ES8401448A1 - Procedimiento para la preparacion de insulinas a partir de compuestos analogos a preproinsulina. - Google Patents

Procedimiento para la preparacion de insulinas a partir de compuestos analogos a preproinsulina.

Info

Publication number
ES8401448A1
ES8401448A1 ES520493A ES520493A ES8401448A1 ES 8401448 A1 ES8401448 A1 ES 8401448A1 ES 520493 A ES520493 A ES 520493A ES 520493 A ES520493 A ES 520493A ES 8401448 A1 ES8401448 A1 ES 8401448A1
Authority
ES
Spain
Prior art keywords
insulins
preproinsulin
analogues
conversion
trypsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520493A
Other languages
English (en)
Other versions
ES520493A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES520493A0 publication Critical patent/ES520493A0/es
Publication of ES8401448A1 publication Critical patent/ES8401448A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE INSULINAS A PARTIR DE COMPUESTOS ANALOGOS A PREPROINSULINA.SE HACEN REACCIONAR COMPUESTOS ANALOGOS A PREPROINSULINAS A UN VALOR DEL PH POR DEBAJO DEL PUNTO ISOELECTRI CO DE LAS INSULINAS, ENTRE 3,8 Y 5,5, EN PRESENCIA DE TRIPSINA O DE UNA ENZIMA O UNA ENDOPEPTIDASA SIMILAR A LA TRIPSINA, CON UN ESTER DE AMINOACIDOS NATURALES O CON LOS DERIVADOS DE DICHO ESTER, TALES COMO ALA-OTBU O THR (TBU)OTBU, Y DESPUES DE ELLO SE SEPARA EL GRUPO ESTER Y OTROS GRUPOS PROTECTORES EVENTUALMENTE PRESENTES. LA PROPORCION DE ENZIMA ASUSTRATO ES DE 1:1 A 1:100 PARTES EN PESO; SE UTILIZA UN EXCESO DE 50 A 500 VECES LA CANTIDAD EQUIMOLAR DE ESTER DE AMINOACIDO O DE SU DERIVADO; Y LA TEMPERATURA DE REACCION ESTA ENTRE 2JC Y 37JC.DE APLICACION COMO MEDICAMENTO PARA EL TRATAMIENTO DE LA DIABETES MELLITUS.
ES520493A 1982-03-13 1983-03-11 Procedimiento para la preparacion de insulinas a partir de compuestos analogos a preproinsulina. Expired ES8401448A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823209184 DE3209184A1 (de) 1982-03-13 1982-03-13 Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen

Publications (2)

Publication Number Publication Date
ES520493A0 ES520493A0 (es) 1983-12-16
ES8401448A1 true ES8401448A1 (es) 1983-12-16

Family

ID=6158163

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520493A Expired ES8401448A1 (es) 1982-03-13 1983-03-11 Procedimiento para la preparacion de insulinas a partir de compuestos analogos a preproinsulina.

Country Status (15)

Country Link
US (1) US4639333A (es)
EP (1) EP0089007B1 (es)
JP (1) JPS58190398A (es)
KR (1) KR900003502B1 (es)
AT (1) ATE21118T1 (es)
AU (1) AU553832B2 (es)
CA (1) CA1195273A (es)
DE (2) DE3209184A1 (es)
DK (1) DK154573C (es)
ES (1) ES8401448A1 (es)
FI (1) FI79117C (es)
GR (1) GR78453B (es)
IE (1) IE54605B1 (es)
IL (1) IL68103A (es)
ZA (1) ZA831693B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
US4569791A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4569792A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4581165A (en) * 1984-06-14 1986-04-08 Eli Lilly And Company Anti-diabetic compounds
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
NZ223630A (en) * 1987-02-25 1989-11-28 Novo Industri As Insulin derivative and pharmaceutical compositions
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
NZ239652A (en) * 1990-09-05 1992-09-25 Hoechst Ag Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
RU2458989C1 (ru) 2008-08-07 2012-08-20 Байокон Лимитид Способ получения аналогов инсулина из их соответствующих предшественников (варианты)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
GB1426061A (en) * 1972-12-28 1976-02-25 Ici Ltd Polypeptides
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
PH16156A (en) * 1980-03-27 1983-07-18 Lilly Co Eli Process for producing an insulin precursor
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

Also Published As

Publication number Publication date
DK117883A (da) 1983-09-14
ZA831693B (en) 1983-11-30
JPH0536034B2 (es) 1993-05-28
IE830529L (en) 1983-09-13
CA1195273A (en) 1985-10-15
AU553832B2 (en) 1986-07-31
FI830813L (fi) 1983-09-14
FI830813A0 (fi) 1983-03-10
ATE21118T1 (de) 1986-08-15
FI79117B (fi) 1989-07-31
ES520493A0 (es) 1983-12-16
EP0089007A1 (de) 1983-09-21
US4639333A (en) 1987-01-27
AU1242883A (en) 1983-09-15
FI79117C (fi) 1989-11-10
KR900003502B1 (ko) 1990-05-21
DK154573C (da) 1989-05-22
DE3364838D1 (en) 1986-09-04
KR840004169A (ko) 1984-10-10
IE54605B1 (en) 1989-12-06
DK154573B (da) 1988-11-28
GR78453B (es) 1984-09-27
JPS58190398A (ja) 1983-11-07
IL68103A (en) 1986-01-31
IL68103A0 (en) 1983-06-15
EP0089007B1 (de) 1986-07-30
DE3209184A1 (de) 1983-09-15
DK117883D0 (da) 1983-03-11

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