NZ580974A - Immunogens from uropathogenic escherichia coli - Google Patents

Info

Publication number

NZ580974A

NZ580974A NZ580974A NZ58097406A NZ580974A NZ 580974 A NZ580974 A NZ 580974A NZ 580974 A NZ580974 A NZ 580974A NZ 58097406 A NZ58097406 A NZ 58097406A NZ 580974 A NZ580974 A NZ 580974A

Authority

NZ

New Zealand

Prior art keywords

seq

polypeptide

amino acid

peptide

acid sequence

Prior art date

2005-02-18

Links

• Espacenet
• Global Dossier
• Discuss

• 241000588724 Escherichia coli Species 0.000 title claims abstract description 60
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 322
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 254
• 229920001184 polypeptide Polymers 0.000 claims abstract description 232
• 230000001717 pathogenic effect Effects 0.000 claims abstract description 46
• 239000012634 fragment Substances 0.000 claims abstract description 44
• 208000015181 infectious disease Diseases 0.000 claims abstract description 15
• 238000003259 recombinant expression Methods 0.000 claims abstract description 12
• 239000000203 mixture Substances 0.000 claims description 136
• 150000001413 amino acids Chemical class 0.000 claims description 107
• 238000000034 method Methods 0.000 claims description 55
• 230000002163 immunogen Effects 0.000 claims description 51
• 230000028993 immune response Effects 0.000 claims description 34
• 238000004519 manufacturing process Methods 0.000 claims description 28
• 239000008194 pharmaceutical composition Substances 0.000 claims description 27
• 241000894006 Bacteria Species 0.000 claims description 26
• 210000003719 b-lymphocyte Anatomy 0.000 claims description 20
• 230000003053 immunization Effects 0.000 claims description 20
• 230000008569 process Effects 0.000 claims description 18
• 239000003814 drug Substances 0.000 claims description 17
• 239000012528 membrane Substances 0.000 claims description 15
• 238000006467 substitution reaction Methods 0.000 claims description 14
• 238000013467 fragmentation Methods 0.000 claims description 10
• 238000006062 fragmentation reaction Methods 0.000 claims description 10
• 230000001681 protective effect Effects 0.000 claims description 5
• 239000012646 vaccine adjuvant Substances 0.000 claims description 4
• 229940124931 vaccine adjuvant Drugs 0.000 claims description 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 50
• 102000040430 polynucleotide Human genes 0.000 claims 8
• 108091033319 polynucleotide Proteins 0.000 claims 8
• 239000002157 polynucleotide Substances 0.000 claims 8
• 241000237519 Bivalvia Species 0.000 claims 1
• 235000020639 clam Nutrition 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 abstract description 161
• 102000004169 proteins and genes Human genes 0.000 abstract description 137
• 229960005486 vaccine Drugs 0.000 abstract description 48
• 238000011282 treatment Methods 0.000 abstract description 8
• 235000018102 proteins Nutrition 0.000 description 133
• 108091007433 antigens Proteins 0.000 description 115
• 102000036639 antigens Human genes 0.000 description 115
• 239000000427 antigen Substances 0.000 description 113
• 150000007523 nucleic acids Chemical class 0.000 description 90
• 108020004707 nucleic acids Proteins 0.000 description 81
• 102000039446 nucleic acids Human genes 0.000 description 81
• 239000002671 adjuvant Substances 0.000 description 78
• 235000001014 amino acid Nutrition 0.000 description 40
• 229940024606 amino acid Drugs 0.000 description 39
• 210000004027 cell Anatomy 0.000 description 37
• 239000013598 vector Substances 0.000 description 37
• -1 aromatic amino acids Chemical class 0.000 description 30
• 238000002649 immunization Methods 0.000 description 29
• 230000000295 complement effect Effects 0.000 description 28
• 108700039887 Essential Genes Proteins 0.000 description 27
• 125000000217 alkyl group Chemical group 0.000 description 24
• 239000013615 primer Substances 0.000 description 24
• 210000001744 T-lymphocyte Anatomy 0.000 description 23
• 239000000839 emulsion Substances 0.000 description 22
• 239000002773 nucleotide Substances 0.000 description 22
• 125000003729 nucleotide group Chemical group 0.000 description 22
• 108091034117 Oligonucleotide Proteins 0.000 description 21
• 108020004414 DNA Proteins 0.000 description 20
• 241000699670 Mus sp. Species 0.000 description 18
• 150000001875 compounds Chemical class 0.000 description 18
• 239000000243 solution Substances 0.000 description 18
• 229930182490 saponin Natural products 0.000 description 17
• 235000017709 saponins Nutrition 0.000 description 17
• 150000007949 saponins Chemical class 0.000 description 17
• 108091028043 Nucleic acid sequence Proteins 0.000 description 16
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 16
• 241000700605 Viruses Species 0.000 description 15
• 230000001580 bacterial effect Effects 0.000 description 14
• 238000009472 formulation Methods 0.000 description 14
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 14
• 150000003839 salts Chemical class 0.000 description 14
• 102000004127 Cytokines Human genes 0.000 description 13
• 108090000695 Cytokines Proteins 0.000 description 13
• 229910019142 PO4 Inorganic materials 0.000 description 13
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 13
• 239000002158 endotoxin Substances 0.000 description 13
• 229920006008 lipopolysaccharide Polymers 0.000 description 13
• 238000009396 hybridization Methods 0.000 description 12
• 239000002245 particle Substances 0.000 description 12
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 12
• 235000021317 phosphate Nutrition 0.000 description 12
• 241000701806 Human papillomavirus Species 0.000 description 11
• 125000000623 heterocyclic group Chemical group 0.000 description 11
• 238000007912 intraperitoneal administration Methods 0.000 description 11
• 239000010452 phosphate Substances 0.000 description 11
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 10
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 10
• 239000000872 buffer Substances 0.000 description 10
• 229910052500 inorganic mineral Inorganic materials 0.000 description 10
• 239000011707 mineral Substances 0.000 description 10
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 10
• 229920000053 polysorbate 80 Polymers 0.000 description 10
• 239000000523 sample Substances 0.000 description 10
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 9
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
• 238000006243 chemical reaction Methods 0.000 description 9
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 9
• 206010022000 influenza Diseases 0.000 description 9
• 238000007920 subcutaneous administration Methods 0.000 description 9
• 238000003786 synthesis reaction Methods 0.000 description 9
• 239000003981 vehicle Substances 0.000 description 9
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 8
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
• 241001148064 Photorhabdus luminescens Species 0.000 description 8
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 8
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 8
• 230000000890 antigenic effect Effects 0.000 description 8
• 125000003118 aryl group Chemical group 0.000 description 8
• 238000003556 assay Methods 0.000 description 8
• 239000000499 gel Substances 0.000 description 8
• 230000003308 immunostimulating effect Effects 0.000 description 8
• 230000001965 increasing effect Effects 0.000 description 8
• 239000003550 marker Substances 0.000 description 8
• 230000004048 modification Effects 0.000 description 8
• 238000012986 modification Methods 0.000 description 8
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 8
• 231100000252 nontoxic Toxicity 0.000 description 8
• 230000003000 nontoxic effect Effects 0.000 description 8
• 238000002360 preparation method Methods 0.000 description 8
• 229940031439 squalene Drugs 0.000 description 8
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 8
• 230000004083 survival effect Effects 0.000 description 8
• 108091026890 Coding region Proteins 0.000 description 7
• 108020004705 Codon Proteins 0.000 description 7
• 201000005702 Pertussis Diseases 0.000 description 7
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
• 229940001007 aluminium phosphate Drugs 0.000 description 7
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 7
• 238000004458 analytical method Methods 0.000 description 7
