
James Staunton
Jesus Cortes
Michael Stephen Pacey
Original Assignee
Biotica Tech Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd
Publication of OA10952A publication Critical patent/OA10952A/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
OA9900002A 1996-07-05 1999-01-04 Erythromycins and process for their preparation OA10952A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
OA10952A true OA10952A (en) 2002-02-25

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900002A OA10952A (en) 1996-07-05 1999-01-04 Erythromycins and process for their preparation

Country Status (28)

Country Link
EP (3) EP0910633B1 (es)
JP (2) JP2000511063A (es)
KR (1) KR20000023579A (es)
CN (1) CN1179046C (es)
AP (1) AP1029A (es)
AT (2) ATE451455T1 (es)
AU (2) AU731301B2 (es)
BG (1) BG103133A (es)
BR (1) BR9710209A (es)
CA (2) CA2259420C (es)
DE (2) DE69739688D1 (es)
DK (2) DK0909327T3 (es)
EA (1) EA001744B1 (es)
EE (1) EE03976B1 (es)
ES (2) ES2244001T3 (es)
GB (1) GB2331518B (es)
GE (1) GEP20012348B (es)
IL (1) IL127916A0 (es)
IS (1) IS4940A (es)
NO (1) NO990012L (es)
NZ (1) NZ333861A (es)
OA (1) OA10952A (es)
PL (1) PL331285A1 (es)
PT (1) PT909327E (es)
SI (1) SI0910633T1 (es)
SK (1) SK182498A3 (es)
TR (1) TR199900006T2 (es)
WO (2) WO1998001571A2 (es)

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US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
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US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
DE69634127D1 (de) 1995-07-06 2005-02-03 Univ Leland Stanford Junior Zellfreie synthese von polyketiden
EP0870053A4 (en) 1995-12-19 2002-09-11 Univ Minnesota METABOLIC PROCESS FOR THE MANUFACTURE OF POLYHYDROXYALCANOATE MONOMER SYNTHASES
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
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US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
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Family Cites Families (4)

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WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
WO1995008548A1 (en) * 1993-09-20 1995-03-30 The Leland Stanford Junior University Recombinant production of novel polyketides

Also Published As

Publication number Publication date
AP9901444A0 (en) 1999-03-31
KR20000023579A (ko) 2000-04-25
JP2000511063A (ja) 2000-08-29
PL331285A1 (en) 1999-07-05
AU731654B2 (en) 2001-04-05
EA001744B1 (ru) 2001-08-27
JP2000516450A (ja) 2000-12-12
BR9710209A (pt) 2000-01-11
EP2182067A2 (en) 2010-05-05
AU3451497A (en) 1998-02-02
EP0910633A2 (en) 1999-04-28
DK0909327T3 (da) 2005-09-26
EA199900087A1 (ru) 1999-08-26
WO1998001571A3 (en) 1998-02-19
NO990012L (no) 1999-02-23
DE69733416D1 (de) 2005-07-07
CN1229438A (zh) 1999-09-22
BG103133A (en) 2000-04-28
EP2182067A3 (en) 2010-07-14
NZ333861A (en) 2000-08-25
IS4940A (is) 1999-01-04
GB2331518A (en) 1999-05-26
CA2259420C (en) 2007-09-18
GB2331518B (en) 2001-03-14
EE03976B1 (et) 2003-02-17
NO990012D0 (no) 1999-01-04
ATE296893T1 (de) 2005-06-15
CA2259463A1 (en) 1998-01-15
GB9900156D0 (en) 1999-02-24
IL127916A0 (en) 1999-11-30
SI0910633T1 (sl) 2010-04-30
DK0910633T3 (da) 2010-03-29
ES2244001T3 (es) 2005-12-01
EE9900014A (et) 1999-08-16
TR199900006T2 (xx) 1999-04-21
AU731301B2 (en) 2001-03-29
DE69733416T2 (de) 2006-04-27
AP1029A (en) 2001-12-11
EP0909327B1 (en) 2005-06-01
EP0910633B1 (en) 2009-12-09
WO1998001546A2 (en) 1998-01-15
WO1998001571A2 (en) 1998-01-15
CN1179046C (zh) 2004-12-08
ES2337424T3 (es) 2010-04-23
CA2259420A1 (en) 1998-01-15
GEP20012348B (en) 2001-01-25
ATE451455T1 (de) 2009-12-15
AU3450997A (en) 1998-02-02
SK182498A3 (en) 2000-05-16
WO1998001546A3 (en) 1998-04-09
PT909327E (pt) 2005-10-31
DE69739688D1 (de) 2010-01-21
JP4173551B2 (ja) 2008-10-29
EP0909327A2 (en) 1999-04-21

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