AR003915A1 - Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre - Google Patents

Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre

Info

Publication number
AR003915A1
AR003915A1 ARP950100165A AR10016595A AR003915A1 AR 003915 A1 AR003915 A1 AR 003915A1 AR P950100165 A ARP950100165 A AR P950100165A AR 10016595 A AR10016595 A AR 10016595A AR 003915 A1 AR003915 A1 AR 003915A1
Authority
AR
Argentina
Prior art keywords
amino group
insulin
free
proinsulin
epsilon
Prior art date
Application number
ARP950100165A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR003915A1 publication Critical patent/AR003915A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ARP950100165A 1994-11-17 1995-11-14 Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre AR003915A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
AR003915A1 true AR003915A1 (es) 1998-09-30

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100165A AR003915A1 (es) 1994-11-17 1995-11-14 Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre

Country Status (27)

Country Link
US (2) US5646242A (forum.php)
EP (2) EP1227107A1 (forum.php)
JP (1) JP4312828B2 (forum.php)
CN (1) CN1171742A (forum.php)
AR (1) AR003915A1 (forum.php)
AT (1) ATE328902T1 (forum.php)
AU (2) AU691066B2 (forum.php)
BR (1) BR9509652A (forum.php)
CA (1) CA2205061A1 (forum.php)
CO (1) CO4520285A1 (forum.php)
CZ (1) CZ287731B6 (forum.php)
DE (1) DE69535031T2 (forum.php)
DK (1) DK0712862T3 (forum.php)
ES (1) ES2264124T3 (forum.php)
HU (2) HU9903007D0 (forum.php)
IL (1) IL115972A (forum.php)
IN (1) IN179820B (forum.php)
NO (1) NO972185D0 (forum.php)
NZ (1) NZ297256A (forum.php)
PL (1) PL320556A1 (forum.php)
PT (1) PT712862E (forum.php)
RU (1) RU2155773C2 (forum.php)
SI (1) SI0712862T1 (forum.php)
TR (1) TR199501421A2 (forum.php)
WO (1) WO1996015803A1 (forum.php)
YU (1) YU71495A (forum.php)
ZA (1) ZA959680B (forum.php)

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KR101159559B1 (ko) * 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
RU2393168C2 (ru) 2004-07-19 2010-06-27 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
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JP6199956B2 (ja) 2012-04-11 2017-09-20 ノヴォ ノルディスク アー／エス インスリン製剤
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SI3055325T1 (en) 2013-10-07 2018-05-31 Novo Nordisk A/S NEW DERIVATIVE ANALOGUE INSULINE
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CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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Also Published As

Publication number Publication date
DE69535031T2 (de) 2006-12-28
AU720820B2 (en) 2000-06-15
AU4237296A (en) 1996-06-17
CO4520285A1 (es) 1997-10-15
HU9903007D0 (en) 1999-11-29
ATE328902T1 (de) 2006-06-15
ZA959680B (en) 1997-05-14
HK1014007A1 (en) 1999-09-17
WO1996015803A1 (en) 1996-05-30
ES2264124T3 (es) 2006-12-16
JPH10509176A (ja) 1998-09-08
IL115972A0 (en) 1996-01-31
CN1171742A (zh) 1998-01-28
MX9703506A (es) 1997-07-31
NO972185L (no) 1997-05-13
IN179820B (forum.php) 1997-12-13
CZ287731B6 (en) 2001-01-17
PT712862E (pt) 2006-08-31
US5646242A (en) 1997-07-08
AU691066B2 (en) 1998-05-07
DK0712862T3 (da) 2006-09-25
USRE37971E1 (en) 2003-01-28
NO972185D0 (no) 1997-05-13
JP4312828B2 (ja) 2009-08-12
NZ297256A (en) 2000-01-28
HU217585B (hu) 2000-02-28
HUT77737A (hu) 1998-07-28
IL115972A (en) 2000-09-28
RU2155773C2 (ru) 2000-09-10
EP0712862A2 (en) 1996-05-22
EP0712862A3 (en) 1998-03-04
PL320556A1 (en) 1997-10-13
EP0712862B1 (en) 2006-06-07
DE69535031D1 (de) 2006-07-20
AU7885498A (en) 1998-11-05
YU71495A (sh) 1998-09-18
BR9509652A (pt) 1997-09-16
TR199501421A2 (tr) 1996-06-21
CZ145697A3 (en) 1997-12-17
EP1227107A1 (en) 2002-07-31
CA2205061A1 (en) 1996-05-30
SI0712862T1 (sl) 2006-10-31

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