• 230000015572 biosynthetic process Effects 0.000 description 7
• 230000029087 digestion Effects 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 239000002953 phosphate buffered saline Substances 0.000 description 7
• 230000004044 response Effects 0.000 description 7
• 239000007787 solid Substances 0.000 description 7
• 239000000725 suspension Substances 0.000 description 7
• 239000003053 toxin Substances 0.000 description 7
• 231100000765 toxin Toxicity 0.000 description 7
• 108700012359 toxins Proteins 0.000 description 7
• 208000019206 urinary tract infection Diseases 0.000 description 7
• 230000003612 virological effect Effects 0.000 description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
• NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 6
• 125000003545 alkoxy group Chemical group 0.000 description 6
• 230000003321 amplification Effects 0.000 description 6
• 239000012472 biological sample Substances 0.000 description 6
• 238000004422 calculation algorithm Methods 0.000 description 6
• 150000001720 carbohydrates Chemical class 0.000 description 6
• 239000003153 chemical reaction reagent Substances 0.000 description 6
• 210000000349 chromosome Anatomy 0.000 description 6
• 239000003599 detergent Substances 0.000 description 6
• 229940079593 drug Drugs 0.000 description 6
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 6
• 238000000338 in vitro Methods 0.000 description 6
• 238000001727 in vivo Methods 0.000 description 6
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 6
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
• 238000003199 nucleic acid amplification method Methods 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• 239000011780 sodium chloride Substances 0.000 description 6
• 239000000126 substance Substances 0.000 description 6
• 230000009885 systemic effect Effects 0.000 description 6
• 230000029069 type 2 immune response Effects 0.000 description 6
• 241000588626 Acinetobacter baumannii Species 0.000 description 5
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 5
• 102000014914 Carrier Proteins Human genes 0.000 description 5
• 108010078791 Carrier Proteins Proteins 0.000 description 5
• 102100038385 Coiled-coil domain-containing protein R3HCC1L Human genes 0.000 description 5
• 238000002965 ELISA Methods 0.000 description 5
• 102000004190 Enzymes Human genes 0.000 description 5
• 108090000790 Enzymes Proteins 0.000 description 5
• 101000743767 Homo sapiens Coiled-coil domain-containing protein R3HCC1L Proteins 0.000 description 5
• 241000186779 Listeria monocytogenes Species 0.000 description 5
• 108091081024 Start codon Proteins 0.000 description 5
• 108090000631 Trypsin Proteins 0.000 description 5
• 102000004142 Trypsin Human genes 0.000 description 5
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
• 238000013459 approach Methods 0.000 description 5
• 238000010367 cloning Methods 0.000 description 5
• 229940088598 enzyme Drugs 0.000 description 5
• 238000001415 gene therapy Methods 0.000 description 5
• 125000001475 halogen functional group Chemical group 0.000 description 5
• 150000002632 lipids Chemical class 0.000 description 5
• 239000011859 microparticle Substances 0.000 description 5
• 239000008188 pellet Substances 0.000 description 5
• 238000010647 peptide synthesis reaction Methods 0.000 description 5
• 238000001556 precipitation Methods 0.000 description 5
• 239000000047 product Substances 0.000 description 5
• 230000010076 replication Effects 0.000 description 5
• 230000000638 stimulation Effects 0.000 description 5
• 238000004885 tandem mass spectrometry Methods 0.000 description 5
• 230000001225 therapeutic effect Effects 0.000 description 5
• 239000012588 trypsin Substances 0.000 description 5
• 239000000277 virosome Substances 0.000 description 5
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
• 241000606153 Chlamydia trachomatis Species 0.000 description 4
• 241000701022 Cytomegalovirus Species 0.000 description 4
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• 241000606768 Haemophilus influenzae Species 0.000 description 4
• 108010002616 Interleukin-5 Proteins 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 4
• 241000699666 Mus <mouse, genus> Species 0.000 description 4
• 108700020354 N-acetylmuramyl-threonyl-isoglutamine Proteins 0.000 description 4
• 101500027983 Rattus norvegicus Octadecaneuropeptide Proteins 0.000 description 4
• PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 4
• 229930182558 Sterol Natural products 0.000 description 4
• 206010043376 Tetanus Diseases 0.000 description 4
• 159000000013 aluminium salts Chemical class 0.000 description 4
• 210000004369 blood Anatomy 0.000 description 4
• 239000008280 blood Substances 0.000 description 4
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
• GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
• 206010013023 diphtheria Diseases 0.000 description 4
• 230000000694 effects Effects 0.000 description 4
• 239000007850 fluorescent dye Substances 0.000 description 4
• 230000006870 function Effects 0.000 description 4
• 238000001476 gene delivery Methods 0.000 description 4
• 230000002068 genetic effect Effects 0.000 description 4
• 210000000987 immune system Anatomy 0.000 description 4
• 230000005847 immunogenicity Effects 0.000 description 4
• 230000001976 improved effect Effects 0.000 description 4
• 238000011534 incubation Methods 0.000 description 4
• 239000002502 liposome Substances 0.000 description 4
• 210000002540 macrophage Anatomy 0.000 description 4
• 239000000463 material Substances 0.000 description 4
• 229930182817 methionine Natural products 0.000 description 4
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 4
• 238000002493 microarray Methods 0.000 description 4
• 238000010172 mouse model Methods 0.000 description 4
• JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 4
• 229940046166 oligodeoxynucleotide Drugs 0.000 description 4
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 4
• 229920000642 polymer Polymers 0.000 description 4
• 229920000136 polysorbate Polymers 0.000 description 4
• 239000002987 primer (paints) Substances 0.000 description 4
• 239000012460 protein solution Substances 0.000 description 4
• 238000000746 purification Methods 0.000 description 4
• 238000011160 research Methods 0.000 description 4
• 238000012552 review Methods 0.000 description 4
• 239000007921 spray Substances 0.000 description 4
• 229940032094 squalane Drugs 0.000 description 4
• 235000003702 sterols Nutrition 0.000 description 4
• 238000012360 testing method Methods 0.000 description 4
• UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 4
• 238000013519 translation Methods 0.000 description 4
• 238000011144 upstream manufacturing Methods 0.000 description 4
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
• 241000186032 Alloiococcus otitis Species 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 108010039939 Cell Wall Skeleton Proteins 0.000 description 3
• 241001647372 Chlamydia pneumoniae Species 0.000 description 3
• MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 3
• NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 3
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 3
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 3
• 108010002350 Interleukin-2 Proteins 0.000 description 3
• 108090000978 Interleukin-4 Proteins 0.000 description 3
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 3
• 108010052285 Membrane Proteins Proteins 0.000 description 3
• 201000009906 Meningitis Diseases 0.000 description 3
• 241001465754 Metazoa Species 0.000 description 3
• 229910003827 NRaRb Inorganic materials 0.000 description 3
• 241000588652 Neisseria gonorrhoeae Species 0.000 description 3
• DTAFLBZLAZYRDX-UHFFFAOYSA-N OOOOOO Chemical compound OOOOOO DTAFLBZLAZYRDX-UHFFFAOYSA-N 0.000 description 3
• 101710116435 Outer membrane protein Proteins 0.000 description 3
• 241000223960 Plasmodium falciparum Species 0.000 description 3
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
• 108010076504 Protein Sorting Signals Proteins 0.000 description 3
• 206010037596 Pyelonephritis Diseases 0.000 description 3
• 206010040047 Sepsis Diseases 0.000 description 3
• 241000191967 Staphylococcus aureus Species 0.000 description 3
• 241000193985 Streptococcus agalactiae Species 0.000 description 3
• 244000057717 Streptococcus lactis Species 0.000 description 3
• 235000014897 Streptococcus lactis Nutrition 0.000 description 3
