NZ297256A - selective acylation of epsilon-amino groups - Google Patents

selective acylation of epsilon-amino groups

Info

Publication number
NZ297256A
NZ297256A NZ297256A NZ29725695A NZ297256A NZ 297256 A NZ297256 A NZ 297256A NZ 297256 A NZ297256 A NZ 297256A NZ 29725695 A NZ29725695 A NZ 29725695A NZ 297256 A NZ297256 A NZ 297256A
Authority
NZ
New Zealand
Prior art keywords
epsilon
amino group
amino groups
selective acylation
relates
Prior art date
Application number
NZ297256A
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Victor John Chen
Jose Michael Hanquier
Aidas Vladas Kriauciunas
Brian Allen Moser
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NZ297256A publication Critical patent/NZ297256A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ297256A 1994-11-17 1995-11-14 selective acylation of epsilon-amino groups NZ297256A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups
PCT/US1995/014872 WO1996015803A1 (en) 1994-11-17 1995-11-14 SELECTIVE ACYLATION OF ε-AMINO GROUPS

Publications (1)

Publication Number Publication Date
NZ297256A true NZ297256A (en) 2000-01-28

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ297256A NZ297256A (en) 1994-11-17 1995-11-14 selective acylation of epsilon-amino groups

Country Status (27)

Country Link
US (2) US5646242A (forum.php)
EP (2) EP1227107A1 (forum.php)
JP (1) JP4312828B2 (forum.php)
CN (1) CN1171742A (forum.php)
AR (1) AR003915A1 (forum.php)
AT (1) ATE328902T1 (forum.php)
AU (2) AU691066B2 (forum.php)
BR (1) BR9509652A (forum.php)
CA (1) CA2205061A1 (forum.php)
CO (1) CO4520285A1 (forum.php)
CZ (1) CZ287731B6 (forum.php)
DE (1) DE69535031T2 (forum.php)
DK (1) DK0712862T3 (forum.php)
ES (1) ES2264124T3 (forum.php)
HU (2) HU217585B (forum.php)
IL (1) IL115972A (forum.php)
IN (1) IN179820B (forum.php)
NO (1) NO972185D0 (forum.php)
NZ (1) NZ297256A (forum.php)
PL (1) PL320556A1 (forum.php)
PT (1) PT712862E (forum.php)
RU (1) RU2155773C2 (forum.php)
SI (1) SI0712862T1 (forum.php)
TR (1) TR199501421A2 (forum.php)
WO (1) WO1996015803A1 (forum.php)
YU (1) YU71495A (forum.php)
ZA (1) ZA959680B (forum.php)

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US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US20030082671A1 (en) * 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
US7595172B2 (en) 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
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US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
DK1430082T3 (da) 2001-09-07 2010-01-18 Biocon Ltd Fremgangsmåde til syntese af insulinpolypeptid-oligomer-konjugater og proinsulinpolypeptid-oligomerkonjugater samt fremgangsmåde til syntese deraf
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
BR0314289B8 (pt) * 2002-09-25 2021-07-27 Novo Nordisk As método para produzir um peptídeo n-acilado
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
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WO2005047508A1 (en) 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
NO345613B1 (no) 2004-07-19 2021-05-10 Biocon Ltd Insulinoligomerkonjugater, formuleringer og bruk derav
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ES2371361T3 (es) * 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
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CN101677947B (zh) 2007-06-13 2013-07-17 诺沃-诺迪斯克有限公司 包含胰岛素衍生物的药物制剂
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JP5422003B2 (ja) * 2009-02-20 2014-02-19 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ ３４位にプロリン置換を有する神経ペプチドｙの類似体
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JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
US10724025B2 (en) * 2016-05-05 2020-07-28 Codexis, Inc. Penicillin-G acylases
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Also Published As

Publication number Publication date
PT712862E (pt) 2006-08-31
AR003915A1 (es) 1998-09-30
IL115972A (en) 2000-09-28
USRE37971E1 (en) 2003-01-28
CO4520285A1 (es) 1997-10-15
MX9703506A (es) 1997-07-31
CZ287731B6 (en) 2001-01-17
ATE328902T1 (de) 2006-06-15
NO972185L (no) 1997-05-13
CN1171742A (zh) 1998-01-28
AU691066B2 (en) 1998-05-07
HUT77737A (hu) 1998-07-28
WO1996015803A1 (en) 1996-05-30
NO972185D0 (no) 1997-05-13
EP1227107A1 (en) 2002-07-31
EP0712862A2 (en) 1996-05-22
AU7885498A (en) 1998-11-05
HK1014007A1 (en) 1999-09-17
CA2205061A1 (en) 1996-05-30
AU720820B2 (en) 2000-06-15
SI0712862T1 (sl) 2006-10-31
EP0712862A3 (en) 1998-03-04
BR9509652A (pt) 1997-09-16
CZ145697A3 (en) 1997-12-17
HU217585B (hu) 2000-02-28
DE69535031T2 (de) 2006-12-28
TR199501421A2 (tr) 1996-06-21
HU9903007D0 (en) 1999-11-29
US5646242A (en) 1997-07-08
ES2264124T3 (es) 2006-12-16
RU2155773C2 (ru) 2000-09-10
PL320556A1 (en) 1997-10-13
JPH10509176A (ja) 1998-09-08
AU4237296A (en) 1996-06-17
YU71495A (sh) 1998-09-18
DE69535031D1 (de) 2006-07-20
IL115972A0 (en) 1996-01-31
DK0712862T3 (da) 2006-09-25
ZA959680B (en) 1997-05-14
JP4312828B2 (ja) 2009-08-12
EP0712862B1 (en) 2006-06-07
IN179820B (forum.php) 1997-12-13

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