• 241000193998 Streptococcus pneumoniae Species 0.000 description 3
• RHTNTTODYGNRSP-UHFFFAOYSA-N Tolazoline hydrochloride Chemical compound Cl.C=1C=CC=CC=1CC1=NCCN1 RHTNTTODYGNRSP-UHFFFAOYSA-N 0.000 description 3
• 239000007983 Tris buffer Substances 0.000 description 3
• VQQVWGVXDIPORV-UHFFFAOYSA-N Tryptanthrine Chemical class C1=CC=C2C(=O)N3C4=CC=CC=C4C(=O)C3=NC2=C1 VQQVWGVXDIPORV-UHFFFAOYSA-N 0.000 description 3
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 3
• 229910052782 aluminium Inorganic materials 0.000 description 3
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 3
• 239000000227 bioadhesive Substances 0.000 description 3
• 230000003115 biocidal effect Effects 0.000 description 3
• 239000000969 carrier Substances 0.000 description 3
• 238000004113 cell culture Methods 0.000 description 3
• 210000004520 cell wall skeleton Anatomy 0.000 description 3
• 238000005119 centrifugation Methods 0.000 description 3
• 229940038705 chlamydia trachomatis Drugs 0.000 description 3
• 235000012000 cholesterol Nutrition 0.000 description 3
• 230000000052 comparative effect Effects 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 3
• 238000004925 denaturation Methods 0.000 description 3
• 230000036425 denaturation Effects 0.000 description 3
• 238000001514 detection method Methods 0.000 description 3
• 201000010099 disease Diseases 0.000 description 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
• 150000002148 esters Chemical class 0.000 description 3
• 238000002474 experimental method Methods 0.000 description 3
• 239000013604 expression vector Substances 0.000 description 3
• 235000019253 formic acid Nutrition 0.000 description 3
• 230000004927 fusion Effects 0.000 description 3
• 230000013595 glycosylation Effects 0.000 description 3
• 238000006206 glycosylation reaction Methods 0.000 description 3
• ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 description 3
• 229940029575 guanosine Drugs 0.000 description 3
• 229910052739 hydrogen Inorganic materials 0.000 description 3
• 230000036039 immunity Effects 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 238000003780 insertion Methods 0.000 description 3
• 230000037431 insertion Effects 0.000 description 3
• 230000000968 intestinal effect Effects 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 239000011159 matrix material Substances 0.000 description 3
• 230000001404 mediated effect Effects 0.000 description 3
• 230000000813 microbial effect Effects 0.000 description 3
• JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 description 3
• 229960005225 mifamurtide Drugs 0.000 description 3
• 239000000178 monomer Substances 0.000 description 3
• 230000003232 mucoadhesive effect Effects 0.000 description 3
• 230000016379 mucosal immune response Effects 0.000 description 3
• 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 3
• 230000035772 mutation Effects 0.000 description 3
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 3
• 210000001322 periplasm Anatomy 0.000 description 3
• 229920002401 polyacrylamide Polymers 0.000 description 3
• 229920000056 polyoxyethylene ether Polymers 0.000 description 3
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 3
• 229940068968 polysorbate 80 Drugs 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 239000002244 precipitate Substances 0.000 description 3
• 230000035755 proliferation Effects 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• 239000007790 solid phase Substances 0.000 description 3
• 238000001179 sorption measurement Methods 0.000 description 3
• 229940031000 streptococcus pneumoniae Drugs 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 150000003584 thiosemicarbazones Chemical class 0.000 description 3
• 210000001519 tissue Anatomy 0.000 description 3
• 235000010384 tocopherol Nutrition 0.000 description 3
• 229960001295 tocopherol Drugs 0.000 description 3
• 229930003799 tocopherol Natural products 0.000 description 3
• 239000011732 tocopherol Substances 0.000 description 3
• 101150088820 tolR gene Proteins 0.000 description 3
• 238000013518 transcription Methods 0.000 description 3
• 230000035897 transcription Effects 0.000 description 3
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
• 241000701161 unidentified adenovirus Species 0.000 description 3
• 241001430294 unidentified retrovirus Species 0.000 description 3
• 238000002255 vaccination Methods 0.000 description 3
• 210000002268 wool Anatomy 0.000 description 3
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
• AXTGOJVKRHFYBT-XAZAIFFQSA-N (1r,2r,3r,6s,7s,8r)-3-(hydroxymethyl)-2,3,5,6,7,8-hexahydro-1h-pyrrolizine-1,2,6,7-tetrol Chemical compound O[C@@H]1[C@@H](O)CN2[C@H](CO)[C@@H](O)[C@H](O)[C@H]21 AXTGOJVKRHFYBT-XAZAIFFQSA-N 0.000 description 2
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 2
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
• RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical class C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 description 2
• QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• TZYVRXZQAWPIAB-FCLHUMLKSA-N 5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4h-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione Chemical compound O=C1SC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O TZYVRXZQAWPIAB-FCLHUMLKSA-N 0.000 description 2
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
• 102100034613 Annexin A2 Human genes 0.000 description 2
• 108090000668 Annexin A2 Proteins 0.000 description 2
• 238000011725 BALB/c mouse Methods 0.000 description 2
• 208000031729 Bacteremia Diseases 0.000 description 2
• 241000588832 Bordetella pertussis Species 0.000 description 2
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 2
• 101710132601 Capsid protein Proteins 0.000 description 2
• 102000053642 Catalytic RNA Human genes 0.000 description 2
• 108090000994 Catalytic RNA Proteins 0.000 description 2
• LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
• 241000186427 Cutibacterium acnes Species 0.000 description 2
• 102100026398 Cyclic AMP-responsive element-binding protein 3 Human genes 0.000 description 2
• 101710128029 Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 2
• 150000008574 D-amino acids Chemical class 0.000 description 2
• 241000305071 Enterobacterales Species 0.000 description 2
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
• 241000700721 Hepatitis B virus Species 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 241000701828 Human papillomavirus type 11 Species 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• 102000003960 Ligases Human genes 0.000 description 2
• 108090000364 Ligases Proteins 0.000 description 2
• 108090001030 Lipoproteins Proteins 0.000 description 2
• 102000004895 Lipoproteins Human genes 0.000 description 2
• 239000006137 Luria-Bertani broth Substances 0.000 description 2
• 102000043131 MHC class II family Human genes 0.000 description 2
• 108091054438 MHC class II family Proteins 0.000 description 2
• 102000018697 Membrane Proteins Human genes 0.000 description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
• 241000588650 Neisseria meningitidis Species 0.000 description 2
• 206010028980 Neoplasm Diseases 0.000 description 2
• 101710163270 Nuclease Proteins 0.000 description 2
• JLNTWVDSQRNWFU-UHFFFAOYSA-N OOOOOOO Chemical compound OOOOOOO JLNTWVDSQRNWFU-UHFFFAOYSA-N 0.000 description 2
• UIQWBVPFHHQZHH-UHFFFAOYSA-N OOOOOOOOOOOOOO Chemical compound OOOOOOOOOOOOOO UIQWBVPFHHQZHH-UHFFFAOYSA-N 0.000 description 2
• 208000002606 Paramyxoviridae Infections Diseases 0.000 description 2
• 108091093037 Peptide nucleic acid Proteins 0.000 description 2
• 241001442654 Percnon planissimum Species 0.000 description 2
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
• 206010037660 Pyrexia Diseases 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 241000219287 Saponaria Species 0.000 description 2
• 241000710960 Sindbis virus Species 0.000 description 2
• 241000194017 Streptococcus Species 0.000 description 2
• 241000193990 Streptococcus sp. 'group B' Species 0.000 description 2
• 229930006000 Sucrose Natural products 0.000 description 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
• 230000024932 T cell mediated immunity Effects 0.000 description 2
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
• 102100040247 Tumor necrosis factor Human genes 0.000 description 2
• 206010046865 Vaccinia virus infection Diseases 0.000 description 2
• 108010067390 Viral Proteins Proteins 0.000 description 2
• 239000002253 acid Substances 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• 125000002015 acyclic group Chemical group 0.000 description 2
• 238000012382 advanced drug delivery Methods 0.000 description 2
• 125000000304 alkynyl group Chemical group 0.000 description 2
• NWMHDZMRVUOQGL-CZEIJOLGSA-N almurtide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)CO[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O NWMHDZMRVUOQGL-CZEIJOLGSA-N 0.000 description 2
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
• 229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000000692 anti-sense effect Effects 0.000 description 2
• 239000011324 bead Substances 0.000 description 2
• 229960002685 biotin Drugs 0.000 description 2
• 235000020958 biotin Nutrition 0.000 description 2
• 239000011616 biotin Substances 0.000 description 2
• UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 125000002091 cationic group Chemical group 0.000 description 2
• 239000013592 cell lysate Substances 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 239000012228 culture supernatant Substances 0.000 description 2
• 238000012258 culturing Methods 0.000 description 2
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• 201000003146 cystitis Diseases 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 238000001784 detoxification Methods 0.000 description 2
• 239000001177 diphosphate Substances 0.000 description 2
• XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
• 235000011180 diphosphates Nutrition 0.000 description 2
• 229960003983 diphtheria toxoid Drugs 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 238000001962 electrophoresis Methods 0.000 description 2
• 239000003623 enhancer Substances 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 238000004108 freeze drying Methods 0.000 description 2
• 108020001507 fusion proteins Proteins 0.000 description 2
• 102000037865 fusion proteins Human genes 0.000 description 2
• 150000004676 glycans Chemical class 0.000 description 2
• 229930182470 glycoside Natural products 0.000 description 2
• 230000012010 growth Effects 0.000 description 2
• 210000002443 helper t lymphocyte Anatomy 0.000 description 2
• 238000004128 high performance liquid chromatography Methods 0.000 description 2
• 229930186900 holotoxin Natural products 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 2
• 239000002955 immunomodulating agent Substances 0.000 description 2
• 229940121354 immunomodulator Drugs 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 229940029583 inactivated polio vaccine Drugs 0.000 description 2
• 239000002054 inoculum Substances 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
• 230000005865 ionizing radiation Effects 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• 238000005304 joining Methods 0.000 description 2
• 239000006193 liquid solution Substances 0.000 description 2
• 210000004698 lymphocyte Anatomy 0.000 description 2
• 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
• 210000001806 memory b lymphocyte Anatomy 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 description 2
• 230000003472 neutralizing effect Effects 0.000 description 2
• 239000002777 nucleoside Substances 0.000 description 2
• 150000003833 nucleoside derivatives Chemical class 0.000 description 2
• 239000007764 o/w emulsion Substances 0.000 description 2
• 229940066429 octoxynol Drugs 0.000 description 2
• 229920002113 octoxynol Polymers 0.000 description 2
• 229920001542 oligosaccharide Polymers 0.000 description 2
• 150000002482 oligosaccharides Chemical class 0.000 description 2
• UNEIHNMKASENIG-UHFFFAOYSA-N para-chlorophenylpiperazine Chemical compound C1=CC(Cl)=CC=C1N1CCNCC1 UNEIHNMKASENIG-UHFFFAOYSA-N 0.000 description 2
• 244000052769 pathogen Species 0.000 description 2
• 238000009521 phase II clinical trial Methods 0.000 description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
• 239000008363 phosphate buffer Substances 0.000 description 2
• 150000003904 phospholipids Chemical class 0.000 description 2
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
• 229920001983 poloxamer Polymers 0.000 description 2
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
• 230000008488 polyadenylation Effects 0.000 description 2
• 229920001282 polysaccharide Polymers 0.000 description 2
• 239000005017 polysaccharide Substances 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 230000037452 priming Effects 0.000 description 2
• 229940055019 propionibacterium acne Drugs 0.000 description 2
• 230000002685 pulmonary effect Effects 0.000 description 2
• NKXSJFUIFJMXED-UHFFFAOYSA-N quinoline-2,4-diamine Chemical compound C1=CC=CC2=NC(N)=CC(N)=C21 NKXSJFUIFJMXED-UHFFFAOYSA-N 0.000 description 2
• 230000002285 radioactive effect Effects 0.000 description 2
• 238000003127 radioimmunoassay Methods 0.000 description 2
• 102000005962 receptors Human genes 0.000 description 2
• 108020003175 receptors Proteins 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 230000003362 replicative effect Effects 0.000 description 2
• BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 description 2
• 108091008146 restriction endonucleases Proteins 0.000 description 2
• 108091092562 ribozyme Proteins 0.000 description 2
• 238000012216 screening Methods 0.000 description 2
• 238000010845 search algorithm Methods 0.000 description 2
• 238000001228 spectrum Methods 0.000 description 2
• 150000003432 sterols Chemical class 0.000 description 2
• 239000005720 sucrose Substances 0.000 description 2
• 239000013589 supplement Substances 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• 229960000814 tetanus toxoid Drugs 0.000 description 2
• 230000002103 transcriptional effect Effects 0.000 description 2
• 238000010361 transduction Methods 0.000 description 2
• 230000026683 transduction Effects 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 108091005703 transmembrane proteins Proteins 0.000 description 2
• 102000035160 transmembrane proteins Human genes 0.000 description 2
• XETCRXVKJHBPMK-MJSODCSWSA-N trehalose 6,6'-dimycolate Chemical compound C([C@@H]1[C@H]([C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C(CCCCCCCCCCC3C(C3)CCCCCCCCCCCCCCCCCC)C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)O2)O)O1)O)OC(=O)C(C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC XETCRXVKJHBPMK-MJSODCSWSA-N 0.000 description 2
• 239000001226 triphosphate Substances 0.000 description 2
• 235000011178 triphosphate Nutrition 0.000 description 2
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 241001529453 unidentified herpesvirus Species 0.000 description 2
• 241000712461 unidentified influenza virus Species 0.000 description 2
• 208000007089 vaccinia Diseases 0.000 description 2
• 230000001018 virulence Effects 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
• NNWQLZWAZSJGLY-VKHMYHEASA-N (2s)-2-azaniumyl-4-azidobutanoate Chemical compound OC(=O)[C@@H](N)CCN=[N+]=[N-] NNWQLZWAZSJGLY-VKHMYHEASA-N 0.000 description 1
• UGXDVELKRYZPDM-XLXQKPBQSA-N (4r)-4-[[(2s,3r)-2-[[(2r)-2-[(2r,3r,4r,5r)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](C)O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O UGXDVELKRYZPDM-XLXQKPBQSA-N 0.000 description 1
• BGHRHIHHDCODHX-UHFFFAOYSA-N 1,1-didodecoxy-2,2-dimethylhexane-1,6-diamine Chemical compound CCCCCCCCCCCCOC(C(C)(C)CCCCN)(N)OCCCCCCCCCCCC BGHRHIHHDCODHX-UHFFFAOYSA-N 0.000 description 1
• PRPYWMVCMRUCOA-UHFFFAOYSA-N 1-(2-methylpropyl)-2-n-propylimidazo[4,5-c]quinoline-2,4-diamine Chemical compound C1=CC=CC2=C(N(C(NCCC)=N3)CC(C)C)C3=C(N)N=C21 PRPYWMVCMRUCOA-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• 101150029062 15 gene Proteins 0.000 description 1
• HCQFIHRPZXGXCK-UHFFFAOYSA-N 1h-benzimidazol-2-amine;1h-quinolin-2-one Chemical compound C1=CC=C2NC(N)=NC2=C1.C1=CC=C2NC(=O)C=CC2=C1 HCQFIHRPZXGXCK-UHFFFAOYSA-N 0.000 description 1
• XBHQOFFGGAPTOF-UHFFFAOYSA-N 2-[[4-amino-1-(2-methylpropyl)imidazo[4,5-c]quinolin-2-yl]-methylamino]ethanol Chemical compound C1=CC=CC2=C3N(CC(C)C)C(N(C)CCO)=NC3=C(N)N=C21 XBHQOFFGGAPTOF-UHFFFAOYSA-N 0.000 description 1
• JDPCOTDCJCPHAX-UHFFFAOYSA-N 2-[[4-amino-1-(2-methylpropyl)imidazo[4,5-c]quinolin-2-yl]-methylamino]ethyl acetate Chemical compound C1=CC=CC2=C3N(CC(C)C)C(N(C)CCOC(C)=O)=NC3=C(N)N=C21 JDPCOTDCJCPHAX-UHFFFAOYSA-N 0.000 description 1
• PFCLMNDDPTZJHQ-XLPZGREQSA-N 2-amino-7-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=CC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PFCLMNDDPTZJHQ-XLPZGREQSA-N 0.000 description 1
• VDCRFBBZFHHYGT-IOSLPCCCSA-N 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-3h-purine-6,8-dione Chemical compound O=C1N(CC=C)C=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VDCRFBBZFHHYGT-IOSLPCCCSA-N 0.000 description 1
• QBZUNKUEGZZDKZ-UHFFFAOYSA-N 2-n,2-n-dimethyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-2,4-diamine Chemical compound C1=CC=CC2=C3N(CC(C)C)C(N(C)C)=NC3=C(N)N=C21 QBZUNKUEGZZDKZ-UHFFFAOYSA-N 0.000 description 1
• NPZAROHMGGHDPW-UHFFFAOYSA-N 2-n-butyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-2,4-diamine Chemical compound C1=CC=CC2=C(N(C(NCCCC)=N3)CC(C)C)C3=C(N)N=C21 NPZAROHMGGHDPW-UHFFFAOYSA-N 0.000 description 1
• NHENDFIAUHZKHD-UHFFFAOYSA-N 2-n-methyl-1-(2-methylpropyl)-2-n-pentylimidazo[4,5-c]quinoline-2,4-diamine Chemical compound C1=CC=CC2=C(N(C(N(C)CCCCC)=N3)CC(C)C)C3=C(N)N=C21 NHENDFIAUHZKHD-UHFFFAOYSA-N 0.000 description 1
• FNJDXMQQFKYYFB-UHFFFAOYSA-N 2-n-methyl-1-(2-methylpropyl)-2-n-prop-2-enylimidazo[4,5-c]quinoline-2,4-diamine Chemical compound C1=CC=CC2=C3N(CC(C)C)C(N(C)CC=C)=NC3=C(N)N=C21 FNJDXMQQFKYYFB-UHFFFAOYSA-N 0.000 description 1
• BWIQMBLDRUXPEN-UHFFFAOYSA-N 2-n-methyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-2,4-diamine Chemical compound C1=CC=CC2=C(N(C(NC)=N3)CC(C)C)C3=C(N)N=C21 BWIQMBLDRUXPEN-UHFFFAOYSA-N 0.000 description 1
• UMCMPZBLKLEWAF-BCTGSCMUSA-N 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 UMCMPZBLKLEWAF-BCTGSCMUSA-N 0.000 description 1
• YVKSFIVQBWDSHR-UHFFFAOYSA-N 4-n,4-n-dibenzyl-2-n,2-n-dimethyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-2,4-diamine Chemical compound N1=C2C=CC=CC2=C2N(CC(C)C)C(N(C)C)=NC2=C1N(CC=1C=CC=CC=1)CC1=CC=CC=C1 YVKSFIVQBWDSHR-UHFFFAOYSA-N 0.000 description 1
• LWEOGJDQDPSCLA-UHFFFAOYSA-N 4-n,4-n-dibenzyl-2-n-butyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-2,4-diamine Chemical compound N1=C2C=CC=CC2=C2N(CC(C)C)C(NCCCC)=NC2=C1N(CC=1C=CC=CC=1)CC1=CC=CC=C1 LWEOGJDQDPSCLA-UHFFFAOYSA-N 0.000 description 1
• GYSNQANFUBOXHG-UHFFFAOYSA-N 4-n,4-n-dibenzyl-2-n-butyl-2-n-methyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-2,4-diamine Chemical compound N1=C2C=CC=CC2=C2N(CC(C)C)C(N(C)CCCC)=NC2=C1N(CC=1C=CC=CC=1)CC1=CC=CC=C1 GYSNQANFUBOXHG-UHFFFAOYSA-N 0.000 description 1
• PXBWLHQLSCMJEM-IOSLPCCCSA-N 9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]-3h-purin-6-one Chemical compound C1=NC2=C(O)N=CN=C2N1[C@]1(C)O[C@H](CO)[C@@H](O)[C@H]1O PXBWLHQLSCMJEM-IOSLPCCCSA-N 0.000 description 1
• 208000030507 AIDS Diseases 0.000 description 1
• 108010013043 Acetylesterase Proteins 0.000 description 1
• 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
• 101000621943 Acholeplasma phage L2 Probable integrase/recombinase Proteins 0.000 description 1
• 241000588625 Acinetobacter sp. Species 0.000 description 1
• 208000020154 Acnes Diseases 0.000 description 1
• 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 description 1
• 101000618348 Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) Uncharacterized protein Alvin_0065 Proteins 0.000 description 1
• 241001439211 Almeida Species 0.000 description 1
• KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
• 238000006412 Alper carbonylation reaction Methods 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 241000710929 Alphavirus Species 0.000 description 1
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
• ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
• 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
• 241001135961 Amsacta moorei entomopoxvirus Species 0.000 description 1
• 102100033899 Ankyrin repeat and SOCS box protein 14 Human genes 0.000 description 1
• 101710109637 Antigen 43 Proteins 0.000 description 1
• 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
• 108010037365 Arabidopsis Proteins Proteins 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 241001225321 Aspergillus fumigatus Species 0.000 description 1
• 101000781117 Autographa californica nuclear polyhedrosis virus Uncharacterized 12.4 kDa protein in CTL-LEF2 intergenic region Proteins 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 101000708323 Azospirillum brasilense Uncharacterized 28.8 kDa protein in nifR3-like 5'region Proteins 0.000 description 1
• 101000770311 Azotobacter chroococcum mcd 1 Uncharacterized 19.8 kDa protein in nifW 5'region Proteins 0.000 description 1
• 241000193738 Bacillus anthracis Species 0.000 description 1
• 101000748761 Bacillus subtilis (strain 168) Uncharacterized MFS-type transporter YcxA Proteins 0.000 description 1
• 101000765620 Bacillus subtilis (strain 168) Uncharacterized protein YlxP Proteins 0.000 description 1
• 101000916134 Bacillus subtilis (strain 168) Uncharacterized protein YqxJ Proteins 0.000 description 1
• 101100203377 Bacillus subtilis (strain 168) slp gene Proteins 0.000 description 1
• 101100053456 Bacillus subtilis (strain 168) yqbF gene Proteins 0.000 description 1
• 101100377426 Bacillus subtilis (strain 168) znuA gene Proteins 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 231100000699 Bacterial toxin Toxicity 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
• 241001213452 Bifidobacterium longum NCC2705 Species 0.000 description 1
• ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
• 241001118702 Border disease virus Species 0.000 description 1
• 101000754349 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) UPF0065 protein BP0148 Proteins 0.000 description 1
• 238000009010 Bradford assay Methods 0.000 description 1
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
• MUMOLHONSJYYEK-HJWRWDBZSA-N CCCC/C=C\CCCCCCCCOC(CCCN)(C(C)(C)C)N Chemical compound CCCC/C=C\CCCCCCCCOC(CCCN)(C(C)(C)C)N MUMOLHONSJYYEK-HJWRWDBZSA-N 0.000 description 1
• 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 description 1
• 101100039010 Caenorhabditis elegans dis-3 gene Proteins 0.000 description 1
• 102000013830 Calcium-Sensing Receptors Human genes 0.000 description 1
• 108010050543 Calcium-Sensing Receptors Proteins 0.000 description 1
• 101000827633 Caldicellulosiruptor sp. (strain Rt8B.4) Uncharacterized 23.9 kDa protein in xynA 3'region Proteins 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 108090000565 Capsid Proteins Proteins 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 208000032840 Catheter-Related Infections Diseases 0.000 description 1
• 102100023321 Ceruloplasmin Human genes 0.000 description 1
• 229920001661 Chitosan Polymers 0.000 description 1
• 241000606161 Chlamydia Species 0.000 description 1
• 206010008631 Cholera Diseases 0.000 description 1
• 101000947628 Claviceps purpurea Uncharacterized 11.8 kDa protein Proteins 0.000 description 1
• 241000193163 Clostridioides difficile Species 0.000 description 1
• 101000686796 Clostridium perfringens Replication protein Proteins 0.000 description 1
• 101710094648 Coat protein Proteins 0.000 description 1
• 108010060123 Conjugate Vaccines Proteins 0.000 description 1
• 241000186226 Corynebacterium glutamicum Species 0.000 description 1
• 240000008067 Cucumis sativus Species 0.000 description 1
• 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
• 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 239000003155 DNA primer Substances 0.000 description 1
• 238000011238 DNA vaccination Methods 0.000 description 1
• 229940032024 DPT vaccine Drugs 0.000 description 1
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 1
• 241000710829 Dengue virus group Species 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• 102100037713 Down syndrome cell adhesion molecule Human genes 0.000 description 1
• 101710199377 Down syndrome cell adhesion molecule Proteins 0.000 description 1
• 241000255601 Drosophila melanogaster Species 0.000 description 1
• 101100242529 Drosophila melanogaster Pal2 gene Proteins 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 108010067770 Endopeptidase K Proteins 0.000 description 1
• 241000194032 Enterococcus faecalis Species 0.000 description 1
• 206010066919 Epidemic polyarthritis Diseases 0.000 description 1
• 241001337814 Erysiphe glycines Species 0.000 description 1
• 101000878139 Escherichia coli (strain K12) Ferrichrome outer membrane transporter/phage receptor Proteins 0.000 description 1
• 101100215951 Escherichia coli (strain K12) amiB gene Proteins 0.000 description 1
• 101100148339 Escherichia coli (strain K12) rutF gene Proteins 0.000 description 1
• 241001426329 Escherichia coli 536 Species 0.000 description 1
• 241001646719 Escherichia coli O157:H7 Species 0.000 description 1
• 101000788129 Escherichia coli Uncharacterized protein in sul1 3'region Proteins 0.000 description 1
• 101000788370 Escherichia phage P2 Uncharacterized 12.9 kDa protein in GpA 3'region Proteins 0.000 description 1
• 241000710781 Flaviviridae Species 0.000 description 1
• 241000710831 Flavivirus Species 0.000 description 1
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
• 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
• 208000000666 Fowlpox Diseases 0.000 description 1
• 108700007698 Genetic Terminator Regions Proteins 0.000 description 1
• 101000787096 Geobacillus stearothermophilus Uncharacterized protein in gldA 3'region Proteins 0.000 description 1
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
• 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
• 101000976889 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in cox-rep intergenic region Proteins 0.000 description 1
• 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
• 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
• 241000711549 Hepacivirus C Species 0.000 description 1
• 229940124872 Hepatitis B virus vaccine Drugs 0.000 description 1
• 241000724675 Hepatitis E virus Species 0.000 description 1
• 241000709721 Hepatovirus A Species 0.000 description 1
• 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
• 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
• 241000606831 Histophilus somni Species 0.000 description 1
• 101700012268 Holin Proteins 0.000 description 1
• 101000925508 Homo sapiens Ankyrin repeat and SOCS box protein 14 Proteins 0.000 description 1
• 101000871851 Homo sapiens Bromodomain-containing protein 3 Proteins 0.000 description 1
• 101100005713 Homo sapiens CD4 gene Proteins 0.000 description 1
• 101000957351 Homo sapiens Myc-associated zinc finger protein Proteins 0.000 description 1
• 101001116302 Homo sapiens Platelet endothelial cell adhesion molecule Proteins 0.000 description 1
• 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
• 241000702617 Human parvovirus B19 Species 0.000 description 1
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 238000012404 In vitro experiment Methods 0.000 description 1
• SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 108010002586 Interleukin-7 Proteins 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 229920001202 Inulin Polymers 0.000 description 1
• 102000004195 Isomerases Human genes 0.000 description 1
• 108090000769 Isomerases Proteins 0.000 description 1
• 241000710842 Japanese encephalitis virus Species 0.000 description 1
• 101000827627 Klebsiella pneumoniae Putative low molecular weight protein-tyrosine-phosphatase Proteins 0.000 description 1
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• 150000008575 L-amino acids Chemical class 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 101150012565 LRIT1 gene Proteins 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 229920002884 Laureth 4 Polymers 0.000 description 1
• 241000589242 Legionella pneumophila Species 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 description 1
• 208000035752 Live birth Diseases 0.000 description 1
• 239000006142 Luria-Bertani Agar Substances 0.000 description 1
• 108010074338 Lymphokines Proteins 0.000 description 1
• 102000008072 Lymphokines Human genes 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 102000043129 MHC class I family Human genes 0.000 description 1
• 108091054437 MHC class I family Proteins 0.000 description 1
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 1
• 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 1
• 101710125418 Major capsid protein Proteins 0.000 description 1
• 101710082149 Major fimbrial subunit Proteins 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 201000005505 Measles Diseases 0.000 description 1
• 241000712079 Measles morbillivirus Species 0.000 description 1
• 241000219828 Medicago truncatula Species 0.000 description 1
• 206010058780 Meningitis neonatal Diseases 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• 101001130841 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF5 Proteins 0.000 description 1
• 241001092142 Molina Species 0.000 description 1
• 102100036617 Monoacylglycerol lipase ABHD2 Human genes 0.000 description 1
• 101001059401 Moraxella bovis Type IV major alpha-pilin Proteins 0.000 description 1
• 241000588655 Moraxella catarrhalis Species 0.000 description 1
• 208000005647 Mumps Diseases 0.000 description 1
• 101100477497 Mus musculus Shcbp1 gene Proteins 0.000 description 1
• 102100038750 Myc-associated zinc finger protein Human genes 0.000 description 1
• 241000186359 Mycobacterium Species 0.000 description 1
• 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
• 241000204031 Mycoplasma Species 0.000 description 1
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
• 108700015872 N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Proteins 0.000 description 1
• PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical group CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 description 1
• 125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
• 108091061960 Naked DNA Proteins 0.000 description 1
• 241001644525 Nastus productus Species 0.000 description 1
• 241000588653 Neisseria Species 0.000 description 1
• 241001174901 Neisseria meningitidis alpha275 Species 0.000 description 1
• 241000921898 Neisseria meningitidis serogroup A Species 0.000 description 1
• 241000588677 Neisseria meningitidis serogroup B Species 0.000 description 1
• 241000947238 Neisseria meningitidis serogroup C Species 0.000 description 1
• 241001573069 Neisseria meningitidis serogroup Y Species 0.000 description 1
• 108700019961 Neoplasm Genes Proteins 0.000 description 1
• 102000048850 Neoplasm Genes Human genes 0.000 description 1
• 102000005348 Neuraminidase Human genes 0.000 description 1
• 108010006232 Neuraminidase Proteins 0.000 description 1
• 238000000636 Northern blotting Methods 0.000 description 1
• 241000714209 Norwalk virus Species 0.000 description 1
• 101710141454 Nucleoprotein Proteins 0.000 description 1
• 108010079246 OMPA outer membrane proteins Proteins 0.000 description 1
• RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
• KUGRPPRAQNPSQD-UHFFFAOYSA-N OOOOO Chemical compound OOOOO KUGRPPRAQNPSQD-UHFFFAOYSA-N 0.000 description 1
• YAVWDJDEOLOYQO-UHFFFAOYSA-N OOOOOOOOOO Chemical compound OOOOOOOOOO YAVWDJDEOLOYQO-UHFFFAOYSA-N 0.000 description 1
• RTYZCUMXOXNVSI-UHFFFAOYSA-N OOOOOOOOOOOOOOOOOO Chemical compound OOOOOOOOOOOOOOOOOO RTYZCUMXOXNVSI-UHFFFAOYSA-N 0.000 description 1
• RXJRSPBZRVRVLM-UHFFFAOYSA-N OOOOOOOOOOOOOOOOOOOOOOOOOO Chemical compound OOOOOOOOOOOOOOOOOOOOOOOOOO RXJRSPBZRVRVLM-UHFFFAOYSA-N 0.000 description 1
• 240000007594 Oryza sativa Species 0.000 description 1
• 235000007164 Oryza sativa Nutrition 0.000 description 1
• 108091081548 Palindromic sequence Proteins 0.000 description 1
• 241001631646 Papillomaviridae Species 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108010013639 Peptidoglycan Proteins 0.000 description 1
• 102100040283 Peptidyl-prolyl cis-trans isomerase B Human genes 0.000 description 1
• 108010020062 Peptidylprolyl Isomerase Proteins 0.000 description 1
• 108010081690 Pertussis Toxin Proteins 0.000 description 1
• 241000710778 Pestivirus Species 0.000 description 1
• 235000008577 Pinus radiata Nutrition 0.000 description 1
• 241000218621 Pinus radiata Species 0.000 description 1
• 101710183389 Pneumolysin Proteins 0.000 description 1
• 208000000474 Poliomyelitis Diseases 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 239000004372 Polyvinyl alcohol Substances 0.000 description 1
• 108010013381 Porins Proteins 0.000 description 1
• 241000605862 Porphyromonas gingivalis Species 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 241000350158 Prioria balsamifera Species 0.000 description 1
• 101710083689 Probable capsid protein Proteins 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 206010060862 Prostate cancer Diseases 0.000 description 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 101800004937 Protein C Proteins 0.000 description 1
• 102000017975 Protein C Human genes 0.000 description 1
• 101710188053 Protein D Proteins 0.000 description 1
• 241000125945 Protoparvovirus Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 206010037742 Rabies Diseases 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 102000018120 Recombinases Human genes 0.000 description 1
• 108010091086 Recombinases Proteins 0.000 description 1
• 101710132893 Resolvase Proteins 0.000 description 1
• 241000725643 Respiratory syncytial virus Species 0.000 description 1
• 101000974028 Rhizobium leguminosarum bv. viciae (strain 3841) Putative cystathionine beta-lyase Proteins 0.000 description 1
• 101000756519 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) Uncharacterized protein RCAP_rcc00048 Proteins 0.000 description 1
• 101000948219 Rhodococcus erythropolis Uncharacterized 11.5 kDa protein in thcD 3'region Proteins 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 241000710942 Ross River virus Species 0.000 description 1
• 241000702670 Rotavirus Species 0.000 description 1
• 239000012722 SDS sample buffer Substances 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 101800001700 Saposin-D Proteins 0.000 description 1
• 241000710961 Semliki Forest virus Species 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 208000019802 Sexually transmitted disease Diseases 0.000 description 1
• 101710084578 Short neurotoxin 1 Proteins 0.000 description 1
• 241000580858 Simian-Human immunodeficiency virus Species 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 241000362909 Smilax <beetle> Species 0.000 description 1
• 229920002125 Sokalan® Polymers 0.000 description 1
• 239000004147 Sorbitan trioleate Substances 0.000 description 1
• 238000002105 Southern blotting Methods 0.000 description 1
• 102000005782 Squalene Monooxygenase Human genes 0.000 description 1
• 108020003891 Squalene monooxygenase Proteins 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 101000936711 Streptococcus gordonii Accessory secretory protein Asp4 Proteins 0.000 description 1
• 241000193996 Streptococcus pyogenes Species 0.000 description 1
• 241001505901 Streptococcus sp. 'group A' Species 0.000 description 1
• 241000187434 Streptomyces cinnamonensis Species 0.000 description 1
• 101000929863 Streptomyces cinnamonensis Monensin polyketide synthase putative ketoacyl reductase Proteins 0.000 description 1
• 101000788468 Streptomyces coelicolor Uncharacterized protein in mprR 3'region Proteins 0.000 description 1
• 101000845085 Streptomyces violaceoruber Granaticin polyketide synthase putative ketoacyl reductase 1 Proteins 0.000 description 1
• 241000192584 Synechocystis Species 0.000 description 1
• 101000711771 Thiocystis violacea Uncharacterized 76.5 kDa protein in phbC 3'region Proteins 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• 241000710771 Tick-borne encephalitis virus Species 0.000 description 1
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 1
• 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
• 102100033117 Toll-like receptor 9 Human genes 0.000 description 1
• 101710182223 Toxin B Proteins 0.000 description 1
• 101710182532 Toxin a Proteins 0.000 description 1
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
• 239000013504 Triton X-100 Substances 0.000 description 1
• 229920004890 Triton X-100 Polymers 0.000 description 1
• 208000025609 Urogenital disease Diseases 0.000 description 1
• 241000710959 Venezuelan equine encephalitis virus Species 0.000 description 1
• 101000711318 Vibrio alginolyticus Uncharacterized 11.6 kDa protein in scrR 3'region Proteins 0.000 description 1
• 206010051511 Viral diarrhoea Diseases 0.000 description 1
• 201000006793 Walker-Warburg syndrome Diseases 0.000 description 1
• 241000710886 West Nile virus Species 0.000 description 1
• ZWELIJXAKMASLK-UGKPPGOTSA-N [(2r,3r,4r,5r)-4-acetyloxy-5-(5-amino-2-oxo-[1,3]thiazolo[4,5-d]pyrimidin-3-yl)-2-(hydroxymethyl)oxolan-3-yl] acetate Chemical compound CC(=O)O[C@@H]1[C@H](OC(=O)C)[C@@H](CO)O[C@H]1N1C(=O)SC2=CN=C(N)N=C21 ZWELIJXAKMASLK-UGKPPGOTSA-N 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 230000006978 adaptation Effects 0.000 description 1
• 230000000240 adjuvant effect Effects 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 125000003342 alkenyl group Chemical group 0.000 description 1
• 150000005215 alkyl ethers Chemical class 0.000 description 1
• 125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
• 230000004075 alteration Effects 0.000 description 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
• 239000004411 aluminium Substances 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 229910000329 aluminium sulfate Inorganic materials 0.000 description 1
• 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
• 239000001099 ammonium carbonate Substances 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
• 230000000845 anti-microbial effect Effects 0.000 description 1
• 230000000840 anti-viral effect Effects 0.000 description 1
• 238000010913 antigen-directed enzyme pro-drug therapy Methods 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 239000000074 antisense oligonucleotide Substances 0.000 description 1
• 238000012230 antisense oligonucleotides Methods 0.000 description 1
• 239000003443 antiviral agent Substances 0.000 description 1
• 230000006907 apoptotic process Effects 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 238000013528 artificial neural network Methods 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 229940091771 aspergillus fumigatus Drugs 0.000 description 1
• 229940065181 bacillus anthracis Drugs 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000000688 bacterial toxin Substances 0.000 description 1
• 241001609931 bacterium 20 Species 0.000 description 1
• 150000008366 benzophenones Chemical class 0.000 description 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
• 108091008324 binding proteins Proteins 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 239000012620 biological material Substances 0.000 description 1
• 238000010170 biological method Methods 0.000 description 1
• 210000003443 bladder cell Anatomy 0.000 description 1
• 238000006664 bond formation reaction Methods 0.000 description 1
• 108010006025 bovine growth hormone Proteins 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• KQNZDYYTLMIZCT-KQPMLPITSA-N brefeldin A Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](O)C[C@H]21 KQNZDYYTLMIZCT-KQPMLPITSA-N 0.000 description 1
• JUMGSHROWPPKFX-UHFFFAOYSA-N brefeldin-A Natural products CC1CCCC=CC2(C)CC(O)CC2(C)C(O)C=CC(=O)O1 JUMGSHROWPPKFX-UHFFFAOYSA-N 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 159000000007 calcium salts Chemical class 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• AXTGOJVKRHFYBT-UHFFFAOYSA-N causarine Natural products OC1C(O)CN2C(CO)C(O)C(O)C21 AXTGOJVKRHFYBT-UHFFFAOYSA-N 0.000 description 1
• 210000004970 cd4 cell Anatomy 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 239000006285 cell suspension Substances 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 230000007969 cellular immunity Effects 0.000 description 1
• 230000036755 cellular response Effects 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 210000003850 cellular structure Anatomy 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 230000005591 charge neutralization Effects 0.000 description 1
• SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 description 1
• 150000001841 cholesterols Chemical class 0.000 description 1
• 230000002759 chromosomal effect Effects 0.000 description 1
• 239000007979 citrate buffer Substances 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 201000006815 congenital muscular dystrophy Diseases 0.000 description 1
• 229940031670 conjugate vaccine Drugs 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 125000000753 cycloalkyl group Chemical group 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 229940104302 cytosine Drugs 0.000 description 1
• 230000002498 deadly effect Effects 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 231100000517 death Toxicity 0.000 description 1
• 239000008367 deionised water Substances 0.000 description 1
• 229940009976 deoxycholate Drugs 0.000 description 1
• KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 230000008021 deposition Effects 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 229960005097 diphtheria vaccines Drugs 0.000 description 1
• 229940042396 direct acting antivirals thiosemicarbazones Drugs 0.000 description 1
• 150000002016 disaccharides Chemical class 0.000 description 1
• 239000006196 drop Substances 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 235000013601 eggs Nutrition 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 229940032049 enterococcus faecalis Drugs 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 210000002615 epidermis Anatomy 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 238000011239 genetic vaccination Methods 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 239000004333 gold (food color) Substances 0.000 description 1
• 244000000058 gram-negative pathogen Species 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 239000001963 growth medium Substances 0.000 description 1
• 244000005709 gut microbiome Species 0.000 description 1
• 229940047650 haemophilus influenzae Drugs 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 230000013632 homeostatic process Effects 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 102000052285 human BRD3 Human genes 0.000 description 1
• 102000046661 human PECAM1 Human genes 0.000 description 1
• 229940124866 human papillomavirus vaccine Drugs 0.000 description 1
• 230000028996 humoral immune response Effects 0.000 description 1
• 230000004727 humoral immunity Effects 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 229960003160 hyaluronic acid Drugs 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 150000002431 hydrogen Chemical class 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 150000004679 hydroxides Chemical class 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 229940124669 imidazoquinoline Drugs 0.000 description 1
• 229960002751 imiquimod Drugs 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 238000003119 immunoblot Methods 0.000 description 1
• 230000002998 immunogenetic effect Effects 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 230000000091 immunopotentiator Effects 0.000 description 1
• 230000004957 immunoregulator effect Effects 0.000 description 1
• 239000003022 immunostimulating agent Substances 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 229960003971 influenza vaccine Drugs 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 238000011081 inoculation Methods 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 229940047124 interferons Drugs 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000010212 intracellular staining Methods 0.000 description 1
• 229940065638 intron a Drugs 0.000 description 1
• 229940029339 inulin Drugs 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 238000001155 isoelectric focusing Methods 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 150000002545 isoxazoles Chemical class 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229940062711 laureth-9 Drugs 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 229940115932 legionella pneumophila Drugs 0.000 description 1
• 230000021633 leukocyte mediated immunity Effects 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 230000029226 lipidation Effects 0.000 description 1
• 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 150000004668 long chain fatty acids Chemical class 0.000 description 1
• 230000005923 long-lasting effect Effects 0.000 description 1
• 229950005634 loxoribine Drugs 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 230000002101 lytic effect Effects 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 238000013507 mapping Methods 0.000 description 1
• 238000001819 mass spectrum Methods 0.000 description 1
• 230000008774 maternal effect Effects 0.000 description 1
• 229940041323 measles vaccine Drugs 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 210000004925 microvascular endothelial cell Anatomy 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 238000001823 molecular biology technique Methods 0.000 description 1
• 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
• ZLVYMPOQNJTFSG-QMMMGPOBSA-N monoiodotyrosine Chemical compound OC(=O)[C@@H](NI)CC1=CC=C(O)C=C1 ZLVYMPOQNJTFSG-QMMMGPOBSA-N 0.000 description 1
• 230000001459 mortal effect Effects 0.000 description 1
• 208000010805 mumps infectious disease Diseases 0.000 description 1
• 229940095293 mumps vaccine Drugs 0.000 description 1
• 208000025855 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 Diseases 0.000 description 1
• SCIFESDRCALIIM-UHFFFAOYSA-N n-methylphenylalanine Chemical compound CNC(C(O)=O)CC1=CC=CC=C1 SCIFESDRCALIIM-UHFFFAOYSA-N 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 239000007935 oral tablet Substances 0.000 description 1
• 229940096978 oral tablet Drugs 0.000 description 1
• 229960005030 other vaccine in atc Drugs 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 101150077062 pal gene Proteins 0.000 description 1
• 230000000849 parathyroid Effects 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 230000007918 pathogenicity Effects 0.000 description 1
• 108010021711 pertactin Proteins 0.000 description 1
• 238000002823 phage display Methods 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
• 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
• 150000008300 phosphoramidites Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 235000013550 pizza Nutrition 0.000 description 1
• 229940031999 pneumococcal conjugate vaccine Drugs 0.000 description 1
• ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
• 229960000502 poloxamer Drugs 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 239000002745 poly(ortho ester) Substances 0.000 description 1
• 229920001610 polycaprolactone Polymers 0.000 description 1
• 239000004632 polycaprolactone Substances 0.000 description 1
• 108010094020 polyglycine Proteins 0.000 description 1
• 229940051841 polyoxyethylene ether Drugs 0.000 description 1
• 229950008882 polysorbate Drugs 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 102000007739 porin activity proteins Human genes 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 229940002612 prodrug Drugs 0.000 description 1
• 239000000651 prodrug Substances 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
• 229960000856 protein c Drugs 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• 150000003233 pyrroles Chemical class 0.000 description 1
• HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
• 150000003235 pyrrolidines Chemical class 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
• 108010063589 raffinose synthase Proteins 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 239000011347 resin Substances 0.000 description 1
• 229920005989 resin Polymers 0.000 description 1
• 229950010550 resiquimod Drugs 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 201000005404 rubella Diseases 0.000 description 1
• 229960003131 rubella vaccine Drugs 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 239000013605 shuttle vector Substances 0.000 description 1
• 239000004332 silver Substances 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 239000000344 soap Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 235000019337 sorbitan trioleate Nutrition 0.000 description 1
• 229960000391 sorbitan trioleate Drugs 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 210000004989 spleen cell Anatomy 0.000 description 1
• 210000004988 splenocyte Anatomy 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 125000000547 substituted alkyl group Chemical group 0.000 description 1
• 229940031626 subunit vaccine Drugs 0.000 description 1
• 150000005846 sugar alcohols Chemical class 0.000 description 1
• 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 229960002766 tetanus vaccines Drugs 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
• 101150061964 tolA gene Proteins 0.000 description 1
• 101150014665 tolB gene Proteins 0.000 description 1
• 101150026694 tolQ gene Proteins 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 150000003918 triazines Chemical class 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
• 239000000439 tumor marker Substances 0.000 description 1
• 102000003390 tumor necrosis factor Human genes 0.000 description 1
• 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
• 238000005199 ultracentrifugation Methods 0.000 description 1
• 210000000689 upper leg Anatomy 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 229940021648 varicella vaccine Drugs 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1